Effects of exercise training on adiposity, insulin sensitivity, and plasma hormone and lipid concentrations in overweight or obese, insulin-resistant horses

American Journal of Veterinary Research

Volumn 71, Issue 3, 2010, Pages 314-321

  Carter, Rebecca A ^a,b   McCutcheon, L Jill ^a,c   Valle, Emanuela ^a   Meilahn, Elaine N ^a   Geor, Raymond J ^a,c  

^a VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; LEPTIN; LIPID; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY FAT; BODY WEIGHT; CONTROLLED STUDY; EXERCISE; FATTY ACID BLOOD LEVEL; GELDING; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; LIPID BLOOD LEVEL; MALE; MORPHOMETRICS; NONHUMAN; OBESITY; SUBCUTANEOUS FAT; TOTAL BODY WATER; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; HORMONES; HORSE DISEASES; HORSES; INSULIN; INSULIN RESISTANCE; LIPIDS; LONGITUDINAL STUDIES; MALE; NECK; OBESITY; ORCHIECTOMY; OVERWEIGHT; PHYSICAL CONDITIONING, ANIMAL; WEIGHT LOSS;

ANIMALIA; EQUIDAE;

EID: 77951013472     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.71.3.314     Document Type: Article

References (45)

1. Frank N, Elliott SB, Brandt LE, et al. Physical characteristics, blood hormone concentrations, and plasma lipid concentrations in obese horses with insulin resistance. J Am Vet Med Assoc 2006;228:1383-1390.
2. Hoffman RM, Boston RC, Stefanovski D, et al. Obesity and diet affect glucose dynamics and insulin sensitivity in Thoroughbred geldings. J Anim Sci 2003;81:2333-2342. (Pubitemid 38571697)
3. Vick MM, Adams AA, Murphy BA, et al. Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse. J Anim Sci 2007;85:1144-1155.
4. Bailey SR, Habershon-Butcher JL, Ransom KJ, et al. Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis. Am J Vet Res 2008;69:122-129.
5. Treiber KH, Kronfeld DS, Hess TM, et al. Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies. J Am Vet Med Assoc 2006;228:1538-1545.
6. Treiber KH, Hess TM, Kronfeld DS, et al. Insulin resistance and compensation in laminitis-predisposed ponies characterized by the minimal model. Pferdeheilkunde 2007;23:237-240.
7. Vick MM, Sessions DR, Murphy BA, et al. Obesity is associated with altered metabolic and reproductive activity in the mare: effects of metformin on insulin sensitivity and reproductive cyclicity. Reprod Fertil Dev 2006;18:609-617.
8. Carter RA, Treiber KH, Geor RJ, et al. Prediction of incipient pasture-associated laminitis from hyperinsulinaemia, hyperleptinaemia and generalised and localised obesity in a cohort of ponies. Equine Vet J 2009;41:171-178.
9. Pate RR, Pratt M, Blair SN, et al. Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 1995;273:402-407.
10. Houmard JA, Tanner CJ, Slentz CA, et al. Effect of the volume and intensity of exercise training on insulin sensitivity. J Appl Physiol 2004;96:101-106. (Pubitemid 38031988)
11. Johnson JL, Slentz CA, Houmard JA, et al. Exercise training amount and intensity effects on metabolic syndrome (from studies of a targeted risk reduction intervention through defined exercise). Am J Cardiol 2007;100:1759-1766.
12. Zierath JR. Exercise training-induced changes in insulin signaling in skeletal muscle. J Appl Physiol 2002;93:773-781. (Pubitemid 34810245)
13. Ross R, Dagnone D, Jones PJ, et al. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med 2000;133:92-103.
14. Powell DM, Reedy SE, Sessions DR, et al. Effect of short-term exercise training on insulin sensitivity in obese and lean mares. Equine Vet J Suppl 2002;(34):81-84.
15. Stewart-Hunt L, Geor RJ, McCutcheon LJ. Effects of short-term training on insulin sensitivity and skeletal muscle glucose metabolism in standardbred horses. Equine Vet J Suppl 2006;(36):226-232.
16. Freestone JF, Beadle R, Shoemaker K, et al. Improved insulin sensitivity in hyperinsulinaemic ponies through physical conditioning and controlled feed intake. Equine Vet J 1992;24:187-190.
17. Carter RA, McCutcheon LJ, George LA, et al. Effects of diet-induced weight gain on insulin sensitivity and plasma hormone and lipid concentrations in horses. Am J Vet Res 2009;70:1250-1258.
18. Treiber KH, Kronfeld DS, Hess TM, et al. Use of proxies and reference quintiles obtained from minimal model analysis for determination of insulin sensitivity and pancreatic beta-cell responsiveness in horses. Am J Vet Res 2005;66:2114-2121.
19. NRC. In: Nutrient requirements of horses. 6th ed. Washington, DC: National Academies Press, 2007.
20. Carter RA, Geor RJ, Staniar WB, et al. Apparent adiposity assessed by standardised scoring systems and morphometries in horses and ponies. Vet J 2009;179:204-210.
21. Henneke DR, Potter GD, Kreider JL, et al. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet J 1983;15:371-372.
22. Westervelt RG, Stouffer JR, Hintz HF, et al. Estimating fatness in horses and ponies. J Anim Sci 1976;43:781-785.
23. Freestone JF, Wolfsheimer KJ, Kamerling SG, et al. Exercise induced hormonal and metabolic changes in Thoroughbred horses: effects of conditioning and acepromazine. Equine Vet J 1991;23:219-223.
24. McManus CJ, Fitzgerald BP. Effects of a single day of feed restriction on changes in serum leptin, gonadotropins, prolactin, and metabolites in aged and young mares. Dornest Anim Endocrinol 2000;19:1-13.
25. Andrews FM, Nadeau JA, Saabye L, et al. Measurement of total body water content in horses, using deuterium oxide dilution. Am J Vet Res 1997;58:1060-1064. (Pubitemid 127470288)
26. Forro M, Cieslar S, Ecker GL, et al. Total body water and Ecfv measured using bioelectrical impedance analysis and indicator dilution in horses. J Appl Physiol 2000;89:663-671. (Pubitemid 30637116)
27. Wang Z, Deurenberg P, Heymsfield SB. Cellular-level body composition model. A new approach to studying fat-free mass hydration. Ann N Y Acad Sci 2000;904:306-311.
28. Boston RC, Stefanovski D, Moate PJ, et al. MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test. Diabetes Technol Ther 2003;5:1003-1015. (Pubitemid 38009940)
29. Pratt SE, Geor RJ, McCutcheon LJ. Effects of dietary energy source and physical conditioning on insulin sensitivity and glucose tolerance in standardbred horses. Equine Vet J Suppl 2006;(36):579-584.
30. Treiber KH, Hess TM, Kronfeld DS, et al. Glucose dynamics during exercise: dietary energy sources affect minimal model parameters in trained Arabian geldings during endurance exercise. Equine Vet J Suppl 2006;(36):631-636.
31. Pratt SE, Geor RJ, Spriet LL, et al. Time course of insulin sensitivity and skeletal muscle glycogen synthase activity after a single bout of exercise in horses. J Appl Physiol 2007;103:1063-1069.
32. Wojtaszewski JF, Nielsen JN, Richter EA. Effect of acute exercise on insulin signaling and action in humans. J Appl Physiol 2002;93:384-392. (Pubitemid 34686235)
33. Duncan GE, Perri MG, Theriaque DW, et al. Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes Care 2003;26:557-562.
34. Hawley JA. Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance. Diabetes Metab Res Rev 2004;20:383-393.
35. Donaldson MT, McDonnell SM, Schanbacher BJ, et al. Variation in plasma adrenocorticotropic hormone concentration and dexamethasone suppression test results with season, age, and sex in healthy ponies and horses. J Vet Intern Med 2005;19:217-222.
36. Hallgreen CE, Hall KD. Allometric relationship between changes of visceral fat and total fat mass. Int J Obes (Lond) 2008;32:845-852.
37. Mauriege P, Marette A, Atgie C, et al. Regional variation in adipose tissue metabolism of severely obese premenopausal women. J Lipid Res 1995;36:672-684.
38. Stellingwerff T, Boon H, Jonkers RA, et al. Significant intramyocellular lipid use during prolonged cycling in endurance-trained males as assessed by three different methodologies. Am J Physiol Endocrinol Metab 2007;292:E1715-E1723. (Pubitemid 47084707)
39. Goodpaster BH, Theriault R, Watkins SC, et al. Intramuscular lipid content is increased in obesity and decreased by weight loss. Metabolism 2000;49:467-472. (Pubitemid 30196572)
40. McKeen G, Lindinger MI. Prediction of hydration status using multi-frequency bioelectrical impedance analysis during exercise and recovery in horses. Equine Comp Exerc Physiol 2004;1:199-209.
41. Gotch F, Nadell J, Edelman IS. Gastrointestinal water and electroyltes. Iv. The equilibration of deuterium oxide (d2o) in gastrointestinal contents and the proportion of total body water (t.B.W.) in the gastrointestinal tract. J Clin Invest 1957;36:289-296.
42. Hall KD. What is the required energy deficit per unit weight loss? Int J Obes 2008;32:573-576.
43. Garrow JS, Summerbell CD. Meta-analysis: effect of exercise, with or without dieting, on the body composition of overweight subjects. Eur J Clin Nutr 1995;49:1-10.
44. Hunter GR, Byrne NM, Sirikul B, et al. Resistance training conserves fat-free mass and resting energy expenditure following weight loss. Obesity (Silver Spring) 2008;16:1045-1051. (Pubitemid 351620480)
45. Tate DF, Jeffery RW, Sherwood NE, et al. Long-term weight losses associated with prescription of higher physical activity goals. Are higher levels of physical activity protective against weight regain? Am J Clin Nutr 2007;85:954-959.