Functional availability of γ-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a

Biochemical and Biophysical Research Communications

Volumn 394, Issue 4, 2010, Pages 1000-1005

  Yoshioka, Hidenori ^a   Noguchi, Kohji ^a   Katayama, Kazuhiro ^a   Mitsuhashi, Junko ^a   Yamagoe, Satoshi ^b   Fujimuro, Masahiro ^c   Sugimoto, Yoshikazu ^a  

^a KEIO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Cyclin; KSHV; Proteasome; Ubiquitin

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLIN DEPENDENT KINASE 6; K CYCLIN PROTEIN; PHOSPHOTRANSFERASE; PROTEASOME; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LYMPHOMA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; UBIQUITINATION;

CELL LINE; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLINS; GENE SILENCING; HERPESVIRUS 4, HUMAN; HERPESVIRUS 8, HUMAN; HUMANS; PROTEIN STABILITY; SARCOMA, KAPOSI; UBIQUITINATION; VIRAL PROTEINS;

HERPESVIRIDAE; HUMAN HERPESVIRUS 8; MAMMALIA;

EID: 77950867793     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.03.110     Document Type: Article

References (37)

1. Boshoff C., and Chang Y. Kaposi's sarcoma-associated herpesvirus: a new DNA tumor virus. Annu. Rev. Med. 52 (2001) 453-470
2. Moore P.S., and Chang Y. Kaposi's sarcoma-associated herpesvirus immunoevasion and tumorigenesis: two sides of the same coin?. Annu. Rev. Microbiol. 57 (2003) 609-639
3. Verma S.C., and Robertson E.S. Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus. FEMS Microbiol. Lett. 222 (2003) 155-163
4. Friborg Jr. J., Kong W., Hottiger M.O., and Nabel G.J. P53 inhibition by the LANA protein of KSHV protects against cell death. Nature 402 (1999) 889-894
5. Radkov S.A., Kellam P., and Boshoff C. The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nat. Med. 6 (2000) 1121-1127
6. Fujimuro M., Wu F.Y., ApRhys C., Kajumbula H., Young D.B., Hayward G.S., and Hayward S.D. A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nat. Med. 9 (2003) 300-306
7. Fujimuro M., and Hayward S.D. Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers. J. Mol. Med. 82 (2004) 223-231
8. Thome M., Schneider P., Hofmann K., Fickenscher H., Meinl E., Neipel F., Mattmann C., Burns K., Bodmer J.L., Schroter M., Scaffidi C., Krammer P.H., Peter M.E., and Tschopp J. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386 (1997) 517-521
9. Liu L., Eby M.T., Rathore N., Sinha S.K., Kumar A., and Chaudhary P.M. The human herpesvirus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex. J. Biol. Chem. 277 (2002) 13745-13751
10. Godden-Kent D., Talbot S.J., Boshoff C., Chang Y., Moore P., Weiss R.A., and Mittnacht S. The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1. J. Virol. 71 (1997) 4193-4198
11. Swanton C., Mann D.J., Fleckenstein B., Neipel F., Peters G., and Jones N. Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins. Nature 390 (1997) 184-187
12. Li M., Lee H., Yoon D.W., Albrecht J.C., Fleckenstein B., Neipel F., and Jung J.U. Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. J. Virol. 71 (1997) 1984-1991
13. Verschuren E.W., Jones N., and Evan G.I. The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin. J. Gen. Virol. 85 (2004) 1347-1361
14. Ojala P.M., Yamamoto K., Castanos-Velez E., Biberfeld P., Korsmeyer S.J., and Makela T.P. The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2. Nat. Cell Biol. 2 (2000) 819-825
15. Chang P.C., and Li M. Kaposi's sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor. J. Virol. 82 (2008) 278-290
16. Verschuren E.W., Klefstrom J., Evan G.I., and Jones N. The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo. Cancer Cell 2 (2002) 229-241
17. Verschuren E.W., Hodgson J.G., Gray J.W., Kogan S., Jones N., and Evan G.I. The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis. Cancer Res. 64 (2004) 581-589
18. Sherr C.J., and Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13 (1999) 1501-1512
19. Russo A.A., Jeffrey P.D., Patten A.K., Massague J., and Pavletich N.P. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 382 (1996) 325-331
20. Mann D.J., Child E.S., Swanton C., Laman H., and Jones N. Modulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirus. EMBO J. 18 (1999) 654-663
21. Jarviluoma A., Child E.S., Sarek G., Sirimongkolkasem P., Peters G., Ojala P.M., and Mann D.J. Phosphorylation of the cyclin-dependent kinase inhibitor p21Cip1 on serine 130 is essential for viral cyclin-mediated bypass of a p21Cip1-imposed G1 arrest. Mol. Cell. Biol. 26 (2006) 2430-2440
22. Jeffrey P.D., Tong L., and Pavletich N.P. Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors. Genes Dev. 14 (2000) 3115-3125
23. Van Dross R., Yao S., Asad S., Westlake G., Mays D.J., Barquero L., Duell S., Pietenpol J.A., and Browning P.J. Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells. J. Natl. Cancer Inst. 97 (2005) 656-666
24. Kaldis P., Ojala P.M., Tong L., Makela T.P., and Solomon M.J. CAK-independent activation of CDK6 by a viral cyclin. Mol. Biol. Cell 12 (2001) 3987-3999
25. Schulze-Gahmen U., and Kim S.H. Structural basis for CDK6 activation by a virus-encoded cyclin. Nat. Struct. Biol. 9 (2002) 177-181
26. Upton J.W., van Dyk L.F., and Speck S.H. Characterization of murine gammaherpesvirus 68 v-cyclin interactions with cellular cdks. Virology 341 (2005) 271-283
27. Murakami Y., Yamagoe S., Noguchi K., Takebe Y., Takahashi N., Uehara Y., and Fukazawa H. Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx. J. Biol. Chem. 281 (2006) 28113-28121
28. Noguchi K., Kokubu A., Kitanaka C., Ichijo H., and Kuchino Y. ASK1-signaling promotes c-Myc protein stability during apoptosis. Biochem. Biophys. Res. Commun. 281 (2001) 1313-1320
29. Noguchi K., Vassilev A., Ghosh S., Yates J.L., and DePamphilis M.L. The BAH domain facilitates the ability of human Orc1 protein to activate replication origins in vivo. EMBO J. 25 (2006) 5372-5382
30. Van Dross R., Browning P.J., and Pelling J.C. Do truncated cyclins contribute to aberrant cyclin expression in cancer?. Cell Cycle 5 (2006) 472-477
31. Kaldis P. The N-terminal peptide of the Kaposi's sarcoma-associated herpesvirus (KSHV)-cyclin determines substrate specificity. J. Biol. Chem. 280 (2005) 11165-11174
32. Laman H., Coverley D., Krude T., Laskey R., and Jones N. Viral cyclin-cyclin-dependent kinase 6 complexes initiate nuclear DNA replication. Mol. Cell. Biol. 21 (2001) 624-635
33. Koopal S., Furuhjelm J.H., Jarviluoma A., Jaamaa S., Pyakurel P., Pussinen C., Wirzenius M., Biberfeld P., Alitalo K., Laiho M., and Ojala P.M. Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis. PLoS Pathog. 3 (2007) 1348-1360
34. Diehl J.A., Zindy F., and Sherr C.J. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev. 11 (1997) 957-972
35. Lin D.I., Barbash O., Kumar K.G., Weber J.D., Harper J.W., Klein-Szanto A.J., Rustgi A., Fuchs S.Y., and Diehl J.A. Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol. Cell 24 (2006) 355-366
36. Germain D., Russell A., Thompson A., and Hendley J. Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286. J. Biol. Chem. 275 (2000) 12074-12079
37. Platt G., Carbone A., and Mittnacht S. p16INK4a loss and sensitivity in KSHV associated primary effusion lymphoma. Oncogene 21 (2002) 1823-1831