Prediction of incipient pasture-associated laminitis from hyperinsulinaemia, hyperleptinaemia and generalised and localised obesity in a cohort of ponies

Equine Veterinary Journal

Volumn 41, Issue 2, 2009, Pages 171-178

  Carter, R A ^a,b   Treiber, K H ^a,b   Geor, R J ^a,b   Douglass, L ^a,c   Harris, P A ^a,d  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b Middleburg Agricultural Research and Extension Center   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d WALTHAM CENTRE FOR PET NUTRITION   (United Kingdom)

Author keywords

Cresty neck; Horse; Insulin; Laminitis; Leptin; Obesity

Indexed keywords

EQUIDAE;

LEPTIN;

ANIMAL; ANIMAL DISEASE; ANIMAL HUSBANDRY; ARTICLE; BLOOD; COHORT ANALYSIS; COMORBIDITY; DIFFERENTIAL DIAGNOSIS; FEMALE; FOOT DISEASE; HORSE; HORSE DISEASE; HYPERINSULINISM; METHODOLOGY; OBESITY; POACEAE; PREDICTION AND FORECASTING; RISK FACTOR;

ANIMAL HUSBANDRY; ANIMALS; COHORT STUDIES; COMORBIDITY; DIAGNOSIS, DIFFERENTIAL; FEMALE; FOOT DISEASES; HORSE DISEASES; HORSES; HYPERINSULINISM; LEPTIN; OBESITY; POACEAE; PREDICTIVE VALUE OF TESTS; RISK FACTORS;

EID: 65549140514     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516408X342975     Document Type: Article

References (35)

1. Altman, D.G., Machin, D., Bryant, T.N. and Gardner, M.J. (2000) Statistics with Confidence, 2nd edn., J.W. Arrowsmith Ltd, Bristol.
2. Anon (1999) Definition, Diagnosis, and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation. World Health Organization, Geneva.
3. Anon (2000) Lameness and Laminitis in U.S. Horses, Ed: C. USDA:APHIS:VS, National Animal Health Monitoring System, Fort Collins, Colorado.
4. Anon (2001) Executive summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). J. Am. med. Ass. 285, 2486-2497.
5. Asplin, K.E., Sillence, M.N., Pollitt, C.C. and McGowan, C.M. (2007) Induction of laminitis by prolonged hyperinsulinaemia in clinically normal ponies. Vet. J. 174, 530-535.
6. Bailey, S.R., Habershon-Butcher, J.L., Ransom, K.J., Elliott, J. and Menzies-Gow, N.J. (2008) Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis. Am. J. vet. Res. 69, 122-129.
7. Bailey, S.R., Menzies-Gow, N.J., Harris, P.A., Habershon-Butcher, J.L., Crawford, C., Berhane, Y., Boston, R.C. and Elliott, J. (2007) Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis. J. Am. vet. med. Ass. 231, 1365-1373.
8. Biggerstaff, B.J. (2000) Comparing diagnostic tests: a simple graphic using likelihood ratios. Stat. Med. 19, 649-663.
9. Buff, P.R., Dodds, A.C., Morrison, C.D., Whitley, N.C., McFadin, E.L., Daniel, J.A., Djiane, J. and Keisler, D.H. (2002) Leptin in horses: tissue localization and relationship between peripheral concentrations of leptin and body condition. J. anim. Sci. 80, 2942-2948.
10. Carter, R.A., Geor, R.J., Staniar, W.B., Cubitt, T.A. and Harris, P.A. (2008) Apparent adiposity assessed by standardised scoring systems and morphometric measurements in horses and ponies. Vet. J. doi:10.1016/j.tvjl.2008.1002.1029.
11. Carter, R.A., Treiber, K.H., Hess, T.M., Kronfeld, D.S. and Geor, R.J. (2006) Pre-laminitic metabolic syndrome: Application to Connemara ponies. In: Proceedings of the 6th Annual Clinical Nutrition and Research Symposium of the American Academy of Veterinary Nutrition. p 17.
12. Cartmill, J.A., Thompson, D.L., Jr., Storer, W.A., Crowley, J.C., Huff, N.K. and Waller, C.A. (2005) Effect of dexamethasone, feeding time, and insulin infusion on leptin concentrations in stallions. J. anim. Sci. 83, 1875-1881.
13. Cartmill, J.A., Thompson, D.L., Jr., Storer, W.A., Gentry, L.R. and Huff, N.K. (2003) Endocrine responses in mares and geldings with high body condition scores grouped by high vs. low resting leptin concentrations. J. anim. Sci. 81, 2311-2321.
14. Coffman, J.R. and Colles, C.M. (1983) Insulin tolerance in laminitic ponies. Can. J. comp. Med. 47, 347-351.
15. Donaldson, M.T., Jorgensen, A.J. and Beech, J. (2004) Evaluation of suspected pituitary pars intermedia dysfunction in horses with laminitis. J. Am. vet. med. Ass. 224, 1123-1127.
16. Frank, N., Elliott, S.B. and Boston, R.C. (2008) Effects of long-term oral administration of levothyroxine sodium on glucose dynamics in healthy adult horses. Am. J. vet. Res. 69, 76-81.
17. Frank, N., Elliott, S.B., Brandt, L.E. and Keisler, D.H. (2006) Physical characteristics, blood hormone concentrations, and plasma lipid concentrations in obese horses with insulin resistance. J. Am. vet. med. Ass. 228, 1383-1390.
18. Freestone, J.F., Wolfsheimer, K.J., Kamerling, S.G., Church, G., Hamra, J. and Bagwell, C. (1991) Exercise induced hormonal and metabolic changes in Thoroughbred horses: effects of conditioning and acepromazine. Equine vet. J. 23, 219-223.
19. Gibson, R.S. (1990) Principles of Nutritional Assessment, Oxford University Press, New York.
20. Harris, P., Bailey, S.R., Elliott, J. and Longland, A. (2006) Countermeasures for pasture-associated laminitis in ponies and horses. J. Nutr. 136, 2114S-2121S.
21. Henneke, D.R., Potter, G.D., Kreider, J.L. and Yeates, B.F. (1983) Relationship between condition score, physical measurements and body fat percentage in mares. Equine vet. J. 15, 371-372.
22. Hoffman, R.M., Boston, R.C., Stefanovski, D., Kronfeld, D.S. and Harris, P.A. (2003) Obesity and diet affect glucose dynamics and insulin sensitivity in Thoroughbred geldings. J. anim. Sci. 81, 2333-2342.
23. Jeffcott, L.B., Field, J.R., McLean, J.G. and O'Dea, K. (1986) Glucose tolerance and insulin sensitivity in ponies and Standardbred horses. Equine vet. J. 18, 97-101.
24. Johnson, P.J. (2002) The equine metabolic syndrome peripheral Cushing's syndrome. Vet. Clin. N. Am.: Equine Pract. 18, 271-293.
25. McFarlane, D., Beech, J. and Cribb, A. (2006) Alpha-melanocyte stimulating hormone release in response to thyrotropin releasing hormone in healthy horses, horses with pituitary pars intermedia dysfunction and equine pars intermedia explants. Domest. Anim. Endocrinol. 30, 276-288.
26. McIntosh, B., Kronfeld, D., Geor, R., Staniar, W., Longland, A., Gay, L., Ward, D. and Harris, P. (2007) Circadian and seasonal fluctuations of glucose and insulin concentrations in grazing horses. In: Proceedings of the 20th Equine Science Society. pp 100-101.
27. McManus, C.J. and Fitzgerald, B.P. (2000) Effects of a single day of feed restriction on changes in serum leptin, gonadotropins, prolactin, and metabolites in aged and young mares. Domest. anim. Endocrinol. 19, 1-13.
28. Murphy, K.G. and Bloom, S.R. (2006) Are all fats created equal? Nat. Med. 12, 32-33.
29. Perkins, G.A., Lamb, S., Erb, H.N., Schanbacher, B., Nydam, D.V. and Divers, T.J. (2002) Plasma adrenocorticotropin (ACTH) concentrations and clinical response in horses treated for equine Cushing's disease with cyproheptadine or pergolide. Equine vet. J. 34, 679-685.
30. Pratt, S.E., Geor, R.J. and McCutcheon, L.J. (2005) Repeatability of 2 methods for assessment of insulin sensitivity and glucose dynamics in horses. J. vet. int. Med. 19, 883-888.
31. Treiber, K.H., Kronfeld, D.S., Hess, T.M., Boston, R.C. and Harris, P.A. (2005) Use of proxies and reference quintiles obtained from minimal model analysis for determination of insulin sensitivity and pancreatic beta-cell responsiveness in horses. Am. J. vet. Res. 66, 2114-2121.
32. Treiber, K.H., Hess, T.M., Kronfeld, D.S., Boston, R.C., Geor, R.J. and Harris, P.A. (2007) Insulin resistance and compensation in laminitis-predisposed ponies characterized by the minimal model. Pferdeheilkunde 23, 237-240.
33. Treiber, K.H., Kronfeld, D.S., Hess, T.M., Byrd, B.M., Splan, R.K. and Staniar, W.B. (2006) Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies. J. Am. vet. med. Ass. 228, 1538-1545.
34. Vick, M.M., Adams, A.A., Murphy, B.A., Sessions, D.R., Horohov, D.W., Cook, R.F., Shelton, B.J. and Fitzgerald, B.P. (2007) Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse. J. anim. Sci. 85, 1144-1155.
35. Zweig, M.H. and Campbell, G. (1993) Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin. Chem. 39, 561-577.