Chronic activation of the epithelial immune system of the fruit fly's salivary glands has a negative effect on organismal growth and induces a peculiar set of target genes

BMC Genomics

Volumn 11, Issue 1, 2010, Pages

  Abdelsadik, Ahmed ^a,b   Roeder, Thomas ^a,c  

^a UNIVERSITY OF KIEL   (Germany)

^b ASWAN UNIVERSITY   (Egypt)

^c RESEARCH CENTER BORSTEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; POLYPEPTIDE ANTIBIOTIC AGENT; POTASSIUM CHANNEL; PRESENILIN; PROTEASOME; PROTEINASE; RIBOSOME PROTEIN; TRANSCRIPTOME; ANTIMICROBIAL CATIONIC PEPTIDE; DROSOPHILA PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; DROSOPHILA; DWARFISM; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE TARGETING; GROWTH RATE; IMMUNOCOMPETENCE; MUCOSAL IMMUNITY; NONHUMAN; NUCLEOTIDE SEQUENCE; SALIVARY GLAND; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; TRACHEA MUCOSA; UPREGULATION; ANIMAL; CYTOLOGY; DIGESTIVE SYSTEM; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; METABOLISM;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; DIGESTIVE SYSTEM; DROSOPHILA; DROSOPHILA PROTEINS; PRESENILINS; SALIVARY GLANDS;

EID: 77951214011     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-11-265     Document Type: Article

References (37)

1. Silverman N, Paquette N. Immunology. The right resident bugs. Science (New York, NY) 2008, 319(5864):734-735.
2. Leclerc V, Reichhart JM. The immune response of Drosophila melanogaster. Immunological reviews 2004, 198:59-71. 10.1111/j.0105-2896.2004.0130.x, 15199954.
3. Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996, 86(6):973-983. 10.1016/S0092-8674(00)80172-5, 8808632.
4. Lemaitre B, Hoffmann J. The host defense of Drosophila melanogaster. Annual review of immunology 2007, 25:697-743. 10.1146/annurev.immunol.25.022106.141615, 17201680.
5. Ferrandon D, Jung AC, Criqui M, Lemaitre B, Uttenweiler-Joseph S, Michaut L, Reichhart J, Hoffmann JA. A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. The EMBO journal 1998, 17(5):1217-1227. 10.1093/emboj/17.5.1217, 1170470, 9482719.
6. Tzou P, Ohresser S, Ferrandon D, Capovilla M, Reichhart JM, Lemaitre B, Hoffmann JA, Imler JL. Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity 2000, 13(5):737-748. 10.1016/S1074-7613(00)00072-8, 11114385.
7. Wagner C, Isermann K, Fehrenbach H, Roeder T. Molecular architecture of the fruit fly's airway epithelial immune system. BMC genomics 2008, 9:446. 10.1186/1471-2164-9-446, 2566315, 18823557.
8. Cronin SJ, Nehme NT, Limmer S, Liegeois S, Pospisilik JA, Schramek D, Leibbrandt A, Simoes Rde M, Gruber S, Puc U, et al. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science (New York, NY) 2009, 325(5938):340-343.
9. Buchon N, Broderick NA, Poidevin M, Pradervand S, Lemaitre B. Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell host & microbe 2009, 5(2):200-211. 10.1016/j.chom.2009.01.003, 19218090.
10. Ha EM, Oh CT, Bae YS, Lee WJ. A direct role for dual oxidase in Drosophila gut immunity. Science (New York, NY) 2005, 310(5749):847-850.
11. Ha EM, Oh CT, Ryu JH, Bae YS, Kang SW, Jang IH, Brey PT, Lee WJ. An antioxidant system required for host protection against gut infection in Drosophila. Developmental cell 2005, 8(1):125-132. 10.1016/j.devcel.2004.11.007, 15621536.
12. Liehl P, Blight M, Vodovar N, Boccard F, Lemaitre B. Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model. PLoS pathogens 2006, 2(6):e56. 10.1371/journal.ppat.0020056, 1475658,1475658, 16789834.
13. Ryu JH, Ha EM, Oh CT, Seol JH, Brey PT, Jin I, Lee DG, Kim J, Lee D, Lee WJ. An essential complementary role of NF-kappaB pathway to microbicidal oxidants in Drosophila gut immunity. The EMBO journal 2006, 25(15):3693-3701. 10.1038/sj.emboj.7601233, 1538556, 16858400.
14. Vodovar N, Vinals M, Liehl P, Basset A, Degrouard J, Spellman P, Boccard F, Lemaitre B. Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species. Proceedings of the National Academy of Sciences of the United States of America 2005, 102(32):11414-11419. 10.1073/pnas.0502240102, 1183552, 16061818.
15. Bischoff V, Vignal C, Duvic B, Boneca IG, Hoffmann JA, Royet J. Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2. PLoS pathogens 2006, 2(2):e14. 10.1371/journal.ppat.0020014, 1383489, 16518472.
16. Zaidman-Remy A, Herve M, Poidevin M, Pili-Floury S, Kim MS, Blanot D, Oh BH, Ueda R, Mengin-Lecreulx D, Lemaitre B. The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Immunity 2006, 24(4):463-473. 10.1016/j.immuni.2006.02.012, 16618604.
17. Lhocine N, Ribeiro PS, Buchon N, Wepf A, Wilson R, Tenev T, Lemaitre B, Gstaiger M, Meier P, Leulier F. PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling. Cell host & microbe 2008, 4(2):147-158. 10.1016/j.chom.2008.07.004, 18692774.
18. Pal S, Wu L. Guts and glory: balancing microbes and the immune response. Developmental cell 2005, 8(1):1-2.
19. Lee WJ. Bacterial-modulated signaling pathways in gut homeostasis. Science signaling 2008, 1(21):pe24. 10.1126/stke.121pe24, 18506033.
20. Andrew DJ. Regulation and formation of the Drosophila salivary glands. Annals of the New York Academy of Sciences 1998, 842:55-69. 10.1111/j.1749-6632.1998.tb09632.x, 9599294.
21. Andrew DJ, Henderson KD, Seshaiah P. Salivary gland development in Drosophila melanogaster. Mechanisms of development 2000, 92(1):5-17. 10.1016/S0925-4773(99)00321-4, 10704884.
22. Isaac DD, Andrew DJ. Tubulogenesis in Drosophila: a requirement for the trachealess gene product. Genes & development 1996, 10(1):103-117. 10.1101/gad.10.1.103, 8557189.
23. Roeder T, Isermann K, Kabesch M. Drosophila in asthma research. American journal of respiratory and critical care medicine 2009, 179(11):979-983. 10.1164/rccm.200811-1777PP, 19342413.
24. Takehana A, Katsuyama T, Yano T, Oshima Y, Takada H, Aigaki T, Kurata S. Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proceedings of the National Academy of Sciences of the United States of America 2002, 99(21):13705-13710. 10.1073/pnas.212301199, 129750, 12359879.
25. Al-Shahrour F, Minguez P, Tarraga J, Medina I, Alloza E, Montaner D, Dopazo J. FatiGO +: a functional profiling tool for genomic data. Integration of functional annotation, regulatory motifs and interaction data with microarray experiments. Nucleic acids research 2007, (35 Web Server):W91-96. 10.1093/nar/gkm260, 1933151, 17478504.
26. De Gregorio E, Spellman PT, Rubin GM, Lemaitre B. Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays. Proceedings of the National Academy of Sciences of the United States of America 2001, 98(22):12590-12595. 10.1073/pnas.221458698, 60098, 11606746.
27. Wagner C, Isermann K, Roeder T. Infection induces a survival program and local remodeling in the airway epithelium of the fly. Faseb J 2009, 23(7):2045-2054. 10.1096/fj.08-114223, 19237508.
28. Lehmann M, Jiang C, Ip YT, Thummel CS. AP-1, but not NF-kappa B, is required for efficient steroid-triggered cell death in Drosophila. Cell death and differentiation 2002, 9(5):581-590. 10.1038/sj.cdd.4401003, 11973616.
29. Onfelt Tingvall T, Roos E, Engstrom Y. The imd gene is required for local Cecropin expression in Drosophila barrier epithelia. EMBO reports 2001, 2(3):239-243. 10.1093/embo-reports/kve048, 1083844, 11266367.
30. Cezard JP, Touati G, Alberti C, Hugot JP, Brinon C, Czernichow P. Growth in paediatric Crohn's disease. Hormone research 2002, 58(Suppl 1):11-15. 10.1159/000064759, 12373007.
31. Walters TD, Griffiths AM. Mechanisms of growth impairment in pediatric Crohn's disease. Nat Rev Gastroenterol Hepatol 2009, 6(9):513-523. 10.1038/nrgastro.2009.124, 19713986.
32. Kreienkamp HJ, Larusson HJ, Witte I, Roeder T, Birgul N, Honck HH, Harder S, Ellinghausen G, Buck F, Richter D. Functional annotation of two orphan G-protein-coupled receptors, Drostar1 and -2, from Drosophila melanogaster and their ligands by reverse pharmacology. The Journal of biological chemistry 2002, 277(42):39937-39943. 10.1074/jbc.M206931200, 12167655.
33. Baumann O, Dames P, Kuhnel D, Walz B. Distribution of serotonergic and dopaminergic nerve fibers in the salivary gland complex of the cockroach Periplaneta americana. BMC physiology 2002, 2:9. 10.1186/1472-6793-2-9, 117224, 12095424.
34. Link CD. Invertebrate models of Alzheimer's disease. Genes, brain, and behavior 2005, 4(3):147-156. 10.1111/j.1601-183X.2004.00105.x, 15810903.
35. Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature 2003, 422(6930):438-441. 10.1038/nature01506, 12660785.
36. Franz O, Bruchhaus I, Roeder T. Verification of differential gene transcription using virtual northern blotting. Nucleic acids research 1999, 27(11):e3. 10.1093/nar/27.11.e3, 148445, 10325436.
37. t'Hoen PA, de Kort F, van Ommen GJ, den Dunnen JT. Fluorescent labelling of cRNA for microarray applications. Nucleic acids research 2003, 31(5):e20. 10.1093/nar/gng020, 149842, 12595569.