Hand2 regulates chondrogenesis in vitro and in vivo

Bone

Volumn 46, Issue 5, 2010, Pages 1359-1368

  Abe, Makoto ^a   Michikami, Ikumi ^a   Fukushi, Toshiya ^a   Abe, Akiko ^a   Maeda, Yoshinobu ^a   Ooshima, Takashi ^a   Wakisaka, Satoshi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Basic helix loop helix; Chondrogenesis; Collagen; Hand2; Transgenic

Indexed keywords

AGGRECAN; AXIN; AXIN 2; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; COLLAGEN TYPE 2; COLLAGENASE 3; DIMER; TRANSCRIPTION FACTOR HAND2; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR TWIST 1; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE; CARTILAGE CELL; CELL MATURATION; CHONDROGENESIS; CONTROLLED STUDY; DNA BINDING; DWARFISM; EMBRYO; ENCHONDRAL OSSIFICATION; GENE EXPRESSION; GENE FUNCTION; GENE INDUCTION; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; LIMB BUD; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; SIGNAL TRANSDUCTION; SKELETON MALFORMATION; SKULL BASE; STERNUM; TRANSGENIC MOUSE;

AGGRECANS; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, WESTERN; CELL LINE; CHONDROGENESIS; COLLAGEN TYPE II; EXTREMITIES; FEMALE; GENOTYPE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MESODERM; MICE; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SOX9 TRANSCRIPTION FACTOR;

EID: 77951254875     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.11.022     Document Type: Article

References (56)

1. Kronenberg H.M. Developmental regulation of the growth plate. Nature 2003, 423:332-336.
2. Lefebvre V., Huang W., Harley V.R., Goodfellow P.N., de Crombrugghe B. SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol. Cell. Biol. 1997, 17:2336-2346.
3. Bi W., Deng J.M., Zhang Z., Behringer R.R., de Crombrugghe B. Sox9 is required for cartilage formation. Nat. Genet. 1999, 22:85-89.
4. Kadesch T. Consequences of heteromeric interactions among helix-loop-helix proteins. Cell. Growth Differ. 1993, 4:49-55.
5. O'Rourke M.P., Tam P.P. Twist functions in mouse development. Int. J. Dev. Biol. 2002, 46:401-413.
6. Olson E.N. Klein WH. bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes Dev. 1994, 8:1-8.
7. Aiyer A.R., Honarpour N., Herz J., Srivastava D. Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype. Dev. Biol. 2005, 278:155-162.
8. Srivastava D., Cserjesi P., Olson E.N. A subclass of bHLH proteins required for cardiac morphogenesis. Science 1995, 270:1995-1999.
9. Srivastava D., Thomas T., Lin Q., Kirby M.L., Brown D., Olson E.N. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat. Genet. 1997, 16:154-160.
10. Yelon D., Ticho B., Halpern M.E., Ruvinsky I., Ho R.K., Silver L.M., et al. The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development. Development 2000, 127:2573-2582.
11. Yamagishi H., Garg V., Matsuoka R., Thomas T., Srivastava D. A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects. Science 1999, 283:1158-1161.
12. Yamagishi H., Olson E.N., Srivastava D. The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. J. Clin. Invest. 2000, 105:261-270.
13. Yanagisawa H., Clouthier D.E., Richardson J.A., Charite J., Olson E.N. Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development. Development 2003, 130:1069-1078.
14. McFadden D.G., McAnally J., Richardson J.A., Charite J. Olson EN Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding. Development 2002, 129:3077-3088.
15. Charite J., McFadden D.G., Olson E.N. The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. Development 2000, 127:2461-2470.
16. Fernandez-Teran M., Piedra M.E., Kathiriya I.S., Srivastava D., Rodriguez-Rey J.C., Ros M.A. Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway. Development 2000, 127:2133-2142.
17. Giles R.H., van Es J.H., Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim. Biophys. Acta 2003, 1653:1-24.
18. Lee H.Y., Kleber M., Hari L., Brault V., Suter U., Taketo M.M., et al. Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells. Science 2004, 303:1020-1023.
19. Dorsky R.I., Moon R.T., Raible D.W. Control of neural crest cell fate by the Wnt signalling pathway. Nature 1998, 396:370-373.
20. Brault V., Moore R., Kutsch S., Ishibashi M., Rowitch D.H., McMahon A.P., et al. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 2001, 128:1253-1264.
21. Hasegawa S., Sato T., Akazawa H., Okada H., Maeno A., Ito M., et al. Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:297-302.
22. Ten Berge D., Brugmann S.A., Helms J.A., Nusse R. Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development. Development 2008, 135:3247-3257.
23. Enomoto-Iwamoto M., Kitagaki J., Koyama E., Tamamura Y., Wu C., Kanatani N., et al. The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis. Dev. Biol. 2002, 251:142-156.
24. Gong Y., Slee R.B., Fukai N., Rawadi G., Roman-Roman S., Reginato A.M., et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 2001, 107:513-523.
25. McFadden D.G., Charite J., Richardson J.A., Srivastava D., Firulli A.B., Olson E.N. A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development 2000, 127:5331-5341.
26. Ruest L.B., Dager M., Yanagisawa H., Charite J., Hammer R.E., Olson E.N., et al. dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development. Dev. Biol. 2003, 257:263-277.
27. Lefebvre V., Mukhopadhyay K., Zhou G., Garofalo S., Smith C., Eberspaecher H., et al. 47-bp sequence of the first intron of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte Expression. Ann. N. Y. Acad. Sci. 1996, 785:284-287.
28. Korinek V., Barker N., Morin P.J., van Wichen D., de Weger R., Kinzler K.W., et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 1997, 275:1784-1787.
29. Abe M., Inagaki S., Furuyama T., Iwamoto M., Wakisaka S. Semaphorin 4D inhibits collagen synthesis of rat pulp-derived cells. Arch. Oral. Biol. 2008, 53:27-34.
30. Reinhold M.I., Abe M., Kapadia R.M., Liao Z., Naski M.C. FGF18 represses noggin expression and is induced by calcineurin. J. Biol. Chem. 2004, 279:38209-38219.
31. Hendershot T.J., Liu H., Sarkar A.A., Giovannucci D.R., Clouthier D.E., Abe M., et al. Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system. Dev. Dyn. 2007, 236:93-105.
32. Gack S., Vallon R., Schmidt J., Grigoriadis A., Tuckermann J., Schenkel J., et al. Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. Cell. Growth Differ. 1995, 6:759-767.
33. Jho E.H., Zhang T., Domon C., Joo C.K., Freund J.N., Costantini F. Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol. Cell. Biol. 2002, 22:1172-1183.
34. Abe M., Tamamura Y., Yamagishi H., Maeda T., Kato J., Tabata M.J., et al. Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis. Cell Tissue Res. 2002, 310:201-212.
35. Bruggeman L.A., Xie H.X., Brown K.S., Yamada Y. Developmental regulation for collagen II gene expression in transgenic mice. Teratology 1991, 44:203-208.
36. Reinhold M.I., Kapadia R.M., Liao Z., Naski M.C. The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis. J. Biol. Chem. 2006, 281:1381-1388.
37. McBratney-Owen B., Iseki S., Bamforth S.D., Olsen B.R., Morriss-Kay G.M. Development and tissue origins of the mammalian cranial base. Dev. Biol. 2008, 322:121-132.
38. Firulli B.A., Krawchuk D., Centonze V.E., Vargesson N., Virshup D.M., Conway S.J., et al. Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat. Genet. 2005, 37:373-381.
39. Hinoi E., Bialek P., Chen Y.T., Rached M.T., Groner Y., Behringer R.R., et al. Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes Dev. 2006, 20:2937-2942.
40. Dao D.Y., Yang X., Flick L.M., Chen D., Hilton M.J., O'Keefe R.J. Axin2 regulates chondrocyte maturation and axial skeletal development. J. Orthop. Res. 2009.
41. Day T.F., Guo X., Garrett-Beal L., Yang Y. Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev. Cell. 2005, 8:739-750.
42. Firulli B.A., Redick B.A., Conway S.J., Firulli A.B., Mutations within helix I. of Twist1 result in distinct limb defects and variation of DNA binding affinities. J. Biol. Chem. 2007, 282:27536-27546.
43. Vincentz J.W., Barnes R.M., Rodgers R., Firulli B.A., Conway S.J., Firulli A.B. An absence of Twist1 results in aberrant cardiac neural crest morphogenesis. Dev. Biol. 2008, 320:131-139.
44. el Ghouzzi V., Le Merrer M., Perrin-Schmitt F., Lajeunie E., Benit P., Renier D., et al. Mutations of the TWIST gene in the Saethre-Chotzen syndrome. Nat. Genet. 1997, 15:42-46.
45. Howard T.D., Paznekas W.A., Green E.D., Chiang L.C., Ma N., Ortiz de Luna R.I., et al. Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome. Nat. Genet. 1997, 15:36-41.
46. Niedrist D., Lurie I.W., Schinzel A. 4q32-q35 and 6q16-q22 are valuable candidate regions for split hand/foot malformation. Eur. J. Hum. Genet. 2009.
47. Sato T., Kurihara Y., Asai R., Kawamura Y., Tonami K., Uchijima Y., et al. An endothelin-1 switch specifies maxillomandibular identity. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:18806-18811.
48. Ovchinnikov D.A., Deng J.M., Ogunrinu G., Behringer R.R. Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice. Genesis 2000, 26:145-146.
49. Funato N., Chapman S.L., McKee M.D., Funato H., Morris J.A., Shelton J.M., et al. Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2. Development 2009, 136:615-625.
50. Enomoto-Iwamoto M., Enomoto H., Komori T., Iwamoto M. Participation of Cbfa1 in regulation of chondrocyte maturation. Osteoarthritis Cartilage 2001, 9(Suppl A):S76-S84.
51. Ueta C., Iwamoto M., Kanatani N., Yoshida C., Liu Y., Enomoto-Iwamoto M., et al. Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J. Cell. Biol. 2001, 153:87-100.
52. Komori T.A. fundamental transcription factor for bone and cartilage. Biochem. Biophys. Res. Commun. 2000, 276:813-816.
53. Guo X., Ramirez A., Waddell D.S., Li Z., Liu X., Wang X.F. Axin and GSK3-control Smad3 protein stability and modulate TGF-signaling. Genes Dev. 2008, 22:106-120.
54. Dao D.Y., Yang X., Chen D., Zuscik M., O'Keefe R.J. Axin1 and Axin2 are regulated by TGF - and mediate cross-talk between TGF - and Wnt signaling pathways. Ann. N.Y. Acad. Sci. 2007, 1116:82-99.
55. Liu W., Rui H., Wang J., Lin S., He Y., Chen M., et al. Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 2006, 25:1646-1658.
56. Furuhashi M., Yagi K., Yamamoto H., Furukawa Y., Shimada S., Nakamura Y., et al. Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway. Mol. Cell. Biol. 2001, 21:5132-5141.