Novel DNA intercalators without basic side chains as efficient antitumor agents: Design, synthesis and evaluation of benzo-[c,d]-indol-malononitrile derivatives

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 9, 2010, Pages 3279-3284

  Li, Xiaolian ^a   Wang, Qianqian ^a   Qing, Yang ^a   Lin, Yanjie ^a   Zhang, Yingli ^a   Qian, Xuhong ^a,b   Cui, Jingnan ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antitumor agents; Benzo c,d indol 2(1H) one; DNA cleavage; DNA intercalator

Indexed keywords

2 (1 ACETYLBENZO[C,D]INDOL 2(1H) YLIDENE)MALONONITRILE; 2 (1 ALLYLBENZO[C,D]INDOL 2(1H) YLIDENE)MALONONITRILE; 2 (1 BENZOYLBENZO[C,D]INDOL 2(1H) YLIDENE)MALONONITRILE; 2 (BENZO[C,D]INDOL 2(1H) YLIDENE)MALONONITRILE; 2 [1 (2 BROMOETHYL)BENZO[C,D]INDOL 2(1H) YLIDENE]MALONONITRILE; 2 [1 (3 BROMOETHYL)BENZO[C,D]INDOL 2(1H) YLIDENE]MALONONITRILE; 2 [1 (3 CHLOROPROPYL)BENZO[C,D]INDOL 2(1H) YLIDENE]MALONONITRILE; 2 [1 (CYANOMETHYL)BENZO[C,D]INDOL 2(1H) YLIDENE]MALONONITRILE; 2 [1 (PROP 2 YNYL)BENZO[C,D]INDOL 2(1H) YLIDENE]MALONONITRILE; ANTINEOPLASTIC AGENT; BENZO[C,D]INDO MALONONITRILE DERIVATIVE; INTERCALATING AGENT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DNA INTERACTION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIVER CANCER; ULTRAVIOLET SPECTROSCOPY; VISCOSITY;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; INTERCALATING AGENTS; MOLECULAR STRUCTURE; NITRILES; SPECTROMETRY, FLUORESCENCE;

EID: 77951206852     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.017     Document Type: Article

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