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Volumn 37, Issue 5-6, 2010, Pages 530-535

Neuroprotective effect of asymmetric dimethylarginine against 1-methyl-4-phenylpyridinium ion-induced damage in PC12 cells

Author keywords

1 methyl 4 phenylpyridinium ion; Asymmetric dimethylarginine; Neuroprotection; Nitric oxide; Nitric oxide synthase; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; ARGININE; N,N-DIMETHYLARGININE; NEUROPROTECTIVE AGENT;

EID: 77951131821     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2010.05344.x     Document Type: Article
Times cited : (8)

References (46)
  • 1
    • 0036829946 scopus 로고    scopus 로고
    • Neuroprotective and neurorestorative strategies for Parkinson's disease
    • Dawson TM, Dawson VL. Neuroprotective and neurorestorative strategies for Parkinson's disease. Nat. Neurosci. 2002 5 (Suppl. 1058 1061.
    • (2002) Nat. Neurosci. , vol.5 , Issue.SUPPL. , pp. 1058-1061
    • Dawson, T.M.1    Dawson, V.L.2
  • 2
    • 0021280826 scopus 로고
    • Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6- tetrahydropyridine in mice
    • Heikkila RE, Hess A, Duvoisin RC. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice. Science 1984 224 : 1451 1453.
    • (1984) Science , vol.224 , pp. 1451-1453
    • Heikkila, R.E.1    Hess, A.2    Duvoisin, R.C.3
  • 3
    • 0024997609 scopus 로고
    • 1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles
    • Hasegawa E, Takeshige K, Oishi T, Murai Y, Minakami S. 1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles. Biochem. Biophys. Res. Commun. 1990 170 : 1049 1055.
    • (1990) Biochem. Biophys. Res. Commun. , vol.170 , pp. 1049-1055
    • Hasegawa, E.1    Takeshige, K.2    Oishi, T.3    Murai, Y.4    Minakami, S.5
  • 4
    • 0027504297 scopus 로고
    • Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds
    • Tipton KF, Singer TP. Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J. Neurochem. 1993 61 : 1191 1206.
    • (1993) J. Neurochem. , vol.61 , pp. 1191-1206
    • Tipton, K.F.1    Singer, T.P.2
  • 5
    • 0032710609 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
    • Liberatore GT, Jackson-Lewis V, Vukosavic S et al. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat. Med. 1999 5 : 1403 1409.
    • (1999) Nat. Med. , vol.5 , pp. 1403-1409
    • Liberatore, G.T.1    Jackson-Lewis, V.2    Vukosavic, S.3
  • 6
    • 0034006478 scopus 로고    scopus 로고
    • Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo
    • Dehmer T, Lindenau J, Haid S, Dichgans J, Schulz JB. Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. J. Neurochem. 2000 74 : 2213 2216.
    • (2000) J. Neurochem. , vol.74 , pp. 2213-2216
    • Dehmer, T.1    Lindenau, J.2    Haid, S.3    Dichgans, J.4    Schulz, J.B.5
  • 8
    • 44949242548 scopus 로고    scopus 로고
    • Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice
    • Yokoyama H, Takagi S, Watanabe Y, Kato H, Araki T. Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice. J. Neural Transm. 2008 115 : 831 842.
    • (2008) J. Neural Transm. , vol.115 , pp. 831-842
    • Yokoyama, H.1    Takagi, S.2    Watanabe, Y.3    Kato, H.4    Araki, T.5
  • 9
    • 0029844003 scopus 로고    scopus 로고
    • Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons
    • Hantraye P, Brouillet E, Ferrante R et al. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat. Med. 1996 2 : 1017 1021.
    • (1996) Nat. Med. , vol.2 , pp. 1017-1021
    • Hantraye, P.1    Brouillet, E.2    Ferrante, R.3
  • 10
    • 0026548912 scopus 로고
    • Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
    • Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992 339 : 572 575.
    • (1992) Lancet , vol.339 , pp. 572-575
    • Vallance, P.1    Leone, A.2    Calver, A.3    Collier, J.4    Moncada, S.5
  • 11
    • 33646790534 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy
    • Beltowski J, Kedra A. Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy. Pharmacol. Rep. 2006 58 : 159 178.
    • (2006) Pharmacol. Rep. , vol.58 , pp. 159-178
    • Beltowski, J.1    Kedra, A.2
  • 12
    • 34347323965 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease
    • Ueda S, Yamagishi S, Matsumoto Y, Fukami K, Okuda S. Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease. Clin. Exp. Nephrol. 2007 11 : 115 121.
    • (2007) Clin. Exp. Nephrol. , vol.11 , pp. 115-121
    • Ueda, S.1    Yamagishi, S.2    Matsumoto, Y.3    Fukami, K.4    Okuda, S.5
  • 13
    • 33645501775 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA): A novel risk marker in cardiovascular medicine and beyond
    • Boger RH. Asymmetric dimethylarginine (ADMA): A novel risk marker in cardiovascular medicine and beyond. Ann. Med. 2006 38 : 126 136.
    • (2006) Ann. Med. , vol.38 , pp. 126-136
    • Boger, R.H.1
  • 14
    • 56249115245 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine: A novel marker of risk and a potential target for therapy in chronic kidney disease
    • Kielstein JT, Zoccali C. Asymmetric dimethylarginine: A novel marker of risk and a potential target for therapy in chronic kidney disease. Curr. Opin. Nephrol. Hypertens. 2008 17 : 609 615.
    • (2008) Curr. Opin. Nephrol. Hypertens. , vol.17 , pp. 609-615
    • Kielstein, J.T.1    Zoccali, C.2
  • 15
    • 0019308385 scopus 로고
    • Storage of dopamine and acetylcholine in granules of PC12, a clonal pheochromocytoma cell line
    • Rebois RV, Reynolds EE, Toll L, Howard BD. Storage of dopamine and acetylcholine in granules of PC12, a clonal pheochromocytoma cell line. Biochemistry 1980 19 : 1240 1248.
    • (1980) Biochemistry , vol.19 , pp. 1240-1248
    • Rebois, R.V.1    Reynolds, E.E.2    Toll, L.3    Howard, B.D.4
  • 16
    • 34250866187 scopus 로고    scopus 로고
    • Erythropoietin prevents PC12 cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis via the Akt/GSK-3beta/caspase-3 mediated signaling pathway
    • Wu Y, Shang Y, Sun S, Liang H, Liu R. Erythropoietin prevents PC12 cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis via the Akt/GSK-3beta/caspase-3 mediated signaling pathway. Apoptosis 2007 12 : 1365 1375.
    • (2007) Apoptosis , vol.12 , pp. 1365-1375
    • Wu, Y.1    Shang, Y.2    Sun, S.3    Liang, H.4    Liu, R.5
  • 17
    • 33947517977 scopus 로고    scopus 로고
    • Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: Relevance to Parkinson disease
    • Yamamoto N, Sawada H, Izumi Y et al. Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: Relevance to Parkinson disease. J. Biol. Chem. 2007 282 : 4364 4372.
    • (2007) J. Biol. Chem. , vol.282 , pp. 4364-4372
    • Yamamoto, N.1    Sawada, H.2    Izumi, Y.3
  • 18
    • 41149131090 scopus 로고    scopus 로고
    • Differential effects of overexpression of wild-type and mutant human alpha-synuclein on MPP+-induced neurotoxicity in PC12 cells
    • Qian JJ, Cheng YB, Yang YP et al. Differential effects of overexpression of wild-type and mutant human alpha-synuclein on MPP+-induced neurotoxicity in PC12 cells. Neurosci. Lett. 2008 435 : 142 146.
    • (2008) Neurosci. Lett. , vol.435 , pp. 142-146
    • Qian, J.J.1    Cheng, Y.B.2    Yang, Y.P.3
  • 19
    • 0019480519 scopus 로고
    • Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy
    • Johnson LV, Walsh ML, Bockus BJ, Chen LB. Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy. J. Cell Biol. 1981 88 : 526 535.
    • (1981) J. Cell Biol. , vol.88 , pp. 526-535
    • Johnson, L.V.1    Walsh, M.L.2    Bockus, B.J.3    Chen, L.B.4
  • 20
    • 0037402817 scopus 로고    scopus 로고
    • Flow cytometry study of polymorphonuclear neutrophil oxidative burst: A comparison of three fluorescent probes
    • Walrand S, Valeix S, Rodriguez C, Ligot P, Chassagne J, Vasson MP. Flow cytometry study of polymorphonuclear neutrophil oxidative burst: A comparison of three fluorescent probes. Clin. Chim. Acta 2003 331 : 103 110.
    • (2003) Clin. Chim. Acta , vol.331 , pp. 103-110
    • Walrand, S.1    Valeix, S.2    Rodriguez, C.3    Ligot, P.4    Chassagne, J.5    Vasson, M.P.6
  • 21
    • 0035936406 scopus 로고    scopus 로고
    • Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: A prospective study
    • Zoccali C, Bode-Boger S, Mallamaci F et al. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: A prospective study. Lancet 2001 358 : 2113 2117.
    • (2001) Lancet , vol.358 , pp. 2113-2117
    • Zoccali, C.1    Bode-Boger, S.2    Mallamaci, F.3
  • 22
    • 24144494527 scopus 로고    scopus 로고
    • The physiology and pathophysiology of nitric oxide in the brain
    • Guix FX, Uribesalgo I, Coma M, Munoz FJ. The physiology and pathophysiology of nitric oxide in the brain. Prog. Neurobiol. 2005 76 : 126 152.
    • (2005) Prog. Neurobiol. , vol.76 , pp. 126-152
    • Guix, F.X.1    Uribesalgo, I.2    Coma, M.3    Munoz, F.J.4
  • 23
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol. Rev. 2007 87 : 315 424.
    • (2007) Physiol. Rev. , vol.87 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 25
  • 26
    • 63149142549 scopus 로고    scopus 로고
    • Copper reduces striatal protein nitration and tyrosine hydroxylase inactivation induced by MPP+ in rats
    • Rubio-Osornio M, Montes S, Perez-Severiano F et al. Copper reduces striatal protein nitration and tyrosine hydroxylase inactivation induced by MPP+ in rats. Neurochem. Int. 2009 54 : 447 451.
    • (2009) Neurochem. Int. , vol.54 , pp. 447-451
    • Rubio-Osornio, M.1    Montes, S.2    Perez-Severiano, F.3
  • 27
    • 34247236735 scopus 로고    scopus 로고
    • Protective effect of glycyrrhizin on 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells
    • Yim SB, Park SE, Lee CS. Protective effect of glycyrrhizin on 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells. J. Pharmacol. Exp. Ther. 2007 321 : 816 822.
    • (2007) J. Pharmacol. Exp. Ther. , vol.321 , pp. 816-822
    • Yim, S.B.1    Park, S.E.2    Lee, C.S.3
  • 28
    • 33745056543 scopus 로고    scopus 로고
    • Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway
    • Chen J, Tang XQ, Zhi JL et al. Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway. Apoptosis 2006 11 : 943 953.
    • (2006) Apoptosis , vol.11 , pp. 943-953
    • Chen, J.1    Tang, X.Q.2    Zhi, J.L.3
  • 29
    • 13944275183 scopus 로고    scopus 로고
    • Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w
    • Yao M, Nguyen TV, Pike CJ. Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w. J. Neurosci. 2005 25 : 1149 1158.
    • (2005) J. Neurosci. , vol.25 , pp. 1149-1158
    • Yao, M.1    Nguyen, T.V.2    Pike, C.J.3
  • 30
    • 0038389668 scopus 로고    scopus 로고
    • Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's disease
    • Fiskum G, Starkov A, Polster BM, Chinopoulos C. Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's disease. Ann. N Y Acad. Sci. 2003 991 : 111 119.
    • (2003) Ann. N y Acad. Sci. , vol.991 , pp. 111-119
    • Fiskum, G.1    Starkov, A.2    Polster, B.M.3    Chinopoulos, C.4
  • 32
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease
    • Blum D, Torch S, Lambeng N et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease. Prog. Neurobiol. 2001 65 : 135 172.
    • (2001) Prog. Neurobiol. , vol.65 , pp. 135-172
    • Blum, D.1    Torch, S.2    Lambeng, N.3
  • 33
    • 10244222286 scopus 로고    scopus 로고
    • MPTP as a mitochondrial neurotoxic model of Parkinson's disease
    • Przedborski S, Tieu K, Perier C, Vila M. MPTP as a mitochondrial neurotoxic model of Parkinson's disease. J. Bioenerg. Biomembr. 2004 36 : 375 379.
    • (2004) J. Bioenerg. Biomembr. , vol.36 , pp. 375-379
    • Przedborski, S.1    Tieu, K.2    Perier, C.3    Vila, M.4
  • 34
    • 0026598930 scopus 로고
    • Irreversible inhibition of mitochondrial complex i by 1-methyl-4-phenylpyridinium: Evidence for free radical involvement
    • Cleeter MW, Cooper JM, Schapira AH. Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: Evidence for free radical involvement. J. Neurochem. 1992 58 : 786 789.
    • (1992) J. Neurochem. , vol.58 , pp. 786-789
    • Cleeter, M.W.1    Cooper, J.M.2    Schapira, A.H.3
  • 35
    • 0025945089 scopus 로고
    • Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brain
    • Chan P, DeLanney LE, Irwin I, Langston JW, Di Monte D. Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brain. J. Neurochem. 1991 57 : 348 351.
    • (1991) J. Neurochem. , vol.57 , pp. 348-351
    • Chan, P.1    Delanney, L.E.2    Irwin, I.3    Langston, J.W.4    Di Monte, D.5
  • 37
    • 0035214256 scopus 로고    scopus 로고
    • Neurochemical findings in the MPTP model of Parkinson's disease
    • Schmidt N, Ferger B. Neurochemical findings in the MPTP model of Parkinson's disease. J. Neural Transm. 2001 108 : 1263 1282.
    • (2001) J. Neural Transm. , vol.108 , pp. 1263-1282
    • Schmidt, N.1    Ferger, B.2
  • 38
    • 0000340348 scopus 로고
    • Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
    • Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. U S A 1985 82 : 2173 2177.
    • (1985) Proc. Natl. Acad. Sci. U S A , vol.82 , pp. 2173-2177
    • Javitch, J.A.1    D'Amato, R.J.2    Strittmatter, S.M.3    Snyder, S.H.4
  • 39
    • 0023186383 scopus 로고
    • Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on activities of the enzymes in the electron transport system in mouse brain
    • Mizuno Y, Sone N, Saitoh T. Effects of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on activities of the enzymes in the electron transport system in mouse brain. J. Neurochem. 1987 48 : 1787 1793.
    • (1987) J. Neurochem. , vol.48 , pp. 1787-1793
    • Mizuno, Y.1    Sone, N.2    Saitoh, T.3
  • 40
    • 1542328165 scopus 로고    scopus 로고
    • Altered nitric oxide production in mouse brain after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridin or methamphetamine
    • Halasz AS, Palfi M, Tabi T, Magyar K, Szoko E. Altered nitric oxide production in mouse brain after administration of 1-methyl-4-phenyl-1,2,3,6- tetrahydro-pyridin or methamphetamine. Neurochem. Int. 2004 44 : 641 646.
    • (2004) Neurochem. Int. , vol.44 , pp. 641-646
    • Halasz, A.S.1    Palfi, M.2    Tabi, T.3    Magyar, K.4    Szoko, E.5
  • 41
    • 0027194540 scopus 로고
    • A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
    • Lipton SA, Choi YB, Pan ZH et al. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 1993 364 : 626 632.
    • (1993) Nature , vol.364 , pp. 626-632
    • Lipton, S.A.1    Choi, Y.B.2    Pan, Z.H.3
  • 42
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
    • Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U S A 1990 87 : 1620 1624.
    • (1990) Proc. Natl. Acad. Sci. U S A , vol.87 , pp. 1620-1624
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3    Marshall, P.A.4    Freeman, B.A.5
  • 43
    • 34250769329 scopus 로고    scopus 로고
    • S-Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding
    • Nakamura T, Lipton SA. S-Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding. Cell Death Differ. 2007 14 : 1305 1314.
    • (2007) Cell Death Differ. , vol.14 , pp. 1305-1314
    • Nakamura, T.1    Lipton, S.A.2
  • 44
    • 33847623629 scopus 로고    scopus 로고
    • Microdialysis-based analysis of interstitial NO in situ: NO synthase-independent NO formation during myocardial ischemia
    • Martin C, Schulz R, Post H et al. Microdialysis-based analysis of interstitial NO in situ: NO synthase-independent NO formation during myocardial ischemia. Cardiovasc. Res. 2007 74 : 46 55.
    • (2007) Cardiovasc. Res. , vol.74 , pp. 46-55
    • Martin, C.1    Schulz, R.2    Post, H.3
  • 45
    • 67649265352 scopus 로고    scopus 로고
    • Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: Potential role in cardioprotection
    • Lohr NL, Keszler A, Pratt P, Bienengraber M, Warltier DC, Hogg N. Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: Potential role in cardioprotection. J. Mol. Cell. Cardiol. 2009 47 : 256 263.
    • (2009) J. Mol. Cell. Cardiol. , vol.47 , pp. 256-263
    • Lohr, N.L.1    Keszler, A.2    Pratt, P.3    Bienengraber, M.4    Warltier, D.C.5    Hogg, N.6
  • 46
    • 0037072804 scopus 로고    scopus 로고
    • Endogenous methylarginines regulate neuronal nitric-oxide synthase and prevent excitotoxic injury
    • Cardounel AJ, Zweier JL. Endogenous methylarginines regulate neuronal nitric-oxide synthase and prevent excitotoxic injury. J. Bio. Chem. 2002 277 : 33995 33002.
    • (2002) J. Bio. Chem. , vol.277 , pp. 33995-33002
    • Cardounel, A.J.1    Zweier, J.L.2


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