Sulfur dioxide and benzo(a)pyrene modulates CYP1A and tumor-related gene expression in rat liver

Environmental Toxicology

Volumn 25, Issue 2, 2010, Pages 169-179

  Qin, Guohua ^a   Meng, Ziqiang ^a  

^a SHANXI UNIVERSITY   (China)

Author keywords

Benzo(a)pyrene; CYP1A; Oncogene; Sulfur dioxide; Tumor suppressor

Indexed keywords

APOPTOSIS; BENZO(A)PYRENE; DEMETHYLASE; ENVIRONMENTAL CONTAMINANT; GENE PRODUCTS; MRNA EXPRESSION; MULTIPLE CELLS; PROTEIN LEVEL; PROTO-ONCOGENES; RAT LIVERS; REAL TIME RT-PCR; REGULATORY PROTEIN; SYNERGISTIC EFFECT; TUMOR SUPPRESSOR GENES; TUMOR SUPPRESSORS; WESTERN BLOTS; WISTAR RAT;

BIOCHEMISTRY; CELL DEATH; CELL PROLIFERATION; FOOD ADDITIVES; GENE EXPRESSION; ONCOGENIC VIRUSES; PROTEINS; RUBIDIUM; SULFUR; SULFUR DIOXIDE; TUMORS;

GENE EXPRESSION REGULATION;

BENZO[A]PYRENE; CYTOCHROME P450 1A; ETHOXYRESORUFIN DEETHYLASE; MESSENGER RNA; METHOXYRESORUFIN DEMETHYLASE; PROTEIN; PROTEIN P16; PROTEIN P53; RETINOBLASTOMA PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SULFUR DIOXIDE; UNCLASSIFIED DRUG; UNCLASSIFIED ENZYME; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYTOCHROME P450; CYTOCHROME P450 1A1; METHOXYRESORUFIN O DEMETHYLASE; METHOXYRESORUFIN-O-DEMETHYLASE; MYC PROTEIN; ONCOPROTEIN; PROTEIN C FOS; PROTEIN C JUN; PROTEIN P21; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; DATA SET; DISEASE PREVALENCE; ENZYME ACTIVITY; FUNCTIONAL MORPHOLOGY; GENE EXPRESSION; OCCUPATIONAL EXPOSURE; PAH; RODENT; SULFUR DIOXIDE; TUMOR;

ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EXPOSURE; GENE EXPRESSION; LIVER; LIVER TOXICITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE C FOS; ONCOGENE H RAS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; WISTAR RAT; ANIMAL; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; POLLUTANT;

RATTUS; RATTUS NORVEGICUS;

ANIMALS; BENZO(A)PYRENE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; MALE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; PROTO-ONCOGENE PROTEINS P21(RAS); RATS; RATS, WISTAR; SULFUR DIOXIDE; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 77950875979     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20484     Document Type: Article

References (57)

1. 2)-induced oxidative stress. Toxicol In Vitro 14:159-167.
2. Bai J, Meng Z. 2005. Expression of apoptosis-related genes in livers from rats exposed to sulfur dioxide. Toxicology 216:253-260. (Pubitemid 41712014)
3. Barhoumi R, Mouneimne Y, Ramos KS, Safe SH, Phillips TD, Centonze VE, Ainley C, Gupta MS, Burghardt RC. 2000. Analysis of benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line. Toxicol Sci 53:264-270. (Pubitemid 30100143)
4. Bartosiewicz M, Penn S, Buckpitt A. 2001. Applications of gene arrays in environmental toxicology: Fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene. Environ Health Perspect 109:71-74. (Pubitemid 32118029)
5. Blazka ME, Bruccoleri A, Simeonova PP, Germolec DR, Pennypacker KR, Luster MI. 1996. Acetaminophen-induced hepatoxicity is associated with early changes in AP-1 DNA binding activity. Res Commun Mol Pathol Pharmacol 92:259-273. (Pubitemid 26243047)
6. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
7. Bral CM, Ramos KS. 1997. Identification of benzo(a)pyreneinducible cis-acting elements within c-Ha-ras transcriptional regulatory sequences. Mol Pharmacol 52:974-982.
8. Bral CM, Sadhu DN, Ramos KS. 1996. Transcriptional activation of the c-Ha-ras protooncogene in vascular smooth muscle cells by benzo-(a)pyrene. In Vitro Cell Dev Biol 32:599-601. (Pubitemid 27045036)
9. Burke MD, Thompson S, Elcombe CR, Halpert J, Haaparanta T, Mayer RT. 1985. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P450. Biochem Pharmacol 34:3337-3345. (Pubitemid 16215699)
10. Chen ZM, Liu BQ, Boreham J, Wu YP, Chen JS, Peto R. 2003. Smoking and liver cancer in China: Case-control comparison of 36,000 liver cancer deaths vs. 17,000 cirrhosis deaths. Int J Cancer 107:106-112. (Pubitemid 37100093)
11. Ding M, Li JJ, Leonard SS, Ye JP, Shi X, Colburn NH, Castranova V, Vallyathan V. 1999. Vanadate-induced activation of activator protein-1: Role of reactive oxygen species. Carcinogenesis 20:663-668. (Pubitemid 29151305)
12. Fields WR, Desiderio JG, Leonard RM, Burger EE, Brown BG, Doolittle DJ. 2004. Differential c-myc expression profiles in normal human bronchial epithelial cells following treatment with benzo[a]pyrene, benzo[a]pyrene-4,5 epoxide, and benzo[a]pyrene-7,8-9,10 diol epoxide. Mol Carcinog 40:79-89.
13. Fouchecourt MO, Riviere JL. 1995. Activities of cytochrome P450-dependent monooxygenases and antioxidant enzymes in different organs of Norway rats (Rattus norvegicus) inhabiting reference and contaminated sites. Chemosphere 31:4375-4386.
14. Goldsworthy TL, Goldsworthy SM, Sprankle CS, Butterworth BE. 1994. Expression of myc, fos, and Ha-ras associated with chemically induced cell proliferation in the rat liver. Cell Prolif 27:269-275.
15. 2 determination and method sensitivity analysis. J Environ Monit 3:666-670.
16. Green JL, Jones BC, Reed GA. 1994. Effects of sulfite on the uptake and binding of benzo[a]pyrene diol epoxide in cultured murine respiratory epithelial cells. Environ Health Perspect 102:216-220.
17. Green JL, Reed GA. 1990. Benzo[a]pyrene bay-region sulfonates, a novel class of reactive intermediates. Chem Res Toxicol 3:59-64.
18. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, Phillips DH. 2007. AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines. Chem Res Toxicol 20:1797-1810.
19. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW. 1991. Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51:6304-6311.
20. Kim JM, Kim JD, Yu R, Kim BS, Shin MK, Han IS. 1999. Effects of capsaicin on induction of c-jun proto-oncogene expression in Fisher-344 rats by N-methyl-N′-nitro-N-nitrosoguanidine. Cancer Lett 142:155-160. (Pubitemid 29304571)
21. Kim KB, Lee BM. 1997. Oxidative stress to DNA, protein, and antioxidant enzymes (superoxide dismutase and catalase) in rats treated with benzo(a)pyrene. Cancer Lett 113:205-212.
22. Kuper H, Tzonou A, Kaklamani E, Hsieh CC, Lagiou P, Adami HO, Trichopoulos D, Stuver SO. 2000. Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma. Int J Cancer 85:498-502. (Pubitemid 30075127)
23. 3) in vitro. Hum Exp Toxicol 17:600-605.
24. Lee C, Chen S, Lee YG., Huang CF., Chen YA. 2006. Benzo[a]-pyrene and glycine N-methyltransferse interactions: Gene expression profiles of the liver detoxification pathway. Toxicol Appl Pharmacol 214:126-135. (Pubitemid 44026610)
25. Leung KH, Keller DA, Menzel DB. 1989. Effect of sulfite on the covalent reaction of benzo[a]pyrene metabolites with DNA. Carcinogenesis 10:259-264.
26. Manjanatha MG, Li EE, Fu PP, Heflich RH. 1996. H- and K-ras mutational profiles in chemically induced liver tumors from B6C3F1 and CD-1 mice. J Toxicol Environ Health 47:195-208. (Pubitemid 26060368)
27. Mehta R. 1995. The potential for the use of cell proliferation and oncogene expression as intermediate markers during liver carcinogenesis. Cancer Lett 93:85-102.
28. Melendez-Colon VJ, Luch A, Seidel A, Baird WM. 1999. Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites. Carcinogenesis 20:1885-1891. (Pubitemid 29476112)
29. Meng Z. 2003. Oxidative damage of sulfur dioxide on various organs of mice: Sulfur dioxide is a systemic oxidative damage agent. Inhal Toxicol 15:181-195. (Pubitemid 36222338)
30. Meng Z, Liu Y. 2007. Cell morphological ultrastructural changes in various organs from mice exposed by inhalation to sulfur dioxide. Inhal Toxicol 19:543-551. (Pubitemid 46748125)
31. Meng Z, Qin G, Zhang B. 2005. DNA damage in mice treated with sulfur dioxide by inhalation. Environ Mol Mutagen 46:150-155. (Pubitemid 41642306)
32. Meng Z, Qin G, Zhang B, Bai J. 2004. DNA damaging effects of sulfur dioxide derivatives in cells from various organs of mice. Mutagenesis 19:465-468. (Pubitemid 39611596)
33. Nebert DW, Dalton TP, Okey AB, Gonzalez FJ. 2004. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem 279:23847-23850.
34. Park SY, Lee SM, Ye SK, Yoon SH, Chung MH, Choi J. 2006. Benzo[a]pyrene-induced DNA damage and p53 modulation in human hepatoma HepG2 cells for the identification of potential biomarkers for PAH monitoring and risk assessment. Toxicol Lett 167:27-33. (Pubitemid 44548274)
35. Parrish AR, Fisher R, Bral CM, Burghardt RC, Gandolfi AJ, Ramos KS. 1998. Benzo(a)pyrene-induced alterations in growth-related gene expression and signaling in precision-cut adult rat liver and kidney slices. Toxicol Appl Pharmacol 152:302-308. (Pubitemid 28492272)
36. Pelkonen O, Nebert DW. 1982. Metabolism of polycyclic aromatic hydrocarbons: Etiologic role in carcinogenesis. Pharmacol Rev 34:189-222. (Pubitemid 13048212)
37. Perera F. 1981. Carcinogenicity of airborne fine particulate benzo(a)pyrene: An appraisal of the evidence and the need for control. Environ Health Perspect 42:163-185. (Pubitemid 12077196)
38. Pfeifer GP, Denissenko MF, Olivier M, Tretyakova N, Hecht SS, Hainaut P. 2002. Tobacco smoke carcinogens. DNA damage and p53 mutations in smoking-associated cancers. Oncogene 21:7435-7451.
39. Pohl RJ, Fouts JR. 1980. A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions. Anal Biochem 107:150-155.
40. 2 or NOx on toxic and genotoxic properties of chemical carcinogens. II. Short term in vivo studies. Carcinogenesis 9:1247-1252.
41. 2 and NOx on benzo(a)pyrene activating enzymes of the rat liver. Exp Pathol 39:207-212.
42. Qin G, Meng Z. 2005. Effect of sulfur dioxide inhalation on CYP1A1 and CYP1A2 in rat liver and lung. Toxicol lett 160:34-42. (Pubitemid 41501596)
43. Qin G, Meng Z. 2006a. The expression of protooncogenes and CYP1A in lungs of rats exposed to sulfur dioxide and benzo(a)-pyrene. Regul Toxicol Pharm. 45:36-43. (Pubitemid 43751100)
44. Qin G, Meng Z. 2006b. Effect of sulfur dioxide inhalation on CYP2B1/2 and CYP2E1 in rat liver and lung. Inhal Toxicol 18:581-588. (Pubitemid 43977254)
45. Reed GA. 1987. Sulfite-dependent mutagenicity of benzo[a]pyrene derivatives. Carcinogenesis 8:1145-1148.
46. Reed GA, Curtis JF, Mottley C, Eling TE, Mason RP. 1986. Epoxidation of (±)-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene during (bi)sulfite autoxidation: Activation of a procarcinogen by a cocarcinogen. Proc Natl Acad Sci USA 83:7499-7502. (Pubitemid 16000550)
47. Rodriguez LV, Dunsford HA, Steinberg M, Chaloupka KK, Zhu L, Safe S, Womack JE, Goldstein LS. 1997. Carcinogenicity of benzo(a)pyrene and manufactured gas plant residues in infant mice. Carcinogenesis 18:127-135. (Pubitemid 28134626)
48. Schmiedeberg P, Biempica L, Czaja MJ. 1993. Timing of protoon-cogene expression varies in toxin-induced liver regeneration. J Cell Physiol 154:294-300. (Pubitemid 23048010)
49. Shackelford RE, Kaufmann WK, Paules RS. 1999. Cell cycle control, checkpoint mechanisms, and genotoxic stress. Environ Health Perspect 107:5-24. (Pubitemid 29164196)
50. Shapiro R. 1977. Genetic effects of bisulfite (sulfur dioxide). Mutat Res 38:149-176. (Pubitemid 8047072)
51. Supino R, Perego P, Gatti L, Caserini C, Leonetti C, Colantuono M, Zuco V, Carenini N, Zupi G, Zunino F. 2001. A role for c-myc in DNA damage-induced apoptosis in a human TP53-mutant small-cell lung cancer cell line. Eur J Cancer. 37:2247-2256.
52. Toyokuni S. 2008. Molecular mechanisms of oxidative stress-induced carcinogenesis: From epidemiology to oxygenomics. IUBMB Life 60:441-447.
53. Wang Z, Zheng R, Fu S, Chen Y, Duan G, Qin D, Liu G. 1998. Role of superoxide anion on the proliferation and c-Ha-ras or p53 expression in prostate cancer cell line PC3. Urol Res 26:349-353.
54. Whitlock JP Jr. 1999. Induction of cytochome P4501A1. Annu Rev Pharmacol Toxicol 39:103-125.
55. Yamada K, Suzuki T, Kohara A, Hayashi M, Hakura A, Mizutani T, Saeki K. 2002. Effect of 10-aza-substitution on benzo[a]pyrene mutagenicity in vivo and in vitro. Mutat Res 521:187-200.
56. Zhang Y, Ramos KS. 1997. The induction of proliferative vascular smooth muscle cell phenotypes by benzo[a]pyrene does not involve mutational activation of ras genes. Mutat Res 373:285-292.
57. Zhao W, Ramos KS. 1998. Cytotoxicity of selected aromatic hydrocarbons in cultured rat hepatocytes. Toxicol In Vitro 12:395-402.