Genetically modified mice-successes and failures of a widely used technology

Pflugers Archiv European Journal of Physiology

Volumn 459, Issue 4, 2010, Pages 557-567

  Castrop, Hayo ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Embryo; Gene expression; Phenotype; RNA editing; Transgenic mouse

Indexed keywords

4 HYDROXYTAMOXIFEN; ADENOSINE A1 RECEPTOR; CRE RECOMBINASE; CYCLOOXYGENASE 2; DNA; DRE RECOMBINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTROGEN RECEPTOR; HYBRID PROTEIN; MESSENGER RNA; NEOMYCIN; RECOMBINASE; RNA; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG; WNT PROTEIN; ZINC FINGER NUCLEASE; ZINC FINGER PROTEIN;

DNA MODIFICATION; DNA RECOMBINATION; DNA SEQUENCE; EMBRYONIC STEM CELL; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE TARGETING; GENE TECHNOLOGY; GENE TRAP TECHNOLOGY; GENETIC TRANSFECTION; HOMOLOGOUS RECOMBINATION; HYDRODYNAMICS BASED TRANSFECTION; JUXTAGLOMERULAR CELL; KIDNEY DISEASE; KNOCKOUT MOUSE; LOXP SITE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; REVIEW; RNA INTERFERENCE; RNA SPLICING; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; VASODILATATION;

ALTERNATIVE SPLICING; ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; GENOME; LINKAGE (GENETICS); MICE; MICE, TRANSGENIC; RNA INTERFERENCE; TRANSGENES;

EID: 77950919216     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-009-0770-z     Document Type: Review

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