Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population

Journal of Neural Transmission

Volumn 117, Issue 3, 2010, Pages 393-401

  Zhang, Kerang ^a   Yang, Chunxia ^a   Xu, Yong ^a   Sun, Ning ^a   Yang, Hong ^a   Liu, Jinli ^a   Xu, Qi ^b   Shen, Yan ^b  

^a SHANXI MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

Brain derived neurotrophic factor (bdnf); Gene gene interaction; Genetic association; Glycogen synthase kinase 3 beta (gsk3b); Major depressive disorder (mdd)

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN KINASE B; PROTEIN KINASE B1; UNCLASSIFIED DRUG;

ADULT; AGE DISTRIBUTION; ALLELE; ARTICLE; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; FEMALE; GENE INTERACTION; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; SEX DETERMINATION; SIGNAL TRANSDUCTION;

ADOLESCENT; ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHINA; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS C-AKT; YOUNG ADULT;

EID: 77951456168     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-009-0360-4     Document Type: Article

References (47)

1. Adli M, Hollinde DL, Stamm T, Wiethoff K, Tsahuridu M, Kirchheiner J, Heinz A, Bauer M (2007) Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism. Biol Psychiatry 62:1295-1302 (Pubitemid 350060894)
2. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Press, Washington
3. Aydemir O, Deveci A, Taneli F (2005) The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study. Prog Neuropsychopharmacol Biol Psychiatry 29:261-265 (Pubitemid 40202912)
4. Aydemir C, Yalcin ES, Aksaray S, Kisa C, Yildirim SG, Uzbay T, Goka E (2006) Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women. Prog Neuropsychopharmacol Biol Psychiatry 30:1256-1260 (Pubitemid 44216065)
5. Barrett JC, Fry B, Mailer J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (Oxford, England) 21:263-265 (Pubitemid 40202029)
6. Benedetti F, Serretti A, Colombo C, Lorenzi C, Tubazio V, Smeraldi E (2004) A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression. Neurosci Lett 368:123-126 (Pubitemid 39194855)
7. Bierut LJ, Heath AC, Bucholz KK, Dinwiddie SH, Madden PA, Statham DJ, Dunne MP, Martin NG (1999) Major depressive disorder in a community-based twin sample: are there different genetic and environmental contributions for men and women? Arch Gen Psychiatry 56:557-563
8. Cervilla JA, Molina E, Rivera M, Torres-González F, Bellón JA, Moreno B, Luna JD, Lorente JA, Mayoral F, King M, Nazareth I, PREDICT Study Core Group, Gutiérrez B (2007) The risk for depression conferred by stressful life events is modified by variation at the serotonin transporter 5HTTLPR genotype: evidence from the Spanish PREDICT-Gene cohort. Mol Psychiatry 12:748-755 (Pubitemid 47172690)
9. Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT (2001) Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry 50:260-265 (Pubitemid 32778442)
10. Chen L, Lawlor DA, Lewis SJ, Yuan W, Abdollahi MR, Timpson NJ, Day IN, Ebrahim S, Smith GD, Shugart YY (2008) Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis. Am J Med Genet B Neuropsychiatr Genet 147B:814-821
11. Choi MJ, Kang RH, Lim SW, Oh KS, Lee MS (2006) Brain-derived neurotrophic factor gene polymorphism (Val66Met) and Citalopram response in major depressive disorder. Brain Res 1118:176-182 (Pubitemid 44633860)
12. Dudbridge F (2003) Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25:11.5-121
13. Dudbridge F (2008) Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum. Hered 66:87-98
14. Dupont WD, Plummer WD Jr (1998) Power and sample size calculations for studies involving linear regression. Control Clin Trials 19:589-601 (Pubitemid 29057724)
15. Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN (2003) Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 60:804-815 (Pubitemid 36960912)
16. Foulstone EJ, Tavaré JM, Gunn-Moore FJ (1999) Sustained phosphorylation and activation of protein kinase B correlates with brain-derived neurotrophic factor and insulin stimulated survival of cerebellar granule cells. Neurosci Lett 264:125-128
17. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D (2002) The structure of haplotype blocks in the human genome. Science 296:2225-2229 (Pubitemid 34680308)
18. Grimes CA, Jope RS (2001) The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog Neurobiol 65:391-426
19. Hong CJ, Huo SJ, Yen FC, Tung CL, Pan GM, Tsai SJ (2003) Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 48:186-189
20. Hsiung SC, Adlersberg M, Arango V, Mann JJ, Tamir H, Liu KP (2003) Attenuated 5HTIa receptor signaling in brains of suicide victims: Involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen activated protein kinase. J Neurochem 87:182-194 (Pubitemid 37210652)
21. Huang EJ, Reichardt LF (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677-736 (Pubitemid 32695243)
22. Hwang JP, Tsai SJ, Hong CJ, Yang CH, Lirng JF, Yang YM (2006) The Val66Met polymorphism of the brain-derived neurotrophicfactor gene is associated with geriatric depression. Neurobiol Aging 27:1.834-1837 (Pubitemid 44572586)
23. Janssen J, Hulshoff Pol HE, de Leeuw FE, Schnack HG, Lampe IK, Kok RM, Kahn RS, Heeren TJ (2007) Hippocampal volume and subcortical white matter lesions in late life depression: comparison of early- and late-onset depression. J Neurol Neurosurg Psychiatry 78:638-640 (Pubitemid 46853904)
24. Jope RS, Bijur GN (2002) Mood stabilizers, glycogen synthase kinase-3 beta and cell survival. MoI Psychiatry 7:S35-S45
25. Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM (2002) Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 109:143-148 (Pubitemid 34258493)
26. Karege F, Vaudan G, Schwald M, Perroud N, La Harpe R (2005) Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Brain Res MoI Brain Res 136:29-37 (Pubitemid 40704606)
27. Karege F, Perroud N, Burkhardt S, Schwald M, Ballmann E, La Harpe R, Malafosse A (2007) Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3beta in ventral prefrontal cortex of depressed suicide victims. Biol Psychiatry 61:240-245 (Pubitemid 46072784)
28. Kato M, Serretti A (2008) Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. MoI Psychiatry [Epub ahead of print]
29. Kim YK, Lee HP, Won SD, Park EY, Lee HY, Lee BH, Yoon D, Han C, Kim DJ, Choi SH (2007) Low plasma BDNF is associated with suicidal behavior in major depression. Prog Neuropsychopharmacol Biol Psychiatry 31:78-85 (Pubitemid 44959250)
30. Li M, Li C (2008) Assessing departure from Hardy-Weinberg equilibrium in the presence of disease association. Genet Epidemiol 32:589-599
31. Mai L, Jope RS, Li X (2002) BDNF-mediated signal transduction is modulated by GSK3Beta and mood stabilizing agents. J Neurochem. 82:75-83 (Pubitemid 34755251)
32. Neumeister A, Wood S, Bonne O, Nugent AC, Luckenbaugh DA, Young T, Bain EE, Charney DS, Drevets WC (2005) Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects. Biol Psychiatry 57:935-937 (Pubitemid 40488364)
33. Park SW, Lee JG, Kong BG, Lee SJ, Lee CH, Kim JI, Kim YH (2009) Genetic association of BDNF val66met and GSK-3beta-50T/C polymorphisms with tardive dyskinesia. Psychiatry Clin Neurosci 63:433-439
34. Ribeiro L, Busnello JV, Cantor RM, Whelan F, Whittaker P, Deloukas P, Wong ML, Licinio J (2007) The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. Neuroreport 18:1291-1293 (Pubitemid 47075599)
35. Serretti A, Benedetti F, Mandelli L, Calati R, Caneva B, Lorenzi C, Fontana V, Colombo C, Smeraldi E (2008) Association between GSK-3beta -50T/C polymorphism and personality and psychotic symptoms in mood disorders. Psychiatry Res 158:132-140 (Pubitemid 351291662)
36. Sheline YI, Gado MH, Kraemer HC (2003) Untreated depression and hippocampal volume loss. Am J Psychiatry 160:1516-1518 (Pubitemid 41070930)
37. ShimizuE,HashimotoK,IyoM(2004)EthnicdifferenceoftheBDNF196G/A(val66met) polymorphismfrequencies:thepossibility-explainethnicmentaltraits. AmJMedGenetBNeuropsychiatrGenet126B:122-123(Pubitemid38420134)
38. Sullivan PF, Neale MC, Kendler KS (2000) Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 157:1552-1562
39. Sun N, Xu Y, Wang Y, Duan H, Wang S, Ren Y, Peng J, Du Q, Shen Y, Xu Q, Zhang K (2008) The combined effect of norepinephrine transporter gene and negative life events in major depression of Chinese Han population. J Neural Transm 115:1681-1686
40. Thoenen H (1995) Neurotrophins and neuronal plasticity. Science 270:593-598
41. Toyota T, Yamada K, Detera -Wadleigh SD, Yoshikawa T (2003) Analysis of a cluster of polymorphisms in AKTl gene in bipolar pedigrees: a family-based association study. Neurosci Lett 339:5-8 Tozzi F, Prokopenko I, Perry JD, Kennedy JL, McCarthy AD, Holsboer F, Berrettini W, Middleton LT, Chilcoat HD, Muglia P (2008) Family history of depression is associated with younger age of onset in patients with recurrent depression. Psychol Med 38:641-649 (Pubitemid 36263208)
42. Tsai SJ, Cheng CY, Yu YW, Chen TJ, Hong CJ (2003) Association study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response. Am J Med Genet B Neuropsychiatr Genet 123B: 19-22
43. Tsai SJ, Lion YJ, Hong CJ, Yu YW, Chen TJ (2008) Glycogen synthase kinase-3beta gene is associated with, antidepressant treatment response in Chinese major depressive disorder. Pharmacogenomics J 8:384-390
44. Verhagen M, van der Meij A, van Deurzen PA, Janzing JG, AriasVásquez A, Buitelaar JK, Franke B (2008) Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. MoI Psychiatry [Epub ahead of print]
45. Wang Q, Liu L, Pei L, Ju W, Ahmadian G, Lu J, Wang Y, Liu F, Wang YT (2003) Control of synaptic strength, a novel function of Akt. Neuron 38:91.5-928 (Pubitemid 36782383)
46. Wittchen HU, Essau CA, von Zerssen D, Krieg JC, Zaudig M (1992) Lifetime and six-month prevalence of mental disorders in the Munich Follow-Up Study. Eur Arch Psychiatry Clin Neurosci 241:247-258
47. Zanardini R, Gazzoli A, Ventriglia M, Perez J, Bignotti S, Rossini PM, Gennarelli M, Bocchio-Chiavetto L (2006) Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients. J Affect Disord 91:83-86 (Pubitemid 43254643)