Optimizing the power of genome-wide association studies by using publicly available reference samples to expand the control group

Genetic Epidemiology

Volumn 34, Issue 4, 2010, Pages 319-326

  Zhuang, Joanna J ^a   Zondervan, Krina ^a   Nyberg, Fredrik ^b,c   Harbron, Chris ^d   Jawaid, Ansar ^d   Cardon, Lon R ^a,e   Barratt, Bryan J ^d   Morris, Andrew P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d ASTRAZENECA   (United Kingdom)

^e Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Expanded control group; Genome wide association study; Model selection; Multidimensional scaling; Population structure

Indexed keywords

ARTICLE; FALSE POSITIVE RESULT; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC RISK; GENETIC VARIABILITY; HUMAN; POPULATION GENETIC STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; FALSE POSITIVE REACTIONS; GENE FREQUENCY; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HETEROZYGOTE; HUMANS; MODELS, GENETIC; MODELS, STATISTICAL; ODDS RATIO; REFERENCE VALUES; RESEARCH DESIGN; RISK;

EID: 77951601304     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20482     Document Type: Article

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