Prevention of UVB-induced skin inflammation, genotoxicity, and photocarcinogenesis in mice by WHI-P131, a dual-function inhibitor of Janus kinase 3 and EGF receptor kinase

Arzneimittel-Forschung/Drug Research

Volumn 60, Issue 4, 2010, Pages 218-225

  Uckun, Fatih M ^a,b,c   Dibirdik, Ilker ^c   Qazi, Sanjive ^d  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c PARKER HUGHES INSTITUTE   (United States)

^d GUSTAVUS ADOLPHUS COLLEGE   (United States)

Author keywords

CAS 202475 60 3; JAK3 tyrosine kinase inhibitor; Non melanoma skin cancer, chemoprevention; Photocarcinogenesis; WHI P131

Indexed keywords

4 (4 HYDROXYANILINO) 6,7 DIMETHOXYQUINAZOLINE; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; JANUS KINASE 3;

ACTINIC KERATOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; FEMALE; GENOTOXICITY; LONG TERM EXPOSURE; MALE; MOUSE; NONHUMAN; PHOTOCARCINOGENESIS; RADIATION EXPOSURE; SKIN INFLAMMATION; SKINFOLD THICKNESS; SQUAMOUS CELL CARCINOMA; SUNBURN; TRANSGENE; TUMOR VOLUME; ULTRAVIOLET B RADIATION;

EID: 77951713751     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296276     Document Type: Article

References (42)

1. Marks R. An overview of skin cancers: incidence and causation. Cancer 1995; 75:607-612.
2. Miller DL, Weinstock MA. Non-melanoma skin cancer in the United States: Incidence. J Am Acad Dermatol. 1994;30:774-776.
3. Leffell DJ, Carucci JA. Management of skin cancer. In: De-Vita VT Jr, Hellman S, Rosenberg SA, editors. Cancer: Principles and Practice of Oncology. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 1976-1998.
4. Uckun FM, Vassilev A, Dibirdik I, Tibbles H. Targeting JAK3 tyrosine kinase-linked signal transduction pathways with rationally designed inhibitors. Anticancer Agents Med Chem. 2007;7:612-623 (Pubitemid 350237766)
5. Uckun FM, Tibbles H, Ozer Z, Qazi S, Vassilev A. Anti-inflammatory activity profile of JANEX-1 in preclinical animal models. Bioorg Med Chem. 2008;16:1287-1298 (Pubitemid 351191774)
6. Malaviya R, Zhu D, Dibirdik I, Uckun FM. Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis. J Biol Chem. 1999;274:27028-27038 (Pubitemid 129520227)
7. Goodman PA, Niehoff LB, Uckun FM. Role of tyrosine kinases in induction of the c-jun proto-oncogene in irradiated B-lineage lymphoid cells. J Biol Chem 1998;273:17742-17748.
8. Liu YP, Tan YN, Wang ZL, Zeng L, Lu ZX, Li LL, et al. Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. Int J Mol Med. 2008;21:153-162 (Pubitemid 351222848)
9. Scharfe N, Dadi HK, Roifman CM. JAK3 protein tyrosine kinase mediates interleukin-7 induced activation of phosphatidylinositol-3 kinase. Blood 1995;86:2077-2085.
10. Suiqing C, Min Z, Lirong C. Overexpression of phosphorylated STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinoma. J Dermatol 2005;32:354-360 (Pubitemid 40874460)
11. Welss T, Papoutsaki M, Michel G, Reifenberger J, Chimenti S, Ruzicka T, et al. Molecular basis of basal cell carcinoma: analysis of differential gene expression by differential display PCR and expression array. Int J Cancer 2003;10:66-72. (Pubitemid 36184148)
12. Serewko MM, Popa C, Dahler AL, Smith L, Strutton GM, Coman W, et al. Alterations in gene expression and activity during squamous cell carcinoma development. Cancer Res 2002;62:3759-3765 (Pubitemid 34728858)
13. Kim AL, Athar M, Bickers DR, Gautier J. Stage-specific alterations of cyclin expression during UVB-induced murine skin tumor development. Photochem Photobiol. 2002;75:58-67.
14. Robles AI, Rodriguez-Puebla ML, Glick AB, Trempus C, Hansen L, Sicinski P, et al. Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. Genes Dev. 1998;12:2469-2474 (Pubitemid 28406950)
15. Sauter ER, Nesbit M, Litwin S, Klein-Szanto AJ, Cheffetz S, Herlyn M. Antisense cyclin D1 induces apoptosis and tumor shrinkage in human squamous carcinomas. Cancer Res. 1999;59:4876-4881 (Pubitemid 29472891)
16. Hsu TC, Young MR, Cmarik J, Colburn NH. Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis. Free Radic Biol Med. 2000;28:1338-1348 (Pubitemid 30621478)
17. Leslie K, Lang C, Devgan G, Azare J, Berishaj M, Gerald W, et al. Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res. 2006;66:2544-2552.
18. Sudbeck EA, Liu X, Narla RK, Mahajan S, Ghosh S, Mao C, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999;5:1569-1582 (Pubitemid 29282966)
19. Cetkovic-Cvrlje M, Roers BA, Waurzyniak B, Liu XP, Uckun FM. Targeting Janus kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibiloity barrier in mice. Blood. 2001;98:1607-1613.
20. Cetkovic-Cvrlje M, Dragt AL, Vassilev A, Liu XP, Uckun FM. Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice. Clin Immunol. 2003;106:213-225 (Pubitemid 36428993)
21. Lin Q, Lai R, Chirieac LR, Li C, Thomazy VA, Grammatikakis I, et al. Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines. Inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am J Pathol. 2005;167:969-980.
22. Amin HM, Medeiros LJ, Ma Y, Feretzaki M, Das P, Leventaki V, et al. Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma. Oncogene. 2003;22:5399-5407 (Pubitemid 37072194)
23. Hu W, Zhang C, Zhang P, Wei D, Zhao Z, Cai M. Inhibition of constitutively activated JAK3 and induction of apoptosis in NALM-6 cell line. Hua Xi Yi Ke Da Xue Bao. 2002;33:25-27.
24. Uckun FM, Erbeck D, Qazi S, Venkatachalam T, Tibbles HE, Vassilev A. Effect of targeting Janus Kinase 3 on the development of intestinal tumors in the adenomatous polyposis coli (min) mouse model of familial adenomatous polyposis. Nutr Cancer. Forthcoming 2010.
25. Nosaka T, van Deursen JM, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, et al. Defective lymphoid development in mice lacking Jak3. Science. 1995;270:800-802.
26. Jakubczak JL, Merlino G, French JE, Muller WJ, Paul B, Adhya S, et al. Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivomutations in a bacteriophage lambda transgene target. Proc Natl Acad Sci U S A. 1996;93: 9073-9078 (Pubitemid 26282020)
27. Morris RJ, Tacker KC, Baldwin JK, Fischer SM, Slaga TJ. A new medium for primary cultures of adult murine epidermal cells: application to experimental carcinogenesis. Cancer Lett. 1987;34:297-304.
28. Kligman LH, Akin FJ, Kligman AM. Prevention of ultraviolet damage to the dermis of hairless mice by sunscreens. J Invest Dermatol. 1982;78:181-189.
29. Learn DB, Beasley DG, Giddens LD, Beard J, Stanfield JW, Roberts LK. Minimum doses of ultraviolet radiation required to induce murine skin edema and immunosuppression are different and depend on the ultraviolet emission spectrum of the source. Photochem Photobiol. 1995;62:1066-1075.
30. Uckun FM, Ek O, Liu XP, Chen CL. In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131[4-(4′hydroxyphenyl)- amino-6,7-dimethoxyquinazoline. Clin Cancer Res. 1999;5:2954-2962.
31. Narla RK, Liu X, Klis D, Uckun FM. Inhibition of human glioblastoma cell adhesion and invasion by 4-(4′-hydroxylphenyl)-amino-6,7- dimethoxyquinazoline (WHI-P131) and 4-(3′-bromo-4′-hydroxylphenyl)- amino-6,7-dimethoxyquinazoline (WHI-P154). Clin Cancer Res. 1998;4:2463-2471 (Pubitemid 28477913)
32. Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 2004;4:71-78.
33. Coussens LM, Raymond WW, Bergers G, Laig-Webster M, Behrendtsen O, Werb Z, et al. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev. 1999;13:1382-1397 (Pubitemid 29270244)
34. Ardestani SK, Inserra P, Solkoff D, Watson RR. The role of cytokines and chemokines on tumor progression: a review. Cancer Detect Prev. 1999;23:215-225 (Pubitemid 29233606)
35. Fitzpatrick FA. Inflammation, carcinogenesis and cancer. Int Immunopharmacol. 2001;1:1651-1667.
36. Li WQ, Dehnade F, Zafarullah M. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. J Immunol. 2001;166:3491-3498 (Pubitemid 33117353)
37. Kim S, Kim Y, Lee Y, Chung JH. Ceramide accelerates ultraviolet-induced MMP-1 expression through JAK/STAT pathway in cultured human dermal fibroblasts. J Lipid Res. 2008;49:2571-2581.
38. Kang-Rotondo CH, Miller CC, Morrison AR, Pentland AP. Enhanced keratinocyte prostaglandin synthesis after UV injury is due to increased phospholipase activity. Am J Physiol. 1993;264:C396-401.
39. An KP, Athar M, Tang X, Katiyar SK, Russo J, Beech J, et al. Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. Photochem Photobiol. 2002;76:73-80.
40. Rundhaug JE, Fischer SM. Cyclooxygenase 2 plays a critical role in UV induced skin carcinogenesis. Photochem Photobiol. 2008;84:322-329.
41. El-Abaseri TB, Putta S, Hansen LA. Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor. Carcinogenesis. 2006;27:225-231 (Pubitemid 43159873)
42. Cooper SJ, Bowden GT. Ultraviolet B regulation of transcription factor families: roles of nuclear factor kappa B (NFkB) and activator protein-1 (AP-1) in UVB-induced skin carcinogenesis. Curr Cancer Drug Targets. 2007;7:325-334.