BCR-ABL gene expression is required for its mutations in a novel KCL-22 cell culture model for acquired resistance of chronic myelogenous leukemia

Journal of Biological Chemistry

Volumn 285, Issue 7, 2010, Pages 5085-5096

  Yuan, Hongfeng ^a   Wang, Zhiqiang ^a   Gao, Chunggang ^a   Chen, Wengang ^a   Huang, Qin ^a   Yee, Jiing Kuan ^a   Bhatia, Ravi ^b   Chen, WenYong ^a  

^a City of Hope ^*  (United States)

^b Division of Hematopoietic Stem Cell and Leukemia Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED RESISTANCE; CANCER THERAPY; CELL CLONES; CELL LINES; CHRONIC MYELOGENOUS LEUKEMIA; GENETIC MUTATIONS; IMATINIB; MUTATION RATES; NEW TOOLS; PHOSPHORIBOSYLTRANSFERASE; RESISTANCE MECHANISMS; SUBCLONES;

ATMOSPHERIC BOUNDARY LAYER; CELL CULTURE; CLONE CELLS; CLONING; DRUG THERAPY; GENE EXPRESSION;

TROPOSPHERE;

BCR ABL PROTEIN; COMPLEMENTARY DNA; IMATINIB; LENTIVIRUS VECTOR; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CELL CLONE; CELL CLONING; CELL CYCLE; CELL PROLIFERATION; CELL STRAIN KCL 22; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KARYOTYPE; LEUKEMIA RELAPSE; MUTAGENESIS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL LINE; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; FUSION PROTEINS, BCR-ABL; HUMANS; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MUTATION; PIPERAZINES; PYRIMIDINES; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING;

EID: 77951199808     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.039206     Document Type: Article

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