DA-8159, a new PDE5 inhibitor, induces penile erection in conscious and acute spinal cord injured rabbits

European Urology

Volumn 43, Issue 6, 2003, Pages 689-695

  Kang, Kyung Koo ^a   Ahn, Gook Jun ^a   Ahn, Byoung Ok ^a   Yoo, M ^a   Kim, Won Bae ^a  

^a Dong A Pharmaceutical Company   (South Korea)

Author keywords

DA 8159; Penile erection; Phosphodiesterase inhibitor; Rabbit; Spinal cord injury

Indexed keywords

NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; PHOSPHODIESTERASE INHIBITOR; UDENAFIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONSCIOUSNESS; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; ERECTILE DYSFUNCTION; HISTOPATHOLOGY; INHIBITION KINETICS; MALE; MEASUREMENT; NEUROLOGIC EXAMINATION; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RABBIT; REPERFUSION INJURY; SPINAL CORD INJURY;

EID: 0038362174     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0302-2838(03)00153-2     Document Type: Article

References (32)

1. Andersson KE, Wagner G. Physiology of penile erection. Physiol Rev 1995;75:191-236.
2. Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH. Nitric oxide: a physiologic mediator of penile erection. Science 1992;257:401-5.
3. Meinhardt W, Kropman RF, Vermeij P, Nijeholt AA, Zwartendijk J. The influence of medication on erectile dysfunction. Int J Impot Res 1997;9:17-26.
4. Aydin S, Ozbek H, Yilmaz Y, Atilla MK, Bayrakli H, Cetin H. Effects of sildenafil citrate, acethylcholine, and sodium nitroprusside on the relaxation of rabbit cavernosal tissue in vitro. Urol 2001;58:119-24.
5. Bodner DR, Haas CA, Krueger B, Seftel AD. Intraurethral alprostadil for treatment of erectile dysfunction in patients with spinal cord injury. Urol 1999;53:199-202.
6. Azadzoi KM, Kim N, Brown ML, Goldstein I, Cohen RA, Saenz de Tejada I. Endothelium-derived nitric oxide and cyclooxygenase products modulate corpus cavernosum smooth muscle tone. J Urol 1992;147:220-5.
7. Trigo-Rocha F, Hsu GL, Donatucci CF, Lue TF. The role of cyclic adenosine monophosphate, cyclic guanosine monophosphate, endothelium and nonadrenergic noncholinergic neurotransmission in canine penile erection. J Urol 1993;149:872-7.
8. Lugg JA, Gonzales-Cadaved NF, Rajfer J. The role of nitric oxide in erectile function. J Androl 1995;16:2-4.
9. Burnett AL. Nitric oxide in the penis; physiology and pathology. J Urol 1997;157:320-4.
10. Beavo JL. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev 1995;75:725-48.
11. Ballard SA, Gingell CJ, Tang K, Turner LA, Price ME, Naylor AM. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol 1998;59:2164-71.
12. Ahn BO, Oh TY, Kang KK, Yoo M, Kim WB. DA-8159, a selective phosphodiesterase-5 inhibitor, increases intracavernosal pressure in anaesthetized rats and dog. 9th World Meeting on Impotence Research, Australia 2000. [Podium Abstract No. 43].
13. Oh TY, Kang KK, Ahn BO, Yoo M, Kim WB. Erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159. Arch Pharm Res 2000;23:471-6.
14. Bischoff E, Niewoehner U, Haning H, Es Sayed M, Schenke T, Schlemmer KH. The oral efficacy of vardenafil hydrochloride for inducing penile erection in a conscious rabbit model. J Urol 2001;165:1316-8.
15. Tetik O, Islamoglu F, Yagdi T, Atay Y, Calkavur T, Ozbek C, et al. An intraaortic solution trial to prevent spinal cord injury in a rabbit model. Eur J Vasc Endovasc Surg 2001;22:175-9.
16. 2A agonist ameliorates ischemic reperfusion injury in the rabbit spinal cord. Ann Thorac Surg 2001;72:1245-50.
17. Parrino PE, Kron IL, Ross SD, Shockey KS, Fisher MJ, Gaughen JR, et al. Spinal cord protection during aortic cross-clamping using retrograde venous perfusion. Ann Thorac Surg 1999;67:1589-95.
18. Agee JM, Flanagan T, Blackbourne LH, Kron IL, Tribble CG. Reducing postischemic paraplesia using conjugated superoxide dismutase. Ann Thorac Surg 1991;51:911-5.
19. Herold JA, Kron IL, Langenburg SE, Blackbourne LH, Tribble CG. Complete prevention of postischemic spinal cord injury by means of regional infusion with hypothermic saline and adenosine. J Thorac Cardiovasc Surg 1994;107:536-42.
20. Okita Y, Takamoto S, Ando M, Morota T, Yamaki F, Matsukawa R, et al. Repair of aneurysm of the entire descending thoracic aorta or thoracoabdominal aorta using a deep hypothermia. Eur J Cardiothorac Surg 1997;12:120-6.
21. Simpson JI, Eide TR, Schiff GA, Clagnaz JF, Hossain I, Tverskoy A, et al. Intrathecal magnesium sulfate protects the spinal cord from ischemic injury thoracic aortic cross-clamping. Anaesthesiology 1994;81:1493-9.
22. Carter AJ, Ballard SA, Naylor AM. Effect of the selective phosphodiesterase type 5 inhibitor sildenafil on erectile function in the anaesthetized dog. J Urol 1998;160:242-6.
23. Naganuma H, Egashira T, Fujii I. Neuroleptics induce penile erection in the rabbit. Clin Exp Pharmacol Physiol 1993;20:177-83.
24. Bischoff E, Schneider K. A conscious rabbit model to study vardenafil hydrochloride and other agents that influence penile erection. Int J Import Res 2001;13:230-5.
25. Comarr AE. Sexuality and fertility among spinal cord and/or cauda equine injuries. J Am Paraplesia Soc 1985;8:67-75.
26. Sonda LP, Mazo R, Chancellor MB. The role of yohimbine for the treatment of erectile impotence. J Sex Marital Therap 1990;16:15-21.
27. Rivas DA, Chancellor MB, Huang B, Salzman SK. Erectile response to topical, intraurethral and intracorporal pharmacotherapy in a rat model of spinal cord injury. J Spinal Cord Med 1995;18:145-50.
28. Hall ED, Wolf DL. Pharmacological analysis of the pathophysiological mechanism of post-traumatic spinal cord ischemia. J Neurosurg 1986;64:951-61.
29. Hall ED, Wolf DL. Neuroprotective pharmacology of methylprednisolone. J Neurosurg 1992;76:13-22.
30. Rahman A, Ustundag B, Burma O, Ozercan IH, Erol FS. Neuroprotective effect of regional carnitine on spinal cord ischemia-reperfusion injury. Eur J Cardiothorac Surg 2001;20:65-70.
31. Mautes AEM, Weinzierl MR, Donovan F, Noble LJ. Vascular events after spinal cord injury: contribution to secondary pathogenesis. Physical Therapy 2000;80:673-87.
32. Aloni R, Heller L, Keren O, Mendelson E, Davidoff G. Non-invasive treatment for erectile dysfunction in the neurologically disabled population. J Sex Marital Ther 1992;18:243-9.