Global changes of mRNA expression reveals an increased activity of the interferon-induced signal transducer and activator of transcription (STAT) pathway by repression of miR-221/222 in glioblastoma U251 cells

International Journal of Oncology

Volumn 36, Issue 6, 2010, Pages 1503-1512

  Zhang, Chunzhi ^a,b,c   Han, Lei ^a,b   Zhang, Anling ^a,b   Yang, Weidong ^a   Zhou, Xuan ^a,b   Pu, Peiyu ^a,b   Du, Yue ^b   Zeng, Huazong ^d   Kang, Chunsheng ^a,b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b Tian Jin Normal University   (China)

^c TIANJIN HUANHU HOSPITAL   (China)

^d Shanghai Sensichip Co Ltd   (China)

Author keywords

Glioma; INF ; miR 221; miR 222; STAT1; STAT2

Indexed keywords

ALPHA INTERFERON; MESSENGER RNA; MICRORNA; STAT1 PROTEIN; STAT2 PROTEIN;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GLIOMA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL LINE, TUMOR; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GLIOBLASTOMA; HUMANS; INTERFERON-ALPHA; MICRORNAS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS;

EID: 77951587074     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000637     Document Type: Article

References (41)

1. Lee RC and Ambros V: An extensive class of small RNAs in Caenorhabditis elegans. Science 294: 862-864, 2001.
2. Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer 6: 857-866, 2006.
3. Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269, 2006.
4. He L and Hannon GJ: MicroRNAs: Small RNAs with a big role in gene regulation. Nat Rev Genet 5: 522-531, 2004. (Pubitemid 38868508)
5. Calin GA, Sevignani C, Dumitru CD, et al: Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 101: 2999-3004, 2004. (Pubitemid 38327724)
6. Cimmino A, Calin GA, Fabbri M, et al: miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 102: 13944-13949, 2005. (Pubitemid 41377683)
7. Mercatelli N, Coppola V, Bonci D, et al: The inhibition of the highly expressed mir-221 and mir-222 impairs the growth of prostate carcinoma xenografts in mice. PLoS One 3: e4029, 2008.
8. Cancer Genome Atlas Research Network: Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455: 1061-1068, 2008.
9. Kim S, Dougherty E, Shmulevich I, et al: Identification of combination gene sets for glioma classification. Mol Cancer Ther 1: 1229-1236, 2002.
10. Rickman DS, Bobek MP, Misek DE, et al: Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis. Cancer Res 61: 6885-6891, 2001.
11. Fuller GN, Mircean C, Tabus I, et al: Molecular voting for glioma classification reflecting heterogeneity in the continuum of cancer progression. Oncol Rep 14: 651-656, 2005.
12. Shai R, Shi T, Kremen TJ, et al: Gene expression profiling identifies molecular subtypes of gliomas. Oncogene 22: 4918-4923, 2003. (Pubitemid 36981282)
13. Godard S, Getz G, Delorenzi M, et al: Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes. Cancer Res 63: 6613-6625, 2003. (Pubitemid 37322939)
14. Freije WA, Castro-Vargas FE, Fang Z, et al: Gene expression profiling of gliomas strongly predicts survival. Cancer Res 64: 6503-6510, 2004. (Pubitemid 39297907)
15. Ciafre SA, Galardi S, Mangiola A, et al: Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun 334: 1351-1358, 2005. (Pubitemid 41074723)
16. Yang YH, Dudoit S, Luu P, et al: Normalization for cDNA microarray data: A robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res 30: e15, 2002.
17. Shannon P, Markiel A, Ozier O, et al: Cytoscape: a software environment for integrated models of biomolecular Interaction networks. Genome Res 13: 2498-2504, 2003. (Pubitemid 37428274)
18. Ramkissoon SH, Mainwaring LA, Sloand EM, Young NS and Kajigaya S: Nonisotopic detection of microRNA using digoxigenin labeled RNA probes. Mol Cell Probes 20: 1-4, 2006.
19. Kang CS, Zhang ZY, Jia ZF, et al: Suppression of EGFR expression by antisense or small interference RNA inhibits U251 glioma cell growth in vitro and in vivo. Cancer Gene Ther 13: 530-538, 2006.
20. Zhang C, Kang C, You Y, et al: Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo. Int J Oncol l34: 1653-1660, 2009.
21. Guo Y, Guo H, Zhang L, et al: Genomic analysis of antihepatitis B virus (HBV) activity by small interfering RNA and lamivudine in stable HBV-producing cells. J Virol 79: 14292-14303, 2005.
22. MAQC Consortium, Shi L, Reid LH, et al: The microarray quality control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol 24: 1151-1161, 2006. (Pubitemid 44359727)
23. Shalgi R, Lieber D, Oren M and Pilpel Y: Global and local architecture of the mammalian microRNA-transcription factor regulatory network. PLoS Comput Biol 3: e131, 2007.
24. Takamizawa J, Konishi H, Yanagisawa K, et al: Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 64: 3753-3756, 2004. (Pubitemid 38697282)
25. Iorio MV, Ferracin M, Liu CG, et al: MicroRNA gene expression deregulation in human breast cancer. Cancer Res 65: 7065-7070, 2005. (Pubitemid 41161233)
26. Le Sage C, Nagel R, Egan DA,et al: Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J 26: 3699-3708, 2007. (Pubitemid 47236875)
27. Visone R, Russo L, Pallante P, et al: MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle. Endocr Relat Cancer 14: 791-798, 2007. (Pubitemid 350074067)
28. Galardi S, Mercatelli N, Giorda E, et al: miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. J Biol Chem 282: 23716-23724, 2007. (Pubitemid 47311902)
29. Miller TE, Ghoshal K, Ramaswamy B, et al: MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27(Kip1). J Biol Chem 283: 29897-29903, 2008.
30. Ferrantini M, Capone I and Belardelli F: Interferon-alpha and cancer: mechanisms of action and new perspectives of clinical use. Biochimie 89: 884-893, 2007. (Pubitemid 47001642)
31. Belardelli F and Gresser I: The neglected role of type 1 interferon in the T-cell response: implications for its clinical use. Immunol Today 17: 369-372, 1996. (Pubitemid 26247796)
32. Kisseleva T, Bhattacharya S, Braunstein J and Schindler CW: Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 285: 1-24, 2002. (Pubitemid 34246317)
33. Jove R: Preface: STAT signaling. Oncogene 19: 2466-2467, 2000.
34. Bluyssen HA and Levy DE: Stat2 is a transcriptional activator that requires sequence-specific contacts provided by STAT1 and p48 for stable interaction with DNA. J Biol Chem 272: 4600-4605, 1997.
35. Dale TC, Rosen JM, Guille MJ, Lewin AR, Porter AG, Kerr IM and Stark GR: Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription. EMBO J 8: 831-839, 1989.
36. Stark GR, Kerr IM, Williams BRG, Silverman RH and Schreiber RD: How cells respond to interferons. Annu Rev Biochem 67: 227-264, 1998.
37. Schindler C and Strehlow I: Cytokines and STAT signaling. Adv Pharmacol 47: 113-174, 2000.
38. Clifford JL, Walch E, Yang X, et al: Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis. Clin Cancer Res 8: 2067-2072, 2002. (Pubitemid 34753575)
39. Landolfo S, Guarini A, Riera L, et al: Chronic myeloid leukemia cells resistant to interferon-alpha lack STAT1 expression. Hematol J 1: 7-14, 2000.
40. Wong LH, Krauer KG, Hatzinisiriou I, et al: Interferon-resistant human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48-ISGF3gamma. J Biol Chem 272: 28779-28785, 1997. (Pubitemid 27517837)
41. Huang S, Bucana CD, Van Arsdall M and Fidler IJ: STAT1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells. Oncogene 21: 2504-2512, 2002. (Pubitemid 34438103)