Hippocampal volume and subcortical white matter lesions in late life depression: Comparison of early and late onset depression

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 78, Issue 6, 2007, Pages 638-640

  Janssen, Joost ^a   Hulshoff Pol, Hilleke E ^b   De Leeuw, Frank Erik ^c   Schnack, Hugo G ^b   Lampe, Indrag K ^c   Kok, Rob M ^d   Kahn, Rene S ^b   Heeren, Thea J ^d  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d Department of Old Age Psychiatry ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN CIRCULATION; BRAIN CORTEX; BRAIN DAMAGE; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; HIPPOCAMPUS; HUMAN; HYPERTENSION; MINI MENTAL STATE EXAMINATION; MONTGOMERY ASBERG DEPRESSION RATING SCALE; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; PRIORITY JOURNAL; RISK FACTOR; SMOKING HABIT; WHITE MATTER; BRAIN DISEASE; COMPARATIVE STUDY; MAJOR DEPRESSION; MIDDLE AGED; ORGAN SIZE; PATHOLOGY; RECURRENT DISEASE; TIME;

AGE OF ONSET; BRAIN DISEASES; CEREBRAL CORTEX; DEPRESSIVE DISORDER, MAJOR; FEMALE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; ORGAN SIZE; RECURRENCE; TIME FACTORS;

EID: 34249675449     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2006.098087     Document Type: Article

References (20)

1. Sheline YI, Sanghavi M, Mintun MA, et al. Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. J Neurosci 1999;19:5034-43.
2. Bell-McGinty S, Butters MA, Meltzer CC, et al. Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration. Am J Psychiatry 2002;159:1424-7.
3. O'Brien JT, Lloyd A, McKeith I, et al. A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects. Am J Psychiatry 2004;161:2081-90.
4. MacQueen GM, Campbell S, McEwen BS, et al. Course of illness, hippocampal function, and hippocampal volume in major depression. Proc Natl Acad Sci USA 2003;100:1387-92.
5. Lloyd AJ, Ferrier IN, Barber R, et al. Hippocampal volume change in depression: late- and early-onset illness compared. Br J Psychiatry 2004;184:488-95.
6. Hickie I, Naismith S, Ward PB, et al. Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression. Br J Psychiatry 2005;186:197-202.
7. Figiel GS, Krishnan KR, Doraiswamy PM, et al. Subcortical hyperintensities on brain magnetic resonance imaging: a comparison between late age onset and early onset elderly depressed subjects. Neurobiol Aging 1991;12:245-7.
8. Salloway S, Malloy P, Kohn R, et al. MRI and neuropsychological differences in early- and late-life-onset geriatric depression. Neurology 1996;46:1567-74.
9. de Groot JC, de Leeuw FE, Oudkerk M, et al. Cerebral white matter lesions and depressive symptoms in elderly adults. Arch Gen Psychiatry 2000;57:1071-6.
10. Kril JJ, Patel S, Harding AJ, et al. Patients with vascular dementia due to microvascular pathology have significant hippocampal neuronal loss. J Neurol Neurosurg Psychiatry 2002;72:747-51.
11. de Leeuw FE, Barkhof F, Scheltens P. White matter lesions and hippocampal atrophy in Alzheimer's disease. Neurology 2004;62:310-12.
12. den Heijer T, Launer U, Prins ND, et al. Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe. Neurology 2005;64:263-7.
13. Janssen J, Hulshoff Pol HE, Lampe IK, et al. Hippocampal changes and white matter lesions in early-onset depression. Biol Psychiatry 2004;56:825-31.
14. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
15. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979;134:382-9.
16. Almeida OP, Burton EJ, Ferrier N, et al. Depression with late onset is associated with right frontal lobe atrophy. Psychol Med 2003;33:675-81.
17. Lee SH, Payne ME, Steffens DC, et al. Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression. Biol Psychiatry 2003;54:529-33.
18. Kumar A, Mintz J, Bilker W, et al. Autonomous neurobiological pathways to late-life major depressive disorder. Clinical and pathophysiological implications. Neuropsychopharmacology 2002;26:229-36.
19. Sapolsky RM. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 2000;57:925-35.
20. Krishnan KR, Taylor WD, McQuoid DR, et al. Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression. Biol Psychiatry 2004;55:390-7.