Inhibition of Constitutively Activated Jak3 and Induction of Apoptosis in NALM-6 Cell Line

Journal of West China University of Medical Sciences

Volumn 33, Issue 1, 2002, Pages 25-27

  Hu, Weimin ^a   Zhang, Chongjie ^a   Zhang, Ping ^a   Wei, Dapong ^a   Zhao, Zongrong ^a   Cai, Meiying ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Acute lymphoblastic leukemia; AG490; Apoptosis; Jak3; NALM 6 cell line

Indexed keywords

ANTINEOPLASTIC AGENT; JAK3 PROTEIN, HUMAN; JANUS KINASE 3; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN TYROSINE KINASE; TYRPHOSTIN; TYRPHOSTIN AG-490;

ACUTE LYMPHOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; B CELL LEUKEMIA; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; PATHOLOGY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; HUMANS; JANUS KINASE 3; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, PRE-B-CELL; PROTEIN-TYROSINE KINASES; TUMOR CELLS, CULTURED; TYRPHOSTINS;

EID: 0038543368     PISSN: 02577712     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Sakai I, Kraft AS. The kinase domain of Jak2 mediates induction of Bcl-2 and delays cell death in hematopoietic cells. J Biol Chem, 1997; 272(19): 12350
2. Nieborowska-Skorska M, Wasik MA, Slupianek A, et al. Signal transducer and activator of transcription (STAT) 5 activation by BCR/ABL and is required for leukemogenesis. J Exp Med, 1999; 189(8): 1229
3. Wang LH, Kirken RA, Erwin RA, et al. JAK3 as novel molecular targets for the tyrphostin AG490 regulation of IL-2-mediated T cell response. J Immunol, 1999; 1629(7): 3897
4. Meydan N, Grunberger T, Dadi H, et al. Inhibition of acute lymphoblastic leukemia by a Jak-2 inhibitor. Nature, 1996; 379 (6566): 645