Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice

BMC Molecular Biology

Volumn 11, Issue , 2010, Pages

  Marshall, Henderson ^a   Bhaumik, Mantu ^b   Aviv, Hana ^a   Moore, Dirk ^b   Yao, Ming ^a   Dutta, Jayeeta ^a   Rahim, Hussein ^a   Gounder, Murugesan ^a   Ganesan, Shridar ^a   Saleem, Ahamed ^a   Rubin, Eric ^a,c  

^a RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROCHROMATIN PROTEIN 1; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; MUTANT PROTEIN; NUCLEAR PROTEIN; SATELLITE DNA; TOPORS; TOPOTECAN; TRICHOSTATIN A; UNCLASSIFIED DRUG; VINBLASTINE; HYDROXAMIC ACID; SUMO PROTEIN; TOPORS PROTEIN, MOUSE; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

ALLELE; ANEUPLOIDY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DNA DAMAGE; DNA TRANSCRIPTION; DRUG RESISTANCE; EMBRYO; FEMALE; FIBROBLAST; GENE MUTATION; GENOMIC INSTABILITY; HETEROCHROMATIN; HETEROZYGOTE; HOMOZYGOTE; LIFESPAN; MALE; MALIGNANT TRANSFORMATION; MICROTUBULE; MOUSE; NONHUMAN; PERINATAL MORTALITY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; ANIMAL; GENETICS; HUMAN; METABOLISM; NEOPLASM;

MUS;

ANIMALS; FIBROBLASTS; GENOMIC INSTABILITY; HETEROZYGOTE; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; MICE; NEOPLASMS; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 77951562677     PISSN: None     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-11-31     Document Type: Article

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