Induction of apoptosis by A3 adenosine receptor agonist N 6-(3-iodobenzyl)-adenosine-5′-N-methylcarboxamide in human leukaemia cells: A possible involvement of intracellular mechanism

Acta Physiologica

Volumn 199, Issue 2, 2010, Pages 171-179

  Mlejnek, P ^a   Dolezel, P ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

ABCB1 transporter; Apoptosis; IB MECA; Multi drug resistance; Purinergic signalling

Indexed keywords

6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE TRIPHOSPHATASE; CASPASE 3; CASPASE 7; CYCLOSPORIN A; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; SHORT HAIRPIN RNA; VERAPAMIL; ADENOSINE; CALCIUM CHANNEL BLOCKING AGENT; MULTIDRUG RESISTANCE PROTEIN; N(6)-(3-IODOBENZYL)-5'-N-METHYLCARBOXAMIDOADENOSINE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL LEVEL; CELL MEMBRANE TRANSPORT; CELL STRAIN HL 60; CELL STRAIN K 562; CHROMATIN CONDENSATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG SENSITIVITY; DRUG TRANSPORT; ENZYME ACTIVATION; ENZYME ASSAY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; GENETICS; HL 60 CELL LINE; K562 CELL LINE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ADENOSINE; ADENOSINE A3 RECEPTOR AGONISTS; ADENOSINE TRIPHOSPHATASES; APOPTOSIS; CALCIUM CHANNEL BLOCKERS; DRUG RESISTANCE, MULTIPLE; HL-60 CELLS; HUMANS; K562 CELLS; P-GLYCOPROTEIN; SIGNAL TRANSDUCTION; VERAPAMIL;

EID: 77951229175     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2010.02087.x     Document Type: Article

References (26)

1. Abbracchio, M.P. Burnstock, G. 1998. Purinergic signalling: pathophysiological roles. Jpn J Pharmacol 78, 113 145. (Pubitemid 28508403)
2. Ambudkar, S.V., Dey, S., Hrycyna, C.A., Ramachandra, M., Pastan, I. Gottesman, M.M. 1999. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 39, 361 398. (Pubitemid 29222564)
3. Cabot, M.C., Han, T.Y. Giuliano, A.E. 1998. The multidrug resistance modulator SDZ PSC 833 is a potent activator of cellular ceramide formation. FEBS Lett 431, 185 188.
4. Chen, Y. Simon, S.M. 2000. In situ biochemical demonstration that P-glycoprotein is a drug efflux pump with broad specificity. J Cell Biol 148, 863 870.
5. Endicott, J.A. Ling, V. 1989. The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58, 137 171. (Pubitemid 19172967)
6. Fishman, P., Bar-Yehuda, S., Madi, L. Cohn, I. 2002. A3 adenosine receptor as a target for cancer therapy. Anticancer Drugs 13, 437 443. (Pubitemid 34621047)
7. Frydrych, I. Mlejnek, P. 2008. Serine protease inhibitors N-α-tosyl-l-lysinyl-chloromethylketone (TLCK) and N-tosyl-l- phenylalaninyl-chloromethylketone (TPCK) are potent inhibitors of activated caspase proteases. J Cell Biochem 103, 1646 1656. (Pubitemid 351490729)
8. Gao, Z., Li, B.S., Day, Y.J. Linden, J. 2001. A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis. Mol Pharmacol 59, 76 82. (Pubitemid 32043088)
9. Gessi, S., Merighi, S., Varani, K., Leung, E., Mac Lennan, S. Borea, P.A. 2008. The A3 adenosine receptor: an enigmatic player in cell biology. Pharmacol Ther 117, 123 140. (Pubitemid 350192673)
10. Gottesman, M.M., Fojo, T. Bates, S.E. 2002. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2, 48 58. (Pubitemid 37328807)
11. Jacobson, K.A. 1998. Adenosine A3 receptors: novel ligands and paradoxical effects. Trends Pharmacol Sci 19, 184 191. (Pubitemid 28255405)
12. Juliano, R.V. Ling, V. 1976. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455, 152 162.
13. Katewa, S.D. Katyare, S.S. 2003. A simplified method for inorganic phosphate determination and its application for phosphate analysis in enzyme assays. Anal Biochem 323, 180 187.
14. Kim, S.G., Ravi, G., Hoffmann, C., Jung, Y.J., Kim, M., Chen, A. Jacobson, K.A. 2002. p53-Independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, IB-MECA. Biochem Pharmacol 63, 871 880. (Pubitemid 34243000)
15. Kohno, Y., Sei, Y., Koshiba, M., Kim, H.O. Jacobson, K.A. 1996. Induction of apoptosis in HL-60 human promyelocytic leukemia cells by adenosine A(3) receptor agonists. Biochem Biophys Res Commun 219, 904 910. (Pubitemid 26106777)
16. Lavie, Y., Cao, H., Volner, A., Lucci, A., Han, T.Y., Geffen, V., Giuliano, A.E. Cabot, M.C. 1997. Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells. J Biol Chem 272, 1682 1687. (Pubitemid 27043253)
17. Ludescher, C., Thaler, J., Drach, D., Drach, J., Spitaler, M., Gattringer, C., Huber, H. Hofmann, J. 1992. Detection of activity of P-glycoprotein in human tumour samples using rhodamine 123. Br J Haematol 82, 161 168.
18. Madi, L., Ochaion, A., Rath-Wolfson, L., Bar-Yehuda, S., Erlanger, A., Ohana, G., Harish, A., Merimski, O., Barer, F. Fishman, P. 2004. The A3 adenosine receptor is highly expressed in tumor versus normal cells: potential target for tumor growth inhibition. Clin Cancer Res 10, 4472 4479. (Pubitemid 38878891)
19. Merighi, S., Mirandola, P., Varani, K., Gessi, S., Leung, E., Baraldi, P.G., Tabrizi, M.A. Borea, P.A. 2003. A glance at adenosine receptors: novel target for antitumor therapy. Pharmacol Ther 100, 31 48. (Pubitemid 37204899)
20. Mlejnek, P., Frydrych, I. Dolezel, P. 2007. Cyclosporin A potentiates cytotoxic effect of methyl methanesulfonate in HL-60 and K562 cells. Altern Lab Anim 35, 79 85. (Pubitemid 46596008)
21. Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65, 55 63. (Pubitemid 14203433)
22. Ohana, G., Bar-Yehuda, S., Barer, F. Fishman, P. 2001. Differential effect of adenosine on tumor and normal cell growth: focus on the A3 adenosine receptor. J Cell Physiol 186, 19 23.
23. Phillips, H.J. Terryberry, J.E. 1957. Counting actively metabolizing tissue cultured cells. Exp Cell Res 13, 341 347.
24. Sarkadi, B., Price, E.M., Boucher, R.C., Germann, U.A. Scarborough, G.A. 1992. Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase. J Biol Chem 267, 4854 4858.
25. Silbermann, M.H., Boersma, A.W., Janssen, A.L., Scheper, R.J., Heweijer, H. Nooter, K. 1989. Effects of cyclosporin A and verapamil on the intracellular daunorubicin accumulation in Chinese hamster ovary cells with increasing levels of drug-resistance. Int J Cancer 44, 722 726. (Pubitemid 19258751)
26. Tang, R., Faussat, A.M., Perrot, J.Y., Marjanovic, Z., Cohen, S., Storme, T., Morjani, H., Legrand, O. Marie, J.P. 2008. Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML). BMC Cancer 8, 51 59.