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Volumn 99, Issue 11, 2002, Pages 4122-4130

BCR-ABL-induced adhesion defects are tyrosine kinase-independent

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; FIBRONECTIN; IMATINIB; PROTEIN TYROSINE KINASE;

EID: 0036625016     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.11.4122     Document Type: Article
Times cited : (68)

References (50)
  • 1
    • 0000286732 scopus 로고
    • A minute chromosome in human chronic granulocytic leukemia
    • Nowell PC, Hungerford DA. A minute chromosome in human chronic granulocytic leukemia. Science. 1960;132:1497-1499.
    • (1960) Science , vol.132 , pp. 1497-1499
    • Nowell, P.C.1    Hungerford, D.A.2
  • 2
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • Sawyers CL. Chronic myeloid leukemia. N Engl J Med. 1999;340:1330-1340.
    • (1999) N Engl J Med , vol.340 , pp. 1330-1340
    • Sawyers, C.L.1
  • 3
    • 0026441040 scopus 로고
    • Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV
    • Verfaillie CM, McCarthy JB, McGlave PB. Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV. J Clin Invest. 1992;90:1232-1241.
    • (1992) J Clin Invest , vol.90 , pp. 1232-1241
    • Verfaillie, C.M.1    McCarthy, J.B.2    McGlave, P.B.3
  • 4
    • 0023270373 scopus 로고
    • Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia
    • Gordon MY, Dowding CR, Riley GP, Goldman JM, Greaves MF, Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia. Nature. 1987;328:342-344.
    • (1987) Nature , vol.328 , pp. 342-344
    • Gordon, M.Y.1    Dowding, C.R.2    Riley, G.P.3    Goldman, J.M.4    Greaves, M.F.5
  • 5
    • 0030038231 scopus 로고    scopus 로고
    • Bcr/Abl expression stimulates integrin function in hematopoietic cell lines
    • Bazzoni G, Carlesso N, Griffin JD, Hemler ME. Bcr/Abl expression stimulates integrin function in hematopoietic cell lines. J Clin Invest. 1996;98:521-528.
    • (1996) J Clin Invest , vol.98 , pp. 521-528
    • Bazzoni, G.1    Carlesso, N.2    Griffin, J.D.3    Hemler, M.E.4
  • 6
    • 0025924674 scopus 로고
    • Activation of tyrosinase kinase and microfilament-binding functions of cabl by bcr sequences in bcr/abl fusion proteins
    • McWhirter JR, Wang JY. Activation of tyrosinase kinase and microfilament-binding functions of cabl by bcr sequences in bcr/abl fusion proteins. Mol Cell Biol. 1991;11:1553-1565.
    • (1991) Mol Cell Biol , vol.11 , pp. 1553-1565
    • McWhirter, J.R.1    Wang, J.Y.2
  • 7
    • 0027536793 scopus 로고
    • An actin-binding function contributes to transformation by the Bcr-Abl onco-protein of Philadelphia chromosome-positive human leukemias
    • McWhirter JR, Wang JY. An actin-binding function contributes to transformation by the Bcr-Abl onco-protein of Philadelphia chromosome-positive human leukemias. EMBO J. 1993;12:1533-1546.
    • (1993) EMBO J , vol.12 , pp. 1533-1546
    • McWhirter, J.R.1    Wang, J.Y.2
  • 8
    • 0030873021 scopus 로고    scopus 로고
    • BCR/ABL induces multiple abnormalities of cytoskeletal function
    • Salgia R, Li JL, Ewaniuk DS, et al. BCR/ABL induces multiple abnormalities of cytoskeletal function. J Clin Invest. 1997;100:46-57.
    • (1997) J Clin Invest , vol.100 , pp. 46-57
    • Salgia, R.1    Li, J.L.2    Ewaniuk, D.S.3
  • 9
    • 0028875460 scopus 로고
    • Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL
    • Salgia R, Brunkhorst B, Pisick E, et al. Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL. Oncogene. 1995;11:1149-1155.
    • (1995) Oncogene , vol.11 , pp. 1149-1155
    • Salgia, R.1    Brunkhorst, B.2    Pisick, E.3
  • 10
    • 0030931805 scopus 로고    scopus 로고
    • Influence of interleukin-3 and other growth factors on alpha4beta1 integrin-mediated adhesion and migration of human hematopoietic progenitor cells
    • Schofield KP, Rushton G, Humphries MJ, Dexter TM, Gallagher JT. Influence of interleukin-3 and other growth factors on alpha4beta1 integrin-mediated adhesion and migration of human hematopoietic progenitor cells. Blood. 1997;90:1858-1866.
    • (1997) Blood , vol.90 , pp. 1858-1866
    • Schofield, K.P.1    Rushton, G.2    Humphries, M.J.3    Dexter, T.M.4    Gallagher, J.T.5
  • 11
    • 0028006156 scopus 로고
    • Use of a temperature-sensitive mutant to define the biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line
    • Carlesso N, Griffin JD, Druker BJ. Use of a temperature-sensitive mutant to define the biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line. Oncogene. 1994;9:149-156.
    • (1994) Oncogene , vol.9 , pp. 149-156
    • Carlesso, N.1    Griffin, J.D.2    Druker, B.J.3
  • 12
    • 0032533620 scopus 로고    scopus 로고
    • Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: A novel model for chronic myelogenous leukemia
    • Zhang X, Ren R. Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: A novel model for chronic myelogenous leukemia. Blood. 1998;92:3829-3840.
    • (1998) Blood , vol.92 , pp. 3829-3840
    • Zhang, X.1    Ren, R.2
  • 13
    • 0029087659 scopus 로고
    • Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation
    • Hurley RW, McCarthy JB, Verfaillie CM. Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation. J Clin Invest. 1995;96:511-519.
    • (1995) J Clin Invest , vol.96 , pp. 511-519
    • Hurley, R.W.1    McCarthy, J.B.2    Verfaillie, C.M.3
  • 14
    • 0027948102 scopus 로고
    • Differential adherence of murine hematopoietic stem cell subsets to fibronectin
    • van der Sluijs JP, Baert MR, Ploemacher RE. Differential adherence of murine hematopoietic stem cell subsets to fibronectin. Exp Hematol. 1994;22:1236-1243.
    • (1994) Exp Hematol , vol.22 , pp. 1236-1243
    • Van der Sluijs, J.P.1    Baert, M.R.2    Ploemacher, R.E.3
  • 15
    • 0033514922 scopus 로고    scopus 로고
    • Adhesion to fibronectin stimulates proliferation of wild-type and bcr/abl-transfected murine hematopoietic cells
    • Kramer A, Homer S, Willer A, et al. Adhesion to fibronectin stimulates proliferation of wild-type and bcr/abl-transfected murine hematopoietic cells. Proc Natl Acad Sci U S A. 1999;96:2087-2092.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 2087-2092
    • Kramer, A.1    Homer, S.2    Willer, A.3
  • 16
    • 0031215026 scopus 로고    scopus 로고
    • Quantification of cell adhesion using a spinning disc device and application to surface-reactive materials
    • Garcia AJ, Ducheyne P, Boettiger D. Quantification of cell adhesion using a spinning disc device and application to surface-reactive materials. Biomaterials. 1997;18:1091-1098.
    • (1997) Biomaterials , vol.18 , pp. 1091-1098
    • Garcia, A.J.1    Ducheyne, P.2    Boettiger, D.3
  • 17
  • 18
    • 0032079456 scopus 로고    scopus 로고
    • 1 integrin-fibronectin bonds in intact adherent cells is sensitive to integrin activation state
    • 1 integrin-fibronectin bonds in intact adherent cells is sensitive to integrin activation state. J Biol Chem. 1998;273:10988-10993.
    • (1998) J Biol Chem , vol.273 , pp. 10988-10993
    • Garcia, A.J.1    Huber, F.2    Boettiger, D.3
  • 19
    • 0029949824 scopus 로고    scopus 로고
    • Neutrophil adhesion on surfaces preadsorbed with high molecular weight kininogen under well-defined flow conditions
    • Yung LY, Lim F, Khan MM, Kunapuli SP, Rick L, Colman RW, Cooper SL. Neutrophil adhesion on surfaces preadsorbed with high molecular weight kininogen under well-defined flow conditions. Immunopharmacology. 1996;32:19-23.
    • (1996) Immunopharmacology , vol.32 , pp. 19-23
    • Yung, L.Y.1    Lim, F.2    Khan, M.M.3    Kunapuli, S.P.4    Rick, L.5    Colman, R.W.6    Cooper, S.L.7
  • 20
    • 0031259844 scopus 로고    scopus 로고
    • The detachment strength and morphology of bone cells contacting materials modified with a peptide sequence found within bone slaloprotein
    • Rezania A, Thomas CH, Branger AB, Waters CM, Healy KE. The detachment strength and morphology of bone cells contacting materials modified with a peptide sequence found within bone slaloprotein. J Biomed Mater Res. 1997;37:9-19.
    • (1997) J Biomed Mater Res , vol.37 , pp. 9-19
    • Rezania, A.1    Thomas, C.H.2    Branger, A.B.3    Waters, C.M.4    Healy, K.E.5
  • 21
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996;2:561-566.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 22
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344:1031-1037.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 23
    • 0032533257 scopus 로고    scopus 로고
    • Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
    • Pear WS, Miller JP, Xu L, et al. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood. 1998;92:3780-3792.
    • (1998) Blood , vol.92 , pp. 3780-3792
    • Pear, W.S.1    Miller, J.P.2    Xu, L.3
  • 24
    • 0020538097 scopus 로고
    • Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines
    • Greenberger JS, Sakakeeny MA, Humphries RK, Eaves CJ, Eckner RJ. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc Natl Acad Sci U S A. 1983;80:2931-2935.
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 2931-2935
    • Greenberger, J.S.1    Sakakeeny, M.A.2    Humphries, R.K.3    Eaves, C.J.4    Eckner, R.J.5
  • 25
    • 0001570660 scopus 로고    scopus 로고
    • Transduction of genes using retrovirus vectors
    • Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K, eds. New York, NY: Wiley
    • Pear WS, Cepko C. Transduction of genes using retrovirus vectors. In: Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K, eds. Current Protocols in Molecular Biology Supplement 36. New York, NY: Wiley; 1996: 9.9.1.
    • (1996) Current Protocols in Molecular Biology Supplement 36 , pp. 991
    • Pear, W.S.1    Cepko, C.2
  • 26
    • 0022353446 scopus 로고
    • Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosome
    • Ogura M, Morishima Y, Ohno R, et al. Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosome. Blood. 1985;66:1384-1392.
    • (1985) Blood , vol.66 , pp. 1384-1392
    • Ogura, M.1    Morishima, Y.2    Ohno, R.3
  • 27
    • 84953001633 scopus 로고
    • Mass transfer, flow, and heat transfer about a rotating disk
    • Sparrow EM, Gregg JL. Mass transfer, flow, and heat transfer about a rotating disk. J Heat Transfer, Trans ASME. 1960:294-302.
    • (1960) J Heat Transfer, Trans ASME , pp. 294-302
    • Sparrow, E.M.1    Gregg, J.L.2
  • 29
    • 0025062061 scopus 로고
    • Receptor-mediated cell attachment and detachment kinetics, II: Experimental model studies with the radial-flow detachment assay
    • Cozens-Roberts C, Quinn JA, Lauffenburger DA. Receptor-mediated cell attachment and detachment kinetics, II: Experimental model studies with the radial-flow detachment assay. Biophys J. 1990;58:857-872.
    • (1990) Biophys J , vol.58 , pp. 857-872
    • Cozens-Roberts, C.1    Quinn, J.A.2    Lauffenburger, D.A.3
  • 30
    • 0025150144 scopus 로고
    • Receptor-mediated cell attachment and detachment kinetics, I: Probabilistic model and analysis
    • Cozens-Roberts C, Lauffenburger DA, Quinn JA. Receptor-mediated cell attachment and detachment kinetics, I: Probabilistic model and analysis. Biophys J. 1990;58:841-856.
    • (1990) Biophys J , vol.58 , pp. 841-856
    • Cozens-Roberts, C.1    Lauffenburger, D.A.2    Quinn, J.A.3
  • 31
    • 0033559259 scopus 로고    scopus 로고
    • Crystal structure of a heparin- and integrin-binding segment of human fibronectin
    • Sharma A, Askari JA, Humphries MJ, Jones EY, Stuart DI. Crystal structure of a heparin- and integrin-binding segment of human fibronectin. EMBO J. 1999;18:1468-1479.
    • (1999) EMBO J , vol.18 , pp. 1468-1479
    • Sharma, A.1    Askari, J.A.2    Humphries, M.J.3    Jones, E.Y.4    Stuart, D.I.5
  • 32
    • 0026496886 scopus 로고
    • The three-dimensional structure of the tenth type III module of fibronectin: An insight into RGD-mediated interactions
    • Main AL, Harvey TS, Baron M, Boyd J, Campbell ID. The three-dimensional structure of the tenth type III module of fibronectin: An insight into RGD-mediated interactions. Cell. 1992;71:671-678.
    • (1992) Cell , vol.71 , pp. 671-678
    • Main, A.L.1    Harvey, T.S.2    Baron, M.3    Boyd, J.4    Campbell, I.D.5
  • 34
    • 0033816156 scopus 로고    scopus 로고
    • Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-Kit and platelet-derived growth factor receptors
    • Buchdunger E, Cioffi CL, Law N, et al. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-Kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther. 2000;295:139-145.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 139-145
    • Buchdunger, E.1    Cioffi, C.L.2    Law, N.3
  • 35
    • 0001044842 scopus 로고
    • Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein
    • Daley GQ, Baltimore D. Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc Natl Acad Sci U S A. 1988;85:9312-9316.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 9312-9316
    • Daley, G.Q.1    Baltimore, D.2
  • 36
    • 0025768012 scopus 로고
    • The hematopoietic microenvironment
    • Greenberger JS. The hematopoietic microenvironment. Crit Rev Oncol Hematol. 1991;11:65-84.
    • (1991) Crit Rev Oncol Hematol , vol.11 , pp. 65-84
    • Greenberger, J.S.1
  • 37
    • 0026742369 scopus 로고
    • Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level
    • Udomsakdi C, Eaves CJ, Swolin B, Reid DS, Barnett MJ, Eaves AC. Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level. Proc Natl Acad Sci U S A. 1992;89:6192-6196.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 6192-6196
    • Udomsakdi, C.1    Eaves, C.J.2    Swolin, B.3    Reid, D.S.4    Barnett, M.J.5    Eaves, A.C.6
  • 38
    • 0025287239 scopus 로고
    • Receptor-mediated adhesion phenomena. Model studies with the radical-flow detachment assay
    • Cozens-Roberts C, Quinn JA, Lauffenberger DA. Receptor-mediated adhesion phenomena. Model studies with the radical-flow detachment assay. Biophys J. 1990;58:107-125.
    • (1990) Biophys J , vol.58 , pp. 107-125
    • Cozens-Roberts, C.1    Quinn, J.A.2    Lauffenberger, D.A.3
  • 40
    • 0025606428 scopus 로고
    • A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization
    • Henkemeyer M, West SR, Gertler FB, Hoffmann FM. A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization. Cell. 1990;63:949-960.
    • (1990) Cell , vol.63 , pp. 949-960
    • Henkemeyer, M.1    West, S.R.2    Gertler, F.B.3    Hoffmann, F.M.4
  • 41
    • 0035122485 scopus 로고    scopus 로고
    • Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase
    • Vigneri P, Wang JY. Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase. Nat Med. 2001;7:228-234.
    • (2001) Nat Med , vol.7 , pp. 228-234
    • Vigneri, P.1    Wang, J.Y.2
  • 43
    • 0033959024 scopus 로고    scopus 로고
    • Abl kinase but not P13-kinase links to the cytoskeletal defects in Bcr-Abl transformed cells
    • Gaston I, Stenberg PE, Bhat A, Druker BJ. Abl kinase but not P13-kinase links to the cytoskeletal defects in Bcr-Abl transformed cells. Exp Hematol. 2000;28:77-86.
    • (2000) Exp Hematol , vol.28 , pp. 77-86
    • Gaston, I.1    Stenberg, P.E.2    Bhat, A.3    Druker, B.J.4
  • 44
    • 0031752846 scopus 로고    scopus 로고
    • 1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors
    • 1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors. Leukemia. 1998;12:1708-1717.
    • (1998) Leukemia , vol.12 , pp. 1708-1717
    • Bhatia, R.1    Munthe, H.A.2    Verfaillie, C.M.3
  • 45
    • 0035910059 scopus 로고    scopus 로고
    • The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actin
    • Wang Y, Miller AL, Mooseker MS, Koleske AJ. The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actin. Proc Natl Acad Sci U S A. 2001;98:14865-14870.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 14865-14870
    • Wang, Y.1    Miller, A.L.2    Mooseker, M.S.3    Koleske, A.J.4
  • 46
    • 0035943739 scopus 로고    scopus 로고
    • Distinct ligand-binding modes for integrin alpha vbeta 3-mediated adhesion to fibronectin versus vitronectin
    • Boettiger D, Lynch L, Blystone S, Huber F. Distinct ligand-binding modes for integrin alpha vbeta 3-mediated adhesion to fibronectin versus vitronectin. J Biol Chem. 2001;276:31684-31690.
    • (2001) J Biol Chem , vol.276 , pp. 31684-31690
    • Boettiger, D.1    Lynch, L.2    Blystone, S.3    Huber, F.4
  • 47
    • 0034665766 scopus 로고    scopus 로고
    • Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants
    • Heisterkamp N, Voncken JW, Senadheera D, et al. Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants. Blood. 2000;96:2226-2232.
    • (2000) Blood , vol.96 , pp. 2226-2232
    • Heisterkamp, N.1    Voncken, J.W.2    Senadheera, D.3
  • 48
    • 0037089427 scopus 로고    scopus 로고
    • The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl
    • He Y, Wertheim JA, Xu L, et al. The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl. Blood. 2002;99:2957-2968.
    • (2002) Blood , vol.99 , pp. 2957-2968
    • He, Y.1    Wertheim, J.A.2    Xu, L.3
  • 49
    • 0035136290 scopus 로고    scopus 로고
    • The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl
    • Zhang X, Subrahmanyam R, Worg R, Gross AW, Ren R. The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl. Mol Cell Biol. 2001;21:840-853.
    • (2001) Mol Cell Biol , vol.21 , pp. 840-853
    • Zhang, X.1    Subrahmanyam, R.2    Worg, R.3    Gross, A.W.4    Ren, R.5
  • 50
    • 0034661522 scopus 로고    scopus 로고
    • The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase
    • Million RP, Van Etten RA. The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase. Blood. 2000;96:664-670.
    • (2000) Blood , vol.96 , pp. 664-670
    • Million, R.P.1    Van Etten, R.A.2


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