Drosophila in asthma research

American Journal of Respiratory and Critical Care Medicine

Volumn 179, Issue 11, 2009, Pages 979-983

  Roeder, Thomas ^a,b   Isermann, Kerstin ^a   Kabesch, Michael ^c  

^a UNIVERSITY OF KIEL   (Germany)

^b RESEARCH CENTER BORSTEL   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Animal model; Drosophila; Genome wide association studies; Susceptibility genes

Indexed keywords

ANIMAL MODEL; ASTHMA; DROSOPHILA; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOME; IMMUNITY; MEDICAL RESEARCH; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT INFECTION; REVIEW;

ANIMALS; ASTHMA; DISEASE MODELS, ANIMAL; DROSOPHILA; EPITHELIAL CELLS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNITY, INNATE;

EID: 66249133369     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200811-1777PP     Document Type: Review

References (40)

1. Laitinen T, Rasanen M, Kaprio J, Koskenvuo M, Laitinen LA. Importance of genetic factors in adolescent asthma: a population-based twin-family study. Am J Respir Crit Care Med 1998;157:1073-1078. (Pubitemid 28225170)
2. Kere J. Mapping and identifying genes for asthma and psoriasis. Philos Trans R Soc Lond B Biol Sci 2005;360:1551-1561.
3. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 2008;8:169-182.
4. Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007;448:470-473. (Pubitemid 47123521)
5. Finkelman FD, Wills-Karp M. Usefulness and optimization of mouse models of allergic airway disease. J Allergy Clin Immunol 2008;121:603-606.
6. Lemaitre B, Hoffmann J. The host defense of Drosophila melanogaster. Annu Rev Immunol 2007;25:697-743. (Pubitemid 46697922)
7. Govind S, Nehm RH. Innate immunity in fruit flies: a textbook example of genomic recycling. PLoS Biol 2004;2:E276.
8. Broide DH, Lawrence T, Doherty T, Cho JY, McElwain K, McElwain S, Karin M. Allergen induced peribronchial fibrosis and mucus production mediated by IκB kinase β-dependent genes in airway epithelium. Proc Natl Acad Sci USA 2005;102:17723-17728. (Pubitemid 41803564)
9. Pantano C, Ather JL, Alcorn JF, Poynter ME, Brown AL, Guala AS, Beuschel SL, Allen GB, Whittaker LA, Bevelander M, et al. Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness. Am J Respir Crit Care Med 2008;177:959-969.
10. Rühle H. Das larvale Tracheensystem von Drosophila melanogaster Meigen und seineVariabilität. Zeit wissenschaftl Zool 1932;141:159-245.
11. Ghabrial A, Luschnig S, Metzstein MM, Krasnow MA. Branching morphogenesis of the Drosophila tracheal system. Annu Rev Cell Dev Biol 2003;19:623-647.12. (Pubitemid 37487363)
12. Liu L, Johnson WA, Welsh MJ. Drosophila DEG/ENaC pickpocket genes are expressed in the tracheal system, where they may be involved in liquid clearance. Proc Natl Acad Sci USA 2003;100:2128-2133. (Pubitemid 36254585)
13. Wagner C, Isermann K, Fehrenbach H, Roeder T. Molecular architecture of the fruit fly's airway epithelial immune system. BMC Genomics 2008;9:446.
14. Ryder E, Ashburner M, Bautista-Llacer R, Drummond J, Webster J, Johnson G, Morley T, Chan YS, Blows F, Coulson D, et al. The DrosDel deletion collection: a Drosophila genome wide chromosomal deficiency resource. Genetics 2007;177:615-629. (Pubitemid 47555876)
15. Bellen HJ, Levis RW, Liao G, He Y, Carlson JW, Tsang G, Evans-Holm M, Hiesinger PR, Schulze KL, Rubin GM, et al. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics 2004;167:761-781. (Pubitemid 38931863)
16. Venken KJ, Bellen HJ. Transgenesis upgrades for Drosophila melanogaster. Development 2007;134:3571-3584. (Pubitemid 350107703)
17. Venken KJ, He Y, Hoskins RA, Bellen HJ. P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science 2006;314:1747-1751. (Pubitemid 44969080)
18. Brand AH, Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993;118:401-415. (Pubitemid 23214028)
19. Duffy JB. GAL4 system in Drosophila: a fly geneticist's Swiss army knife. Genesis 2002;34:1-15.
20. Roman G, Endo K, Zong L, Davis RL. P{Switch}, a system for spatial and temporal control of gene expression in Drosophila melanogaster. Proc Natl Acad Sci USA 2001;98:12602-12607. (Pubitemid 33019992)
21. Kalidas S, Smith DP. Novel genomic cDNA hybrids produce effective RNA interference in adult Drosophila. Neuron 2002;33:177-184. (Pubitemid 34127751)
22. McGuire SE, Le PT, Osborn AJ, Matsumoto K, Davis RL. Spatiotemporal rescue of memory dysfunction in Drosophila. Science 2003;302:1765-1768. (Pubitemid 37505740)
23. Dietzl G, Chen D, Schnorrer F, Su KC, Barinova Y, Fellner M, Gasser B, Kinsey K, Oppel S, Scheiblauer S, et al. A genomewide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 2007;448:151-156. (Pubitemid 47067374)
24. Feany MB, Bender WW. A Drosophila model of Parkinson's disease. Nature 2000;404:394-398. (Pubitemid 30164341)
25. Matthews KA, Kaufman TC, Gelbart WM. Research resources for Drosophila: the expanding universe. Nat Rev Genet 2005;6:179-193. (Pubitemid 40305254)
26. O'Keefe LV, Smibert P, Colella A, Chataway TK, Saint R, Richards RI. Know thy fly. Trends Genet 2007;23:238-242. (Pubitemid 46616970)
27. Chintapalli VR, Wang J, Dow JA. Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Nat Genet 2007;39:715-720. (Pubitemid 46848596)
28. Wagner C, Isermann K, Roeder T. Infection induces a survival program and local remodelling in the airway epithelium of the fly. FASEB J 2009; (in press).
29. Takehana A, Katsuyama T, Yano T, Oshima Y, Takada H, Aigaki T, Kurata S. Overexpression of a pattern-recognition receptor, peptidoglycan recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc Natl Acad Sci USA 2002;99:13705-13710. (Pubitemid 35215445)
30. Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol 2007;8:221-233. (Pubitemid 46310551)
31. Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996;86:973-983. (Pubitemid 26336801)
32. Kabesch M, Carr D, Weiland SK, von Mutius E. Association between polymorphisms in serine protease inhibitor, kazal type 5 and asthma phenotypes in a large German population sample. Clin Exp Allergy 2004;34:340-345. (Pubitemid 38372994)
33. Tang H, Kambris Z, Lemaitre B, Hashimoto C. A serpin that regulates immune melanization in the respiratory system of Drosophila. Dev Cell 2008;15:617-626.
34. Shuai K, Liu B. Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol 2003;3:900-911. (Pubitemid 37411719)
35. Arbouzova NI, Zeidler MP. JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions. Development 2006;133:2605-2611. (Pubitemid 44177882)
36. Roeder T. Tyramine and octopamine: ruling behavior and metabolism. Annu Rev Entomol 2005;50:447-477.
37. He JQ, Connett JE, Anthonisen NR, Paré PD, Sandford AJ. Glutathione S-transferase variants and their interaction with smoking on lung function. Am J Respir Crit Care Med 2004;170:388-394. (Pubitemid 39214612)
38. Tan Z, Randall G, Fan J, Camoretti-Mercado B, Brockman-Schneider R, Pan L, Solway J, Gern JE, Lemanske RF, Nicolae D, et al. Allele-specific targeting of microRNAs to HLAG and risk of asthma. Am J Hum Genet 2007;81:829-834. (Pubitemid 47596550)
39. Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, et al. Requirement of bic/microRNA-155 for normal immune function. Science 2007;316:608-611. (Pubitemid 46683148)
40. Stark A, Brennecke J, Russell RB, Cohen SM. Identification of Drosophila MicroRNA targets. PLoS Biol 2003;1:E60. (Pubitemid 39112138)