HIV-mediated γδ T cell depletion is specific for Vγ2+ cells expressing the Jγ1.2 segment

AIDS Research and Human Retroviruses

Volumn 19, Issue 1, 2003, Pages 21-29

  Enders, Patrick J ^a   Yin, Cheng ^b   Martini, Federico ^c   Evans, Peter S ^a   Propp, Nadia ^a   Poccia, Fabrizio ^c   Pauza, C David ^a  

^a INSTITUTE OF HUMAN VIROLOGY   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN SUBUNIT; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; BYSTANDER EFFECT; CELL LOSS; CELL SPECIFICITY; CELLULAR IMMUNITY; CLONAL VARIATION; CONTROLLED STUDY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPATHOGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; COMPLEMENTARITY DETERMINING REGION; DNA SEQUENCE; GENETICS; IMMUNOLOGY; LYMPHOCYTE COUNT; METABOLISM; MOLECULAR CLONING; PATHOGENICITY; T LYMPHOCYTE RECEPTOR GENE;

CLONING, MOLECULAR; COMPLEMENTARITY DETERMINING REGIONS; GENES, T-CELL RECEPTOR GAMMA; HIV; HIV INFECTIONS; HUMANS; LYMPHOCYTE COUNT; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SEQUENCE ANALYSIS, DNA; T-LYMPHOCYTE SUBSETS;

EID: 0037252740     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/08892220360473934     Document Type: Article

References (37)

1. + T cell receptor-α/β-circulating lymphocytes. J Exp Med 1988;167:694-699.
2. Parker, CM, Groh V, Band H, Porcelli SA, Morita C, Fabbi M, Glass D, Strominger JL, Brenner MB: Evidence for extrathymic changes in the T cell repertoire γ/δ repertoire. J Exp Med 1990;171:1597-1612.
3. Bukowski JF, Morita CT, Brenner MB: Recognition and destruction of virus-infected cells by human γδ CTL. J Immunol 1994;153:5133-5140.
4. Wallace M, Malkovsky M, Carding SR: γ/δ T lymphocytes in viral infections. J Leukoc Biol 1995;58:277-283.
5. Morita CT, Lee HK, Leslie DS, Tanaka Y, Bukowski JF, Marker-Hermann E: Recognition of nonpeptide prenyl pyrophosphate antigens by human γδ T cells. Microbes Infect 1999;1:175-186.
6. Sciammas R, Bluestone JA: TCRγδ cells and viruses. Microbes Infect 1999;1:203-212.
7. Morita CT, Mariuzza RA, Brenner MB: Antigen recognition by human γδ T cells: Pattern recognition by the adaptive immune system. Springer Semin Immunopathol 2000;22:191-217.
8. Davodeau F, Peyrat MA, Hallet MM, Gaschet J, Houde I, Vivien R, Vie H, Bonneville M: Close correlation between Daudi and mycobacterial antigen recognition by human γδ T cells and expression of V9JPC1 γ/V2DJC δ-encoded T cell receptors. J Immunol 1993;151:1214-1223.
9. Bukowski JF, Morita CT, Tanaka Y, Bloom BR, Brenner MB, Band H: V γ 2V δ 2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer. J Immunol 1995;154:998-1006.
10. Bukowski JF, Morita CT, Band H, Brenner MB: Crucial role of TCR γ chain junctional region in prenyl pyrophosphate antigen recognition by γδ T cells. J Immunol 1998;161:286-293.
11. Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H, Bloom BR, Golan DE, Brenner MB: Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity 1995;3:495-507.
12. Miyagawa F, Tanaka Y, Yamashita S, Mikami B, Danno K, Uehara M, Minato N: Essential contribution of germline-encoded lysine residues in Jγ1.2 segment to the recognition of nonpeptide antigens by human γδ T cells. J Immunol 2001;167:6773-6779.
13. Evans PS, Enders PJ, Yin C, Ruckwardt TJ, Malkovsky M, Pauza CD: In vitro stimulation with a non-peptidic alkylphosphate expands cells expressing Vγ2-Jγ1.2/Vδ2 T-cell receptors. Immunology 2001;104:19-27.
14. + clones from thymus and peripheral blood. J Exp Med 1989;170:1521-1535.
15. Delfau MH, Hance AJ, Lecossier D, Vilmer E, Grandchamp B: Restricted diversity of V gamma 9-JP rearrangements in unstimulated human gamma/delta T lymphocytes. Eur J Immunol 1992;22:2437-2443.
16. De Libero G, Casorati G, Giachino C, Carbonara C, Migone N, Matzinger P, Lanzavecchia A: Selection by two powerful antigens may account for the presence of the major population of human peripheral γ/δ T cells. J Exp Med 1991;173:1311-1322.
17. Davodeau F, Peyrat MA, Hallet MM, Houde I, Vie H, Bonneville M: Peripheral selection of antigen receptor junctional features in a major human γδ subset. Eur J Immunol 1993;23:804-808.
18. Hinz T, Wesch D, Friese K, Reckziegel A, Arden B, Kabelitz D: T cell receptor γδ repertoire in HIV-1-infected individuals. Eur J Immunol 1994;24:3044-3049.
19. Wesch D, Hinz T, Kabelitz D: Analysis of the TCR Vγ repertoire in healthy donors and HIV-1-infected individuals. Int Immunol 1998;10:1067-1075.
20. + T cell expansion in the peripheral blood of HIV-infected persons. J Immunol 1995;154:1418-1431.
21. Poccia F, Boullier S, Lecoeur H, Cochet M, Poquet Y, Colizzi V, Fournie JJ, Gougeon ML: Peripheral V γ9/Vδ2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons. J Immunol 1996;157:449-461.
22. Wallace M, Scharko AM, Pauza CD, Fisch P, Imaoka K, Kawabata S, Fujihashi K, Kiyono H, Tanaka Y, Bloom BR, Malkovsky M: Functional γδ T-lymphocyte defect associated with human immunodeficiency virus infections. Mol Med 1997;3:60-71.
23. Brenner MB, McLean J, Scheft H, Riberdy J, Ang SL, Seidman JG, Devlin P, Krangel MS: Two forms of the T-cell receptor γ protein found on peripheral blood cytotoxic T lymphocytes. Nature 1987;325:689-694.
24. Lusso P, Garzino-Demo A, Crowley RW, Malnati MS: Infection of γ/δ T lymphocytes by human herpesvirus 6: Transcriptional induction of CD4 and susceptibility to HIV infection. J Exp Med 1995;181:1303-1310.
25. Martini F, Urso R, Gioia C, De Felici A, Narciso P, Amendola A, Paglia MG, Colizzi V, Poccia F: γδ T-cell anergy in human immunodeficiency virus-infected persons with opportunistic infections and recovery after highly active antiretroviral therapy. Immunology 2000;100:481-486.
26. Pannetier C, Levraud J-P, Lim A, Even J, Kourilsky P: The immunoscopic analysis of T cell repertoires. In The Antigen T Cell Receptor: Selected Prorocols and Applications. Oskenberg J, ed. Chapman & Hall, Detroit, Michigan, pp. 287-385.
27. + T cell receptor repertoire. J Infect Dis 1998;177:579-585.
28. + T-cell repertoire that are not immediately restored by antiviral or immune-based therapies [see comments]. Nat Med 1997;3:533-540.
29. Lehner T, Mitchell E, Bergmeier L, Singh M, Spallek R, Cranage M, Hall G, Dennis M, Villinger F, Wang Y: The role of γδ T cells in generating antiviral factors and β-chemokines in protection against mucosal simian immunodeficiency virus infection. Eur J Immunol 2000;30:2245-2256.
30. Wesch D, Kabelitz D, Friese K, Pechhold K: Mycobacteria-reactive γδ T cells in HIV-infected individuals: Lack of Vγ9 cell responsiveness is due to deficiency of antigen-specific CD4 T helper type 1 cells. Eur J Immunol 1996;26:557-562.
31. Garcia VE, Sieling PA, Gong J, Barnes PF, Uyemura K, Tanaka Y, Bloom BR, Morita CT, Modlin RL: Single-cell cytokine analysis of γδ T cell responses to nonpeptide mycobacterial antigens. J Immunol 1997;159:1328-1335.
32. + T cells. J Immunol 1991;146:35-39.
33. Li B, Bassiri H, Rossman MD, Kramer P, Eyuboglu AF, Torres M, Sada E, Imir T, Carding SR: Involvement of the Fas/Fas ligand pathway in activation-induced cell death of mycobacteria-reactive human γδT cells: A mechanism for the loss of γδT cells in patients with pulmonary tuberculosis. J Immunol 1998;161:1558-1567.
34. Burk MR, Carena I, Donda A, Mariani F, Mori L, De Libero G: Functional inactivation in the whole population of human Vγ9/Vδ2 T lymphocytes induced by a nonpeptidic antagonist. J Exp Med 1997;185:91-97.
35. Li B, Rossman MD, Imir T, Oner-Eyuboglu AF, Lee CW, Biancaniello R, Carding SR: Disease-specific changes in γδ T cell repertoire and function in patients with pulmonary tuberculosis. J Immunol 1996;157:4222-4229.
36. Poccia F, Battistini L, Cipriani B, Mancino G, Martini F, Gougeon ML, Colizzi V: Phosphoantigen-reactive Vγ9Vδ2 T lymphocytes suppress in vitro human immunodeficiency virus type 1 replication by cell-released antiviral factors including CC chemokines. J Infect Dis 1999;180:858-861.
37. Poccia F, Malkovsky M, Gougeon ML, Bonneville M, Lopez-Botet M, Fournie JJ, Colizzi V: γδ T cell activation or anergy during infections: The role of nonpeptidic TCR ligands and HLA class I molecules. J Leukoc Biol 1997;62:287-291.