The expression of p53 and p16 in the course of microcystin-LR inducing of liver tumor

Chinese-German Journal of Clinical Oncology

Volumn 7, Issue 12, 2008, Pages 690-693

  Hu, Zhijian ^a,b   Chen, Hua ^b   Pang, Chunyan ^b   Lin, Qiying ^a  

^a FUJIAN AGRICULTURE AND FORESTRY UNIVERSITY   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

GGT; Microcystin; p16; p53

Indexed keywords

EID: 58049209250     PISSN: 16101979     EISSN: 16139089     Source Type: Journal    
DOI: 10.1007/s10330-008-0137-5     Document Type: Article

References (15)

1. Yu SZ, Dong CH, Zhang YC. Two biotoxins and liver cancer-aflatoxin and algal toxin. J Hygiene Res (Chinese), 2000, 27: 84.
2. Sun CS, Chen H, Xue CG, et al. Study of distribution of algal toxin and algal species in Tong-an environment. Chin Public Health (Chinese), 2000, 16: 147-148.
3. Oh HM, Lee SJ, Jang MH, et al. Microcystin production by microcystis aeruginosa in a phosphorus-limited chemostat. Appl Environ Microbiol, 2000, 66: 176-179.
4. Rutenberg AM, Kim H, Fischbein JW, et al. Histochemical and ultrastructural demonstration of gamma-glutamyl transpeptidase activity. J Histochem Cytochem, 1969, 17: 517-526.
5. Ito N, Tamano S, Shirai T. A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals. Cancer Sci, 2003, 94: 3-8.
6. Beer DG, Schwarz M, Sawada N, et al. Expression of H-ras and c-myc protooncogenes in isolated gamma-glutamyl transpeptidasepositive rat hepatocytes and in hepatocellular carcinomas induced by diethylnitrosamine. Cancer Res, 1996, 46: 2435-2441.
7. Petersen BE, Goff JP, Greenberger JS, et al. Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat. Hepatology, 1998, 27: 433-445.
8. Sheng WD, Huang JF. Progress in specific GGT for diagnosis of liver cancer. World Chin J Digestol (Chinese), 2003, 13: 3-8.
9. Fawell JK, Mitchell RE, Everett DJ, et al. The toxicity of cyanobacterial toxins in the mouse: I microcystin-LR. Hum Exp Toxicol, 1999, 18: 162-167.
10. Nakajima H, Nakajima HO, Tsai SC, et al. Expression of mutant p193 and p53 permits cardiomyocyte cell cycle reentry after myocardial infarection in transgenic mice. Circ Res, 2004, 94: 1606-1614.
11. Offer H, Zurer I, Banfalvi G, et al. p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress. Cancer Res, 2001, 61: 88-96.
12. Li M, Zhou JY, Ge Y, et al. The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation. J Biol Chem, 2003, 278: 41059-41068.
13. Gudas JM, Oka M, Diella F, et al. Expression of wild-type p53 during the cell cycle in normal human mammary epithelial cells. Cell Growth Differ, 1994, 5: 295-304.
14. Spurgers KB, Gold DL, Coombes KR, et al. Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression. J Biol Chem, 2006, 281: 25134-25142.
15. Omura-Minamisawa M, Diccianni MB, Chang RC, et al. p16/p14 (ARF) cell cycle regulatory pathways in primary neuroblastoma: P16 expression is associated with advanced. Clin Cancer Res, 2001, 7: 3481-3490.