Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted ω-phenyl-ω-(3-pyridyl)alkenoic acid derivatives and related compounds

Journal of Medicinal Chemistry

Volumn 41, Issue 27, 1998, Pages 5362-5374

  Takeuchi, Kumiko ^a   Kohn, Todd J ^a   True, Timothy A ^a,b   Mais, Dale E ^a,c   Wikel, James H ^a   Utterback, Barbara G ^a   Wyss, Virginia L ^a   Jakubowski, Joseph A ^a  

^a ELI LILLY AND COMPANY   (United States)

^b GLAXOSMITHKLINE   (United States)

^c LIGAND PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 [4 [4 [[(4 CYCLOHEXYLBUTYL)AMINO]CARBONYL] 2 OXAZOLYL]PHENYL] 7 (3 PYRIDYL) 6 HEPTENOIC ACID; PROSTACYCLIN; PROSTAGLANDIN H2; THROMBOXANE A2; THROMBOXANE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTICOAGULATION; ARTICLE; DRUG RECEPTOR BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHILICITY; MALE; NONHUMAN; PREDICTION; RAT; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION;

ANIMALS; BLOOD PLATELETS; DRUG DESIGN; ENZYME INHIBITORS; EPOPROSTENOL; HEPTANOIC ACIDS; HUMANS; OXAZOLES; PLATELET AGGREGATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, THROMBOXANE; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOXANE B2; THROMBOXANE-A SYNTHASE;

EID: 0032585581     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980173n     Document Type: Article

References (13)

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