Correlation of protein-protein interactions as assessed by affinity chromatography with colloidal protein stability: A case study with lysozyme

Pharmaceutical Development and Technology

Volumn 15, Issue 4, 2010, Pages 421-430

  Le Brun, Virginie ^a   Friess, Wolfgang ^a   Bassarab, Stefan ^b   Garidel, Patrick ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Affinity chromatography; biopharmaceutics; colloidal stability; lysozyme

Indexed keywords

LYSOZYME; COLLOID; PROTEIN BINDING; SODIUM CHLORIDE;

AFFINITY CHROMATOGRAPHY; ARTICLE; COLLOID; DENATURATION; HYDROPHOBICITY; INFRARED SPECTROSCOPY; MICROCALORIMETRY; OSMOSIS; PH; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; TEMPERATURE STRESS; CHEMICAL PHENOMENA; CHEMISTRY; MECHANICAL STRESS; OSMOTIC PRESSURE; PROCEDURES; PROTEIN DENATURATION; STATIC ELECTRICITY; TEMPERATURE;

CHROMATOGRAPHY, AFFINITY; COLLOIDS; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; MURAMIDASE; OSMOTIC PRESSURE; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN STABILITY; SODIUM CHLORIDE; STATIC ELECTRICITY; STRESS, MECHANICAL; TEMPERATURE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS;

EID: 77951652683     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450903262074     Document Type: Article

References (53)

1. Garidel P, Bassarab S. Impact of formulation design on stability and quality. In: Lycson N, editor. Quality for biologics: Critical quality attributes, process and change control, product variation, characterisation, impurites and regulatory concerns. Hampshire: Biopharm Knowledge Publishing; 2009:94-113.
2. Cromwell MEM, Hilario E, Jacobson F. Protein aggregation and bioprocessing. AAPS J 2006;8(3):E572-579.
3. Wang W. Protein aggregation and its inhibition in biopharmaceutics. Int J Pharm 2005;289(1-2):1-30.
4. Weiss WF, Young TM, Roberts CJ. Principles, approaches, and challenges for predicting protein aggregation rates and shelf life. J Pharm Sci 2009; 98(4):1246-1277.
5. Chi EY, Krishnan S, Randolph TW, Carpenter JF. Physical stability of proteins in aqueous solution: Mechanism and driving forces in nonnative protein aggregation. Pharm Res 2003;20(9):1325-1336.
6. Dill KA, Shortle D. Denatured states of proteins. Annu Rev Biochem 1991;60:795-825.
7. Liu W, Cellmer T, Keerl D, Prausnitz JM, Blanch HW. Interactions of lysozyme in guanidinium chloride solutions from static and dynamic light-scattering measurements. Biotech Bioeng 2005;90(4):482-490.
8. Choy WY, Mulder FAA, Crowhurst KA, Muhandiram DR, Millett IS, Doniach S, et al. Distribution of molecular size within an unfolded state ensemble using small-angle X-ray scattering and pulse field gradient NMR techniques. J Mol Biol 2002;316(1):101-112
9. Cieplak M, Sulkowska JI. Thermal unfolding of proteins. J Chem Phys 2005;123(19):1-4.
10. Paci E, Karplus M. Unfolding proteins by external forces and temperature: The importance of topology and energetics. Proc Natl Acad Sci USA 2000;97(12):6521-6526.
11. Irback A, Mitternacht S. Thermal versus mechanical unfolding of ubiquitin. Proteins 2006;65(3):759-766.
12. Saluja A, Badkar AV, Zeng DL, Nema S, Kalonia DS. Ultrasonic storage modulus as a novel parameter for analyzing proteinprotein interactions in high protein concentration solutions: Correlation with static and dynamic light scattering measurements. Biophys J 2007;92(1):234-244.
13. Garidel P, Kebbel F. Protein therapeutics and protein aggregates characterised by photon correlation spectroscopy: An application for high concentration liquid formulations. BioProcess Int 2009, submitted.
14. Alford JR, Kendrick BS, Carpenter JF, Randolph TW. Measurement of the osmotic second virial coefficient for protein solutions exhibiting monomer-dimer equilibrium. Anal Biochem 2008;377(2):128-133.
15. Liu J, Nguyen MD, Andya JD, Shire SJ. Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution. J Pharm Sci 2005;94(9):1928-1940.
16. Tessier PM, Jinkoji J, Cheng YC, Prentice JL, Lenhoff AM. Self-interaction nanoparticle spectroscopy: A nanoparticle based protein interaction assay. J Am Chem Soc 2008; 130(10):3106-3112.
17. Curtis RA, Prausnitz JM, Blanch HW. Protein-protein and protein-salt interactions in aqueous protein solutions containing concentrated electrolytes. Biotechnol Bioeng 1998;57:11-21.
18. George A, Wilson WW. Predicting protein crystallization from a dilute solution property. Acta Crystallogr Sect D-Biol Crystallogr 1994;50(Pt 4):361-365.
19. Ahamed T, Esteban BNA, Ottens M, Van Dedem GWK, Van Der Wielen LAM, Bisschops MAT, et al. Phase behavior of an intact monoclonal antibody. Biophys J 2007;93(2):610-619
20. Ahamed T, Ottens M, van Dedem GW, van der Wielen LA. Design of self-interaction chromatography as an analytical tool for predicting protein phase behavior. J Chromatogr A 2005;1089(1-2):111-124.
21. Bloustine J, Berejnov V, Fraden S. Measurements of proteinprotein interactions by size exclusion chromatography. Biophys J 2003;85(4):2619-2623.
22. Gagnon P, Mayes T, Danielsson A. An adaptation of hydrophobic interaction chromatography for estimation of protein solubility optima. J Pharm Biomed Anal 1997;16:587-592.
23. Katayama DS, Nayar R, Chou DK, Valente JJ, Cooper J, Henry CS, et al. Effect of buffer species on the thermally induced aggregation of interferon-tau. J Pharm Sci 2006;95(6):1212-1226
24. Payne RW, Nayar R, Tarantino R, Del Terzo S, Moschera J, Di J., et al. Second virial coefficient determination of a therapeutic peptide by self-interaction chromatography. Biopolymers 2006;84(5):527-533
25. Tessier PM, Johnson HR, Pazhianur R, Berger BW, Prentice JL, Bahnson BJ, et al. Predictive crystallization of ribonuclease A via rapid screening of osmotic second virial coefficients. Proteins 2003;50(2):303-311
26. Tessier PM, Lenhoff AM, Sandler SI. Rapid measurement of protein osmotic second virial coefficients by self-interaction chromatography. Biophys J 2002;82(3):1620-1631.
27. Valente JJ, Fryksdale BG, Dale DA, Gaertner AL, Henry CS. Screening for physical stability of a Pseudomonas amylase using self-interaction chromatography. Anal Biochem 2006; 357(1):35-42.
28. Attri AK, Minton AP. New methods for measuring macromolecular interactions in solution via static light scattering: Basic methodology and application to nonassociating and self- associating proteins. Anal Biochem 2005;337(1):103-110.
29. Berger BW, Blamey CJ, Naik UP, Bahnson BJ, Lenhoff AM. Roles of additives and precipitants in crystallization of calcium- and integrin- binding protein. Cryst Growth Des 2005;5(4):1499-1507.
30. George A, Chiang Y, Guo B, Arabshahi A, Cai Z, Wilson WW. Second virial coefficient as predictor in protein crystal growth. Macromolec Crystallogr 1997;276:100-110.
31. Demoruelle K, Guo B, Kao SM, McDonald HM, Nikic DB, Holman SC, et al. Correlation between the osmotic second virial coefficient and solubility for equine serum albumin and ovalbumin. Acta Crystallogr Sect D Biol Crystallogr 2002;58:1544-1548
32. Guo B, Kao S, McDonald H, Asanov A, Combs LL, Wilson WW. Correlation of second virial coefficients and solubilities useful in protein crystal growth. J Cryst Growth 1999;196(2-4):424-433.
33. Haas C, Drenth J, Wilson WW. Relation between the solubility of proteins in aqueous solutions and the second virial coefficient of the solution. J Phys Chem 1999;103(14):2808-2811.
34. Ho JGS, Middelberg APJ, Ramage P, Kocher HP. The likelihood of aggregation during protein renaturation can be assessed using the second virial coefficient. Protein Sci 2003;12(4):708-716.
35. Curtis RA, Steinbrecher C, Heinemann A, Blanch HW, Prausnitz JM. Hydrophobic forces between protein molecules in aqueous solutions of concentrated electrolyte. Biophys Chem 2002;98(3):249-265.
36. Alford JR, Kwok SC, Roberts JN, et al.High concentration formulations of recombinant human interleukin-1 receptor antagonist: I. Physical characterization. J Pharm Sci 2008;97(8):3035-3050.
37. Zimm BH. Application of the methods of molecular distribution to solutions of large molecules. J Chem Phys 1946;14(3):164-179.
38. Robertson AD, Murphy KP. Protein structure and the energetics of protein stability. Chem Rev 1997;97:1251-1267.
39. Byler DM, Susi H. Examination of the secondary structure of proteins by deconvolved FTIR spectra. Biopolymers 1986;25:469-487.
40. van de Weert M, Haris PI, Hennink WE, Crommelin DJA. Fourier transform infrared spectrometric analysis of protein conformation: Effect of sampling method and stress factors. Anal Biochem 2001;297:160-169.
41. Garidel P, Schott H. Fourier-transform midinfrared spectroscopy for analysis and screening of liquid protein formulations. Part 2: Detailed analysis and applications. BioProcess Int 2006;4:48-55.
42. Pelton JT, Mclean LR. Spectroscopic methods for analysis of protein secondary structure. Anal Biochem 2000;277:167-176.
43. Patro SY, Przybycien TM. Self-interaction chromatography: A tool for the study of protein-protein interactions in bioprocessing environments. Biotechnol Bioeng 1996;52(2):193-203.
44. Burova TV, Grinberg NV, Grinberg VY, Rariy RV, Klibanov AM. Calorimetric evidence for a native-like conformation of hen egg-white lysozyme dissolved in glycerol. Biochim Biophys Acta 2000;1478(2):309-317.
45. Elkordy AA, Forbes RT, Barry BW. Study of protein conformational stability and integrity using calorimetry and FT-Raman spectroscopy correlated with enzymatic activity. Eur J Pharm Sci 2008;33(2):177-190.
46. Pace CN, Shirley BA, McNutt M, Gajiwala K. Forces contributing to the conformational stability of proteins. FASEB J 1996;10:75-83.
47. Chang JY, Li L. The unfolding mechanism and the disulfide structures of denatured lysozyme. FEBS Lett 2002;511(1-3): 73-78.
48. Cho JH, Sato S, Horng JC, Anil B, Raleigh DP. Electrostatic interactions in the denatured state ensemble: Their effect upon protein folding and protein stability. Arch Biochem Biophys 2008;469(1):20-28.
49. Whitten ST, Garcia-Moreno B. pH dependence of stability of staphylococcal nuclease: Evidence of substantial electrostatic interactions in the denatured state. Biochemistry 2000; 39(46):14292-14304.
50. Klein-Seetharaman J, Oikawa M, Grimshaw SB, Wirmer J, Duchardt E, Ueda T, et al. Long-range interactions within a nonnative protein. Science 2002;295:1719-1722
51. Neri D, Billeter M, Wider G, Wuthrich K. NMR determination of residual structure in a urea-denatured protein, the 434- repressor. Science 1992;257(5076):1559-1563.
52. Bowler BE. Thermodynamics of protein denatured states. Mol Biosyst 2007;3(2):88-99.
53. Le Brun V, Friess W, Schultz-Fademrecht T, Muehlau S, Garidel P. Insights in lysozyme-lysozyme self-interactions as assessed by the osmotic second virial coefficient: Impact for physical protein stabilization. Biotechnol J 2009 (DOI: 10.1002/ biot.200800274).