Effect of 10-aza-substitution on benzo[a]pyrene mutagenicity in vivo and in vitro

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 521, Issue 1-2, 2002, Pages 187-200

  Yamada, Katsuya ^a   Suzuki, Takayoshi ^b   Kohara, Arihiro ^a,b   Hayashi, Makoto ^b   Hakura, Atsushi ^c   Mizutani, Takaharu ^a   Saeki, Ken Ichi ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c EISAI CO LTD   (Japan)

Author keywords

Aza substitution; Human liver microsome; In vivo mutagenesis assay; Mutation spectrum

Indexed keywords

10 AZABENZO[A]PYRENE; BENZO[A]PYRENE; BENZO[A]PYRENE DERIVATIVE; CYTOCHROME P450 1A; ENZYME INDUCING AGENT; FUNCTIONAL GROUP; UNCLASSIFIED DRUG;

AMES TEST; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TOXICITY; COLON DISEASE; CONTROLLED STUDY; FORESTOMACH; GENOTOXICITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER HOMOGENATE; LIVER TOXICITY; LUNG TOXICITY; MALE; MOUSE; MUTAGENICITY; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH DISEASE; STRUCTURE ACTIVITY RELATION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; BENZO(A)PYRENE; BENZOPYRENES; CYTOCHROME P-450 CYP1A1; HUMANS; MALE; MICE; MICE, TRANSGENIC; MICROSOMES, LIVER; MOLECULAR SEQUENCE DATA; MUTAGENICITY TESTS; MUTAGENS; MUTATION; SALMONELLA TYPHIMURIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS MUSCULUS; RODENTIA;

EID: 0037180364     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(02)00240-1     Document Type: Article

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