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Volumn 17, Issue 6, 2008, Pages 609-615

Asymmetric dimethylarginine: A novel marker of risk and a potential target for therapy in chronic kidney disease

Author keywords

Asymmetric dimethylarginine; Chronic kidney disease; Dimethylamine dimethylaminohydrolase; Symmetrical dimethylarginine

Indexed keywords

N(G),N(G) DIMETHYLARGININE;

EID: 56249115245     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e328314b6ca     Document Type: Review
Times cited : (62)

References (69)
  • 1
    • 0014940650 scopus 로고
    • Isolation and identification of N-G,N-G- and N-G,N′-G-dimethyl- arginine, N-epsilon-mono-, di-, and trimethyllysine, and glucosyl-galactosyl- and galactosyl-delta-hydroxylysine from human urine
    • Kakimoto Y, Akazawa S. Isolation and identification of N-G,N-G- and N-G,N′-G-dimethyl- arginine, N-epsilon-mono-, di-, and trimethyllysine, and glucosyl-galactosyl- and galactosyl-delta-hydroxylysine from human urine. J Biol Chem 1970; 245:5751-5758.
    • (1970) J Biol Chem , vol.245 , pp. 5751-5758
    • Kakimoto, Y.1    Akazawa, S.2
  • 2
    • 0026548912 scopus 로고
    • Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
    • Vallance P, Leone A, Calver A, et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992; 339:572-575.
    • (1992) Lancet , vol.339 , pp. 572-575
    • Vallance, P.1    Leone, A.2    Calver, A.3
  • 3
    • 1942438521 scopus 로고    scopus 로고
    • Asymmetrical dimethylarginine: The Uber marker?
    • Cooke JP. Asymmetrical dimethylarginine: the Uber marker? Circulation 2004; 109:1813-1818.
    • (2004) Circulation , vol.109 , pp. 1813-1818
    • Cooke, J.P.1
  • 4
    • 0344791653 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: Relationship to treatment method and atherosclerotic disease
    • Kielstein JT, Boger RH, Bode-Boger SM, et al. Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: relationship to treatment method and atherosclerotic disease. J Am Soc Nephrol 1999; 10:594-600.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 594-600
    • Kielstein, J.T.1    Boger, R.H.2    Bode-Boger, S.M.3
  • 5
    • 0036156916 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease
    • Zoccali C, Benedetto FA, Maas R, et al. Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease. J Am Soc Nephrol 2002; 13:490-496.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 490-496
    • Zoccali, C.1    Benedetto, F.A.2    Maas, R.3
  • 6
    • 0036315607 scopus 로고    scopus 로고
    • Left ventricular hypertrophy, cardiac remodeling and asymmetric dimethylarginine (ADMA) in hemodialysis patients
    • Zoccali C, Mallamaci F, Maas R, et al. Left ventricular hypertrophy, cardiac remodeling and asymmetric dimethylarginine (ADMA) in hemodialysis patients. Kidney Int 2002; 62:339-345.
    • (2002) Kidney Int , vol.62 , pp. 339-345
    • Zoccali, C.1    Mallamaci, F.2    Maas, R.3
  • 7
    • 33847352106 scopus 로고    scopus 로고
    • Asymmetrical dimethylarginine independently predicts total and cardiovascular mortality in individuals with angiographic coronary artery disease (the Ludwigshafen Risk and Cardiovascular Health study)
    • A large clinical trial showing that ADMA concentration predicts all-cause and cardiovascular mortality in individuals with coronary artery disease independent of established and emerging cardiovascular risk factors
    • Meinitzer A, Seelhorst U, Wellnitz B, et al. Asymmetrical dimethylarginine independently predicts total and cardiovascular mortality in individuals with angiographic coronary artery disease (the Ludwigshafen Risk and Cardiovascular Health study). Clin Chem 2007; 53:273-283. A large clinical trial showing that ADMA concentration predicts all-cause and cardiovascular mortality in individuals with coronary artery disease independent of established and emerging cardiovascular risk factors.
    • (2007) Clin Chem , vol.53 , pp. 273-283
    • Meinitzer, A.1    Seelhorst, U.2    Wellnitz, B.3
  • 8
    • 5344246626 scopus 로고    scopus 로고
    • Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence
    • Scalera F, Borlak J, Beckmann B, et al. Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence. Arterioscler Thromb Vasc Biol 2004; 24:1816-1822.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1816-1822
    • Scalera, F.1    Borlak, J.2    Beckmann, B.3
  • 9
    • 34247334276 scopus 로고    scopus 로고
    • The ADMA/DDAH pathway is a critical regulator of endothelial cell motility
    • This is the first study providing evidence that metabolism of ADMA regulates endothelial cell motility, an important factor in angiogenesis and vascular repair
    • Wojciak-Stothard B, Torondel B, Tsang LY, et al. The ADMA/DDAH pathway is a critical regulator of endothelial cell motility. J Cell Sci 2007; 120:929-942. This is the first study providing evidence that metabolism of ADMA regulates endothelial cell motility, an important factor in angiogenesis and vascular repair.
    • (2007) J Cell Sci , vol.120 , pp. 929-942
    • Wojciak-Stothard, B.1    Torondel, B.2    Tsang, L.Y.3
  • 10
    • 23644437626 scopus 로고    scopus 로고
    • Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine
    • Thum T, Tsikas D, Stein S, et al. Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine. J Am Coll Cardiol 2005; 46:1693-1701.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1693-1701
    • Thum, T.1    Tsikas, D.2    Stein, S.3
  • 11
    • 28444435118 scopus 로고    scopus 로고
    • Asymmetrical dimethylarginine predicts progression to dialysis and death in patients with chronic kidney disease: A competing risks modeling approach
    • Ravani P, Tripepi G, Malberti F, et al. Asymmetrical dimethylarginine predicts progression to dialysis and death in patients with chronic kidney disease: a competing risks modeling approach. J Am Soc Nephrol 2005; 16:2449-2455.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2449-2455
    • Ravani, P.1    Tripepi, G.2    Malberti, F.3
  • 12
    • 0035936406 scopus 로고    scopus 로고
    • Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: A prospective study
    • Zoccali C, Bode-Boger S, Mallamaci F, et al. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study. Lancet 2001; 358:2113-2117.
    • (2001) Lancet , vol.358 , pp. 2113-2117
    • Zoccali, C.1    Bode-Boger, S.2    Mallamaci, F.3
  • 13
    • 0041733065 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase
    • Achan V, Broadhead M, Malaki M, et al. Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arterioscler Thromb Vasc Biol 2003; 23:1455-1459.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1455-1459
    • Achan, V.1    Broadhead, M.2    Malaki, M.3
  • 14
    • 1642453719 scopus 로고    scopus 로고
    • Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans
    • Kielstein JT, Impraim B, Simmel S, et al. Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans. Circulation 2004; 109:172-177.
    • (2004) Circulation , vol.109 , pp. 172-177
    • Kielstein, J.T.1    Impraim, B.2    Simmel, S.3
  • 15
    • 21544438174 scopus 로고    scopus 로고
    • Asymmetrical dimethylarginine in idiopathic pulmonary arterial hypertension
    • Kielstein JT, Bode-Boger SM, Hesse G, et al. Asymmetrical dimethylarginine in idiopathic pulmonary arterial hypertension. Arterioscler Thromb Vasc Biol 2005; 25:1414-1418.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1414-1418
    • Kielstein, J.T.1    Bode-Boger, S.M.2    Hesse, G.3
  • 16
    • 33747186695 scopus 로고    scopus 로고
    • ADMA increases arterial stiffness and decreases cerebral blood flow in humans
    • Kielstein JT, Donnerstag F, Gasper S, et al. ADMA increases arterial stiffness and decreases cerebral blood flow in humans. Stroke 2006; 37:2024-2029.
    • (2006) Stroke , vol.37 , pp. 2024-2029
    • Kielstein, J.T.1    Donnerstag, F.2    Gasper, S.3
  • 17
    • 33847392496 scopus 로고    scopus 로고
    • Should we measure asymmetric dimethylarginine in patients with coronary artery disease?
    • Kielstein JT, Cooke JP. Should we measure asymmetric dimethylarginine in patients with coronary artery disease? Clin Chem 2007; 53:161-163.
    • (2007) Clin Chem , vol.53 , pp. 161-163
    • Kielstein, J.T.1    Cooke, J.P.2
  • 18
    • 26444433310 scopus 로고    scopus 로고
    • Income disparities in body mass index and obesity in the United States, 1971-2002
    • Chang VW, Lauderdale DS. Income disparities in body mass index and obesity in the United States, 1971-2002. Arch Intern Med 2005; 165: 2122-2128.
    • (2005) Arch Intern Med , vol.165 , pp. 2122-2128
    • Chang, V.W.1    Lauderdale, D.S.2
  • 19
    • 33644756801 scopus 로고    scopus 로고
    • Body mass index and risk for end-stage renal disease
    • Hsu CY, McCulloch CE, Iribarren C, et al. Body mass index and risk for end-stage renal disease. Ann Intern Med 2006; 144:21-28.
    • (2006) Ann Intern Med , vol.144 , pp. 21-28
    • Hsu, C.Y.1    McCulloch, C.E.2    Iribarren, C.3
  • 20
    • 33748060213 scopus 로고    scopus 로고
    • Body mass index and the risk of chronic renal failure: The Asian experience
    • Iseki K. Body mass index and the risk of chronic renal failure: the Asian experience. Contrib Nephrol 2006; 151:42-56.
    • (2006) Contrib Nephrol , vol.151 , pp. 42-56
    • Iseki, K.1
  • 21
    • 33646898442 scopus 로고    scopus 로고
    • Obesity and risk for chronic renal failure
    • Ejerblad E, Fored CM, Lindblad P, et al. Obesity and risk for chronic renal failure. J Am Soc Nephrol 2006; 17:1695-1702.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1695-1702
    • Ejerblad, E.1    Fored, C.M.2    Lindblad, P.3
  • 22
    • 45449095907 scopus 로고    scopus 로고
    • Waist circumference and visceral fat in CKD: A cross-sectional study
    • Sanches FM, Avesani CM, Kamimura MA, et al. Waist circumference and visceral fat in CKD: a cross-sectional study. Am J Kidney Dis 2008; 52:66-73.
    • (2008) Am J Kidney Dis , vol.52 , pp. 66-73
    • Sanches, F.M.1    Avesani, C.M.2    Kamimura, M.A.3
  • 23
    • 0037305107 scopus 로고    scopus 로고
    • Insulin resistance and risk of chronic kidney disease in nondiabetic US adults
    • Chen J, Muntner P, Hamm LL, et al. Insulin resistance and risk of chronic kidney disease in nondiabetic US adults. J Am Soc Nephrol 2003; 14:469-477.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 469-477
    • Chen, J.1    Muntner, P.2    Hamm, L.L.3
  • 24
    • 0029901974 scopus 로고    scopus 로고
    • Insulin resistance, elevated glomerular filtration fraction, and renal injury
    • Dengel DR, Goldberg AP, Mayuga RS, et al. Insulin resistance, elevated glomerular filtration fraction, and renal injury. Hypertension 1996; 28:127-132.
    • (1996) Hypertension , vol.28 , pp. 127-132
    • Dengel, D.R.1    Goldberg, A.P.2    Mayuga, R.S.3
  • 25
    • 33646420076 scopus 로고    scopus 로고
    • Plasma asymmetric dimethylarginine concentrations are elevated in obese insulin-resistant women and fall with weight loss
    • McLaughlin T, Stuhlinger M, Lamendola C, et al. Plasma asymmetric dimethylarginine concentrations are elevated in obese insulin-resistant women and fall with weight loss. J Clin Endocrinol Metab 2006; 91:1896-1900.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1896-1900
    • McLaughlin, T.1    Stuhlinger, M.2    Lamendola, C.3
  • 26
    • 0037139438 scopus 로고    scopus 로고
    • Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor
    • Stuhlinger MC, Abbasi F, Chu JW, et al. Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor. JAMA 2002; 287:1420-1426.
    • (2002) JAMA , vol.287 , pp. 1420-1426
    • Stuhlinger, M.C.1    Abbasi, F.2    Chu, J.W.3
  • 27
    • 42249090741 scopus 로고    scopus 로고
    • Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity
    • Preclinical study showing that ADMA reduces insulin sensitivity
    • Sydow K, Mondon CE, Schrader J, et al. Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity. Arterioscler Thromb Vasc Biol 2008; 28:692-697. Preclinical study showing that ADMA reduces insulin sensitivity.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 692-697
    • Sydow, K.1    Mondon, C.E.2    Schrader, J.3
  • 28
    • 38149073097 scopus 로고    scopus 로고
    • The enzymatic machinery for ADMA synthesis and degradation is fully expressed in human adipocytes
    • First preclinical study linking adipose tissue to ADMA metabolism
    • Spoto B, Parlongo RM, Parlongo G, et al. The enzymatic machinery for ADMA synthesis and degradation is fully expressed in human adipocytes. J Nephrol 2007; 20:554-559. First preclinical study linking adipose tissue to ADMA metabolism.
    • (2007) J Nephrol , vol.20 , pp. 554-559
    • Spoto, B.1    Parlongo, R.M.2    Parlongo, G.3
  • 29
    • 0036137591 scopus 로고    scopus 로고
    • Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease
    • Kielstein JT, Boger RH, Bode-Boger SM, et al. Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease. J Am Soc Nephrol 2002; 13:170-176.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 170-176
    • Kielstein, J.T.1    Boger, R.H.2    Bode-Boger, S.M.3
  • 30
    • 27444444747 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine and progression of chronic kidney disease: The Mild to Moderate Kidney Disease Study
    • Fliser D, Kronenberg F, Kielstein JT, et al. Asymmetric dimethylarginine and progression of chronic kidney disease: the Mild to Moderate Kidney Disease Study. J Am Soc Nephrol 2005; 16:2456-2461.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2456-2461
    • Fliser, D.1    Kronenberg, F.2    Kielstein, J.T.3
  • 31
    • 0346365087 scopus 로고    scopus 로고
    • Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: Genetic and physiological evidence
    • Dayoub H, Achan V, Adimoolam S, et al. Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence. Circulation 2003; 108:3042-3047.
    • (2003) Circulation , vol.108 , pp. 3042-3047
    • Dayoub, H.1    Achan, V.2    Adimoolam, S.3
  • 32
    • 24944522337 scopus 로고    scopus 로고
    • Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease
    • Tanaka M, Sydow K, Gunawan F, et al. Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease. Circulation 2005; 112:1549-1556.
    • (2005) Circulation , vol.112 , pp. 1549-1556
    • Tanaka, M.1    Sydow, K.2    Gunawan, F.3
  • 33
    • 20144362691 scopus 로고    scopus 로고
    • Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis
    • Jacobi J, Sydow K, von Degenfeld G, et al. Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis. Circulation 2005; 111:1431-1438.
    • (2005) Circulation , vol.111 , pp. 1431-1438
    • Jacobi, J.1    Sydow, K.2    von Degenfeld, G.3
  • 34
    • 33847005404 scopus 로고    scopus 로고
    • Disruption of methylarginine metabolism impairs vascular homeostasis
    • Preclinical study that proves the concept that DDAH is the key regulator of ADMA metabolism using DDAH knockout mice
    • Leiper J, Nandi M, Torondel B, et al. Disruption of methylarginine metabolism impairs vascular homeostasis. Nat Med 2007; 13:198-203. Preclinical study that proves the concept that DDAH is the key regulator of ADMA metabolism using DDAH knockout mice.
    • (2007) Nat Med , vol.13 , pp. 198-203
    • Leiper, J.1    Nandi, M.2    Torondel, B.3
  • 35
    • 34248136447 scopus 로고    scopus 로고
    • Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease
    • First preclinical study providing evidence that augmentation of DDAH activity improves cause and severity of a CKD model
    • Matsumoto Y, Ueda S, Yamagishi S, et al. Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease. J Am Soc Nephrol 2007; 18:2176-2183. First preclinical study providing evidence that augmentation of DDAH activity improves cause and severity of a CKD model.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2176-2183
    • Matsumoto, Y.1    Ueda, S.2    Yamagishi, S.3
  • 36
    • 33846027539 scopus 로고    scopus 로고
    • FXR agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulation
    • Hu T, Chouinard M, Cox AL, et al. FXR agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulation. J Biol Chem 2006; 281:39831-39838.
    • (2006) J Biol Chem , vol.281 , pp. 39831-39838
    • Hu, T.1    Chouinard, M.2    Cox, A.L.3
  • 37
    • 0242693911 scopus 로고    scopus 로고
    • Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells
    • Osanai T, Saitoh M, Sasaki S, et al. Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells. Hypertension 2003; 42:985-990.
    • (2003) Hypertension , vol.42 , pp. 985-990
    • Osanai, T.1    Saitoh, M.2    Sasaki, S.3
  • 38
    • 0034698038 scopus 로고    scopus 로고
    • LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: Involvement of S-adenosylmethionine-dependent methyltransferases
    • Boger RH, Sydow K, Borlak J, et al. LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases. Circ Res 2000; 87:99-105.
    • (2000) Circ Res , vol.87 , pp. 99-105
    • Boger, R.H.1    Sydow, K.2    Borlak, J.3
  • 39
    • 34447293565 scopus 로고    scopus 로고
    • Growth hormone treatment during hemodialysis in a randomized trial improves nutrition, quality of life, and cardiovascular risk
    • Feldt-Rasmussen B, Lange M, Sulowicz W, et al. Growth hormone treatment during hemodialysis in a randomized trial improves nutrition, quality of life, and cardiovascular risk. J Am Soc Nephrol 2007; 18:2161-2171.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2161-2171
    • Feldt-Rasmussen, B.1    Lange, M.2    Sulowicz, W.3
  • 40
    • 6344233637 scopus 로고    scopus 로고
    • Low dialysance of asymmetric dimethylarginine (ADMA): In vivo and in vitro evidence of significant protein binding
    • Kielstein JT, Boger RH, Bode-Boger SM, et al. Low dialysance of asymmetric dimethylarginine (ADMA): in vivo and in vitro evidence of significant protein binding. Clin Nephrol 2004; 62:295-300.
    • (2004) Clin Nephrol , vol.62 , pp. 295-300
    • Kielstein, J.T.1    Boger, R.H.2    Bode-Boger, S.M.3
  • 41
    • 14844326661 scopus 로고    scopus 로고
    • Circulating ADMA concentrations are elevated in hypopituitary adults with and without growth hormone deficiency
    • Krzyzanowska K, Mittermayer F, Schnack C, et al. Circulating ADMA concentrations are elevated in hypopituitary adults with and without growth hormone deficiency. Eur J Clin Invest 2005; 35:208-213.
    • (2005) Eur J Clin Invest , vol.35 , pp. 208-213
    • Krzyzanowska, K.1    Mittermayer, F.2    Schnack, C.3
  • 42
    • 33747032266 scopus 로고    scopus 로고
    • ADMA, proteinuria, and insulin resistance in nondiabetic stage I chronic kidney disease
    • Caglar K, Yilmaz MI, Sonmez A, et al. ADMA, proteinuria, and insulin resistance in nondiabetic stage I chronic kidney disease. Kidney Int 2006; 70:781-787.
    • (2006) Kidney Int , vol.70 , pp. 781-787
    • Caglar, K.1    Yilmaz, M.I.2    Sonmez, A.3
  • 43
    • 0342588054 scopus 로고    scopus 로고
    • Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome)
    • Stenvinkel P, Heimburger O, Lindholm B, et al. Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome). Nephrol Dial Transplant 2000; 15:953-960.
    • (2000) Nephrol Dial Transplant , vol.15 , pp. 953-960
    • Stenvinkel, P.1    Heimburger, O.2    Lindholm, B.3
  • 44
    • 15444379908 scopus 로고    scopus 로고
    • L-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor
    • Boger RH, Ron ES. L-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor. Altem Med Rev 2005; 10:14-23.
    • (2005) Altem Med Rev , vol.10 , pp. 14-23
    • Boger, R.H.1    Ron, E.S.2
  • 45
    • 0742304562 scopus 로고    scopus 로고
    • Trends in use of herbal and nutritional supplements in cardiovascular patients
    • Stys T, Stys A, Kelly P, Lawson W. Trends in use of herbal and nutritional supplements in cardiovascular patients. Clin Cardiol 2004; 27:87-90.
    • (2004) Clin Cardiol , vol.27 , pp. 87-90
    • Stys, T.1    Stys, A.2    Kelly, P.3    Lawson, W.4
  • 46
    • 29944434110 scopus 로고    scopus 로고
    • L-arginine therapy in acute myocardial infarction: The Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial
    • Schulman SP, Becker LC, Kass DA, et al. L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA 2006; 295: 58-64.
    • (2006) JAMA , vol.295 , pp. 58-64
    • Schulman, S.P.1    Becker, L.C.2    Kass, D.A.3
  • 47
    • 34447334222 scopus 로고    scopus 로고
    • L-arginine supplementation in peripheral arterial disease: No benefit and possible harm
    • A major clinical trial showing no benefit of chronic L-arginine supplementation in patients with peripheral arterial disease
    • Wilson AM, Harada R, Nair N, et al. L-arginine supplementation in peripheral arterial disease: no benefit and possible harm. Circulation 2007; 116:188-195. A major clinical trial showing no benefit of chronic L-arginine supplementation in patients with peripheral arterial disease.
    • (2007) Circulation , vol.116 , pp. 188-195
    • Wilson, A.M.1    Harada, R.2    Nair, N.3
  • 48
    • 0024789934 scopus 로고
    • Amino acid metabolism in uremia
    • Furst P. Amino acid metabolism in uremia. J Am Coll Nutr 1989; 8:310-323.
    • (1989) J Am Coll Nutr , vol.8 , pp. 310-323
    • Furst, P.1
  • 49
    • 0009935089 scopus 로고
    • Abnormal cation transport in uremia. Mechanisms in adipocytes and skeletal muscle from uremic rats
    • Druml W, Kelly RA, May RC, Mitch WE. Abnormal cation transport in uremia. Mechanisms in adipocytes and skeletal muscle from uremic rats. J Clin Invest 1988; 81:1197-1203.
    • (1988) J Clin Invest , vol.81 , pp. 1197-1203
    • Druml, W.1    Kelly, R.A.2    May, R.C.3    Mitch, W.E.4
  • 50
    • 0018953706 scopus 로고
    • Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency
    • Tizianello A, De Ferrari G, Garibotto G, et al. Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J Clin Invest 1980; 65:1162-1173.
    • (1980) J Clin Invest , vol.65 , pp. 1162-1173
    • Tizianello, A.1    De Ferrari, G.2    Garibotto, G.3
  • 51
    • 38349048006 scopus 로고    scopus 로고
    • Nitric oxide deficiency in chronic kidney disease
    • A comprehensive review on nitric oxide deficiency in CKD
    • Baylis C. Nitric oxide deficiency in chronic kidney disease. Am J Physiol Renal Physiol 2008; 294:F1-F9. A comprehensive review on nitric oxide deficiency in CKD.
    • (2008) Am J Physiol Renal Physiol , vol.294
    • Baylis, C.1
  • 52
    • 0027289732 scopus 로고
    • The effect of hemodialysis on protein metabolism. A leucine kinetic study
    • Lim VS, Bier DM, Flanigan MJ, Sum-Ping ST. The effect of hemodialysis on protein metabolism. A leucine kinetic study. J Clin Invest 1993; 91:2429-2436.
    • (1993) J Clin Invest , vol.91 , pp. 2429-2436
    • Lim, V.S.1    Bier, D.M.2    Flanigan, M.J.3    Sum-Ping, S.T.4
  • 53
    • 0020039686 scopus 로고
    • Amino acid losses during hemodialysis with infusion of amino acids and glucose
    • Wolfson M, Jones MR, Kopple JD. Amino acid losses during hemodialysis with infusion of amino acids and glucose. Kidney Int 1982; 21:500-506.
    • (1982) Kidney Int , vol.21 , pp. 500-506
    • Wolfson, M.1    Jones, M.R.2    Kopple, J.D.3
  • 54
    • 33845957682 scopus 로고    scopus 로고
    • No benefit of hemodiafiltration over hemodialysis in lowering elevated levels of asymmetric dimethylarginine in ESRD patients
    • Kalousova M, Kielstein JT, Hodkova M, et al. No benefit of hemodiafiltration over hemodialysis in lowering elevated levels of asymmetric dimethylarginine in ESRD patients. Blood Purif 2006; 24:439-444.
    • (2006) Blood Purif , vol.24 , pp. 439-444
    • Kalousova, M.1    Kielstein, J.T.2    Hodkova, M.3
  • 55
    • 0030801352 scopus 로고    scopus 로고
    • Guanidino compounds in serum and urine of nondialyzed patients with chronic renal insufficiency
    • Marescau B, Nagels G, Possemiers I, et al. Guanidino compounds in serum and urine of nondialyzed patients with chronic renal insufficiency. Metabolism 1997; 46:1024-1031.
    • (1997) Metabolism , vol.46 , pp. 1024-1031
    • Marescau, B.1    Nagels, G.2    Possemiers, I.3
  • 56
    • 33750139969 scopus 로고    scopus 로고
    • Symmetric dimethylarginine (SDMA) as endogenous marker of renal function: A meta-analysis
    • Kielstein JT, Salpeter SR, Bode-Boeger SM, et al. Symmetric dimethylarginine (SDMA) as endogenous marker of renal function: a meta-analysis. Nephrol Dial Transplant 2006; 21:2446-2451.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 2446-2451
    • Kielstein, J.T.1    Salpeter, S.R.2    Bode-Boeger, S.M.3
  • 57
    • 0031424947 scopus 로고    scopus 로고
    • Interference of L-arginine analogues with L-arginine transport mediated by the y- carrier hCAT-2B
    • Closs El, Basha FZ, Habermeier A, Forstermann U. Interference of L-arginine analogues with L-arginine transport mediated by the y- carrier hCAT-2B. Nitric Oxide 1997; 1:65-73.
    • (1997) Nitric Oxide , vol.1 , pp. 65-73
    • Closs, E.1    Basha, F.Z.2    Habermeier, A.3    Forstermann, U.4
  • 58
    • 33645473328 scopus 로고    scopus 로고
    • Symmetrical dimethylarginine: A new combined parameter for renal function and extent of coronary artery disease
    • Bode-Boger SM, Scalera F, Kielstein JT, et al. Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease. J Am Soc Nephrol 2006; 17:1128-1134.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1128-1134
    • Bode-Boger, S.M.1    Scalera, F.2    Kielstein, J.T.3
  • 59
    • 12244262222 scopus 로고    scopus 로고
    • Asymmetrical dimethylarginine (ADMA) in critically ill patients: High plasma ADMA concentration is an independent risk factor of ICU mortality
    • Nijveldt RJ, Teerlink T, Van der HB, et al. Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality. Clin Nutr 2003; 22: 23-30.
    • (2003) Clin Nutr , vol.22 , pp. 23-30
    • Nijveldt, R.J.1    Teerlink, T.2    Van der, H.B.3
  • 60
    • 4444273012 scopus 로고    scopus 로고
    • Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock
    • Lopez A, Lorente JA, Steingrub J, et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 2004; 32:21-30.
    • (2004) Crit Care Med , vol.32 , pp. 21-30
    • Lopez, A.1    Lorente, J.A.2    Steingrub, J.3
  • 61
    • 33847662338 scopus 로고    scopus 로고
    • Asymmetric dimethyl-arginine (ADMA) response to inflammation in acute infections
    • A small clinical study showing that the resolution of acute inflammation is characterized by an increase in the plasma concentration of ADMA, suggesting that ADMA suppression may actually serve in stimulating nitric oxide in acute inflammation
    • Zoccali C, Maas R, Cutrupi S, et al. Asymmetric dimethyl-arginine (ADMA) response to inflammation in acute infections. Nephrol Dial Transplant 2007; 22:801-806. A small clinical study showing that the resolution of acute inflammation is characterized by an increase in the plasma concentration of ADMA, suggesting that ADMA suppression may actually serve in stimulating nitric oxide in acute inflammation.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 801-806
    • Zoccali, C.1    Maas, R.2    Cutrupi, S.3
  • 62
    • 36048946363 scopus 로고    scopus 로고
    • Metabolic profiling of arginine and nitric oxide pathways predicts hemodynamic abnormalities and mortality in patients with cardiogenic shock after acute myocardial infarction
    • A small clinical study on cardiogenic shock showing that ADMA levels were the strongest independent predictor of 30-day mortality
    • Nicholls SJ, Wang Z, Koeth R, et al. Metabolic profiling of arginine and nitric oxide pathways predicts hemodynamic abnormalities and mortality in patients with cardiogenic shock after acute myocardial infarction. Circulation 2007; 116:2315-2324. A small clinical study on cardiogenic shock showing that ADMA levels were the strongest independent predictor of 30-day mortality.
    • (2007) Circulation , vol.116 , pp. 2315-2324
    • Nicholls, S.J.1    Wang, Z.2    Koeth, R.3
  • 63
    • 0038000645 scopus 로고    scopus 로고
    • Cardiogenic shock complicating acute myocardial infarction: Expanding the paradigm
    • Hochman JS. Cardiogenic shock complicating acute myocardial infarction: expanding the paradigm. Circulation 2003; 107:2998-3002.
    • (2003) Circulation , vol.107 , pp. 2998-3002
    • Hochman, J.S.1
  • 64
    • 34247392754 scopus 로고    scopus 로고
    • Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: The TRIUMPH randomized controlled trial
    • A large clinical trial showing that L-NMMA did not reduce mortality rates in patients with refractory cardiogenic shock complicating MI
    • Alexander JH, Reynolds HR, Stebbins AL, et al. Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. JAMA 2007; 297:1657-1666. A large clinical trial showing that L-NMMA did not reduce mortality rates in patients with refractory cardiogenic shock complicating MI.
    • (2007) JAMA , vol.297 , pp. 1657-1666
    • Alexander, J.H.1    Reynolds, H.R.2    Stebbins, A.L.3
  • 65
    • 34548381247 scopus 로고    scopus 로고
    • Kielstein JT, Sydow K, Thum T. Tilarginine in patients with acute myocardial infarction and cardiogenic shock. JAMA 2007; 298:971-973.
    • Kielstein JT, Sydow K, Thum T. Tilarginine in patients with acute myocardial infarction and cardiogenic shock. JAMA 2007; 298:971-973.
  • 66
    • 0034754959 scopus 로고    scopus 로고
    • Inhibition of nitric oxide activity by arginine analogs in human renal arteries
    • Segarra G, Medina P, Vila JM, et al. Inhibition of nitric oxide activity by arginine analogs in human renal arteries. Am J Hypertens 2001; 14:1142-1148.
    • (2001) Am J Hypertens , vol.14 , pp. 1142-1148
    • Segarra, G.1    Medina, P.2    Vila, J.M.3
  • 67
    • 37149039563 scopus 로고    scopus 로고
    • Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage
    • Jung CS, Oldfield EH, Harvey-White J, et al. Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg 2007; 107:945-950.
    • (2007) J Neurosurg , vol.107 , pp. 945-950
    • Jung, C.S.1    Oldfield, E.H.2    Harvey-White, J.3
  • 68
    • 0038119508 scopus 로고    scopus 로고
    • Elevated risk of stroke among patients with end-stage renal disease
    • Seliger SL, Gillen DL, Longstreth WT Jr, et al. Elevated risk of stroke among patients with end-stage renal disease. Kidney Int 2003; 64:603-609.
    • (2003) Kidney Int , vol.64 , pp. 603-609
    • Seliger, S.L.1    Gillen, D.L.2    Longstreth Jr, W.T.3
  • 69
    • 34547901364 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA): A modulator of nociception in opiate tolerance and addiction?
    • A short review and outlook on possible involvement of ADMA in processes such as nociception and addiction
    • Kielstein A, Tsikas D, Galloway GP, Mendelson JE. Asymmetric dimethylarginine (ADMA): a modulator of nociception in opiate tolerance and addiction? Nitric Oxide 2007; 17:55-59. A short review and outlook on possible involvement of ADMA in processes such as nociception and addiction.
    • (2007) Nitric Oxide , vol.17 , pp. 55-59
    • Kielstein, A.1    Tsikas, D.2    Galloway, G.P.3    Mendelson, J.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.