Repair of spinal cord injury by neural stem cells modified with BDNF gene in rats

Neuroscience Bulletin

Volumn 22, Issue 1, 2006, Pages 34-40

  Li, Wei ^a   Cai, Wen Qin ^a   Li, Cheng Ren ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Genetic modification; Neural stem cell; Repair; Spinal cord injury

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; EOSIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HEMATOXYLIN; MESSENGER RNA; NEUROFILAMENT PROTEIN; PROTEIN NF 200; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DNA MODIFICATION; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; LUMBAR DISK; MOTOR PERFORMANCE; NERVE FIBER; NERVE FIBER REGENERATION; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PHYSICAL EXAMINATION; RAT; SCIATIC NERVE; SPINAL CORD INJURY;

EID: 33947185281     PISSN: 16737067     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Weidner N, Grill RJ, Tuszynski MH. Related articles elimination of basal lamina and the collagen "scar" after spinal cord injury fails to augment corticospinal tract regeneration. Exp Neurol, 1999, 160(1): 40-50.
2. Li W, Cai WQ, Yao ZX. Isolation, culture and gene transfection of rat NSCs. J Third Milit Med Univer, 2001,23(12):1425-1427.
3. Grill R, Murai K, Blesch A, et al. Cellular delivery of neurotrophin-3 promotes coticospinal axonal growth and partial functional recovery after spinal cord injury. Neuroscience, 1997, 17:5560-5572.
4. Blesch A, Uy HS, Grill R, et al. Leukemia inhibitory factor augments neurotrophin expression and corticospinal axon growth after adult CNS injury. Neuroscience, 1999, 19:3556-3566.
5. Yuszynski MH, Gage FH. Bridging grafts and transient nerve growth factor infusions promote longe-term central nervous system neuronal rescue and partial functional recovery. PNAS, 1995, 92:4621-4625.
6. Liang Z, Nong Y, Yang H, et al. Trophic action of endogenous NT-3 and BDNF of fetal mouse spinal cord on spinal cord neurons. J Fourth Milit Med Univer, 1997, 18: 6 586-589.
7. Sayers H, tonge DA. A study of factors influencing synapse formation by a foreign nerve in skeletal muscle of Rana pipiens. Physiology, 1986, 375:449-460.
8. Rosario CM, Yandava BD, Kosaras B, et al. Differentiation of engrafted multipotent neural progenitors towards replacement of missing granule neurons in meander tail cerebellum may help determine the locus of mutant gene action. Dvelopment, 1997, 124(21):4213-4224.
9. Yu KW, Ye XJ, Feng H, et al, Electrophysiological evaluation of transplant with genetically modified cells in the treatment of spinal cord injury in rats. J Second Milit Univer, 2000, 21(7):621-624.
10. Menei P, Monteromenei C, Whittemor SR, et al. Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord. Eur J Neurosci, 1998, 10:607-621.
11. Kim DH, Cutin PH, Noble LT, et al. Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate covery from traumatic spinal cord injury in the adult rat. Neuroreport, 1996, 7(13):2221-2225.