The induction of proliferative vascular smooth muscle cell phenotypes by benzo[a]pyrene does not involve mutational activation of ras gene

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 373, Issue 2, 1997, Pages 285-292

  Zhang, Y ^a   Ramos, K S ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Benzo a pyrene; Ras gene; Vascular smooth muscle cell proliferation

Indexed keywords

BENZO[A]PYRENE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; GENETIC ANALYSIS; IN VITRO STUDY; MUTATION RATE; NONHUMAN; ONCOGENE RAS; PHENOTYPE; PRIORITY JOURNAL; RAT; THORACIC AORTA; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; BENZO(A)PYRENE; CELL DIVISION; CELLS, CULTURED; GENES, RAS; MALE; MUSCLE, SMOOTH, VASCULAR; MUTATION; PHENOTYPE; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; LAMIINAE;

EID: 0030664880     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(96)00213-8     Document Type: Article

References (37)

1. Thomas, W.A. and D.N. Kim (1983) Biology of disease: atherosclerosis as a hyperplastic and/or neoplastic process, Lab. Invest., 48(3), 245-255.
2. Benditt, P.E. and J.M. Benditt (1973) Evidence for a monoclonal origin of human atherosclerotic plaques, Proc. Natl. Acad. Sci. USA, 70(6), 1753-1756.
3. Penn, A., S.J. Garte and B. Mindich (1986) Transforming gene in human atherosclerotic plaque, Proc. Natl. Acad. Sci. USA, 83, 7951-7955.
4. Parkes, J.L., R.R. Cardell, F.C. Hubbard, C. Hubbard, A. Meltzer and A. Penn (1991) Cultured human atherosclerotic plaque smooth muscle cells retain transforming potential and display enhanced expression of the c-myc proto-oncogene, Am. J. Pathol., 138(3), 765-775.
5. Ramos, K.S. and A.R. Parrish (1995) Growth-related signaling as a target of toxic insult in vascular smooth muscle cells: implications in atherogenesis, Life Sci., 57(7), 627-635.
6. Howard, G., G.L. Burke, M. Szklo, G.S. Tell, J. Eckfeldt, G. Evans and G. Heiss (1994) Active and passive smoking are associated with increased carotid wall thickness. The athero-sclerosis risk in communities study, Arch. Int. Med., 154(11), 1277-1282.
7. Penn, A., L.C. Chen and C.A. Snyder (1994) Inhalation of steady-state sidestream smoke from one cigarette promotes arteriosclerotic plaque development, Circulation, 90(3), 1363-1367.
8. Ramos, K.S. (1992) Vascular toxicology: a cellular and molecular perspective, in: D. Acosta (Eds.), Cardiovascular Toxicology, 2nd edn., Raven Press, New York, pp. 483-516.
9. Albert, R.E., M. Vanderlan, F. Burns and M. Nishizumi (1977) Effect of carcinogens on chicken atherosclerosis, Can. Res., 37, 2232-2235.
10. Paigen, B., M.B. Havens and A. Morrow (1985) Effect of 3-methylcholanthrene on the development of aortic lesions in mice, Can. Res., 45(8), 3850-3855.
11. Hough, J.L., M.B. Baird, G.T. Sfeir, C.S. Pacini, D. Darrow and C. Wheelock (1993) Benzo(a)pyrene enhances atherosclerosis in white carneau and show racer pigeons, Arterioscleros. Thromb., 13(12), 1721-1727.
12. Juchau, M., J.A. Bond and E.P. Benditt (1976) Aryl hydroxylase and cytochrome P-450 in the aorta: possible role in atherosclerosis, Proc. Natl. Acad. Sci. USA, 73, 3723-3726.
13. Bond, A.J., R.M. Kocan, E.P. Benditt and M.R. Juchau (1979) Metabolism of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene in cultured human fetal aortic smooth muscle cells, Life Sci., 25, 425-430.
14. Serabjit-Singh, C.J., J.R. Bend and R.M. Philpot (1986) Cytochrome P-450 monooxygenase system localization in smooth muscle cells of rabbit aorta, Mol. Pharmacol., 28, 72-79.
15. Zwijsen, R., E. Kleef and G. Alink (1990) A comparative study on the metabolic activation of 3,4-benzo(a)pyrene to mutagens by aorta smooth muscle cells of rat and rabbit, Mutation Res., 230, 111-117.
16. Bond, J.A., H.Y. Yang, M.W. Majesky, E.P. Benditt and M.R. Juchau (1980) Metabolism of benzo(a)pyrene and 7,12-dimethyl-benz(a)anthracene in chicken aortas: monooxygenation, bioactivation to mutagens, and covalent binding to DNA in vitro, Toxicol. Appl. Pharmacol., 52(2), 323-335.
17. Izzotti, A., F. D'Agostini, M. Bagnasco, L. Scatolini, A. Rovida, R.M. Balansky, C.F. Cesarone and S. De Flora (1994) Chemoprevention of carcinogen-DNA adducts and chronic degenerative diseases, Can. Res., 54 (Suppl. 7), 1994-1998.
18. Sadhu, N.D., M. Merchant, S.H. Safe and K.S. Ramos (1993) Modulation of protooncogene expression in rat aortic smooth muscle cells by benzo(a)pyrene, Arch. Biochem. Biophys., 300, 124-131.
19. Indolfi, C., E.V. Avvedimento, A. Rapacciuolo, E.D. Lorenzo, G. Esposito, E. Stabile, A. Feliciello, M. Evelina, P. Giuliano, G. Condorelli and M. Chiariello (1995) Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo, Nature Med., 1(6), 541-515.
20. Wong, Y.F., T.K. Chung, T.H. Cheung, S.K. Lam, Y.G. Xu and A.M. Chang (1995) Frequent ras gene mutations in squamous cell cervical cancer, Can. Lett., 95(1-2), 29-32.
21. Mills, N.E., C.L. Fishman, W.N. Rom, N. Dubin and D.R. Jacobson (1995) Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma, Can. Res., 55(7), 1444-1447.
22. Hara, H., N. Fulton, T. Yashiro, K. Ito, L.J. Degroot and E.L. Kaplan (1994) N-ras mutation: an independent prognostic factor for aggressiveness of papillary thyroid carcinoma, Surgery, 116(6), 1010-1016.
23. Bos, L.J. (1988) The ras gene family and human carcinogensis, Mutation Res., 195, 255-271.
24. Colapietro, A.M., A.L., Goodell, R.C. Smart (1993) Characterization of benzo(a)pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C, Carcinogenesis, 14(11), 2289-2295.
25. EJ transfection of rat aortic smooth muscle cells induces epidermal growth factor responsiveness and characteristics of a malignant phenotype, J. Cell. Physiol., 161, 490-500.
26. Cox, L.R. and K.S. Ramos (1991) Biochemical basis of allylamine-induced aortic smooth muscle cell proliferation, Prog. Clin. Biol. Res., 369, 429-438.
27. Chomczynski, P. and Sacchi, N. (1987) Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal. Biochem., 162, 156-159.
28. Sambrook, J., E.F. Fritsch and T. Maniatis (1989) Molecular Cloning: A Laboratory Manual, 2nd edn., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 5.52-5.55.
29. Ou, X. and K.S. Ramos (1992) Proliferative responses of quail aortic smooth muscle cells to benzo(a)pyrene: implications in PAH-induced atherogenesis, Toxicology, 74(2-3), 243-258.
30. Kim, D.N., J. Schmee, K.T. Lee and W.A. Thomas (1987) Atherosclerotic lesions in the coronary arteries of hyperlipidemic swine. Part 1. Cell increases, divisions, losses and cells of origin in first 90 days on diet, Atherosclerosis, 64(2-3), 231-242.
31. Ross, R. (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s, Nature, 362(6423), 801-809.
32. Tennant, R.W., C.C. Harris, D.G. Kaufman, S. Nesnow, T.J., Slaga, D.E. Stevenson and B.F. Trump (1993) Sixth Aspen Cancer Conference: molecular mechanisms of genetic deregulation in toxicity and carcinogenesis, Mol. Carcinog., 7(2), 67-72.
33. Bowes, R.C. III and K.S. Ramos (1993) Allylamine enhances c-Ha-ras protooncogene expression in rat aortic smooth muscle cells, Toxicol. Lett., 66(3), 263-272.
34. Ramos, K.S., Y. Zhang, D.N. Sadhu and R.S. Chapkin (1996) The induction of proliferative vascular smooth muscle cell phenotypes by benzo(a)pyrene is characterized by up-regulation of inositol phospholipid metabolism and c-Ha-ras gene expression, Arch. Biochem. Biophys., 332, 213-222.
35. Dong, R. and L. Wang (1994) Inhibitory effect of interferon on expression of oncogene in over-proliferative smooth muscle cell, Chung-Hua i Hsueh Tsa Chi (Chinese Medical Journal), 74, 335-337.
36. Bral, C.M., D.N. Sadhu and K.S. Ramos (1996) Transcriptional activation of the c-Ha-ras protooncogene in vascular smooth muscle cells by benzo(a)pyrene, In Vitro Cell. Dev. Biol., in press.
37. Ou, X., T.J. Weber, R.S. Chapkin and K.S. Ramos (1995) Interference with protein kinase C-related signal transduction in vascular smooth muscle cells by benzo(a)pyrene, Arch. Biochem. Biophys., 318(1), 122-130.