The process development of a scaleable route to the PDE5 inhibitor UK-357,903

Organic Process Research and Development

Volumn 6, Issue 6, 2002, Pages 767-772

  Dale, David J ^a   Draper, John ^a   Dunn, Peter J ^a   Hughes, Michael L ^a   Hussain, Farhat ^a   Levett, Philip C ^a   Ward, Gordon B ^a   Wood, Albert S ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYETHANOL; BENZENE DERIVATIVE; HYDROXIDE; NICOTINIC ACID DERIVATIVE; PHOSPHODIESTERASE INHIBITOR; PYRIDINE DERIVATIVE; REAGENT; SILDENAFIL; SOLVENT; UK 357 903; UNCLASSIFIED DRUG;

CONFERENCE PAPER; CRYSTALLIZATION; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; PRESSURE; PROCESS DEVELOPMENT; QUALITY CONTROL; STRUCTURE ANALYSIS;

EID: 0036857568     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0200468     Document Type: Conference Paper

References (12)

1. Bell, A. S.; Brown, D.; Terrett, N. K. Eur. Pat. 463756 B1, April 19, 1995.
2. (a) Bunnage, M. E.; DeVries, K. M.; Harris, L. J.; Levett, P. C.; Mathias, J. P.; Negri, J. T.; Street, S. D.; Wood, A. S. WO 01/27113, April 19, 2001.
3. (b) Dunn, P. J.; Levett, P. C. Eur. Pat. Appl. 994115 A2, April 19, 2000
4. (c) DeVries, K. M.; Levett, P. C.; Negri, J. T.; Wood, A. S. Eur. Pat. Appl. 1092720 A2, April 18, 2001.
5. Dale, D. J.; Dunn, P. J.; Golightly, C.; Hughes, M. L.; Levett, P. C.; Pearce, A. K.; Searle, P. M.; Ward, G.; Wood, A. S. Org. Process Res. Dev. 2000, 4, 17.
6. Meislich, H. Pyridine and its derivatives. In Heterocyclic Compounds; Interscience Publishers: New York-London, 1962; Part Three, Chapter XII, p 669.
7. Levin, D. Org. Process Res. Dev. 1997, 1, 182.
8. Salmi, E. J.; Leimu, R. Suom. Kemistil. 1947, 20B, 43. For abstract, see: Chem. Abs. 1947, 41, 5370c.
9. Salmi, E. J.; Leimu, R. Suom. Kemistil. 1947, 20B, 43. For abstract, see: Chem. Abs. 1947, 41, 5370c.
10. Urban, P. Bretherick's Handbook of Reactive Chemical Hazards, 5th Ed.; Butterworth Heinemann: Woburn, MA, 1995; Vol. 2, p 193.
11. Au, W.; Ahmed, E.; Chiechanwit, T.; Hsie, W.; Ma, H.; Moslen, T. Occup. Hyg. 1996, 2, 177.
12. For preparation of amino pyrazole (9), see ref 2c above, examples 1a to 1f, inclusive.