Minocycline promotes long-term survival of neuronal transplant in the brain by inhibiting late microglial activation and T-cell recruitment

Transplantation

Volumn 89, Issue 7, 2010, Pages 816-823

  Michel Monigadon, Delphine ^a,b,c   Nerrière Daguin, Véronique ^a,b,c   Lévèque, Xavier ^a,b,c   Plat, Martine ^d   Venturi, Eric ^e   Brachet, Philippe ^a,b,c   Naveilhan, Philippe ^a,b,c   Neveu, Isabelle ^a,b,c  

^a INSERM   (France)

^b Institut de Transplantation et de Recherche en Transplantation   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d UMR85 PHYSIOLOGIE DE LA REPRODUCTION ET DES COMPORTEMENTS   (France)

^e CEMAGREF   (France)

Author keywords

Cell rejection; Immune response; Microglial cells; Neurons; Rat; Restorative strategies; Xenotransplantation

Indexed keywords

MINOCYCLINE; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; ZACNAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TRANSPLANTATION; CELL ACTIVATION; CONTROLLED STUDY; DRUG PENETRATION; DRUG SAFETY; EMBRYO; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; MICROGLIA; NERVE GRAFT; NEUROBLAST; NONHUMAN; PORCINE EMBRYO; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; XENOGRAFT; XENOTRANSPLANTATION;

EID: 77950927048     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181cbe041     Document Type: Article

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