Alteration in Kinase Activity But Not in Protein Levels of Protein Kinase B and Glycogen Synthase Kinase-3β in Ventral Prefrontal Cortex of Depressed Suicide Victims

Biological Psychiatry

Volumn 61, Issue 2, 2007, Pages 240-245

  Karege, Félicien ^a,b   Perroud, Nader ^a   Burkhardt, Sandra ^b   Schwald, Michèle ^a   Ballmann, Eladia ^a   La Harpe, Romano ^b   Malafosse, Alain ^a,b  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Akt; GSK 3 ; major depression disorder; postmortem prefrontal cortex; suicide

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM; PHOSPHOTRANSFERASE; PROTEIN KINASE B;

ANALYSIS OF VARIANCE; ARTICLE; CADAVER; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; ENZYME ACTIVITY; FEMALE; HUMAN; MAJOR DEPRESSION; MALE; PHOSPHORYLATION; PREFRONTAL CORTEX; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; SUICIDE; VICTIM; WESTERN BLOTTING;

ADULT; AGED; CAUSE OF DEATH; DEPRESSIVE DISORDER, MAJOR; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOBLOTTING; MALE; MIDDLE AGED; PREFRONTAL CORTEX; PROTO-ONCOGENE PROTEINS C-AKT; REFERENCE VALUES; SUICIDE;

EID: 33846095133     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.04.036     Document Type: Article

References (30)

1. Cheng A.T. Mental illness and suicide. A case-control study in east Taiwan. Arch Gen Psychiatry 52 (1995) 594-603
2. Cheng A., Wang S., Yang D., Xsao R., and Mattson M.P. Calmodulin mediates brain-derived neurotrophic factor cell survival signaling upstream of Akt kinase in embryonic neocortical neurons. J Biol Chem 278 (2003) 7591-7599
3. Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., and Hemmings B.A. Inhibition of glycogen synthase kinase-3 by insulin-mediated Protein kinase B. Nature 378 (1995) 785-789
4. Dunner D.L. Cortrelates of suicidal behavior and lithium in bipolar disorder. J Clin Psychiatry 65 suppl 10 (2004) 5-10
5. Dwivedi Y., Mondal A.C., Rizavi H.S., and Conley R.R. Suicide brain is associated with decreased expression of neurotrophins. Biol Psychiatry 58 (2005) 315-324
6. Fang X., Yu S.X., Lu Y., Bast R.C., Woodgett J.R., and Mills G.B. Phosphorylation and inactivation of glycogen synthase kinase-3 by protein kinase A. PNAS 97 (2000) 11960-11965
7. Goode N., Hughes K., Woodget J.R., and Parker P.J. Differential regulation of glycogen synthase kinase-3β by Protein kinse C isotypes. J Biol Chem 267 (1992) 16878-16882
8. Grimes C.A., and Jope R.S. The multifaceted roles of glycogen synthase kinase 3β in cellular signaling. Prog Neurobiol 65 (2001) 391-426
9. Hsiung S.C., Adlersberg M., Arango V., Mann J.J., Tamir H., and Liu K.P. Attenuated 5HT1a receptor signaling in brains of suicide victims: Involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase. J Neurochem 87 (2003) 182-194
10. Jope R.S., and Bijur G.N. Mood stabilizers, glycogen kinase-3β and cell survival. Mol Psychiatry 7 (2002) S35-S45
11. Kamali M., Oquendo M.A., and Mann J. Understanding the neurobiology of suicidal behavior. Depress Anxiety 14 (2001) 164-176
12. Karege F., Vaudan G., Schwald M., Perroud N., and La Harpe R. Neurotrophin levels in postmortem brains of suicide of victims and the effects of antemortem diagnosis and psychotropic drugs. Mol Brain Research 136 (2005) 29-37
13. Kaidanovich-Beilin O., Milman A., Weizman A., Pick C.G., and Eldar-Finkelman H. Rapid antidepressant-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on β-catenin in mouse hippocampus. Biol Psychiatry 55 (2004) 7881-7884
14. Kelly T.M., and Mann J.J. Validity of DSM-III-R diagnosis by psychological autopsy: A comparison with clinician antemortem diagnosis. Acta Psychiatr Scand 94 (1996) 337-343
15. Klein P.S., and Melton D.A. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci U S A 93 (1996) 8455-8459
16. Knable M.B., Barci M.B., Webster M.J., Meador-Woodruff J., and Torrey E.F. Molecular abnormalities of hippocampus in severe psychiatric illness: Post-mortem findings from the Stanley Neuropathology Consortium. Mol Psychiatry 9 (2004) 609-620
17. Kozlovsky N., Belmaker R.H., and Agam G. Low GSK-3β Immunoreactivity in postmortem of schizophrenic patients. Am J Psychiatry 157 (2000) 831-833
18. Lawlor M., and Alessi D. PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?. J Cell Sci 114 (2001) 2903-2910
19. Lesort M., Greendorf A., Stockmeier C., Johnson G.V.W., and Jope L. Glycogen synthase kinase-3β, β-catenin, and tau in postmortem bipolar brain. J Neural Transm 106 (1999) 1217-1222
20. Li X., Zhu W., Roh M.S., Friedman A.B., Rosborough K., and Jope R.S. In vivo regulation of glycogen synthase kinase-3β (GSK-3β) by serotoninergic activity in mouse brain. Neuropsychopharmacol 29 (2004) 1426-1431
21. Malafosse A. Genetics of suicidal behavior. Am J Med Genet C Semin Med Genet 133 (2005) 1-2
22. Mann J.J. Neurobiology of suicide. Nat Med 4 (1998) 25-29
23. Mann J.J., Brent D.A., and Arango V. The neurobiology and genetics of suicide and attempted suicide: A focus on the serotonergic system. Neuropsychopharmacol 24 (2001) 467-477
24. Mann J.J., Huang Y.Y., Underwood M.D., Kassir S.A., Openheim S., and Kelly T.M. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry 57 (2000) 729-738
25. Müller-Oerlinghausen B., Berghofer A., and Ahrens B. The antisuicidal and mortality-reducing effect of lithium prophylaxis: Consequences for guidelines in clinical psychiatry. Can J Psychiatry 48 (2003) 433-439
26. O'Brien W.T., Harper A.D., Jove F., Woodgett J.R., Maretto S., Piccolo S., and Klein P.S. Glycogen synthase kinase-3β haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci 24 (2004) 6791-6798
27. Rajkowska G. Postmortem studies in mood disorders indicate altered number of neurons and glyal cells. Biol Psychiatry 48 (2000) 766-777
28. Rich C.L., Young D., and Fowler R. San Diego suicide study I. Young vs old subjects. Arch Gen Psychiatry 43 (1986) 577-582
29. Stambolic V., Ruel L., and Woodgett J.R. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signaling in intact cells. Current Biol 6 (1996) 1664-1668
30. Weinberg I. The prisoners of despair: Right hemisphere deficiency and suicide. Neurosci Biobehav Rev 24 (2000) 799-815