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Volumn 103, Issue 7, 2010, Pages 929-938

Health effects with consumption of the flax lignan secoisolariciresinol diglucoside

Author keywords

Flax lignans; Health benefits; Secoisolariciresinol diglucoside

Indexed keywords

ENTERODIOL; ENTEROLACTONE; LIGNAN; LIGNAN DERIVATIVE; LINOLENIC ACID; PLACEBO; SECOISOLARICIRESINOL; SECOISOLARICIRESINOL DIGLUCOSE; UNCLASSIFIED DRUG; ANTIOXIDANT; BUTANEDIOL; ENZYME ACTIVATOR; ENZYME INHIBITOR; GLUCOSIDE; LIGNIN; PHYTOESTROGEN; SECOISOLARICIRESINOL DIGLUCOSIDE;

EID: 77951234112     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114509992753     Document Type: Review
Times cited : (227)

References (87)
  • 1
    • 42649086808 scopus 로고    scopus 로고
    • Flaxseed and cardiovascular risk factors: Results from a double blind, randomized, controlled clinical trial
    • Bloedon LT, Balikai S, Chittams J, et al. (2008) Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial. J Am Coll Nutr 27, 65-74.
    • (2008) J Am Coll Nutr , vol.27 , pp. 65-74
    • Bloedon, L.T.1    Balikai, S.2    Chittams, J.3
  • 2
    • 0036277731 scopus 로고    scopus 로고
    • Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women
    • Lucas EA, Wild RD, Hammond LJ, et al. (2002) Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. J Clin Endocrinol Metab 87, 1527-1532.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1527-1532
    • Lucas, E.A.1    Wild, R.D.2    Hammond, L.J.3
  • 3
    • 57449111513 scopus 로고    scopus 로고
    • Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery
    • Demark-Wahnefried W, Polascik TJ, George SL, et al. (2008) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiol Biomarkers Prev 17, 3577-3587.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 3577-3587
    • Demark-Wahnefried, W.1    Polascik, T.J.2    George, S.L.3
  • 4
    • 0029951809 scopus 로고    scopus 로고
    • The influence of flaxseed and lignans on colon carcinogenesis and b-glucuronidase activity
    • Jenab M & Thompson LU (1996) The influence of flaxseed and lignans on colon carcinogenesis and b-glucuronidase activity. Carcinogenesis 17, 1343-1348.
    • (1996) Carcinogenesis , vol.17 , pp. 1343-1348
    • Jenab, M.1    Thompson, L.U.2
  • 5
    • 32344447058 scopus 로고    scopus 로고
    • Variation of mucilage in flax seed and its relationship with other seed characters
    • Diederichsen A (2006) Variation of mucilage in flax seed and its relationship with other seed characters. Crop Sci 46, 365-371.
    • (2006) Crop Sci , vol.46 , pp. 365-371
    • Diederichsen, A.1
  • 6
    • 33846822562 scopus 로고    scopus 로고
    • Physicochemical and quality characteristics of cold-pressed flaxseed oils
    • Choo WS (2007) Physicochemical and quality characteristics of cold-pressed flaxseed oils. J Food Compost Anal 20, 202-211.
    • (2007) J Food Compost Anal , vol.20 , pp. 202-211
    • Choo, W.S.1
  • 7
    • 0033666149 scopus 로고    scopus 로고
    • HPLC method for analysis of secoisolariciresinol diglucoside in flaxseeds
    • Johnsson P, Kamal-Eldin A, Lundgren LN, et al. (2000) HPLC method for analysis of secoisolariciresinol diglucoside in flaxseeds. J Agric Food Chem 48, 5216-5219.
    • (2000) J Agric Food Chem , vol.48 , pp. 5216-5219
    • Johnsson, P.1    Kamal-Eldin, A.2    Lundgren, L.N.3
  • 8
    • 0037467079 scopus 로고    scopus 로고
    • Identification and stereochemical characterization of lignans in flaxseed and pumpkin seeds
    • Sicilia T, Niemeyer HB, Honig DM, et al. (2003) Identification and stereochemical characterization of lignans in flaxseed and pumpkin seeds. J Agric Food Chem 51, 1181-1188.
    • (2003) J Agric Food Chem , vol.51 , pp. 1181-1188
    • Sicilia, T.1    Niemeyer, H.B.2    Honig, D.M.3
  • 9
    • 45549104369 scopus 로고    scopus 로고
    • Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects
    • Zhang W, Wang X, Liu Y, et al. (2008) Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects. Br J Nutr 99, 1301-1309.
    • (2008) Br J Nutr , vol.99 , pp. 1301-1309
    • Zhang, W.1    Wang, X.2    Liu, Y.3
  • 10
    • 0035850944 scopus 로고    scopus 로고
    • An oligomer from flaxseed composed of secoisolariciresinoldiglu-coside and 3-hydroxy-3-methyl glutaric acid residues
    • Kamal-Eldin A, Peerlkamp N, Johnsson P, et al. (2001) An oligomer from flaxseed composed of secoisolariciresinoldiglu-coside and 3-hydroxy-3-methyl glutaric acid residues. Phyto-chemistry 58, 587-590.
    • (2001) Phyto-chemistry , vol.58 , pp. 587-590
    • Kamal-Eldin, A.1    Peerlkamp, N.2    Johnsson, P.3
  • 11
    • 0027440286 scopus 로고
    • Linusitamarin, a new phenylpropanoid glucoside from Linum usitatissimum
    • Luyengi L, Pezzuto JM, Waller DP, et al. (1993) Linusitamarin, a new phenylpropanoid glucoside from Linum usitatissimum. J Nat Prod 56, 2012-2015.
    • (1993) J Nat Prod , vol.56 , pp. 2012-2015
    • Luyengi, L.1    Pezzuto, J.M.2    Waller, D.P.3
  • 12
    • 40249116251 scopus 로고    scopus 로고
    • Separation and determination of secoisolariciresinol diglucoside oligomers and their hydrolysates in the flaxseed extract by high-performance liquid chromatography
    • Li X, Yuan JP, Xu SP, et al. (2008) Separation and determination of secoisolariciresinol diglucoside oligomers and their hydrolysates in the flaxseed extract by high-performance liquid chromatography. J Chromatogr A 1185, 223-232.
    • (2008) J Chromatogr A , vol.1185 , pp. 223-232
    • Li, X.1    Yuan, J.P.2    Xu, S.P.3
  • 13
    • 34548852835 scopus 로고    scopus 로고
    • Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro
    • Hu C, Yuan YV & Kitts DD (2007) Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro. Food Chem Toxicol 45, 2219-2227.
    • (2007) Food Chem Toxicol , vol.45 , pp. 2219-2227
    • Hu, C.1    Yuan, Y.V.2    Kitts, D.D.3
  • 14
    • 4143146361 scopus 로고    scopus 로고
    • Glucuronidation, oxidative metabolism, and bioactivation of enterolactone in rhesus monkeys
    • Dean B, Chang S, Doss GA, et al. (2004) Glucuronidation, oxidative metabolism, and bioactivation of enterolactone in rhesus monkeys. Arch Biochem Biophys 429, 244-251.
    • (2004) Arch Biochem Biophys , vol.429 , pp. 244-251
    • Dean, B.1    Chang, S.2    Doss, G.A.3
  • 16
    • 44649100746 scopus 로고    scopus 로고
    • Enterodiol and enterolactone, two major diet-derived polyphe-nol metabolites have different impact on ERa transcriptional activation in human breast cancer cells
    • Carreau C, Flouriot G, Bennetau-Pelissero C, et al. (2008) Enterodiol and enterolactone, two major diet-derived polyphe-nol metabolites have different impact on ERa transcriptional activation in human breast cancer cells. J Steroid Biochem Mol Biol 110, 176-185.
    • (2008) J Steroid Biochem Mol Biol , vol.110 , pp. 176-185
    • Carreau, C.1    Flouriot, G.2    Bennetau-Pelissero, C.3
  • 17
    • 0023551893 scopus 로고
    • Stimulation of breast cancer cells in vitro by the environmental estrogen enterolactone and the phytoestrogen equol
    • Welshons WV, Murphy CS, Koch R, et al. (1987) Stimulation of breast cancer cells in vitro by the environmental estrogen enterolactone and the phytoestrogen equol. Breast Cancer Res Treat 10, 169-175.
    • (1987) Breast Cancer Res Treat , vol.10 , pp. 169-175
    • Welshons, W.V.1    Murphy, C.S.2    Koch, R.3
  • 18
    • 0030880014 scopus 로고    scopus 로고
    • Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells
    • Wang C & Kurzer MS (1997) Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells. Nutr Cancer 28, 236-247.
    • (1997) Nutr Cancer , vol.28 , pp. 236-247
    • Wang, C.1    Kurzer, M.S.2
  • 19
    • 0028280245 scopus 로고
    • Stimulation of ps2 expression by diet-derived compounds
    • Sathyamoorthy N, Wang TT & Phang JM (1994) Stimulation of ps2 expression by diet-derived compounds. Cancer Res 54, 957-961.
    • (1994) Cancer Res , vol.54 , pp. 957-961
    • Sathyamoorthy, N.1    Wang, T.T.2    Phang, J.M.3
  • 20
    • 3242798960 scopus 로고    scopus 로고
    • Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor a (ERa) and ERb in human cells
    • Mueller SO, Simon S, Chae K, et al. (2004) Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor a (ERa) and ERb in human cells. Toxicol Sci 80, 14-25.
    • (2004) Toxicol Sci , vol.80 , pp. 14-25
    • Mueller, S.O.1    Simon, S.2    Chae, K.3
  • 21
    • 0034993372 scopus 로고    scopus 로고
    • Determinants of serum enterolactone concentration
    • Kilkkinen A, Stumpf K, Pietinen P, et al. (2001) Determinants of serum enterolactone concentration. Am J Clin Nutr 73, 1094-1100.
    • (2001) Am J Clin Nutr , vol.73 , pp. 1094-1100
    • Kilkkinen, A.1    Stumpf, K.2    Pietinen, P.3
  • 22
    • 0027325608 scopus 로고
    • Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chroma-tography-mass spectrometry
    • Adlercreutz H, Fotsis T, Lampe J, et al. (1993) Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chroma-tography-mass spectrometry. Scand J Clin Lab Invest Suppl 215, 5-18.
    • (1993) Scand J Clin Lab Invest Suppl , vol.215 , pp. 5-18
    • Adlercreutz, H.1    Fotsis, T.2    Lampe, J.3
  • 23
    • 69149098470 scopus 로고    scopus 로고
    • Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice
    • Penttinen-Damdimopoulou PE, Power KA, Hurmerinta TT, et al. (2009) Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice. Mol Nutr Food Res 53, 996-1006.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 996-1006
    • Penttinen-Damdimopoulou, P.E.1    Power, K.A.2    Hurmerinta, T.T.3
  • 24
    • 34748891664 scopus 로고    scopus 로고
    • Diet-derived polyphenol metabolite enterolactone is a tissue-specific estrogen receptor activator
    • Penttinen P, Jaehrling J, Damdimopoulos AE, et al. (2007) Diet-derived polyphenol metabolite enterolactone is a tissue-specific estrogen receptor activator. Endocrinology 148, 4875-4886.
    • (2007) Endocrinology , vol.148 , pp. 4875-4886
    • Penttinen, P.1    Jaehrling, J.2    Damdimopoulos, A.E.3
  • 25
    • 0033758487 scopus 로고    scopus 로고
    • Antioxidant activity of secoisolariciresinol diglucoside-derived metabolites, secoisolariciresinol, enterodiol, and enterolactone
    • Prasad K (2000) Antioxidant activity of secoisolariciresinol diglucoside-derived metabolites, secoisolariciresinol, enterodiol, and enterolactone. Int J Angiol 9, 220-225.
    • (2000) Int J Angiol , vol.9 , pp. 220-225
    • Prasad, K.1
  • 26
    • 46749104505 scopus 로고    scopus 로고
    • Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyper-plasia
    • Zhang W, Wang X, Liu Y, et al. (2008) Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyper-plasia. J Med Food 11, 207-214.
    • (2008) J Med Food , vol.11 , pp. 207-214
    • Zhang, W.1    Wang, X.2    Liu, Y.3
  • 27
    • 18144386167 scopus 로고    scopus 로고
    • Mammalian lignans and genistein decrease the activities of aromatase and 17b-hydroxy-steroid dehydrogenase in MCF-7 cells
    • Brooks JD & Thompson LU (2005) Mammalian lignans and genistein decrease the activities of aromatase and 17b-hydroxy-steroid dehydrogenase in MCF-7 cells. J Steroid Biochem Mol Biol 94, 461-467.
    • (2005) J Steroid Biochem Mol Biol , vol.94 , pp. 461-467
    • Brooks, J.D.1    Thompson, L.U.2
  • 28
    • 63849287738 scopus 로고    scopus 로고
    • Phytochemicals for breast cancer prevention by targeting aromatase
    • Adams LS & Chen S (2009) Phytochemicals for breast cancer prevention by targeting aromatase. Front Biosci 14, 3846-3863.
    • (2009) Front Biosci , vol.14 , pp. 3846-3863
    • Adams, L.S.1    Chen, S.2
  • 29
    • 0035072168 scopus 로고    scopus 로고
    • Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component
    • Juurlink BHJ (2001) Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component. Can J Physiol Pharmacol 79, 266-282.
    • (2001) Can J Physiol Pharmacol , vol.79 , pp. 266-282
    • Juurlink, B.H.J.1
  • 30
    • 0031726651 scopus 로고    scopus 로고
    • Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cells
    • Wang W, Liu LQ, Higuchi CM, et al. (1998) Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cells. Biochem Pharmacol 56, 189-195.
    • (1998) Biochem Pharmacol , vol.56 , pp. 189-195
    • Wang, W.1    Liu, L.Q.2    Higuchi, C.M.3
  • 31
    • 68149137606 scopus 로고    scopus 로고
    • Primary and secondary prevention of cardiovascular diseases: A practical evidence-based approach
    • O'Keefe JH, Carter MD & Lavie CJ (2009) Primary and secondary prevention of cardiovascular diseases: a practical evidence-based approach. Mayo Clin Proc 84, 741-757.
    • (2009) Mayo Clin Proc , vol.84 , pp. 741-757
    • O'Keefe, J.H.1    Carter, M.D.2    Lavie, C.J.3
  • 32
    • 64849088450 scopus 로고    scopus 로고
    • Visceral obesity: The link among inflammation, hypertension, and cardiovascular disease
    • Mathieu P, Poirier P, Pibarot P, et al. (2009) Visceral obesity: the link among inflammation, hypertension, and cardiovascular disease. Hypertension 53, 577-584.
    • (2009) Hypertension , vol.53 , pp. 577-584
    • Mathieu, P.1    Poirier, P.2    Pibarot, P.3
  • 33
    • 39449121917 scopus 로고    scopus 로고
    • Regression of hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed
    • Prasad K (2008) Regression of hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Atherosclerosis 197, 34-42.
    • (2008) Atherosclerosis , vol.197 , pp. 34-42
    • Prasad, K.1
  • 34
    • 14944371679 scopus 로고    scopus 로고
    • Hypocholesterolemic and antiatherosclerotic effect of flax lignan complex isolated from flaxseed
    • DOI 10.1016/j.atherosclerosis.2004.11.012
    • Prasad K (2005) Hypocholesterolemic and antiatherosclerotic effect of flax lignan complex isolated from flaxseed. Atherosclerosis 179, 269-275. (Pubitemid 40364620)
    • (2005) Atherosclerosis , vol.179 , Issue.2 , pp. 269-275
    • Prasad, K.1
  • 35
    • 0033574164 scopus 로고    scopus 로고
    • Reduction of serum cholesterol and hyper-cholesterolemic atherosclerosis in rabbits by secoisolarici-resinol diglucoside isolated from flaxseed
    • Prasad K (1999) Reduction of serum cholesterol and hyper-cholesterolemic atherosclerosis in rabbits by secoisolarici-resinol diglucoside isolated from flaxseed. Circulation 99, 1355-1362.
    • (1999) Circulation , vol.99 , pp. 1355-1362
    • Prasad, K.1
  • 36
    • 61449102645 scopus 로고    scopus 로고
    • Flax lignan complex slows down the progression of atherosclerosis in hyperlipidemic rabbits
    • Prasad K (2009) Flax lignan complex slows down the progression of atherosclerosis in hyperlipidemic rabbits. J Cardiovasc Pharmacol Ther 14, 38-48.
    • (2009) J Cardiovasc Pharmacol Ther , vol.14 , pp. 38-48
    • Prasad, K.1
  • 37
    • 37249017171 scopus 로고    scopus 로고
    • A study on regression of hypercholesterolemic atherosclerosis in rabbits by flax lignan complex
    • Prasad K (2007) A study on regression of hypercholesterolemic atherosclerosis in rabbits by flax lignan complex. J Cardiovasc Pharmacol Ther 12, 304-313.
    • (2007) J Cardiovasc Pharmacol Ther , vol.12 , pp. 304-313
    • Prasad, K.1
  • 38
    • 0032006237 scopus 로고    scopus 로고
    • Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low a-linolenic acid
    • Prasad K, Mantha SV, Muir AD, et al. (1998) Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low a-linolenic acid. Atherosclerosis 136, 367-375.
    • (1998) Atherosclerosis , vol.136 , pp. 367-375
    • Prasad, K.1    Mantha, S.V.2    Muir, A.D.3
  • 39
    • 70149102666 scopus 로고    scopus 로고
    • Effects of the flax-seed lignans secoisolariciresinol diglucoside and its aglycone on serum and hepatic lipids in hyperlipidaemic rats
    • Felmlee MA, Woo G, Simko E, et al. (2009) Effects of the flax-seed lignans secoisolariciresinol diglucoside and its aglycone on serum and hepatic lipids in hyperlipidaemic rats. Br J Nutr 102, 361-369.
    • (2009) Br J Nutr , vol.102 , pp. 361-369
    • Felmlee, M.A.1    Woo, G.2    Simko, E.3
  • 40
    • 33846448164 scopus 로고    scopus 로고
    • Secoisolariciresinol diglucoside: Relevance to angiogenesis and cardioprotection against ischemia-reperfusion injury
    • Penumathsa SV, Koneru S, Thirunavukkarasu M, et al. (2007) Secoisolariciresinol diglucoside: relevance to angiogenesis and cardioprotection against ischemia-reperfusion injury. J Pharmacol Exp Ther 320, 951-959.
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 951-959
    • Penumathsa, S.V.1    Koneru, S.2    Thirunavukkarasu, M.3
  • 41
    • 37749035118 scopus 로고    scopus 로고
    • Secoiso-lariciresinol diglucoside induces neovascularization-mediated cardioprotection against ischemia-reperfusion injury in hyper-cholesterolemic myocardium
    • Penumathsa SV, Koneru S, Zhan L, et al. (2008) Secoiso-lariciresinol diglucoside induces neovascularization-mediated cardioprotection against ischemia-reperfusion injury in hyper-cholesterolemic myocardium. J Mol Cell Cardiol 44, 170-179.
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 170-179
    • Penumathsa, S.V.1    Koneru, S.2    Zhan, L.3
  • 42
    • 21244432791 scopus 로고    scopus 로고
    • Antithrombic and anti-atherogenic effects of partially defatted flaxseed meal using a laser-induced thrombosis test in apolipoprotein e and low-density lipoprotein receptor deficient mice
    • Sano T, Oda E, Yamashita T, et al. (2003) Antithrombic and anti-atherogenic effects of partially defatted flaxseed meal using a laser-induced thrombosis test in apolipoprotein E and low-density lipoprotein receptor deficient mice. Blood Coagul Fibrinolysis 14, 707-712.
    • (2003) Blood Coagul Fibrinolysis , vol.14 , pp. 707-712
    • Sano, T.1    Oda, E.2    Yamashita, T.3
  • 43
    • 0033009016 scopus 로고    scopus 로고
    • Health aspects of partially defatted flaxseed, including effects on serum lipids, oxidative measures, and ex vivo androgen and pro-gestin activity: A controlled crossover trial
    • Jenkins DJA, Kendall CWC, Vidgen E, et al. (1999) Health aspects of partially defatted flaxseed, including effects on serum lipids, oxidative measures, and ex vivo androgen and pro-gestin activity: a controlled crossover trial. Am J Clin Nutr 69, 395-402.
    • (1999) Am J Clin Nutr , vol.69 , pp. 395-402
    • Jenkins, D.J.A.1    Kendall, C.W.C.2    Vidgen, E.3
  • 44
    • 0033582124 scopus 로고    scopus 로고
    • Risk of acute coronary events according to serum concentrations of enterolactone: A prospective population-based case-control study
    • Vanharanta M, Voutilainen S, Lakka TA, et al. (1999) Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study. Lancet 354, 2112-2115.
    • (1999) Lancet , vol.354 , pp. 2112-2115
    • Vanharanta, M.1    Voutilainen, S.2    Lakka, T.A.3
  • 45
    • 0037992850 scopus 로고    scopus 로고
    • Risk of cardiovascular disease-related and all-cause death according to serum concentrations of enterolactone: Kuopio Ischaemic Heart Disease Risk Factor Study
    • Vanharanta M, Voutilainen S, Rissanen TH, et al. (2003) Risk of cardiovascular disease-related and all-cause death according to serum concentrations of enterolactone: Kuopio Ischaemic Heart Disease Risk Factor Study. Arch Intern Med 163, 1099-1104.
    • (2003) Arch Intern Med , vol.163 , pp. 1099-1104
    • Vanharanta, M.1    Voutilainen, S.2    Rissanen, T.H.3
  • 46
    • 0347517830 scopus 로고    scopus 로고
    • The effect of flax seed cultivars with differing content of a-linolenic acid and lignans on responses to mental stress
    • Spence JD, Thornton T, Muir AD, et al. (2003) The effect of flax seed cultivars with differing content of a-linolenic acid and lignans on responses to mental stress. J Am Coll Nutr 22, 494-501.
    • (2003) J Am Coll Nutr , vol.22 , pp. 494-501
    • Spence, J.D.1    Thornton, T.2    Muir, A.D.3
  • 47
    • 31544464046 scopus 로고    scopus 로고
    • A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women
    • Hallund J, Ravn-Haren G, Bugel S, et al. (2006) A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmeno-pausal women. J Nutr 136, 112-116. (Pubitemid 43156494)
    • (2006) Journal of Nutrition , vol.136 , Issue.1 , pp. 112-116
    • Hallund, J.1    Ravn-Haren, G.2    Bugel, S.3    Tholstrup, T.4    Tetens, I.5
  • 48
    • 47949126258 scopus 로고    scopus 로고
    • The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women
    • Hallund J, Tetens I, Bügel S, et al. (2008) The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women. Nutr Metab Cardiovasc Dis 18, 497-502.
    • (2008) Nutr Metab Cardiovasc Dis , vol.18 , pp. 497-502
    • Hallund, J.1    Tetens, I.2    Bügel, S.3
  • 49
    • 33748320970 scopus 로고    scopus 로고
    • Daily consumption for six weeks of a lignan complex isolated from flaxseed does not affect endothelial function in healthy postmenopausal women
    • Hallund J, Tetens I, Bugel S, et al. (2006) Daily consumption for six weeks of a lignan complex isolated from flaxseed does not affect endothelial function in healthy postmenopausal women. J Nutr 136, 2314-2318. (Pubitemid 44329988)
    • (2006) Journal of Nutrition , vol.136 , Issue.9 , pp. 2314-2318
    • Hallund, J.1    Tetens, I.2    Bugel, S.3    Tholstrup, T.4    Ferrari, M.5    Teerlink, T.6    Kjaer, A.7    Wiinberg, N.8
  • 50
    • 66149109977 scopus 로고    scopus 로고
    • A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults
    • Cornish SM, Chilibeck PD, Paus-Jennsen L, et al. (2009) A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults. Appl Physiol Nutr Metab 34, 89-98.
    • (2009) Appl Physiol Nutr Metab , vol.34 , pp. 89-98
    • Cornish, S.M.1    Chilibeck, P.D.2    Paus-Jennsen, L.3
  • 51
    • 49649121328 scopus 로고    scopus 로고
    • Flaxseed lignan attenuates high-fat diet-induced fat accumulation and induces adiponectin expression in mice
    • Fukumitsu S, Aida K, Ueno N, et al. (2008) Flaxseed lignan attenuates high-fat diet-induced fat accumulation and induces adiponectin expression in mice. Br J Nutr 100, 669-676.
    • (2008) Br J Nutr , vol.100 , pp. 669-676
    • Fukumitsu, S.1    Aida, K.2    Ueno, N.3
  • 52
    • 0034956076 scopus 로고    scopus 로고
    • Secoisolariciresinol diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat
    • Prasad K (2001) Secoisolariciresinol diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat. J Lab Clin Med 138, 32-39.
    • (2001) J Lab Clin Med , vol.138 , pp. 32-39
    • Prasad, K.1
  • 53
    • 42649116145 scopus 로고    scopus 로고
    • Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: A randomized, double-blind, cross-over trial
    • Pan A, Sun J, Chen Y, et al. (2007) Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial. PLoS ONE 2, e1148.
    • (2007) PLoS ONE , vol.2
    • Pan, A.1    Sun, J.2    Chen, Y.3
  • 54
    • 67649438787 scopus 로고    scopus 로고
    • Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients
    • Pan A, Demark-Wahnefried W, Ye X, et al. (2009) Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients. Br J Nutr 101, 1145-1149.
    • (2009) Br J Nutr , vol.101 , pp. 1145-1149
    • Pan, A.1    Demark-Wahnefried, W.2    Ye, X.3
  • 55
    • 0033013574 scopus 로고    scopus 로고
    • Dietary supplementation with secoisolariciresinol diglycoside (SDG) reduces experimental metastasis of melanoma cells in mice
    • Li D, Yee JA, Thompson LU, et al. (1999) Dietary supplementation with secoisolariciresinol diglycoside (SDG) reduces experimental metastasis of melanoma cells in mice. Cancer Lett 142, 91-96.
    • (1999) Cancer Lett , vol.142 , pp. 91-96
    • Li, D.1    Yee, J.A.2    Thompson, L.U.3
  • 56
    • 0742270542 scopus 로고    scopus 로고
    • Mammary gland morphogenesis is enhanced by exposure to flaxseed or its major lignan during suckling in rats
    • Tan KP, Chen J, Ward WE, et al. (2004) Mammary gland morphogenesis is enhanced by exposure to flaxseed or its major lignan during suckling in rats. Exp Biol Med (Maywood) 229, 147-157.
    • (2004) Exp Biol Med (Maywood) , vol.229 , pp. 147-157
    • Tan, K.P.1    Chen, J.2    Ward, W.E.3
  • 57
    • 0032806446 scopus 로고    scopus 로고
    • Dose effects of flaxseed and its lignan on N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats
    • Rickard SE, Yuan YV, Chen J, et al. (1999) Dose effects of flaxseed and its lignan on N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats. Nutr Cancer 35, 50-57.
    • (1999) Nutr Cancer , vol.35 , pp. 50-57
    • Rickard, S.E.1    Yuan, Y.V.2    Chen, J.3
  • 58
    • 0032824053 scopus 로고    scopus 로고
    • Exposure to flaxseed or its lignan component during different developmental stages influences rat mammary gland structures
    • Tou JC & Thompson LU (1999) Exposure to flaxseed or its lignan component during different developmental stages influences rat mammary gland structures. Carcinogenesis 20, 1831-1835.
    • (1999) Carcinogenesis , vol.20 , pp. 1831-1835
    • Tou, J.C.1    Thompson, L.U.2
  • 59
    • 0033637295 scopus 로고    scopus 로고
    • Exposure to flaxseed or purified lignan during lactation influences rat mammary gland structures
    • Ward WE, Jiang FO & Thompson LU (2000) Exposure to flaxseed or purified lignan during lactation influences rat mammary gland structures. Nutr Cancer 37, 187-192.
    • (2000) Nutr Cancer , vol.37 , pp. 187-192
    • Ward, W.E.1    Jiang, F.O.2    Thompson, L.U.3
  • 60
    • 0141513737 scopus 로고    scopus 로고
    • Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis
    • Chen J, Tan KP, Ward WE, et al. (2003) Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis. Exp Biol Med (Maywood) 228, 951-958.
    • (2003) Exp Biol Med (Maywood) , vol.228 , pp. 951-958
    • Chen, J.1    Tan, K.P.2    Ward, W.E.3
  • 61
    • 0034624313 scopus 로고    scopus 로고
    • Plasma insulin-like growth factor i levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside
    • Rickard SE, Yuan YV & Thompson LU (2000) Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside. Cancer Lett 161, 47-55.
    • (2000) Cancer Lett , vol.161 , pp. 47-55
    • Rickard, S.E.1    Yuan, Y.V.2    Thompson, L.U.3
  • 62
    • 57349104719 scopus 로고    scopus 로고
    • Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts
    • Zhang LY, Wang XL, Sun DX, et al. (2008) Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts. Mol Biol Rep 35, 595-600.
    • (2008) Mol Biol Rep , vol.35 , pp. 595-600
    • Zhang, L.Y.1    Wang, X.L.2    Sun, D.X.3
  • 63
    • 33847392879 scopus 로고    scopus 로고
    • Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo
    • Bergman Jungestrom M, Thompson LU & Dabrosin C (2007) Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo. Clin Cancer Res 13, 1061-1067.
    • (2007) Clin Cancer Res , vol.13 , pp. 1061-1067
    • Bergman Jungestrom, M.1    Thompson, L.U.2    Dabrosin, C.3
  • 64
    • 0347382310 scopus 로고    scopus 로고
    • Serum enterolactone concentration is not associated with breast cancer risk in a nested case-control study
    • Kilkkinen A, Virtamo J, Vartiainen E, et al. (2004) Serum enterolactone concentration is not associated with breast cancer risk in a nested case-control study. Int J Cancer 108, 277-280.
    • (2004) Int J Cancer , vol.108 , pp. 277-280
    • Kilkkinen, A.1    Virtamo, J.2    Vartiainen, E.3
  • 65
    • 64049117580 scopus 로고    scopus 로고
    • Enterolactone inhibits insulin-like growth factor-1 receptor signaling in human prostatic carcinoma PC-3 cells
    • Chen LH, Fang J, Sun Z, et al. (2009) Enterolactone inhibits insulin-like growth factor-1 receptor signaling in human prostatic carcinoma PC-3 cells. J Nutr 139, 653-659.
    • (2009) J Nutr , vol.139 , pp. 653-659
    • Chen, L.H.1    Fang, J.2    Sun, Z.3
  • 66
    • 34748923549 scopus 로고    scopus 로고
    • Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway
    • Chen LH, Fang J, Li H, et al. (2007) Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway. Mol Cancer Ther 6, 2581-2590.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2581-2590
    • Chen, L.H.1    Fang, J.2    Li, H.3
  • 67
    • 0346996531 scopus 로고    scopus 로고
    • Serum enterolactone levels and the risk of breast cancer in women with palpable cysts
    • Boccardo F, Lunardi G, Guglielmini P, et al. (2004) Serum enterolactone levels and the risk of breast cancer in women with palpable cysts. Eur J Cancer 40, 84-89.
    • (2004) Eur J Cancer , vol.40 , pp. 84-89
    • Boccardo, F.1    Lunardi, G.2    Guglielmini, P.3
  • 68
    • 0034906003 scopus 로고    scopus 로고
    • Serum entero-lactone and risk of breast cancer: A case-control study in eastern Finland
    • Pietinen P, Stumpf K, Mannisto S, et al. (2001) Serum entero-lactone and risk of breast cancer: a case-control study in eastern Finland. Cancer Epidemiol Biomarkers Prev 10, 339-344.
    • (2001) Cancer Epidemiol Biomarkers Prev , vol.10 , pp. 339-344
    • Pietinen, P.1    Stumpf, K.2    Mannisto, S.3
  • 69
    • 33645099414 scopus 로고    scopus 로고
    • Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes
    • Gil L, Siems W, Mazurek B, et al. (2006) Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes. Free Radic Res 40, 495-505.
    • (2006) Free Radic Res , vol.40 , pp. 495-505
    • Gil, L.1    Siems, W.2    Mazurek, B.3
  • 70
    • 0036913674 scopus 로고    scopus 로고
    • High blood gluta-thione levels accompany excellent physical and mental health in women aged 60 to 103 years
    • Lang CA, Mills BJ, Lang HL, et al. (2002) High blood gluta-thione levels accompany excellent physical and mental health in women aged 60 to 103 years. J Lab Clin Med 140, 413-417.
    • (2002) J Lab Clin Med , vol.140 , pp. 413-417
    • Lang, C.A.1    Mills, B.J.2    Lang, H.L.3
  • 71
    • 41149150716 scopus 로고    scopus 로고
    • NADPH oxidases, reactive oxygen species, and hypertension: Clinical implications and therapeutic possibilities
    • Paravicini TM & Touyz RM (2008) NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes Care 31, Suppl. 2, S170-S180.
    • (2008) Diabetes Care , vol.31 , Issue.SUPPL. 2
    • Paravicini, T.M.1    Touyz, R.M.2
  • 72
    • 0037111168 scopus 로고    scopus 로고
    • The concept of vascular cognitive impairment
    • Bowler JV (2002) The concept of vascular cognitive impairment. J Neurol Sci 203-204, 11-15.
    • (2002) J Neurol Sci , vol.203-204 , pp. 11-15
    • Bowler, J.V.1
  • 73
    • 0033967258 scopus 로고    scopus 로고
    • Redox regulation of nuclear factor kB: Therapeutic potential for attenuating inflammatory responses
    • Christman JW, Blackwell TS & Juurlink BH (2000) Redox regulation of nuclear factor kB: therapeutic potential for attenuating inflammatory responses. Brain Pathol 10, 153-162.
    • (2000) Brain Pathol , vol.10 , pp. 153-162
    • Christman, J.W.1    Blackwell, T.S.2    Juurlink, B.H.3
  • 74
    • 39649085837 scopus 로고    scopus 로고
    • Inflammaging as a major characteristic of old people: Can it be prevented or cured?
    • Franceschi C (2007) Inflammaging as a major characteristic of old people: can it be prevented or cured? Nutr Rev 65, S173-S176.
    • (2007) Nutr Rev , vol.65
    • Franceschi, C.1
  • 75
    • 0031040390 scopus 로고    scopus 로고
    • Hydroxyl radical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flax-seed
    • Prasad K (1997) Hydroxyl radical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flax-seed. Mol Cell Biochem 168, 117-123.
    • (1997) Mol Cell Biochem , vol.168 , pp. 117-123
    • Prasad, K.1
  • 76
    • 0033400047 scopus 로고    scopus 로고
    • Anti-oxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone
    • Kitts DD, Yuan YV, Wijewickreme AN, et al. (1999) Anti-oxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. Mol Cell Biochem 202, 91-100.
    • (1999) Mol Cell Biochem , vol.202 , pp. 91-100
    • Kitts, D.D.1    Yuan, Y.V.2    Wijewickreme, A.N.3
  • 77
    • 33846943367 scopus 로고    scopus 로고
    • AAPH-mediated antioxidant reactions of secoisolariciresinol and SDG
    • Hosseinian FS, Muir AD, Westcott ND, et al. (2007) AAPH-mediated antioxidant reactions of secoisolariciresinol and SDG. Org Biomol Chem 5, 644-654.
    • (2007) Org Biomol Chem , vol.5 , pp. 644-654
    • Hosseinian, F.S.1    Muir, A.D.2    Westcott, N.D.3
  • 78
    • 53849110625 scopus 로고    scopus 로고
    • Key issues in F2-isoprostane analysis
    • Nourooz-Zadeh J (2008) Key issues in F2-isoprostane analysis. Biochem Soc Trans 36, 1060-1065.
    • (2008) Biochem Soc Trans , vol.36 , pp. 1060-1065
    • Nourooz-Zadeh, J.1
  • 79
    • 0036180010 scopus 로고    scopus 로고
    • Association between low serum enterolactone and increased plasma F2-isoprostanes, a measure of lipid peroxidation
    • Vanharanta M, Voutilainen S, Nurmi T, et al. (2002) Association between low serum enterolactone and increased plasma F2-isoprostanes, a measure of lipid peroxidation. Atherosclerosis 160, 465-469.
    • (2002) Atherosclerosis , vol.160 , pp. 465-469
    • Vanharanta, M.1    Voutilainen, S.2    Nurmi, T.3
  • 80
    • 1542314308 scopus 로고    scopus 로고
    • The effects of dietary flaxseed on the Fischer 344 rat: I Development, behaviour, toxicity and the activity of liver g-glutamyltranspeptidase
    • Hemmings SJ & Barker L (2004) The effects of dietary flaxseed on the Fischer 344 rat: I. Development, behaviour, toxicity and the activity of liver g-glutamyltranspeptidase. Cell Biochem Funct 22, 113-121.
    • (2004) Cell Biochem Funct , vol.22 , pp. 113-121
    • Hemmings, S.J.1    Barker, L.2
  • 81
    • 15844402499 scopus 로고    scopus 로고
    • Effect of chronic administration of lignan complex isolated from flaxseed on the hemopoietic system
    • DOI 10.1007/s11010-005-5283-2
    • Prasad K (2005) Effect of chronic administration of lignan complex isolated from flaxseed on the hemopoietic system. Mol Cell Biochem 270, 139-145. (Pubitemid 40425244)
    • (2005) Molecular and Cellular Biochemistry , vol.270 , Issue.1-2 , pp. 139-145
    • Prasad, K.1
  • 82
    • 0034767830 scopus 로고    scopus 로고
    • Exposure to purified lignan from flaxseed (Linum usitatissimum) alters bone development in female rats
    • Ward WE, Yuan YV, Cheung AM, et al. (2001) Exposure to purified lignan from flaxseed (Linum usitatissimum) alters bone development in female rats. Br J Nutr 86, 499-505.
    • (2001) Br J Nutr , vol.86 , pp. 499-505
    • Ward, W.E.1    Yuan, Y.V.2    Cheung, A.M.3
  • 83
    • 0035844065 scopus 로고    scopus 로고
    • Exposure to flaxseed and its purified lignan reduces bone strength in young but not older male rats
    • Ward WE, Yuan YV, Cheung AM, et al. (2001) Exposure to flaxseed and its purified lignan reduces bone strength in young but not older male rats. J Toxicol Environ Health A 63, 53-65.
    • (2001) J Toxicol Environ Health A , vol.63 , pp. 53-65
    • Ward, W.E.1    Yuan, Y.V.2    Cheung, A.M.3
  • 84
    • 0038402708 scopus 로고    scopus 로고
    • Effects of flaxseed and defatted flaxseed meal on reproduction and development in rats
    • Collins TF, Sprando RL, Black TN, et al. (2003) Effects of flaxseed and defatted flaxseed meal on reproduction and development in rats. Food Chem Toxicol 41, 819-834.
    • (2003) Food Chem Toxicol , vol.41 , pp. 819-834
    • Collins, T.F.1    Sprando, R.L.2    Black, T.N.3
  • 85
    • 0031737636 scopus 로고    scopus 로고
    • Flaxseed and its lignan precursor, secoisolariciresinol diglycoside, affect pregnancy outcome and reproductive development in rats
    • Tou JCL, Chen J & Thompson LU (1998) Flaxseed and its lignan precursor, secoisolariciresinol diglycoside, affect pregnancy outcome and reproductive development in rats. J Nutr 128, 1861-1868.
    • (1998) J Nutr , vol.128 , pp. 1861-1868
    • Tou, J.C.L.1    Chen, J.2    Thompson, L.U.3
  • 86
    • 0035824381 scopus 로고    scopus 로고
    • Exposure to flaxseed or its purified lignan during suckling only or continuously does not alter reproductive indices in male and female offspring
    • Ward WE, Chen J & Thompson LU (2001) Exposure to flaxseed or its purified lignan during suckling only or continuously does not alter reproductive indices in male and female offspring. J Toxicol Environ Health A 64, 567-577.
    • (2001) J Toxicol Environ Health A , vol.64 , pp. 567-577
    • Ward, W.E.1    Chen, J.2    Thompson, L.U.3
  • 87
    • 33846200824 scopus 로고    scopus 로고
    • Effects of flaxseed derivatives in experimental polycystic kidney disease vary with animal gender
    • Ogborn MR, Nitschmann E, Bankovic-Calic N, et al. (2006) Effects of flaxseed derivatives in experimental polycystic kidney disease vary with animal gender. Lipids 41, 1141-1149.
    • (2006) Lipids , vol.41 , pp. 1141-1149
    • Ogborn, M.R.1    Nitschmann, E.2    Bankovic-Calic, N.3


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