Genetic risk of acute pulmonary infections and sepsis

Expert Review of Respiratory Medicine

Volumn 4, Issue 2, 2010, Pages 229-238

  Waterer, Grant W ^a,b   Bruns, Anke Hw ^c  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Genetic risk; Pneumonia; Polymorphisms; Sepsis

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; CD14 ANTIGEN; IMMUNOGLOBULIN G2 RECEPTOR; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 10; MANNOSE BINDING LECTIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

BLOOD CLOTTING; FIBRINOLYSIS; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HUMAN; INFLAMMATION; LUNG INFECTION; NONHUMAN; REVIEW; RISK ASSESSMENT; RISK FACTOR; SEPSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 77951490196     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/ers.10.13     Document Type: Review

References (109)

1. Sorensen TI, Nielsen GG, Andersen PK, Teasdale TW. Genetic and environmental influences on premature death in adult adoptees. N. Engl. J. Med. 318(12), 727-732 (1988).
2. Burgner D, Jamieson SE, Blackwell JM. Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better? Lancet Infect. Dis. 6(10), 653-663 (2006). (Pubitemid 44427734)
3. Murphy PM. Molecular mimicry and the generation of host defense protein diversity. Cell 72(6), 823-826 (1993).
4. Waterer GW. Polymorphism studies in critical illness - we have to raise the bar. Crit. Care Med. 35(5), 1424-1425 (2007).
5. Garred P, Larsen F, Seyfarth J, Fujita R, Madsen HO. Mannose-binding lectin and its genetic variants. Genes Immun. 7(2), 85-94 (2006). (Pubitemid 43336050)
6. Gordon A, Waheed U, Hansen T et al. Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome. Shock 25(1), 88-93 (2006). (Pubitemid 43755992)
7. Garred P, Strøm J, Quist L, Taaning E, Madsen H. Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome. J. Infect. Dis. 188(9), 1394-1403 (2003). (Pubitemid 37433712)
8. Kronborg G, Weis N, Madsen H et al. Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients. J. Infect. Dis. 185(10), 1517-1520 (2002). (Pubitemid 34507977)
9. Henckaerts L, Nielsen KR, Steffensen R et al. Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit. Care Med. 37(1), 192-201, e1-e3 (2009).
10. Endeman H, Herpers BL, de Jong BA et al. Mannose-binding lectin genotypes in susceptibility to community-acquired pneumonia. Chest 134(6), 1135-1140 (2008).
11. Herpers BL, Yzerman EP, de Jong BA et al. Deficient mannose-binding lectin-mediated complement activation despite mannose-binding lectin-sufficient genotypes in an outbreak of Legionella pneumophila pneumonia. Hum. Immunol. 70(2), 125-129 (2009).
12. Roy S, Knox K, Segal S et al. MBL genotype and risk of invasive pneumococcal disease: a case-control study. Lancet 359(9317), 1569-1573 (2002). (Pubitemid 34621123)
13. Moens L, Van Hoeyveld E, Peetermans WE, De Boeck C, Verhaegen J, Bossuyt X. Mannose-binding lectin genotype and invasive pneumococcal infection. Hum. Immunol. 67(8), 605-611 (2006). (Pubitemid 44205326)
14. Brouwer MC, de Gans J, Heckenberg SG, Zwinderman AH, van der Poll T, van de Beek D. Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis. Lancet Infect. Dis. 9(1), 31-44 (2009).
15. Yuan FF, Marks K, Wong M et al. Clinical relevance of TLR2, TLR4, CD14 and FcgRIIA gene polymorphisms in Streptococcus pneumoniae infection. Immunol. Cell Biol. 86(3), 268-270 (2008). (Pubitemid 351430807)
16. Yee AM, Ng SC, Sobel RE, Salmon JE. FcgRIIA polymorphism as a risk factor for invasive pneumococcal infections in systemic lupus erythematosus. Arthritis Rheum. 40(6), 1180-1182 (1997).
17. Yuan FF, Wong M, Pererva N et al. FcgRIIA polymorphisms in Streptococcus pneumoniae infection. Immunol. Cell Biol. 81(3), 192-195 (2003). (Pubitemid 36649265)
18. Moens L, Van Hoeyveld E, Verhaegen J, De Boeck K, Peetermans WE, Bossuyt X. Fcg-receptor IIA genotype and invasive pneumococcal infection. Clin. Immunol. 118(1), 20-23 (2006). (Pubitemid 43012042)
19. van der Pol WL, Huizinga TW, Vidarsson G et al. Relevance of Fcg receptor and interleukin-10 polymorphisms for meningococcal disease. J. Infect. Dis. 184(12), 1548-1555 (2001). (Pubitemid 33139740)
20. D'Avila LC, Albarus MH, Franco CR et al. Effect of CD14 -260C>T polymorphism on the mortality of critically ill patients. Immunol. Cell Biol. 84(4), 342-348 (2006). (Pubitemid 43882839)
21. Barber R, Chang L, Arnoldo BD et al. Innate immunity SNPs are associated with risk for severe sepsis after burn injury. Clin. Med. Res. 4(4), 250-255 (2006). (Pubitemid 46166376)
22. Gibot S, Cariou A, Drouet L, Rossignol M, Ripoll L. Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate. Crit. Care Med. 30(5), 969-973 (2002). (Pubitemid 34508015)
23. Lin J, Yao YM, Huang ZH, Hou XX, Zhu JM, Chai JK. [Association between a genomic polymorphism within the CD14 locus and severe sepsis susceptibility as well as prognosis in patients after extensive burns]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 16(5), 271-273 (2004).
24. Sutherland AM, Walley KR, Russell JA. Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults. Crit. Care Med. 33(3), 638-644 (2005).
25. Heesen M, Bloemeke B, Schade U, Obertacke U, Majetschak M. The -260 C→T promoter polymorphism of the lipopolysaccharide receptor CD14 and severe sepsis in trauma patients. Intensive Care Med. 28(8), 1161-1163 (2002). (Pubitemid 34985244)
26. Hubacek JA, Stuber F, Frohlich D et al. The common functional C(-159)T polymorphism within the promoter region of the lipopolysaccharide receptor CD14 is not associated with sepsis development or mortality. Genes Immun. 1(6), 405-407 (2000).
27. Nakada TA, Hirasawa H, Oda S et al. Influence of Toll-like receptor 4, CD14, tumor necrosis factor, and interleukin-10 gene polymorphisms on clinical outcome in japanese critically ill patients. J. Surg. Res. (2005).
28. Lin J, Yao YM, Huang ZH et al. [The influence of CD14 genomic polymorphism on CD14 gene expression as well as protein release and its clinical significance in patients with extensive burns]. Zhonghua Wai Ke Za Zhi 44(13), 907-910 (2006).
29. de Aguiar BB, Girardi I, Paskulin DD et al. CD14 expression in the first 24h of sepsis: effect of -260C>T CD14 SNP. Immunol. Invest. 37(8), 752-769 (2008).
30. Temple SE, Cheong KY, Almeida CM, Price P, Waterer GW. Polymorphisms in lymphotoxin a and CD14 genes influence TNFa production induced by Gram-positive and Gram-negative bacteria. Genes Immun. 4(4), 283-288 (2003). (Pubitemid 39562128)
31. Weiss J. Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): structure, function and regulation in host defence against Gram-negative bacteria. Biochem. Soc. Trans. 31(Pt 4), 785-790 (2003). (Pubitemid 36981128)
32. Michalek J, Svetlikova P, Fedora M et al. Bactericidal permeability increasing protein gene variants in children with sepsis. Intensive Care Med. 33(12), 2158-2164 (2007). (Pubitemid 350164567)
33. Hubacek JA, Stuber F, Frohlich D et al. Gene variants of the bactericidal/ permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis. Crit. Care Med. 29(3), 557-561 (2001). (Pubitemid 32225297)
34. Beutler B. Toll-like receptors: how they work and what they do. Curr. Opin. Hematol. 9(1), 2-10 (2002). (Pubitemid 34025305)
35. Barber RC, Chang LY, Arnoldo BD et al. Innate immunity SNPs are associated with risk for severe sepsis after burn injury. Clin. Med. Res. 4(4), 250-255 (2006).
36. Lorenz E, Mira J, Frees K, Schwartz D. Relevance of mutations in the TLR4 receptor in patients with Gram-negative septic shock. Arch. Intern. Med. 162(9), 1028-1032 (2002). (Pubitemid 34492532)
37. Jessen KM, Lindboe SB, Petersen AL, Eugen-Olsen J, Benfield T. Common TNF-a, IL-1 b, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis. BMC Infect. Dis. 7, 108 (2007).
38. Moens L, Verhaegen J, Pierik M et al. Toll-like receptor 2 and Toll-like receptor 4 polymorphisms in invasive pneumococcal disease. Microbes Infect. 9(1), 15-20 (2007). (Pubitemid 46151757)
39. Yoon HJ, Choi JY, Kim CO et al. Lack of Toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia. J. Korean Med. Sci. 21(6), 979-982 (2006).
40. Brenmoehl J, Herfarth H, Gluck T et al. Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients. Intensive Care Med. 33(9), 1541-1548 (2007). (Pubitemid 47312477)
41. Everett B, Cameron B, Li H et al. Polymorphisms in Toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever. Genes Immun. 8(8), 699-702 (2007). (Pubitemid 350238441)
42. Hawn TR, Verbon A, Lettinga KD et al. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J. Exp. Med. 198(10), 1563-1572 (2003). (Pubitemid 37467170)
43. Wurfel MM, Gordon AC, Holden TD et al. Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am. J. Respir. Crit. Care Med. 178(7), 710-720 (2008).
44. Khor CC, Chapman SJ, Vannberg FO et al. A MAL functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat. Genet. 39(4), 523-528 (2007).
45. Gu W, Shan Y, Zhou J et al. Functional significance of gene polymorphisms in the promoter of myeloid differentiation-2. Ann. Surg. 246(1), 151-158 (2007). (Pubitemid 47012220)
46. Arcaroli J, Silva E, Maloney J et al. Variant IRAK-1 haplotype is associated with increased nuclear factor-kB activation and worse outcomes in sepsis. Am. J. Respir. Crit. Care Med. 173(12), 1335-1341 (2006). (Pubitemid 43900707)
47. Chapman SJ, Khor CC, Vannberg FO et al. IkB genetic polymorphisms and invasive pneumococcal disease. Am. J. Respir. Crit. Care Med. 176(2), 181-187 (2007). (Pubitemid 47057855)
48. Chapman SJ, Khor CC, Vannberg FO et al. NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations. Genes Immun. DOI:10.1038/gene.2009.76 (2009) (Epub ahead of print).
49. Ku CL, Picard C, Erdos M et al. IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease. J. Med. Genet. 44(1), 16-23 (2007). (Pubitemid 46142834)
50. Menges T, Konig IR, Hossain H et al. Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor. Crit. Care Med. 36(5), 1456-1462, e1-e6 (2008).
51. Schueller AC, Heep A, Kattner E et al. Prevalence of two tumor necrosis factor gene polymorphisms in premature infants with early onset sepsis. Biol. Neonate 90(4), 229-232 (2006). (Pubitemid 44775194)
52. Azim K, McManus R, Brophy K, Ryan A, Kelleher D, Reynolds JV. Genetic polymorphisms and the risk of infection following esophagectomy positive association with TNF-a gene -308 genotype. Ann. Surg. 246(1), 122-128 (2007). (Pubitemid 47012216)
53. O'Keefe GE, Hybki DL, Munford RS. The G→A single nucleotide polymorphism at the -308 position in the tumor necrosis factor-a promoter increases the risk for severe sepsis after trauma. J. Trauma 52(5), 817-825; discussion 825-1816 (2002).
54. Mira JP, Cariou A, Grall F et al. Association of TNF2, a TNF-a promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study. JAMA 282(6), 561-568 (1999). (Pubitemid 29380293)
55. Cipriano C, Caruso C, Lio D et al. The -308G/A polymorphism of TNF-a influences immunological parameters in old subjects affected by infectious diseases. Int. J. Immunogenet. 32(1), 13-18 (2005). (Pubitemid 40222588)
56. Hedberg CL, Adcock K, Martin J, Loggins J, Kruger TE, Baier RJ. Tumor necrosis factor a - 308 polymorphism associated with increased sepsis mortality in ventilated very low birth weight infants. Pediatr. Infect. Dis. J. 23(5), 424-428 (2004). (Pubitemid 38621481)
57. Nuntayanuwat S, Dharakul T, Chaowagul W, Songsivilai S. Polymorphism in the promoter region of tumor necrosis factor-a gene is associated with severe meliodosis. Hum. Immunol. 60(10), 979-983 (1999). (Pubitemid 29518123)
58. Stuber F, Udalova IA, Book M et al. -308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter. J. Inflamm. 46(1), 42-50 (1995). (Pubitemid 26090861)
59. Calvano JE, Um JY, Agnese DM et al. Influence of the TNF-a and TNF-b polymorphisms upon infectious risk and outcome in surgical intensive care patients. Surg. Infect. (Larchmt) 4(2), 163-169 (2003).
60. Westendorp RG, Langermans JA, Huizinga TW et al. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 349(9046), 170-173 (1997). (Pubitemid 27039197)
61. Waterer GW, Quasney MW, Cantor RM, Wunderink RG. Septic shock and respiratory failure in community-acquired pneumonia have different TNF polymorphism associations. Am. J. Respir. Crit. Care Med. 163(7), 1599-1604 (2001).
62. Pappachan JV, Coulson TG, Child NJ et al. Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF-238A polymorphism. Immunogenetics 61(10), 657-662 (2009).
63. Bayley JP, Ottenhoff TH, Verweij CL. Is there a future for TNF promoter polymorphisms? Genes Immun. 5(5), 315-329 (2004).
64. Stuber F, Petersen M, Bokelmann F, Schade U. A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-a concentrations and outcome of patients with severe sepsis. Crit. Care Med. 24(3), 381-384 (1996). (Pubitemid 26097828)
65. Majetschak M, Flohe S, Obertacke U et al. Relation of a TNF gene polymorphism to severe sepsis in trauma patients. Ann. Surg. 230(2), 207-214 (1999). (Pubitemid 30191887)
66. Temple SE, Cheong KY, Ardlie KG, Sayer D, Waterer GW. The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B. Intensive Care Med. 30(9), 1761-1767 (2004). (Pubitemid 39297180)
67. Waterer GW, ElBahlawan L, Quasney MW, Zhang Q, Kessler LA, Wunderink RG. Heat shock protein 70-72+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia. Crit. Care Med. 31(5), 1367-1372 (2003). (Pubitemid 36583845)
68. Pociot F, Molvig J, Wogensen L, Worsaae H, Nerup J. A TaqI polymorphism in the human interleukin-1 b (IL-1 b) gene correlates with IL-1 b secretion in vitro. Eur. J. Clin. Invest. 22(6), 396-402 (1992).
69. Read RC, Camp NJ, di Giovine FS et al. An interleukin-1 genotype is associated with fatal outcome of meningococcal disease. J. Infect. Dis. 182(5), 1557-1560 (2000).
70. Fang XM, Schroder S, Hoeft A, Stuber F. Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis. Crit. Care Med. 27(7), 1330-1334 (1999). (Pubitemid 29379372)
71. Arnalich F, Lopez-Maderuelo D, Codoceo R et al. Interleukin-1 receptor antagonist gene polymorphism and mortality in patients with severe sepsis. Clin. Exp. Immunol. 127(2), 331-336 (2002). (Pubitemid 34233940)
72. Ma P, Chen D, Pan J, Du B. Genomic polymorphism within interleukin-1 family cytokines influences the outcome of septic patients. Crit. Care Med. 30(5), 1046-1050 (2002). (Pubitemid 34508027)
73. Schluter B, Raufhake C, Erren M et al. Effect of the interleukin-6 promoter polymorphism (-174 G/C) on the incidence and outcome of sepsis. Crit. Care Med. 30(1), 32-37 (2002). (Pubitemid 34112173)
74. Sutherland AM, Walley KR, Manocha S, Russell JA. The association of interleukin 6 haplotypeclades with mortality in critically ill adults. Arch. Intern. Med. 165(1), 75-82 (2005). (Pubitemid 40096085)
75. Baier R, Loggins J, Yanamandra K. IL-10, IL-6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight infants. BMC Med. 12(4), 10-12 (2006).
76. Calandra T, Roger T. Macrophage migration inhibitory factor: a regulator of innate immunity. Nat. Rev. Immunol. 3(10), 791-800 (2003). (Pubitemid 37328657)
77. Gao L, Flores C, Fan-Ma S et al. Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations. Trans. Res. 150(1), 18-29 (2007).
78. Yende S, Angus DC, Kong L et al. The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia. FASEB J. 23(8), 2403-2411 (2009).
79. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur. J. Immunogenet. 24(1), 1-8 (1997).
80. Temple SE, Lim E, Cheong KY et al. Alleles carried at positions -819 and -592 of the IL10 promoter affect transcription following stimulation of peripheral blood cells with Streptococcus pneumoniae. Immunogenetics 55(9), 629-632 (2003).
81. Schaaf BM, Boehmke F, Esnaashari H et al. Pneumococcal septic shock is associated with the interleukin-10-1082 gene promoter polymorphism. Am. J. Respir. Crit. Care Med. 168(4), 476-480 (2003).
82. Gallagher PM, Lowe G, Fitzgerald T et al. Association of IL-10 polymorphism with severity of illness in community acquired pneumonia. Thorax 58(2), 154-156 (2003).
83. Stanilova SA, Miteva LD, Karakolev ZT, Stefanov CS. Interleukin-10-1082 promoter polymorphism in association with cytokine production and sepsis susceptibility. Intensive Care Med. 32(2), 260-266 (2006).
84. Gong MN, Thompson BT, Williams PL et al. Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome. Eur. Respir. J. 27(4), 674-681 (2006).
85. Shu Q, Fang X, Chen Q, Stuber F. IL-10 polymorphism is associated with increased incidence of severe sepsis. Chin. Med. J. (Engl.) 116(11), 1756-1759 (2003).
86. Wattanathum A, Manocha S, Groshaus H, Russell JA, Walley KR. Interleukin-10 haplotype associated with increased mortality in critically ill patients with sepsis from pneumonia but not in patients with extrapulmonary sepsis. Chest 128(3), 1690-1698 (2005).
87. Bastarache JA, Ware LB, Bernard GR. The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome. Semin. Respir. Crit. Care Med. 27(4), 365-376 (2006).
88. Weiler H, Kerlin B, Lytle MC. Factor V Leiden polymorphism modifies sepsis outcome: evidence from animal studies. Crit. Care Med. 32(5 Suppl.), S233-S238 (2004).
89. Yan SB, Nelson DR. Effect of factor V Leiden polymorphism in severe sepsis and on treatment with recombinant human activated protein C. Crit. Care Med. 32(5 Suppl.), S239-S246 (2004).
90. Chen QX, Wu SJ, Wang HH et al. Protein C -1641A/-1654C haplotype is associated with organ dysfunction and the fatal outcome of severe sepsis in Chinese Han population. Hum. Genet. 123(3), 281-287 (2008).
91. Walley K, Russell J. Protein C-1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis. Crit. Care Med. 35(1), 12-17 (2007).
92. Russell JA. Genetics of coagulation factors in acute lung injury. Crit. Care Med. 31(4 Suppl.), S243-S247 (2003).
93. Geishofer G, Binder A, Muller M et al. 4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene in children with systemic meningococcaemia. Eur. J. Pediatr. 164(8), 486-490 (2005).
94. Haralambous E, Hibberd ML, Hermans PW, Ninis N, Nadel S, Levin M. Role of functional plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism in susceptibility, severity, and outcome of meningococcal disease in Caucasian children. Crit. Care Med. 31(12), 2788-2793 (2003).
95. Hermans PW, Hibberd ML, Booy R et al. 4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococcal disease. Meningococcal Research Group. Lancet 354(9178), 556-560 (1999).
96. Westendorp RG, Hottenga JJ, Slagboom PE. Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock. Lancet 354(9178), 561-563 (1999).
97. Binder A, Endler G, Muller M, Mannhalter C, Zenz W. 4G4G genotype of the plasminogen activator inhibitor-1 promoter polymorphism associates with disseminated intravascular coagulation in children with systemic meningococcemia. J. Thromb. Haemost. 5(10), 2049-2054 (2007).
98. Domingo P, Muniz-Diaz E, Baraldes MA et al. Relevance of genetically determined host factors to the prognosis of meningococcal disease. Eur. J. Clin. Microbiol. Infect. Dis. 23(8), 634-637 (2004).
99. Yende S, Angus DC, Ding J et al. 4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia. Am. J. Respir. Crit. Care Med. 176(11), 1129-1137 (2007).
100. Sapru A, Hansen H, Ajayi T et al. 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia. Anesthesiology 110(5), 1086-1091 (2009).
101. Chen QX, Lv C, Huang LX et al. Genomic variations within DEFB1 are associated with the susceptibility to and the fatal outcome of severe sepsis in Chinese Han population. Genes Immun. 8(5), 439-443 (2007).
102. Stassen NA, Breit CM, Norfleet LA, Polk HC Jr. IL-18 promoter polymorphisms correlate with the development of post-injury sepsis. Surgery 134(2), 351-356 (2003).
103. Stassen NA, Leslie-Norfleet LA, Robertson AM, Eichenberger MR, Polk HC Jr. Interferon-g gene polymorphisms and the development of sepsis in patients with trauma. Surgery 132(2), 289-292 (2002).
104. Flores C, Maca-Meyer N, Perez-Mendez L et al. A CXCL2 tandem repeat promoter polymorphism is associated with susceptibility to severe sepsis in the Spanish population. Genes Immun. 7(2), 141-149 (2006).
105. Chen Q, Zhou H, Wu S et al. Lack of association between TREM-1 gene polymorphisms and severe sepsis in a Chinese Han population. Hum. Immunol. 69(3), 220-226 (2008).
106. Payton A, Payne D, Mankhambo LA et al. Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease. BMC Med. Genet. 10, 28 (2009).
107. Moretti EW, Morris RW, Podgoreanu M et al. APOE polymorphism is associated with risk of severe sepsis in surgical patients. Crit. Care Med. 33(11), 2521-2526 (2005).
108. Bunker-Wiersma HE, Koopmans RP, Kuipers TW, Knoester H, Bos AP. Single nucleotide polymorphisms in genes of circulatory homeostasis in surviving pediatric intensive care patients with meningococcal infection. Pediatr. Crit. Care Med. 9(5), 517-523 (2008).
109. Kleiman DA, Calvano JE, Coyle SM, Macor MA, Calvano SE, Lowry SF. A single nucleotide polymorphism in the Mdm2 promoter and risk of sepsis. Am. J. Surg. 197(1), 43-48 (2009).