Ligand-induced conformational changes in wild-type and mutant yeast pyruvate kinase

Protein Engineering

Volumn 9, Issue 12, 1996, Pages 1203-1210

  Collins, Richard A ^a,b   Kelly, Sharon M ^c   Price, Nicholas C ^c   Fothergill Gilmore, Linda A ^a   Muirhead, Hilary ^d  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY OF STIRLING   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Mutant; NEM; Proteolysis; Pyruvate kinase; R T state

Indexed keywords

SACCHAROMYCES CEREVISIAE;

FRUCTOSE 1,6 BISPHOSPHATE; MUTANT PROTEIN; N ETHYLMALEIMIDE; PHOSPHOENOLPYRUVATE; PROLINE; PROTEIN SUBUNIT; PYRUVATE KINASE; SERINE;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STABILITY; FLUORESCENCE; GENETIC ENGINEERING; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE; YEAST;

ADENOSINE DIPHOSPHATE; ALLOSTERIC REGULATION; CATIONS; CIRCULAR DICHROISM; ETHYLMALEIMIDE; FRUCTOSEDIPHOSPHATES; HEAT; HYDROGEN-ION CONCENTRATION; LIGANDS; MUTATION; PHOSPHOENOLPYRUVATE; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN ENGINEERING; PYRUVATE KINASE; SACCHAROMYCES CEREVISIAE; SPECTROMETRY, FLUORESCENCE; SULFHYDRYL REAGENTS;

EID: 0030447826     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/9.12.1203     Document Type: Article

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