Remodeling of dynamic structures of HIV-1 envelope proteins leads to synthetic antigen molecules inducing neutralizing antibodies

Bioconjugate Chemistry

Volumn 21, Issue 4, 2010, Pages 709-714

  Nakahara, Toru ^a   Nomura, Wataru ^a   Ohba, Kenji ^b   Ohya, Aki ^a   Tanaka, Tomohiro ^a   Hashimoto, Chie ^a   Narumi, Tetsuo ^a   Murakami, Tsutomu ^b   Yamamoto, Naoki ^b   Tamamura, Hirokazu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CELL MEMBRANES;

ANTIGEN-TARGETING; DYNAMIC STRUCTURE; ENVELOPE PROTEINS; FUSION MECHANISM; HIV-1 INFECTIONS; INHIBITORY ACTIVITY; MEMBRANE FUSION; NATIVE STRUCTURES; NEUTRALIZING ANTIBODIES; SYMMETRICS;

ANTIGENS;

ENVELOPE PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY;

ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; DRUG DESIGN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNIZATION; INFECTION PREVENTION; MALE; MOUSE; NONHUMAN; PROTEIN MODIFICATION; PROTEIN STRUCTURE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77951287748     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc900502z     Document Type: Article

References (37)

1. Cabezas, E., Wang, M., Parren, P. W. H. I., Stanfield, R. L., and Satterthwait, A. C. (2000) A structure-based approach to a synthetic vaccine for HIV-1 Biochemistry 39, 14377-14391
2. Burton, D. R., Barbas, C. F., III, Persson, M. A. A., Koenig, S., Chanock, R. M., and Lerner, R. A. (1991) A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals Proc. Natl. Acad. Sci. U.S.A. 88, 10134-10137
3. Conley, A. J., Kessler, J. A. II, Boots, L. J., Tung, J. S., Arnold, B. A., Keller, P. M., Shaw, A. R., and Emini, R. A. (1994) Neutralization of divergent human immunodeficiency virus type 1 variants and primary isolates by IAM-41-2F5, an anti-gp41 human monoclonal antibody Proc. Natl. Acad. Sci. U.S.A. 91, 3348-3352
4. Ofek, G., Tang, M., Sambor, A., Katinger, H., Mascola, J. R., Wyatt, R., and Kwong, P. D. (2004) Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope J. Virol. 78, 10724-10737
5. Alam, S. M., McAdams, M., Boren, D., Rak, M., Scearce, R. M., Gao, F., Camacho, Z. T., Gewirth, D., Kelsoe, G., Chen, P., and Haynes, B. F. (2007) The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes J. Immunol. 178, 4424-4435
6. Nelson, J. D., Brunel, F. M., Jensen, R., Crooks, E. T., Cardoso, R. M. F., Wang, M., Hessell, A., Wilson, I. A., Binley, J. M., Dawson, P. E., Burton, D. R., and Zwick, M. B. (2007) An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10 J. Virol. 81, 4033-4043
7. Cardoso, R. M. F., Zwick, M. B., Stanfield, R. L., Kunert, R., Binley, J. M., Katinger, H., Burton, D. R., and Wilson, I. A. (2005) Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41 Immunity 22, 163-173
8. Trkola, A., Purtscher, M., Muster, T., Ballaun, C., Buchacher, A., Sullivan, N., Srinivasan, K., Sodroski, J., Moore, J. P., and Katinger, H. (1996) Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1 J. Virol. 70, 1100-1108 (Pubitemid 26029030)
9. Pantophlet, R., Saphire, E. O., Poignard, P., Parren, P. W. H. I., Wilson, I. A., and Burton, D. R. (2003) Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120 J. Virol. 77, 642-658
10. Sanders, R. W., Vesanen, M., Schuelke, N., Master, A., Schiffner, L., Kalyanaraman, R., Paluch, M., Berkhout, B., Maddon, P. J., Olson, W. C., Lu, M., and Moore, J. P. (2002) Stabilization of the soluble, cleaved, trimeric form of the envelope glycoprotein complex of human immunodeficiency virus type 1 J. Virol. 76, 8875-8889
11. Yang, X., Wyatt, R., and Sodroski, J. (2001) Improved elicitation of neutralizing antibodies against primary human immunodeficiency viruses by soluble stabilized envelope glycoprotein trimers J. Virol. 75, 1165-1171
12. Grundner, C., Mirzabekov, T., Sodroski, J., and Wyatt, R. (2002) Solid-phase proteoliposomes containing human immunodeficiency virus envelope glycoproteins J. Virol. 76, 3511-3521
13. De Rosny, E., Vassell, R., Wingfield, R. T., Wild, C. T., and Weiss, C. D. (2001) Peptides corresponding to the heptad repeat motifs in the transmembrane protein (gp41) of human immunodeficiency virus type 1 elicit antibodies to receptor-activated conformations of the envelope glycoprotein J. Virol. 75, 8859-8863
14. Tam, J. P. and Yu, Q. (2002) A facile ligation approach to prepare three-helix bundles of HIV fusion-state protein mimetics Org. Lett. 4, 4167-4170
15. Xu, W. and Taylor, J. W. (2007) A template-assembled model of the N-peptide helix bundle from HIV-1 gp-41 with high affinity for C-peptide Chem. Biol. Drug Des. 70, 319-328
16. Louis, J. M., Nesheiwat, I., Chang, L., Clore, G. M., and Bewlet, C. A. (2003) Covalent trimers of the internal N-terminal trimeric coiled-coil of gp41 and antibodies directed against them are potent inhibitors of HIV envelope-mediated cell fusion J. Biol. Chem. 278, 20278-20285
17. Chen, Y.-H., Yang, J. T., and Chau, K. H. (1974) Determination of the helix and β form of proteins in aqueous solution by circular dichroism Biochemistry 13, 3350-3359
18. Gans, P. J., Lyu, P. C., Manning, M. C., Woody, R. W., and Kallenbach, N. R. (1991) The helix-coil transition in heterogeneous peptides with specific side-chain interactions: theory and comparison with CD spectral data Biopolymers 13, 1605-1614
19. Jackson, D. Y., King, D. S., Chmielewski, J., Singh, S., and Schultz, P. G. (1991) A general approach to the synthesis of short alpha-helical peptides J. Am. Chem. Soc. 113, 9391-9392
20. Ohba, K., Ryo, A., Dewan, M. Z., Nishi, M., Naito, T., Qi, X., Inagaki, Y., Nagashima, Y., Tanaka, Y., Okamoto, T., Terashima, K., and Yamamoto, N. (2009) Follicular dendritic cells activate HIV-1 replication in monocytes/macrophages through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand 1 J. Immunol. 183, 524-532
21. Liu, J., Shu, W., Fagan, M. B., Nunberg, J. H., and Lu, H. (2001) Structural and functional analysis of the HIV gp41 core containing an Ile573 to Thr substitution: implications for membrane fusion Biochemistry 40, 2797-2807
22. Liu, C. F. and Tam, J. P. (1994) Peptide segment ligation strategy without use of protecting groups Proc. Natl. Acad. Sci. U.S.A. 91, 6584-6588
23. Tam, J. P. and Miao, Z. (1999) Stereospecific pseudoproline ligation of N-terminal serine, threonine, or cysteine-containing unprotected peptides J. Am. Chem. Soc. 121, 9013-9022
24. Tam, J. P., Yu, Q., and Yang, J.-L. (2001) Tandem ligation of unprotected peptides through thiaprolyl and cysteinyl bonds in water J. Am. Chem. Soc. 123, 2487-94
25. Eom, K. D., Miao, Z., Yang, J.-L., and Tam, J. P. (2003) Tandem ligation of multipartite peptides with cell-permeable activity J. Am. Chem. Soc. 125, 73-82
26. Sadler, K., Zhang, Y., Xu, J., Yu, Q., and Tam, J. P. (2008) Quaternary protein mimetics of gp41 elicit neutralizing antibodies against HIV fusion-active intermediate state Biopolym. (Pept. Sci.) 90, 320-329
27. Bychkova, V. E., Dujsekina, A. E., Klenin, S. I., Tiktopulo, E. I., Uversky, V. N., and Ptitsyn, O. B. (1996) Molten globule-like state of cytochrome c under conditions simulating those near the membrane surface Biochemistry 35, 6058-6063
28. 1-acid glycoprotein FEBS Lett. 579, 3596-3600
29. Chan, D. C., Chutkowski, C. T., and Kim, P. S. (1998) Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target Proc. Natl. Acad. Sci. U.S.A. 95, 15613-15617
30. Liu, S., Jing, W., Cheng, B., Lu, H., Sun, J., Yan, X., Niu, J., Farmar, J., Wu, S., and Jiang, S. (2007) HIV gp41 C-terminal heptad repeat contains multifunctional domains: relation to mechanism of action of anti-HIV peptides J. Biol. Chem. 282, 9612-9620
31. Franke, R., Hirsch, T., Overwin, H., and Eichler, J. (2007) Synthetic mimetics of the CD4 binding site of HIV-1 gp120 for the design of immunogens Angew. Chem., Int. Ed. 46, 1253-1255
32. Robinson, J. A. (2008) β-hairpin peptidomimetics: design, structures and biological activities Acc. Chem. Res. 41, 1278-1288
33. Lu, M., Ji, H., and Shen, S. (1999) Subdomain folding and biological activity of the core structure from human immunodeficiency virus type 1 gp41: implications for viral membrane fusion J. Virol. 73, 4433-4438
34. Eckert, D. M. and Kim, P. S. (2001) Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region Proc. Natl. Acad. Sci. U.S.A. 98, 11187-11192
35. Bianchi, E., Finotto, M., Ingallinella, P., Hrin, R., Carella, A. V., Hous, X. S., Schleif, W. A., and Miller, M. D. (2005) Covalent stabilization of coiled coils of the HIV gp41 N region yields extreamely potent and broad inhibitors of viral infection Proc. Natl. Acad. Sci. U.S.A. 102, 12903-12908
36. Zwick, M. B., Saphire, E. O., and Burton, D. R. (2004) gp41: HIVs shy protein Nat. Med. 10, 133-134
37. Walker, L. M., Phogat, S. K., Chan-Hui, P.-Y., Wagner, D., Phung, P., Goss, J. L., Wrin, T., Simek, M. D., Fling, S., Mitcham, J. L., Lehrman, J. K., Priddy, F. H., Olsen, O. A., Frey, S. M., Hammond, P. W., Kaminsky, S., Zamb, T., Moyle, M., Koff, W. C., Poignard, P., and Burton, D. R. (2009) Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target Science 326, 285-289