Effects of neuronal and glial restricted precursor cells transplantation on erectile function after experimentally induced spinal cord injury

Journal of Sexual Medicine

Volumn 6, Issue 12, 2009, Pages 3265-3273

  Temeltas, Gokhan ^a   Dagci, Taner ^b   Evren, Vedat ^b   Lekili, Murat ^a  

^a CELAL BAYAR UNIVERSITY   (Turkey)

^b EGE UNIVERSITY   (Turkey)

Author keywords

Erectile Function; Glial Restricted Precursors; Neurologic Erectile Dysfunction; Neuronal Restricted Precursors; Spinal Cord Injury

Indexed keywords

CYCLOSPORIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; EMBRYO; ERECTILE DYSFUNCTION; GRAFT REJECTION; LOCOMOTION; MALE; NERVE STIMULATION; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; THERAPY EFFECT; ANIMAL; CELL TRANSPLANTATION; CONVALESCENCE; CYTOLOGY; DISEASE MODEL; GLIA; HOSPITALIZATION; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSPLANTATION; TREATMENT OUTCOME;

ANIMALS; CELL TRANSPLANTATION; DISEASE MODELS, ANIMAL; ERECTILE DYSFUNCTION; LOCOMOTION; MALE; NEUROGLIA; RATS; RECOVERY OF FUNCTION; SEVERITY OF ILLNESS INDEX; SPINAL CORD INJURIES; TREATMENT OUTCOME;

EID: 77950912650     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2009.01376.x     Document Type: Article

References (34)

1. Comarr AE. Sexuality and fertility among spinal cord and/or cauda equine injuries. J Am Paraplesia Soc 1985, 8:67-5.
2. Sonda LP, Mazo R, Chancellor MB. The role of yohimbine for the treatment of erectile impotence. J Sex Marital Ther 1990, 16:15-21.
3. Rivas DA, Chancellor MB, Huang B, Salzman SK. Erectile response to topical, intraurethral and intracorporal pharmacotherapy in a rat model of spinal cord injury. J Spinal Cord Med 1995, 18:245-50.
4. Courtois F, Charvier K, Leriche A, Vézina JG, Côté I, Raymond D, Jacquemin G, Fournier C, Bélanger M. Perceived physiological and orgasmic sensations at ejaculation in spinal cord injured men. J Sex Med 2008, 5:2419-30.
5. Soler JM, Previnaire JG, Plante P, Denys P, Chartier-Kastler E. Midodrine improves orgasm in spinal cord-injured men: The effects of autonomic stimulation. J Sex Med 2008, 5:2935-41.
6. Aizawa N, Ishizuka O, Ogawa T, Mizusawa H, Igawa Y, Nishizawa O. Role of 5-HT receptor antagonists in mediating intracavernous pressure response induced by fluvoxamine in conscious rats. J Sex Med 2007, 4:1108-16.
7. Kang KK, Ahn JG, Ahn BO, Yoo M, Kim WB. DA-8159, a new PDE5 inhibitor, induced penile erection in conscious and acute spinal cord injury. Eur Urol 2003, 43:689-95.
8. Vargas VM, Torres D, Corona F, Vergara M, Gomez LE, Delgado-Lezama R, Cueva-Rolon R. Cholinergic facilitation of erection and ejaculation in spinal cord-transected rats. Int J Impot Res 2004, 16:86-90.
9. Ogawa Y, Sawamoto K, Miyata T, Miyao S, Watanabe M, Nakamura M, Bregman BS, Koike M, Uchiyama Y, Toyama Y, Okano H. Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adults rat. J Neurosci Res 2002, 69:925-33.
10. Fischer I. Candidate cells for transplantation into the injured CNS. Prog Brain Res 2000, 128:273-92.
11. Rao MS, Mayer-Proschel M. Precursor cells for transplantation. Prog Brain Res 2000, 128:273-92.
12. Petter-Puchner AH, Froestcher W, Krametter-Froestcher R, Lorinson D, Redl H, van Griensven M. The long-term neurocompatibility of human fibrin sealant and equine collagen as biomatrices in experimental spinal cord injury. Exp Toxicol Pathol 2007, 58:237-45.
13. Han SS, Liu Y, Tyler-Polsz C, Rao MS, Fischer I. Transplantation of glial-restricted precursor cells into the adult spinal cord: Survival, glial-specific differantiation, and preferential migration in white matter. Glia 2004, 45:1-16.
14. Warren JA, Harry GG. MK-801 upregulates NR2A protein levels and induces functional recovery of the ipsilateral hemidiaphragm following acute C2 hemisection in adult rats. J Spinal Cord Med 2007, 30:346-54.
15. Yamaji T, Yamazaki S, Li J, Price RD, Matsuoka N, Mutoh S. FK1706, a novel non-immunosuppressant neurophilin ligand, ameliorates motor dysfunction following spinal cord injury through its neuroregenerative action. Eur J Pharmacol 2008, 591:147-52.
16. Iseda T, Okuda T, Kane-Goldsmith N, Mathew M, Ahmed S, Chang YW, Young W, Grumet M. Single, high-dose intraspinal injection of chondroitinase reduces glycosaminoglycans in injured spinal cord and promotes corticospinal axonal regrowth after hemisection but not contusion. J Neurotrauma 2008, 25:334-49.
17. Lepore AC, Han SS, Tyler-Polsz CJ, Cai J, Rao MS, Fischer I. Differantial fate of multipotent and lineage restricted neural precursors following transplantation into the adult CNS. Neuron Glia Biol 2004, 1:113-26.
18. Lepore AC, Fischer I. Lineage-restricted neural precursors survive, migrate, and differentiate following transplantation into the injured adult spinal cord. Exp Neurol 2005, 194:230-42.
19. Ragazzi E, Meggiato C, Chinellato A, Italiano G, Pagano F, Calabrò A. Chronic treatment with cyclosporine A in New Zealand rabbit: Aortic and erectile tissue alterations. Urol Res 1996, 24:323-8.
20. El-Bahnasawy MS, El-Assmy A, El-Sawy E, Ali-El Dein B, Shehab El-Dein AB, Refaie A, El-Hammady S. Critical evaluation of the factors influencing erectile function after renal transplantation. Int J Impot Res 2004, 16:521-6.
21. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995, 12:1-21.
22. Yakubu MT, Afolayan AJ. Effect of aqueous extract of Bulbine natalensis (Baker) stem on the sexual behaviour of male rats: Int J Androl. 2008, Aug 15. [Epub ahead of print]. doi: 10.1111/j.1365-2605.2008.00910.x
23. Nout YS, Bresnahan JC, Culp E, Tovar CA, Beattie MS, Schmidt MH. Novel technique for monitoring micturition and sexual function in male rats using telemetry. Am J Physiol Regul Integr Comp Physiol 2007, 292:1359-67.
24. Tajuddin AS, Latif A, Qasmi IA, Amin KM. An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). BMC Complement Altern Med 2005, 20:16.
25. Benett NE, Kim JH, Wolfe DP, Sasaki K, Yoshimura N, Goins WF, Huang S, Nelson JB, de Groat WC, Glorioso JC, Chancellor MB. Improvement in erectile dysfunction after neurotrophic factor gene therapy in diabetic rats. J Urol 2005, 173:1820-4.
26. Lang B, Liu HL, Liu R, Feng GD, Jiao XY, Ju G. Astrocytes in injured adult rat spinal cord may acquire the potential of neural stem cells. Neuroscience 2004, 128:775-83.
27. Lepore AC, Bakshi A, Swanger SA, Rao MS, Fischer I. Neural precursor cells can be delivered into the injured cervical spinal cord by intrathecal injection at the lumbar cord. Brain Res 2005, 1045:206-16.
28. Liang P, Ji{dotless}n L, Liang T, Liu E, Zhao S. Human neural stem cells promote corticospinal axons regeneration and synapse reformation in injured spinal cord of rats. Chin Med J 2006, 119:1331-8.
29. Cao Q, Xu XM, Devries WH, Enzmann GU, Ping P, Tsoulfas P, Wood PM, Bunge MB, Whittemore SR. Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells. J Neurosci 2005, 25:6947-57.
30. Parr AM, Kulbatski I, Zahir T, Wang X, Yue C, Keating A, Tator CH. Transplanted adult spinal cord-derived neural stem/progenitor cells promote early functional recovery after rat spinal cord injury. Neuroscience 2008, 155:760-70.
31. Li W, Cai WQ, Li CR. Repair of spinal cord injury by neural stem cells modified with BDNF gene in rats. Neurosci Bull 2006, 22:34-40.
32. Mitsui T, Kakizaki H, Tanaka H, Shibata T, Matsuoka I, Koyanagi T. Immortalized neural stem cells transplanted into the injured spinal cord promote recovery of voiding function in the rat. J Urol 2003, 170:1421-5.
33. Mitsui T, Sumsky JS, Lepore AC, Murray M, Fischer I. Transplantation of neural and glial restricted precursors into contused spinal cord improves bladder and motor functions, decreases thermal hypersensitivity, and modifies intraspinal circuitry. J Neurosci 2005, 25:9624-36.
34. Allard J, Edmunds NJ. Reflex penile erection in anesthetized mice: An exploratory study. Neuroscience 2008, 155:283-90.