The permissive effect of zinc deficiency on uroguanylin and inducible nitric oxide synthase gene upregulation in rat intestine induced by interleukin 1α is rapidly reversed by zinc repletion

Journal of Nutrition

Volumn 133, Issue 1, 2003, Pages 51-56

  Cui, Li ^a   Blanchard, Raymond K ^a   Cousins, Robert J ^a  

^a NONE

Author keywords

Diarrheal disease; Gene regulation; Inflammation; Interleukin 1; Rats; Zinc deficiency

Indexed keywords

DNA; INTERLEUKIN 1ALPHA; MESSENGER RNA; NITRIC OXIDE SYNTHASE; SEROTONIN; UROGUANYLIN; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; DIARRHEA; DNA SEQUENCE; ENTERITIS; GENE CONTROL; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; INTESTINE FLUID; INTESTINE VILLUS; LAMINA PROPRIA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RAT; ZINC DEFICIENCY;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0037229006     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.1.51     Document Type: Article

References (34)

1. Golden, M. H. & Golden, B. E. (1981) Effect of zinc supplementation on the dietary intake, rate of weight gain, and energy cost of tissue deposition in children recovering from severe malnutrition. Am. J. Clin. Nutr. 34: 900-908.
2. 2. Hambidge, K. M. (1992) Zinc and diarrhea. Acta Paediatr. Suppl. 381: 82-83.
3. Okada, A., Takagi, T., Itakura, T., Satani, M., Manabe, H., Iida, Y., Tanigaki, T., Iwasaki, M. & Kasahara, N. (1976) Skin lesions during intravenous hyperalimentation: zinc deficiency. Surgery 80: 629-635.
4. Rosado, J. L., Lopez, P., Munoz, E., Martinez, H. & Allen, L. (1997) Zinc supplementation reduced morbidity, but neither zinc nor iron supplementation affected growth or body composition of Mexican preschoolers. Am. J. Clin. Nutr. 65: 13-19.
5. Sazawal, S., Black, R. E., Bhan, M. K., Bhandari, N., Sinha, A. & Jalla, S. (1995) Zinc supplementation in young children with acute diarrhea in India. N. Engl. J. Med. 333: 839-844.
6. Wapnir, R. A. 2000 Zinc deficiency, malnutrition and the gastrointestinal tract. J. Nutr. 130: 1388S-1392S.
7. Vallance, P. & Moncada, S. (1994) Nitric oxide - from mediator to medicines. J. R. Coll. Physicians Lond. 28: 209-219.
8. Cui, L., Takagi, Y., Wasa, M., Sando, K., Khan, J. & Okada, A. (1999) Nitric oxide synthase inhibitor attenuates intestinal damage induced by zinc deficiency in rats. J. Nutr. 129: 792-798.
9. Greenberg, R. N., Hill, M., Crytzer, J., Krause, W. J., Eber, S. L., Hamra, F. K. & Forte, L. R. (1997) Comparison of effects of uroguanylin, guanylin, and Escherichia coli heat stable enterotoxin STa in mouse intestine and kidney: evidence that uroguanylin is an intestinal natriuretic hormone. J. Investig. Med. 45: 276-282.
10. Forte, L. R. (1999) Guanylin regulatory peptides: structures, biological activities mediated by cyclic GMP and pathobiology. Regul. Pept. 81: 25-39.
11. - secretion by uroguanylin. Am. J. Physiol. 274: G633-G644.
12. Pitari, G. M., Di Guglielmo, M. D., Park, J., Schulz, S. & Waldman, S. A. (2001) Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells. Proc. Natl. Acad. Sci. U.S.A. 98: 7846-7851.
13. Blanchard, R. K. & Cousins, R. J. (1996) Differential display of intestinal mRNAs regulated by dietary zinc. Proc. Natl. Acad. Sci. U.S.A. 93: 6863-6868.
14. Blanchard, R. K. & Cousins, R. J. (1997) Upregulation of rat intestinal uroguanylin mRNA by dietary zinc restriction. Am. J. Physiol. 272: G972-G978.
15. Cui, L., Blanchard, R. K., Coy, L. M. & Cousins, R. J. (2000) Prouroguanylin overproduction and localization in the intestine of zinc-deficient rats. J. Nutr. 130: 2726-2732.
16. Ciancio, M. J., Vitiritti, L., Dhar, A. & Chang, E. B. (1992) Endotoxininduced alterations in rat colonic water and electrolyte transport. Gastroenterology 103: 1437-1443.
17. Blanchard, R. K., Moore, J. B., Green, C. L. & Cousins, R. J. (2001) Modulation of intestinal gene expression by dietary zinc status: effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency. Proc. Natl. Acad. Sci. U.S.A. 98: 13507-13513.
18. Villanueva, A., Stockert, J. C. & Armas-Portela, R. (1984) A simple method for the fluorescence analysis of nucleic acid-dye complexes in cytological preparations. Histochemistry 81: 103-104.
19. Mourelle, M., Vilaseca, J., Guarner, F., Salas, A. & Malagelada, J. R. (1996) Toxic dilatation of colon in a rat model of colitis is linked to an inducible form of nitric oxide synthase. Am. J. Physiol. 270: G425-G430.
20. Singer, I. I., Kawka, D. W., Scott, S., Weidner, J. R., Mumford, R. A., Riehl, T. E. & Stenson, W.F. (1996) Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease. Gastroenterology 111: 871-885.
21. Alican, I. & Kubes, P. (1996) A critical role for nitric oxide in intestinal barrier function and dysfunction. Am. J. Physiol. 270: G225-G237.
22. Currie, M. G., Fok, K. F., Kato, J., Moore, R. J., Hamra, F. K., Duffin, K. L. & Smith, C.E. (1992) Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc. Natl. Acad. Sci. U.S.A. 89: 947-951.
23. Fan, X., Wang, Y., London, R. M., Eber, S. L., Krause, W. J., Freeman, R. H. & Forte, L. R. (1997) Signaling pathways for guanylin and uroguanylin in the digestive, renal, central nervous, reproductive, and lymphoid systems. Endocrinology 138: 4636-4648.
24. Medvedev, A., Bussygyna, O., Pyatakova, N., Glover, V. & Severina, I. (2002) Effect of isatin on nitric oxide-stimulated soluble guanylate cyclase from human platelets. Biochem. Pharmacol. 63: 763-766.
25. Closs, E. I., Enseleit, F., Koesling, D., Pfeilschifter, J. M., Schwarz, P. M. & Forstermann, U. (1998) Coexpression of inducible NO synthase and soluble guanylyl cyclase in colonic enterocytes: a pathophysiologic signaling pathway for the initiation of diarrhea by gram-negative bacteria? FASEB J. 12: 1643-1649.
26. Podolsky, D. K. (2002) Inflammatory bowel disease. N. Engl. J. Med. 347: 417-429.
27. Hamra, F. K., Forte, L. R., Eber, S. L., Pldhorodeckyj, N. V., Krause, W. J., Freeman, R. H., Chin, D. T., Tompkins, J. A., Fok, K. F., Smith, C. E., Duffin, K. L., Siegel, N. R. & Currie, M. (1993) Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase. Proc. Natl. Acad. Sci. U.S.A. 90: 10464-10468.
28. Dube, P. H., Revell, P. A., Chaplin, D. D., Lorenz, R. G. & Miller, V. L. (2001) A role for IL-1α in inducing pathologic inflammation during bacterial infection. Proc. Natl. Acad. Sci. U.S.A, 98: 10880-10885.
29. Fondacaro, J. D., Kolpak, D. C., Burnham, D. B. & McCafferty, G. P. (1990) Cecectomized rat. A model of experimental secretory diarrhea in conscious animals. J. Pharmacol. Methods 24: 59-71.
30. Ben-Neriah, Y. (2002) Regulatory functions of ubiquitination in the immune system. Nat. Immunol. 3: 20-26.
31. 2+ inhibits nitric oxide formation in response to lipopolysaccharides: implication in its anti-inflammatory activity. Eur. J. Pharmacol. 341: 265-272.
32. Gow, A. & Ischiropoulos, H. (2002) NO running on MT: regulation of zinc homeostasis by interaction of nitric oxide with metallothionein. Am. J. Physiol. 282: L183-L184.
33. St. Croix, C. M., Wasserloos, K. J., Dineley, K. E., Reynolds, I. J., Levitan, E. S. & Pitt, B. R. (2002) Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein. Am. J. Physiol. 282: L185-L192.
34. Goode, H. F., Howdle, P. D., Walker, B. E. & Webster, N. R. (1995) Nitric oxide synthase activity is increased in patients with sepsis syndrome. Clin. Sci. (Lond.) 88: 131-133.