Evaluation of the bioadhesive properties of hyaluronan derivatives: Detachment weight and mucociliary transport rate studies

International Journal of Pharmaceutics

Volumn 129, Issue 1-2, 1996, Pages 137-145

  Pritchard, Kelly ^a   Lansley, Alison B ^a   Martin, Gary P ^a   Helliwell, Mark ^a   Marriott, Christopher ^a   Benedetti, Luca M ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Fidia Advanced Biopolymers   (Italy)

Author keywords

Bioadhesion; Carbopol; Detachment force; Epithelia; Hyaluronan; Microsphere; Mucoadhesion; Mucociliary; Mucus; Transport rate

Indexed keywords

ALGINIC ACID; CARBOMER; HYALURONIC ACID; HYALURONIC ACID DERIVATIVE; MICROSPHERE;

ADHESION; ARTICLE; DRUG DOSAGE FORM; DRUG FORMULATION; FROG; MOLECULAR WEIGHT; MUCOCILIARY TRANSPORT; PALATE; PRIORITY JOURNAL;

EID: 0029869670     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04280-6     Document Type: Article

References (31)

1. Barbucci, R., Magnani, A., Baszkin, A., Da Costa, M.L., Bauser, H., Hellwig, G., Martuscelli, E. and Cimmino, S., Physico-chemical surface characterisation of hyaluronic acid derivatives as a new class of biomaterials. J. Biomater. Sci. Polymer Edn., 4 (1993) 245-273.
2. Benedetti, L.M., New biomaterails from hyaluronic acid. Med. Device Technol., 5 (9) (1994) 32-37.
3. Benedetti, L.M., Topp, E.M. and Stella, V.J., Microspheres of hyaluronic acid esters - fabrication methods and in vitro hydrocortisone release. J. Controlled Release, 13 (1990) 33-41.
4. Bottenberg, P., Cleymaet, R., de Muynck, C., Remon, J.P., Coomans, D., Michotte, Y. and Slop, D., Development and testing of bioadhesive, fluoride-containing slow-release tablets for oral use. J. Pharm. Pharmacol., 43 (1991) 457-464.
5. Caston, A.J., Davis, S.S. and Williams, P., The potential of fimbrial proteins for delaying intestinal transit of oral drug delivery systems. Proc. Intern. Symp. Controlled Release Bioact. Mater., 17 (1990) 313-314.
6. Ch'ng, H.S., Park, H., Kelly, P. and Robinson, J.R., Bioadhesive polymers as platforms for oral controlled drug delivery. II. Synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers. J. Pharm. Sci., 74 (1985) 399-405.
7. Gu, J.-M., Robinson, J.R. and Leung, S.-H.S., Binding of acrylic polymers to mucin/epithelial surfaces: structure-property relationships. Crit. Rev. Ther. Drug Carrier Sys., 5 (1988) 21-67.
8. Helliwell, M., The Production and Characterisation of Mucoadhesive Microcapsules. PhD Thesis, CNAA, Brighton Polytechnic, UK, 1991.
9. Helliwell, M., The use of bioadhesives in targeted delivery within the gastrointestinal tract. Adv. Drug Del. Rev., 11 (1993) 221-251.
10. Helliwell, M., Martin, G.P. and Marriott, C., The preparation of microcapsule-poly(acrylic acid) conjugates and assessment of in vitro mucoadhesion. J. Pharm. Pharmacol., 43 (1991) 27P.
11. Helliwell, M. and Sektere, M.A.O., The formulation of bioadhesive suppositories. In: Urtti, A. (Ed.), Methods to Overcome Biological Barriers in Drug Delivery, Kuopio University Publications (Pharmaceutical Sciences 10), 1993, p. 79.
12. Hunt, J.A., Joshi, H.N., Stella, V.J. and Topp, E.M., Diffusion and drug release in polymer films prepared from ester derivatives of hyaluronic acid. J. Controlled Release, 12 (1990) 159-169.
13. Illum, L., Joergensen, H., Bisgaad, H., Krogsgaad, O. and Rossig, N., Bioadhesive microspheres as a potential nasal drug delivery system. Int. J. Pharm., 39 (1987) 189-194.
14. Khoshla, R. and Davis, S.S., The effect of polycarbophil on the gastric emptying of pellets. J. Pharm. Pharmacol., 39 (1987) 47-49.
15. Kyyronen, K., Hume, L., Benedetti, L.M., Urtti, A., Topp, E. and Stella, V.J., Methylprednisolone esters of hyaluronic acid in ophthalmic drug delivery: in vitro and in vivo release studies. Int. J. Pharm., 80 (1992) 161-169.
16. Lehr, C.M., Bouwstra, J.A., Kok, W., Noach, A.B.J., de Boer, A.G. and Junginger, H.E., Bioadhesion by means of specific binding. In: Lehr, C.M. (Ed.), Bioadhesive Drug Delivery Systems for Oral Application, Leiden University, The Netherlands, 1991a, pp. 155-169.
17. Lehr, C.M., Bouwstra, J.A., Bodde, H.E. and Junginger, H.E., A surface energy analysis of mucoadhesion. I. Contact angle measurements of polycarbophil and pig intestinal mucosa in physiologically relevant fluids. In: Lehr, C.M. (Ed.), Bioadhesive Drug Delivery Systems for Oral Application, Leiden University, The Netherlands, 1991b, pp. 37-52.
18. Leung, S.-H.S. and Robinson, J.R., The contribution of anionic polymer structural features to mucoadhesion. J. Controlled Release, 5 (1988) 223-231.
19. Middleton, D.L., Leung, S.-H.S. and Robinson, J.R., Ocular bioadhesive delivery systems. In: Lenaerts, V. and Gurny, R. (Eds.), Bioadhesive Drug Delivery Systems, CRC Press Inc., Boca Raton, FL, 1990, pp. 179-202.
20. Morimoto, K., Yamaguchi, H., Iwakura, Y., Morisaka, K., Ohashi, Y. and Nakai, Y., Effects of viscous hyaluronate-sodium solutions on the nasal absorption of vasopressin and an analogue. Pharm. Res., 8 (1991) 471-474.
21. Nagai, T. and Konishi, R., Buccal/gingival drug delivery systems. J. Controlled Release, 6 (1987) 353-360.
22. Park, H., On The Mechanism of Bioadhesion. PhD Thesis, University of Wisconsin, Madison, 1986.
23. Park, H. and Robinson, J.R., Physico-chemical properties of water insoluble polymers important to mucin/epithelial adhesion. J. Controlled Release, 2 (1985) 47-57.
24. Ponchel, G., Touchard, F., Duchene, D. and Peppas, N.A., Bioadhesive analysis of controlled release systems. I. Fracture and interpenetration analysis in poly(acrylic acid)-containing systems. J. Controlled Release, 5 (1987) 129-141.
25. Rastrelli, A., Beccaro, M., Biviano, F., Calderini, G. and Pastorello, A., Hyaluronic acid esters, a new class of semisynthetic biopolymers: chemical and physico-chemical properties. In: Heimke, G., Soltesz, U. and Lee, A.J.C. (Eds.), Clinical Implant Materials, Elsevier Science Publishers, Amsterdam, 1990, pp. 199-205.
26. Richardson, J.L., Ramires, P.A., Benedetti, L.M., Pastorello, A. and Callegaro, L., Polymeric delivery systems for vaginal drug administration. Proc. Intern. Symp. Controlled Release Bioact. Mater., 19 (1992) 308-309.
27. Richardson, J.L., Miglietta, M., Ramires, P.A., Rochira, M., Fisher, A.N., Farraj, N.F., Illum, L. and Benedetti, L.M., Vaginal administration of calcitonin in rats and in sheep using microspheres of hyaluronan esters. Proc. Intern. Symp. Controlled Release Bioact. Mater., 20 (1993) 103-104.
28. Saettone, M.F., Chetoni, P., Torracca, M.T., Burgalassi, S. and Giannaccini, B., Evaluation of muco-adhesive properties and in vivo activity of ophthalmic vehicles based on hyaluronic acid. Int. J. Pharm., 51 (1989) 203-212.
29. Smart, J.D., An in vitro assessment of some mucosa-adhesive dosage forms. Int. J. Pharm., 73 (1991) 69-74.
30. Smart, J.D., Kellaway, I.W. and Worthington, H.E.C., An in vitro investigation of mucosa-adhesive materials for use in controlled drug delivery. J. Pharm. Pharmacol., 36 (1984) 295-299.
31. della Valle, F. and Romeo, A., Crosslinked carboxypolysaccharides. EP 341745B1 (1989).