Developmental and oncogenic effects of Insulin-like Growth Factor-I in Ptc1+/- mouse cerebellum

Molecular Cancer

Volumn 9, Issue , 2010, Pages

  Tanori, Mirella ^a   Santone, Melissa ^a   Mancuso, Mariateresa ^a   Pasquali, Emanuela ^a   Leonardi, Simona ^a   Di Majo, Vincenzo ^a   Rebessi, Simonetta ^a   Saran, Anna ^a   Pazzaglia, Simonetta ^a  

^a ENEA C R CASACCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

NESTIN; PROTEIN PATCHED 1; SOMATOMEDIN C; SONIC HEDGEHOG PROTEIN; CELL SURFACE RECEPTOR; INTERMEDIATE FILAMENT PROTEIN; NERVE PROTEIN; PATCHED RECEPTORS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN GROWTH; BRAIN INJURY; CANCER STAGING; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CEREBELLUM; CONTROLLED STUDY; EMBRYO; GENE FUNCTION; GENE INTERACTION; GENE MUTATION; GENE OVEREXPRESSION; KNOCKOUT MOUSE; MEDULLOBLASTOMA; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; PHENOTYPE; PRECURSOR; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR DIFFERENTIATION; TUMOR GROWTH; TUMOR PROMOTION; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL DIFFERENTIATION; GENETICS; HUMAN; METABOLISM; MUTATION; NERVE CELL; ORGAN SIZE; PATHOLOGY; PRECANCER; PRENATAL DEVELOPMENT; PROMOTER REGION; STEM CELL; TRANSGENE;

MUS;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CEREBELLUM; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTERMEDIATE FILAMENT PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; NEURONS; ORGAN SIZE; PHENOTYPE; PRECANCEROUS CONDITIONS; PROMOTER REGIONS, GENETIC; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; STEM CELLS; TRANSGENES;

EID: 77951186551     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-53     Document Type: Article

References (47)

1. Lee Y, Miller HL, Jensen P, Hernan R, Connelly M, Wetmore C, Zindy F, Roussel MF, Curran T, Gilbertson RJ, McKinnon PJ. A molecular fingerprint for medulloblastoma. Cancer Res 2003, 63:5428-37.
2. Kho AT, Zhao Q, Cai Z, Butte AJ, Kim JY, Pomeroy SL, Rowitch DH, Kohane IS. Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev 2004, 18:629-40. 10.1101/gad.1182504, 387239, 15075291.
3. Goldowitz D, Hamre K. The cells and molecules that make a cerebellum. Trends Neurosci 1998, 21:375-82. 10.1016/S0166-2236(98)01313-7, 9735945.
4. Pietsch T, Waha A, Koch A, Kraus J, Albrecht S, Tonn J, Sörensen N, Berthold F, Henk B, Schmandt N, Wolf HK, von Deimling A, Wainwright B, Chenevix-Trench G, Wiestler OD, Wicking C. Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res 1997, 57:2085-8.
5. Thompson MC, Fuller C, Hogg TL, Dalton J, Finkelstein D, Lau CC, Chintagumpala M, Adesina A, Ashley DM, Kellie SJ, Taylor MD, Curran T, Gajjar A, Gilbertson RJ. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol 2006, 24:1924-31. 10.1200/JCO.2005.04.4974, 16567768.
6. Pazzaglia S, Mancuso M, Atkinson MJ, Tanori M, Rebessi S, Di Majo V, Covelli V, Hahn H, Saran A. High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice. Oncogene 2002, 21:7580-4. 10.1038/sj.onc.1205973, 12386820.
7. Pazzaglia S, Pasquali E, Tanori M, Mancuso M, Leonardi S, Di Majo V, Rebessi S, Saran A. Physical, heritable and age-related factors as modifiers of radiation cancer risk in patched heterozygous mice. Int J Radiat Oncol Biol Phys 2009, 73:1203-10.
8. Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT, Lin SM, Wechsler-Reya RJ. Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. Development 2005, 132:2425-39. 10.1242/dev.01793, 15843415.
9. Pazzaglia S, Tanori M, Mancuso M, Gessi M, Pasquali E, Leonardi S, Oliva MA, Rebessi S, Di Majo V, Covelli V, Giangaspero F, Saran A. Two-hit model for progression of medulloblastoma preneoplasia in Patched heterozygous mice. Oncogene 2006, 25:5575-80. 10.1038/sj.onc.1209544, 16636673.
10. Wetmore C, Eberhart DE, Curran T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 2001, 61:513-6.
11. Uziel T, Zindy F, Sherr CJ, Roussel MF. The CDK inhibitor p18Ink4c is a tumor suppressor in medulloblastoma. Cell Cycle 2006, 5:363-5.
12. Tanori M, Mancuso M, Pasquali E, Leonardi S, Rebessi S, Di Majo V, Guilly MN, Giangaspero F, Covelli V, Pazzaglia S, Saran A. PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma. Carcinogenesis 2008, 29:1911-9. 10.1093/carcin/bgn174, 18660545.
13. Carson MJ, Behringer RR, Brinster RL, McMorris FA. Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice. Neuron 1993, 10:729-40. 10.1016/0896-6273(93)90173-O, 8386530.
14. Ye P, Carson J, D'Ercole AJ. In vivo actions of insulin-like growth factor-I (IGF-I) on brain myelination: studies of IGF-I and IGF binding protein-1 (IGFBP-1) transgenic mice. J Neurosci 1995, 15:7344-56.
15. Popken GJ, Hodge RD, Ye P, Zhang J, Ng W, O'Kusky JR, D'Ercole AJ. In vivo effects of insulin-like growth factor-I (IGF-I) on prenatal and early postnatal development of the central nervous system. Eur J Neurosci 2004, 19:2056-68. 10.1111/j.0953-816X.2004.03320.x, 15090033.
16. Zimmerman L, Parr B, Lendahl U, Cunningham M, McKay R, Gavin B, Mann J, Vassileva G, McMahon A. Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors. Neuron 1994, 12:11-24. 10.1016/0896-6273(94)90148-1, 8292356.
17. Read TA, Fogarty MP, Markant SL, McLendon RE, Wei Z, Ellison DW, Febbo PG, Wechsler-Reya RJ. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell 2009, 15:135-47. 10.1016/j.ccr.2008.12.016, 2664097, 19185848.
18. Wood KA, Dipasquale B, Youle RJ. In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum. Neuron 1993, 11:621-32. 10.1016/0896-6273(93)90074-2, 8398151.
19. Ye P, Xing Y, Dai Z, D'Ercole AJ. In vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development in transgenic mice: evidence that IGF-I increases proliferation of granule cell progenitors. Brain Res Dev Brain Res 1996, 95:44-54. 10.1016/0165-3806(96)00492-0, 8873975.
20. Ramocki NM, Wilkins HR, Magness ST, Simmons JG, Scull BP, Lee GH, McNaughton KK, Lund PK. Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypts stem cell region, limits Apcmin/+ tumors, and regulates Sox9. Endocrinology 2008, 149:261-267. 10.1210/en.2007-0869, 2194604, 17916629.
21. Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV. Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2. Cell Cycle 2007, 6:705-13.
22. Del Valle L, Enam S, Lassak A, Wang JY, Croul S, Khalili K, Reiss K. Insulin-like growth factor I receptor activity in human medulloblastomas. Clin Cancer Res 2002, 8:1822-30.
23. Rao G, Pedone CA, Del Valle L, Reiss K, Holland EC, Fults DW. Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice. Oncogene 2004, 23:6156-62. 10.1038/sj.onc.1207818, 15195141.
24. Wang JY, Del Valle L, Gordon J, Rubini M, Romano G, Croul S, Peruzzi F, Khalili K, Reiss K. Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas. Oncogene 2001, 20:3857-68. 10.1038/sj.onc.1204532, 11439349.
25. Hartmann W, Koch A, Brune H, Waha A, Schüller U, Dani I, Denkhaus D, Langmann W, Bode U, Wiestler OD, Schilling K, Pietsch T. Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells. Am J Pathol 2005, 166:1153-62. 1602379, 15793295.
26. Canzoniere D, Farioli-Vecchioli S, Conti F, Ciotti MT, Tata AM, Augusti-Tocco G, Mattei E, Lakshmana MK, Krizhanovsky V, Reeves SA, Giovannoni R, Castano F, Servadio A, Ben-Arie N, Tirone F. Dual control of neurogenesis by PC3 through cell cycle inhibition and induction of Math1. J Neurosci 2004, 24:3355-69. 10.1523/JNEUROSCI.3860-03.2004, 15056715.
27. Farioli-Vecchioli S, Tanori M, Micheli L, Mancuso M, Leonardi L, Saran A, Ciotti MT, Ferretti E, Gulino A, Pazzaglia S, Tirone F. Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3. FASEB J 2007, 21:2215-25. 10.1096/fj.06-7548com, 17371797.
28. Vatten LJ, Nilsen ST, Odegård RA, Romundstad PR, Austgulen R. Insulin-like growth factor I and leptin in umbilical cord plasma and infant birth size at term. Pediatrics 2002, 109:1131-5. 10.1542/peds.109.6.1131, 12042554.
29. McCormack VA, dos Santos Silva I, De Stavola BL, Mohsen R, Leon DA, Lithell HO. Fetal growth and subsequent risk of breast cancer: results from long term follow up of Swedish cohort. BMJ 2003, 326:248. 10.1136/bmj.326.7383.248, 140759, 12560272.
30. Sandhu MS, Luben R, Day NE, Khaw KT. Self-reported birth weight and subsequent risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2002, 11:935-8.
31. Tibblin G, Eriksson M, Cnattingius S, Ekbom A. High birthweight as a predictor of prostate cancer risk. Epidemiology 1995, 6:423-4. 10.1097/00001648-199507000-00017, 7548353.
32. Gunnell D, Okasha M, Smith GD, Oliver SE, Sandhu J, Holly JM. Height, leg length, and cancer risk: a systematic review. Epidemiol Rev 2001, 23:313-42.
33. Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 2008, 8:915-28. 10.1038/nrc2536, 19029956.
34. Sullivan KA, Castle VP, Hanash SM, Feldman EL. Insulin-like growth factor II in the pathogenesis of human neuroblastoma. Am J Pathol 1995, 147:1790-8. 1869938, 7495303.
35. Bol DK, Kiguchi K, Gimenez-Conti I, Rupp T, DiGiovanni J. Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice. Oncogene 1997, 14:1725-34. 10.1038/sj.onc.1201011, 9135074.
36. DiGiovanni J, Bol DK, Wilker E, Beltrán L, Carbajal S, Moats S, Ramirez A, Jorcano J, Kiguchi K. Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion. Cancer Res 2000, 60:1561-70.
37. DiGiovanni J, Kiguchi K, Frijhoff A, Wilker E, Bol DK, Beltrán L, Moats S, Ramirez A, Jorcano J, Conti C. Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice. Proc Natl Acad Sci USA 2000, 97:3455-60. 10.1073/pnas.97.7.3455, 16261, 10737798.
38. Kaplan-Lefko PJ, Sutherland BW, Evangelou AI, Hadsell DL, Barrios RJ, Foster BA, Demayo F, Greenberg NM. Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis. Oncogene 2008, 27:2868-76. 10.1038/sj.onc.1210943, 18026134.
39. Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, Hennekens CH, Pollak M. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 1998, 279:563-6. 10.1126/science.279.5350.563, 9438850.
40. Pollak M. Insulin-like growth factor physiology and cancer risk. Eur J Cancer 2000, 36:1224-8. 10.1016/S0959-8049(00)00102-7, 10882860.
41. Vadgama JV, Wu Y, Datta G, Khan H, Chillar R. Plasma insulin-like growth factor-I and serum IGF-binding protein 3 can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in African-American and Hispanic women. Oncology 1999, 57:330-40. 10.1159/000012052, 10575321.
42. Yu H, Jin F, Shu XO, Li BD, Dai Q, Cheng JR, Berkel HJ, Zheng W. Insulin-like growth factors and breast cancer risk in Chinese women. Cancer Epidemiol Biomarkers Prev 2002, 11:705-12.
43. Hankinson SE, Willett WC, Colditz GA, Hunter DJ, Michaud DS, Deroo B, Rosner B, Speizer FE, Pollak M. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 1998, 351:1393-6. 10.1016/S0140-6736(97)10384-1, 9593409.
44. Ma J, Pollak MN, Giovannucci E, Chan JM, Tao Y, Hennekens CH, Stampfer MJ. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst 1999, 91:620-5. 10.1093/jnci/91.7.620, 10203281.
45. Reeves SG, Rich D, Meldrum CJ, Colyvas K, Kurzawski G, Suchy J, Lubinski J, Scott RJ. IGF1 is a modifier of disease risk in hereditary non-polyposis colorectal cancer. Int J Cancer 2008, 123:1339-43. 10.1002/ijc.23668, 18623088.
46. Hahn H, Wojnowski L, Zimmer AM, Hall J, Miller G, Zimmer A. Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med 1998, 4:619-22. 10.1038/nm0598-619, 9585239.
47. Pazzaglia S, Tanori M, Mancuso M, Rebessi S, Leonardi S, Di Majo V, Covelli V, Atkinson MJ, Hahn H, Saran A. Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice. Oncogene 2006, 25:1165-73. 10.1038/sj.onc.1209032, 16407852.