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Volumn 7, Issue 2, 2010, Pages 125-135

Sublethal total body irradiation leads to early cerebellar damage and oxidative stress

Author keywords

Calcium; Cerebellum; Inflammatory response; Oxidative stress; Purkinje cell; Sublethal radiation

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIOLOGICAL MARKER; CALBINDIN; CALCIUM; CD28 ANTIGEN; CD45 ANTIGEN; MALONALDEHYDE; PROTEIN P53; VASCULOTROPIN RECEPTOR 2; VESICULAR GLUTAMATE TRANSPORTER 2;

EID: 77951700591     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720210791184880     Document Type: Article
Times cited : (25)

References (48)
  • 2
    • 0029011907 scopus 로고
    • Encephalopathy with parkinsonian features in children following bone marrow transplantations and high-dose amphotericin B
    • Mott SH, Packer RJ, Vezina LG, et al. Encephalopathy with parkinsonian features in children following bone marrow transplantations and high-dose amphotericin B. Ann Neurol 1995; 37(6): 810-814
    • (1995) Ann Neurol , vol.37 , Issue.6 , pp. 810-814
    • Mott, S.H.1    Packer, R.J.2    Vezina, L.G.3
  • 3
    • 34249683231 scopus 로고    scopus 로고
    • Sensitivity of cerebellar glutathione system to neonatal ionizing radiation exposure
    • Di Toro CG, Di Toro PA, Zieher LM, Guelman LR. Sensitivity of cerebellar glutathione system to neonatal ionizing radiation exposure. Neurotoxicology 2007; 28(3): 555-561
    • (2007) Neurotoxicology , vol.28 , Issue.3 , pp. 555-561
    • Di Toro, C.G.1    Di Toro, P.A.2    Zieher, L.M.3    Guelman, L.R.4
  • 4
    • 36348993683 scopus 로고    scopus 로고
    • The effect of damage to the cerebellum on sensorimotor and cognitive function in children and adolescents
    • DOI 10.1016/j.neubiorev.2007.04.014, PII S0149763407000504, Lesions in the Developing Nervous System: Theoretical Cinsiderations, Early Detection and Perspectives for Tratment
    • Konczak J, Timmann D. The effect of damage to the cerebellum on sensorimotor and cognitive function in children and adolescents. Neurosci Biobehav Rev 2007; 31(8): 1101-1113 (Pubitemid 350160946)
    • (2007) Neuroscience and Biobehavioral Reviews , vol.31 , Issue.8 , pp. 1101-1113
    • Konczak, J.1    Timmann, D.2
  • 5
    • 0017340378 scopus 로고
    • Effects of low level X irradiation on cat cerebella at different postnatal intervals. II. Changes in purkinje cell morphology
    • DOI 10.1002/cne.901710104
    • Anderson WJ, Stromberg MW. Effects of low-level x-irradiation on cat cerebella at different postnatal intervals. II. Changes in Purkinje cell morphology. J Comp Neurol 1977; 171(1): 39-50. (Pubitemid 8008571)
    • (1977) Journal of Comparative Neurology , vol.171 , Issue.1 , pp. 39-50
    • Anderson, W.J.1    Stromberg, M.W.2
  • 6
    • 33846427416 scopus 로고    scopus 로고
    • α-Lipoic acid attenuates x-irradiation-induced oxidative stress in mice
    • DOI 10.1007/s10565-006-0137-6
    • Manda K, Ueno M, Moritake T, Anzai K. α-Lipoic acid attenuates x-irradiation-induced oxidative stress in mice. Cell Biol Toxicol 2007a; 23(2): 129-137 (Pubitemid 46147191)
    • (2007) Cell Biology and Toxicology , vol.23 , Issue.2 , pp. 129-137
    • Manda, K.1    Ueno, M.2    Moritake, T.3    Anzai, K.4
  • 7
    • 33845973382 scopus 로고    scopus 로고
    • Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: Protective effect of alpha-lipoic acid
    • DOI 10.1016/j.bbr.2006.11.013, PII S016643280600622X
    • Manda K, Ueno M, Moritake T, Anzai K. Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: protective effect of alpha-lipoic acid. Behav Brain Res 2007b; 177(1): 7-14. (Pubitemid 46054202)
    • (2007) Behavioural Brain Research , vol.177 , Issue.1 , pp. 7-14
    • Manda, K.1    Ueno, M.2    Moritake, T.3    Anzai, K.4
  • 8
    • 39149135821 scopus 로고    scopus 로고
    • 56Fe particle irradiation
    • DOI 10.1111/j.1600-079X.2007.00507.x
    • Manda K, Ueno M, Anzai K. Melatonin mitigates oxidative damage and apoptosis in mouse cerebellum induced by high-LET 56Fe particle irradiation. J Pineal Res 2008a; 44(2): 189-196 (Pubitemid 351252922)
    • (2008) Journal of Pineal Research , vol.44 , Issue.2 , pp. 189-196
    • Manda, K.1    Ueno, M.2    Anzai, K.3
  • 9
    • 38049055711 scopus 로고    scopus 로고
    • Memory impairment, oxidative damage and apoptosis induced by space radiation: Ameliorative potential of alpha-lipoic acid
    • Manda K, Ueno M, Anzai K. Memory impairment, oxidative damage and apoptosis induced by space radiation: ameliorative potential of alpha-lipoic acid. Behav Brain Res 2008b; 187(2): 387-395
    • (2008) Behav Brain Res , vol.187 , Issue.2 , pp. 387-395
    • Manda, K.1    Ueno, M.2    Anzai, K.3
  • 10
    • 0035180676 scopus 로고    scopus 로고
    • Radiation-induced apoptosis of oligodendrocytes in the adult rat brain
    • DOI 10.1179/016164101101199324
    • Kurita H, Kawahara N, Asai A, Ueki K, Shin M, Kirino T. Radiation-induced apoptosis of oligodendrocytes in the adult rat brain. Neurol Res 2001; 23(8): 869-874 (Pubitemid 33096909)
    • (2001) Neurological Research , vol.23 , Issue.8 , pp. 869-874
    • Kurita, H.1    Kawahara, N.2    Asai, A.3    Ueki, K.4    Shin, M.5    Kirino, T.6
  • 12
    • 0024582837 scopus 로고
    • 400 protein characteristic of Purkinje cells in the mouse cerebellum
    • DOI 10.1016/0012-1606(89)90297-2
    • Maeda N, Niinobe M, Inoue Y, Mikoshiba K. Developmental expression and intracellular location of P400 protein characteristic of Purkinje cells in the mouse cerebellum. Dev Biol 1989; 133(1): 67-76. (Pubitemid 19118474)
    • (1989) Developmental Biology , vol.133 , Issue.1 , pp. 67-76
    • Maeda, N.1    Niinobe, M.2    Inoue, Y.3    Mikoshiba, K.4
  • 13
    • 0025092047 scopus 로고
    • A cerebellar Purkinje cell marker P400 protein is an inositol 1,4,5-trisphosphate (InsP3) receptor protein. Purification and characterization of InsP3 receptor complex
    • Maeda N, Niinobe M, Mikoshiba K. A cerebellar Purkinje cell marker P400 protein is an inositol 1,4,5-trisphosphate (InsP3) receptor protein. Purification and characterization of InsP3 receptor complex. EMBO J 1990; 9(1): 61-67
    • (1990) EMBO J , vol.9 , Issue.1 , pp. 61-67
    • Maeda, N.1    Niinobe, M.2    Mikoshiba, K.3
  • 14
    • 0024263699 scopus 로고
    • cDNA cloning and characterization of three genes uniquely expressed in cerebellum by Purkinje neurons
    • Nordquist DT, Kozak CA, Orr HT. cDNA cloning and characterization of three genes uniquely expressed in cerebellum by Purkinje neurons. J Neurosci 1988; 8(12): 4780-4789
    • (1988) J Neurosci , vol.8 , Issue.12 , pp. 4780-4789
    • Nordquist, D.T.1    Kozak, C.A.2    Orr, H.T.3
  • 15
    • 0027447304 scopus 로고
    • Calcium-binding proteins: Selective markers of nerve cells
    • Andressen C, Blumcke I, Celio MR. Calcium-binding proteins: selective markers of nerve cells. Cell Tissue Res 1993; 271(2): 181-208. (Pubitemid 23077890)
    • (1993) Cell and Tissue Research , vol.271 , Issue.2 , pp. 181-208
    • Andressen, C.1    Blumcke, I.2    Celio, M.R.3
  • 16
    • 0025358573 scopus 로고
    • Calbindin D-28k and parvalbumin in the rat nervous system
    • DOI 10.1016/0306-4522(90)90091-H
    • Celio MR. Calbindin D-28k and parvalbumin in the rat nervous system. Neuroscience 1990; 35(2): 375-475. (Pubitemid 20176750)
    • (1990) Neuroscience , vol.35 , Issue.2 , pp. 375-475
    • Celio, M.R.1
  • 17
    • 0024528673 scopus 로고
    • Inhibition of free radical processes by antioxidants - Tryptophan and 5-hydroxytryptophan
    • Simic MG, al-Sheikhly M, Jovanovic SV. Inhibition of free radical processes by antioxidants - tryptophan and 5-hydroxytryptophan. Bibl Nutr Diet 1989(43): 288-296
    • (1989) Bibl Nutr Diet , Issue.43 , pp. 288-296
    • Simic, M.G.1    Al-Sheikhly, M.2    Jovanovic, S.V.3
  • 18
    • 0018614020 scopus 로고
    • Quantitative separation of bone and muscle radioactivity in small rodents using dermestid beetles
    • Walburg HE, Eisele GR, Mraz FR. Quantitative separation of bone and muscle radioactivity in small rodents using dermestid beetles. Health Phys 1979; 37(3): 400-401
    • (1979) Health Phys , vol.37 , Issue.3 , pp. 400-401
    • Walburg, H.E.1    Eisele, G.R.2    Mraz, F.R.3
  • 19
    • 0002891986 scopus 로고
    • Antioxidant mechanisms in radiation injury and radioprotection
    • Chow CK, Ed. Cellular Antioxidant Defense. USA: CRC Press
    • Weiss JF, Kumar KS. Antioxidant mechanisms in radiation injury and radioprotection. In: Cellular Antioxidant Defense. Chow CK, Ed. Cellular Antioxidant Defense. USA: CRC Press 1988; pp. 163-189.
    • (1988) Cellular Antioxidant Defense , pp. 163-189
    • Weiss, J.F.1    Kumar, K.S.2
  • 20
    • 34248570041 scopus 로고    scopus 로고
    • Neuroprotection from secondary injury by polyethylene glycol requires its internalization
    • DOI 10.1242/jeb.02756
    • Liu-Snyder P, Logan MP, Shi R, Smith DT, Borgens RB. Neuroprotection from secondary injury by polyethylene glycol requires its internalization. J Exp Biol 2007; 210(Pt 8): 1455-1462 (Pubitemid 46762002)
    • (2007) Journal of Experimental Biology , vol.210 , Issue.8 , pp. 1455-1462
    • Liu-Snyder, P.1    Logan, M.P.2    Shi, R.3    Smith, D.T.4    Borgens, R.B.5
  • 22
    • 0042358676 scopus 로고    scopus 로고
    • Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase
    • DOI 10.1161/01.RES.0000089257.94002.96
    • Jin ZG, Ueba H, Tanimoto T, Lungu AO, Frame MD, Berk BC. Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase. Circ Res 2003; 93(4): 354-363 (Pubitemid 37048248)
    • (2003) Circulation Research , vol.93 , Issue.4 , pp. 354-363
    • Jin, Z.-G.1    Ueba, H.2    Tanimoto, T.3    Lungu, A.O.4    Frame, M.D.5    Berk, B.C.6
  • 26
    • 65649117679 scopus 로고    scopus 로고
    • Comparison of the effects of ramipril versus telmisartan on high-sensitivity C-reactive protein and endothelial progenitor cells after acute coronary syndrome
    • Porto I, Di VL, De Maria GL, et al. Comparison of the effects of ramipril versus telmisartan on high-sensitivity C-reactive protein and endothelial progenitor cells after acute coronary syndrome. Am J Cardiol 2009; 103(11): 1500-1505
    • (2009) Am J Cardiol , vol.103 , Issue.11 , pp. 1500-1505
    • Porto, I.1    Di, V.L.2    De Maria, G.L.3
  • 27
    • 75749088594 scopus 로고    scopus 로고
    • Timing of bone marrow cell delivery has minimal effects on cell viability and cardiac recovery after myocardial infarction
    • Swijnenburg RJ, Govaert JA, van der Bogt KE, et al. Timing of bone marrow cell delivery has minimal effects on cell viability and cardiac recovery after myocardial infarction. Circ Cardiovasc Imaging 2010; 3(1): 77-85.
    • (2010) Circ Cardiovasc Imaging , vol.3 , Issue.1 , pp. 77-85
    • Swijnenburg, R.J.1    Govaert, J.A.2    Van Der Bogt, K.E.3
  • 28
    • 0037229006 scopus 로고    scopus 로고
    • The permissive effect of zinc deficiency on uroguanylin and inducible nitric oxide synthase gene upregulation in rat intestine induced by interleukin 1α is rapidly reversed by zinc repletion
    • Cui L, Blanchard RK, Cousins RJ. The permissive effect of zinc deficiency on uroguanylin and inducible nitric oxide synthase gene upregulation in rat intestine induced by interleukin 1α is rapidly reversed by zinc repletion. J Nutr 2003; 133(1): 51-56 (Pubitemid 36070576)
    • (2003) Journal of Nutrition , vol.133 , Issue.1 , pp. 51-56
    • Cui, L.1    Blanchard, R.K.2    Cousins, R.J.3
  • 29
    • 0032962141 scopus 로고    scopus 로고
    • Role of intestinal mucus on the uptake of latex beads by Peyer's patches and on their transport to mesenteric lymph nodes in rats
    • Khan J, Iiboshi Y, Cui L, Wasa M, Okada A. Role of intestinal mucus on the uptake of latex beads by Peyer's patches and on their transport to mesenteric lymph nodes in rats. JPEN J Parenter Enteral Nutr 1999; 23(1): 19-23.
    • (1999) JPEN J Parenter Enteral Nutr , vol.23 , Issue.1 , pp. 19-23
    • Khan, J.1    Iiboshi, Y.2    Cui, L.3    Wasa, M.4    Okada, A.5
  • 31
    • 65249086293 scopus 로고    scopus 로고
    • Comparison of lifelong and late life exercise on oxidative stress in the cerebellum
    • Cui L, Hofer T, Rani A, Leeuwenburgh C, Foster TC. Comparison of lifelong and late life exercise on oxidative stress in the cerebellum. Neurobiol Aging 2009; 30(6): 903-909
    • (2009) Neurobiol Aging , vol.30 , Issue.6 , pp. 903-909
    • Cui, L.1    Hofer, T.2    Rani, A.3    Leeuwenburgh, C.4    Foster, T.C.5
  • 33
    • 34548443831 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition
    • DOI 10.1016/j.cellsig.2007.05.013, PII S0898656807001532
    • Holmes K, Roberts OL, Thomas AM, Cross MJ. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Cell Signal 2007; 19(10): 2003-2012 (Pubitemid 47354167)
    • (2007) Cellular Signalling , vol.19 , Issue.10 , pp. 2003-2012
    • Holmes, K.1    Roberts, O.L.2    Thomas, A.M.3    Cross, M.J.4
  • 34
    • 60549098262 scopus 로고    scopus 로고
    • Positron emission tomography imaging of poststroke angiogenesis
    • Cai W, Guzman R, Hsu AR, et al. Positron emission tomography imaging of poststroke angiogenesis. Stroke 2009; 40(1): 270-277
    • (2009) Stroke , vol.40 , Issue.1 , pp. 270-277
    • Cai, W.1    Guzman, R.2    Hsu, A.R.3
  • 35
    • 0027432324 scopus 로고
    • Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis
    • Plate KH, Breier G, Millauer B, Ullrich A, Risau W. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res 1993; 53(23): 5822-5827 (Pubitemid 23360294)
    • (1993) Cancer Research , vol.53 , Issue.23 , pp. 5822-5827
    • Plate, K.H.1    Breier, G.2    Millauer, B.3    Ullrich, A.4    Risau, W.5
  • 36
    • 52949107240 scopus 로고    scopus 로고
    • Correlation between tumor growth delay and expression of cancer and host VEGF, VEGFR2, and osteopontin in response to radiotherapy
    • Solberg TD, Nearman J, Mullins J, Li S. Baranowska-Kortylewicz J. Correlation between tumor growth delay and expression of cancer and host VEGF, VEGFR2, and osteopontin in response to radiotherapy. Int J Radiat Oncol Biol Phys 2008; 72(3): 918-926
    • (2008) Int J Radiat Oncol Biol Phys , vol.72 , Issue.3 , pp. 918-926
    • Solberg, T.D.1    Nearman, J.2    Mullins, J.3    Li, S.4    Baranowska-Kortylewicz, J.5
  • 37
    • 0035950528 scopus 로고    scopus 로고
    • Inflammatory-type responses after exposure to ionizing radiation in vivo: A mechanism for radiation-induced bystander effects?
    • Lorimore SA, Coates PJ, Scobie GE, Milne G, Wright EG. Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects? Oncogene 2001; 20(48): 7085-7095
    • (2001) Oncogene , vol.20 , Issue.48 , pp. 7085-7095
    • Lorimore, S.A.1    Coates, P.J.2    Scobie, G.E.3    Milne, G.4    Wright, E.G.5
  • 38
    • 41649108191 scopus 로고    scopus 로고
    • Ongoing activation of p53 pathway responses is a long-term consequence of radiation exposure in vivo and associates with altered macrophage activities
    • Coates PJ, Robinson JI, Lorimore SA, Wright EG. Ongoing activation of p53 pathway responses is a long-term consequence of radiation exposure in vivo and associates with altered macrophage activities. J Pathol 2008; 214(5): 610-616
    • (2008) J Pathol , vol.214 , Issue.5 , pp. 610-616
    • Coates, P.J.1    Robinson, J.I.2    Lorimore, S.A.3    Wright, E.G.4
  • 39
    • 0029086989 scopus 로고
    • The role of free radicals and p53 in neuron apoptosis in vivo
    • Wood KA, Youle RJ. The role of free radicals and p53 in neuron apoptosis in vivo. J Neurosci 1995; 15(8): 5851-5857
    • (1995) J Neurosci , vol.15 , Issue.8 , pp. 5851-5857
    • Wood, K.A.1    Youle, R.J.2
  • 40
    • 34147167012 scopus 로고    scopus 로고
    • Radiation-induced apoptosis in retinal progenitor cells is p53-dependent with caspase-independent DNA fragmentation
    • Herzog KH, Schulz A, Buerkle C, Gromoll C, Braun JS. Radiation-induced apoptosis in retinal progenitor cells is p53-dependent with caspase-independent DNA fragmentation. Eur J Neurosci 2007; 25(5): 1349-1356
    • (2007) Eur J Neurosci , vol.25 , Issue.5 , pp. 1349-1356
    • Herzog, K.H.1    Schulz, A.2    Buerkle, C.3    Gromoll, C.4    Braun, J.S.5
  • 41
    • 0023069451 scopus 로고
    • Intracellular calcium homeostasis
    • Carafoli E. Intracellular calcium homeostasis. Annu Rev Biochem 1987; 56: 395-433.
    • (1987) Annu Rev Biochem , vol.56 , pp. 395-433
    • Carafoli, E.1
  • 42
    • 0021733359 scopus 로고
    • Par albumin, an intracellular calcium-binding protein; distribution, properties and possible roles in mammalian cells
    • Heizmann CW. Par albumin, an intracellular calcium-binding protein; distribution, properties and possible roles in mammalian cells. Experientia 1984; 40(9): 910-921
    • (1984) Experientia , vol.40 , Issue.9 , pp. 910-921
    • Heizmann, C.W.1
  • 43
    • 0034111417 scopus 로고    scopus 로고
    • Alterations in Purkinje cell spines of calbindin D-28 k and parvalbumin knock-out mice
    • DOI 10.1046/j.1460-9568.2000.00986.x
    • Vecellio M, Schwaller B, Meyer M, Hunziker W, Celio MR. Alterations in Purkinje cell spines of calbindin D-28 k and parvalbumin knock-out mice. Eur J Neurosci 2000; 12(3): 945-954 (Pubitemid 30168772)
    • (2000) European Journal of Neuroscience , vol.12 , Issue.3 , pp. 945-954
    • Vecellio, M.1    Schwaller, B.2    Meyer, M.3    Hunziker, W.4    Celio, M.R.5
  • 44
    • 76749107996 scopus 로고    scopus 로고
    • Age-related changes in calbindind28k, parvalbumin, and calretinin immunoreactivity in the dog main olfactory bulb
    • Choi JH, Lee CH, Yoo KY, et al. Age-related changes in calbindind28k, parvalbumin, and calretinin immunoreactivity in the dog main olfactory bulb. Cell Mol Neurobiol 2010; 30(1): 1-12.
    • (2010) Cell Mol Neurobiol , vol.30 , Issue.1 , pp. 1-12
    • Choi, J.H.1    Lee, C.H.2    Yoo, K.Y.3
  • 45
    • 42749086194 scopus 로고    scopus 로고
    • Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus
    • Carter DS, Harrison AJ, Falenski KW, Blair RE, DeLorenzo RJ. Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus. Epilepsy Res 2008; 79(2-3): 213-223
    • (2008) Epilepsy Res , vol.79 , Issue.2-3 , pp. 213-223
    • Carter, D.S.1    Harrison, A.J.2    Falenski, K.W.3    Blair, R.E.4    Delorenzo, R.J.5
  • 46
    • 0023129890 scopus 로고
    • Effect of internal irradiation on the maturing Purkinje cells in the rat. a Golgi study
    • DOI 10.1016/0022-510X(87)90082-7
    • Gopinath G, Banerjee R, Gopinath PG. Effect of internal irradiation on the maturing Purkinje cells in the rat. A Golgi study. J Neurol Sci 1987; 78(1): 93-109. (Pubitemid 17014621)
    • (1987) Journal of the Neurological Sciences , vol.78 , Issue.1 , pp. 93-109
    • Gopinath, G.1    Banerjee, R.2    Gopinath, P.G.3
  • 47
    • 0038008179 scopus 로고    scopus 로고
    • Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum
    • DOI 10.1046/j.1460-9568.2003.02698.x
    • Miyazaki T, Fukaya M, Shimizu H, Watanabe M. Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum. Eur J Neurosci 2003; 17(12): 2563-2572 (Pubitemid 36819281)
    • (2003) European Journal of Neuroscience , vol.17 , Issue.12 , pp. 2563-2572
    • Miyazaki, T.1    Fukaya, M.2    Shimizu, H.3    Watanabe, M.4
  • 48
    • 70349151315 scopus 로고    scopus 로고
    • Dual regulation of Ca2+-dependent glutamate release from astrocytes: Vesicular glutamate transporters and cytosolic glutamate levels
    • Ni Y, Parpura V. Dual regulation of Ca2+-dependent glutamate release from astrocytes: vesicular glutamate transporters and cytosolic glutamate levels. Glia 2009; 57(12): 1296-1305.
    • (2009) Glia , vol.57 , Issue.12 , pp. 1296-1305
    • Ni, Y.1    Parpura, V.2


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