ω-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn

Neuropharmacology

Volumn 55, Issue 5, 2008, Pages 860-864

  Motin, Leonid ^a   Adams, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Conotoxin; Calcium channel; Nociception; Primary afferent fibres; Spinal cord; Synaptic transmission

Indexed keywords

CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; OMEGA CONOTOXIN CVID; OMEGA CONOTOXIN GVIA; OMEGA CONOTOXIN MVIIA; OMEGA CONOTOXIN MVIIC;

ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; MUSCLE SPINDLE AFFERENT NERVE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL GANGLION; SYNAPTIC INHIBITION;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; CALCIUM CHANNEL BLOCKERS; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; NEURAL INHIBITION; OMEGA-CONOTOXINS; PATCH-CLAMP TECHNIQUES; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL NERVE ROOTS;

EID: 50849107634     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.06.049     Document Type: Article

References (22)

1. Berry M.S., and Pentreath V.W. Criteria for distinguishing between monosynaptic and polysynaptic transmission. Brain Research 105 (1976) 1-20
2. 2+ channels are involved in neurotransmitter release but not synaptic depression in the spinal cord of the neonatal rat. Neuroscience Letters 295 (2000) 29-32
3. 2+ channels governing generation of miniature and evoked excitatory synaptic currents in spinal laminae I and II. Journal of Neuroscience 18 (1998) 8740-8750
4. Gruner W., and Silva L.R. ω-Conotoxin sensitivity and presynaptic inhibition of glutamatergic sensory neurotransmission in vitro. Journal of Neuroscience 14 (1994) 2800-2808
5. 2+ channels to nociceptive transmission in rat spinal lamina I neurons. European Journal of Neuroscience 19 (2004) 103-111
6. Lewis R.J., Nielsen K.J., Craik D.J., Loughnan M.L., Adams D.A., Sharpe I.A., Luchian T., Adams D.J., Bond T., Thomas L., Jones A., Matheson J.L., Drinkwater R., Andrews P.R., and Alewood P.F. Novel ω-conotoxins isolated from Conus catus discriminate among neuronal calcium channel subtypes. Journal of Biological Chemistry 275 (2000) 35335-35344
7. McDonough S.I., Swartz K.J., Mintz I.M., Boland L.M., and Bean B.P. Inhibition of calcium channels in rat central and peripheral neurons by ω-conotoxin MVIIC. Journal of Neuroscience 16 (1996) 2612-2623
8. Miljanich G. Ziconotide: neuronal calcium channel blocker for treating severe chronic pain. Current Medicinal Chemistry 11 (2004) 3029-3040
9. Moore K.A., Baba H., and Woolf C.J. Gabapentin - actions on adult superficial dorsal horn neurons. Neuropharmacology 43 (2002) 1077-1081
10. Motin L., Yasuda T., Schroeder C.I., Lewis R.J., and Adams D.J. ω-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels. European Journal of Neuroscience 25 (2007) 435-444
11. Motin L., Lewis R.J., and Adams D.J. Modulation of synaptic transmission by ω-conotoxins CVID and CVIB in spinal superficial dorsal horn. Proceedings of the Australian Physiological Society 37 (2007) 104
12. 2δ auxiliary subunit reduces affinity of ω-conotoxins for recombinant N-type (Cav2.2) calcium channels. Journal of Biological Chemistry 279 (2004) 34705-34714
13. Nielsen K.J., Adams D., Thomas L., Bond T., Alewood P.F., Craik D.J., and Lewis R.J. Structure-activity relationships of ω-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels. Journal of Molecular Biology 289 (1999) 1405-1421
14. Prescott S.A., and De Koninck Y. Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat. Journal of Physiology (London) 539 (2002) 817-836
15. Rycroft B.K., Vikman K.S., and Christie M.J. Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn. Journal of Physiology (London) 580 (2007) 883-894
16. Schroeder C.I., Lewis R.J., and Adams D.J. Block of voltage-gated calcium channels by peptide toxins. In: Zamponi G.W. (Ed). Voltage-gated Calcium Channels (2004), Landes Bioscience, Georgetown, TX 294-308
17. Scott D.A., Wright C.E., and Angus J.A. Actions of intrathecal ω-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat. European Journal of Pharmacology 451 (2002) 279-286
18. Smith M.T., Cabot P.J., Ross F.B., Robertson A.D., and Lewis R.J. The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices. Pain 96 (2002) 119-127
19. Soeda H., Tatsumi H., Kozawa Y., Mishima H., Imai K., and Katayama Y. Functional characterization of calcium channels localized on the growth cones of cultured rat dorsal root ganglion cells. Neuroscience Letters 325 (2002) 5-8
20. Takahashi T., and Momiyama A. Different types of calcium channels mediate central synaptic transmission. Nature 366 (1993) 156-158
21. Uchitel O.D. Toxins affecting calcium channels in neurons. Toxicon 35 (1997) 1161-1191
22. 2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals. Journal of Neuroscience 18 (1998) 6319-6330