Manipulation of lyophilization-induced phase separation: Implications for pharmaceutical proteins

Biotechnology Progress

Volumn 13, Issue 5, 1997, Pages 590-596

  Heller, Martin C ^a   Carpenter, John F ^b   Randolph, Theodore W ^a  

^a UCB 450   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; DRYING; HEMOGLOBIN; POLYETHYLENE GLYCOLS; POTASSIUM COMPOUNDS; SODIUM CHLORIDE;

DEXTRAN; FREEZE DRYING; LYOPHILIZATION; POTASSIUM CHLORIDE;

PHASE SEPARATION;

DEXTRAN; HEMOGLOBIN; MACROGOL DERIVATIVE; POTASSIUM CHLORIDE; PROTEIN; RECOMBINANT PROTEIN; SODIUM CHLORIDE;

ARTICLE; CHEMISTRY; DRUG STABILITY; FREEZE DRYING; PH; PHARMACEUTICS; PHYSICAL CHEMISTRY; PROTEIN SECONDARY STRUCTURE; SCANNING ELECTRON MICROSCOPY;

CHEMISTRY, PHYSICAL; DEXTRANS; DRUG STABILITY; FREEZE DRYING; HEMOGLOBINS; HYDROGEN-ION CONCENTRATION; MICROSCOPY, ELECTRON, SCANNING; POLYETHYLENE GLYCOLS; POTASSIUM CHLORIDE; PROTEIN STRUCTURE, SECONDARY; PROTEINS; RECOMBINANT PROTEINS; SODIUM CHLORIDE; TECHNOLOGY, PHARMACEUTICAL;

EID: 0031239857     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp970081b     Document Type: Article

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