Aberrant T-cell receptor signalling of interferon-γ-and tumour necrosis factor-α-producing cytotoxic CD8+ Vδ1/Vβ16 T cells in a patient with chronic neutropenia

Scandinavian Journal of Immunology

Volumn 58, Issue 1, 2003, Pages 89-98

  Bank, I ^a,c   Cohen, L ^b   Kneller, A ^a   De Rosbo, N K ^b   Book, M ^a   Ben Nun, A ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c SHEBA MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; MONOCLONAL ANTIBODY CD3; PHORBOL ESTER; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN SPECIFICITY; ARTICLE; BLOOD DISEASE; CELL PROLIFERATION; CHRONIC DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOPATHOLOGY; LYMPHOCYTE CLONE; LYMPHOCYTE CULTURE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; NEUTROPENIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANTIGENS, CD3; BASE SEQUENCE; CHRONIC DISEASE; HUMANS; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; LYMPHOKINES; MOLECULAR SEQUENCE DATA; NEUTROPENIA; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES, CYTOTOXIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037670721     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2003.01272.x     Document Type: Article

References (25)

1. Strominger JL. Developmental biology of T cell receptors. Science 1989;244:943-50.
2. Haas W, Pereira P, Tonegawa S. Gamma/delta cells. Annu Rev Immunol 1993;11:637-85.
3. Hansen-Hagge TE, Mahotka C, Panzer-Grumayer RE et al. Alternative splicing restricts translation of rearrangements at the T-cell receptor delta/alpha locus. Blood 1995;85:1888-96.
4. Peyrat MA, Davodeau F, Houde I et al. Repertoire analysis of human peripheral blood lymphocytes using a human V delta 3 region-specific monoclonal antibody. Characterization of dual T cell receptor (TCR) delta-chain expressors and alpha beta T cells expressing V delta 3J alpha C alpha-encoded TCR chains. J Immunol 1995;155:3060-7.
5. Giachino C, Rocci MP, Bottaro M, Matullo G, De Libero G, Migone N. T cell receptor V delta 2-C alpha transcripts are present in the thymus but virtually absent in the periphery. J Immunol 1994; 153:1637-44.
6. Sottini A, Imberti L, Fiordalisi G, Primi D. Use of variable human V delta genes to create functional T cell receptor alpha chain transcripts. Eur J Immunol 1991;21:2455-9.
7. Miossec C, Faure F, Ferradini L et al. Further analysis of the T cell receptor gamma/delta+ peripheral lymphocyte subset. The V delta 1 gene segment is expressed with either C alpha or C delta. J Exp Med 1990;171:1171-88.
8. Miossec C, Caignard A, Ferradini L et al. Molecular characterization of human T cell receptor alpha chains including a V delta 1-encoded variable segment. Eur J Immunol 1991;21:1061-4.
9. Castelli C, Mazzocchi A, Salvi S, Anichini A, Sensi M. Use of the V delta 1 variable region in the functional T-cell receptor alpha chain of a WT31+ cytotoxic T lymphocyte clone which specifically recognizes HLA-A2 molecule. Scand J Immunol 1992;35:487-94.
10. Bank I, Book M, Cohen L et al. Expansion of a unique subpopulation of cytotoxic T cells that express a C alpha V delta 1 T-cell receptor gene in a patient with severe persistent neutropenia. Blood 1992;80:3157-63.
11. Loughran TP Jr. Clonal diseases of large granular lymphocytes. Blood 1993;82:1-14.
12. Bank I, Tanay A, Migdal A, Book M, Livneh A. V gamma 9-V delta 2+ gamma delta T cells from a patient with Felty syndrome that exhibit aberrant response to triggering of the CD3 molecule can regulate immunoglobulin secretion by B cells. Clin Immunol Immunopathol 1995;74:162-9.
13. Sood R, Stewart CC, Aplan PD et al. Neutropenia associated with T-cell large granular lymphocyte leukemia: long-term response to cyclosporine therapy despite persistence of abnormal cells. Blood 1998;91:3372-8.
14. Bank I, Cohen L, Mouallem M, Farfel Z, Grossman E, Ben-Nun A. Gammadelta T cell subsets in patients with arthritis and chronic neutropenia. Ann Rheum Dis 2002;61:438-43.
15. Selleri C, Sato T, Anderson S, Young NS, Maciejewski JP. Interferon-gamma and tumor necrosis factor-alpha suppress both early and late stages of hematopoiesis and induce programmed cell death. J Cell Physiol 1995;165:538-46.
16. Selleri C, Maciejewski JP, Sato T, Young NS. Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition. Blood 1996;87:4149-57.
17. Kasten-Sportes C, Zaknoen S, Steis RG, Chan WC, Winton EF, Waldmann TA. T-cell receptor gene rearrangement in T-cell large granular leukocyte leukemia: preferential V alpha bur diverse J alpha usage in one of five patients. Blood 1994;83:767-75.
18. + leukemic large granular lymphocytes utilize diverse T-cell receptor V beta genes. Blood 1995;85:146-50.
19. Langerak AW, van Den Beemd R, Wolvers-Tettero IL et al. Molecular and flow cytometric analysis of the V beta repertoire for clonality assessment in mature TCRalphabeta T-cell proliferations. Blood 2001;98:165-73.
20. Lima M, Almeida J, Santos AH et al. Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 persistent expansions of CD3(+)/TCR-alphabeta(+) large granular lymphocytes: utility in assessing clonality and insights into the pathogenesis of the disease. Am J Pathol 2001;159:1861-8.
21. + T cells in large granular lymphocyte leukemia are not defective in activation- and replication-related apoptosis. Leuk Res 2001;25:699-708.
22. Ebert O, Finke S, Salahi A et al. Lymphocyte apoptosis: induction by gene transfer techniques. Gene Ther 1997;4:296-302.
23. Mountz JD, Zhou T, Su X et al. Autoimmune disease results from multiple interactive defects in apoptosis induction molecules and signaling pathways. Behring Inst Mitt 1996, 200-19.
24. Liu JH, Wei S, Lamy T et al. Chronic neutropenia mediated by fas ligand. Blood 2000;95:3219-22.
25. Brinkman K, van Dongen JJ, van Lom K, Groeneveld K, Misere JF, van der Heul C. Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vbeta antibodies. Leukemia 1998;12:150-4.