Increased potency of the PHSCN dendrimer as an inhibitor of human prostate cancer cell invasion, extravasation, and lung colony formation

Clinical and Experimental Metastasis

Volumn 27, Issue 3, 2010, Pages 173-184

  Yao, Hongren ^a   Veine, Donna M ^a   Zeng, Zhao Zhu ^a   Fay, Kevin S ^a   Staszewski, Evan D ^a   Livant, Donna L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Extravasation; Integrin fibronectin receptor; Invasion; Lung metastasis; Prostate cancer

Indexed keywords

PEPTIDE; PEPTIDE DERIVATIVE; POLYLYSINE; PROPYLHISTIDINYLSERYLCYSTEINYLASPARAGINE; PROPYLHISTIDINYLSERYLCYSTEINYLASPARAGINE POLYLYSINE DENDRIMER; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER GROWTH; CELL ASSAY; CELL INVASION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; MOUSE; NONHUMAN; NUDE MOUSE; PROSTATE CANCER;

ANGIOGENESIS INHIBITORS; ANIMALS; DENDRIMERS; DISEASE PROGRESSION; HUMANS; INHIBITORY CONCENTRATION 50; INTEGRIN ALPHA5BETA1; LUNG NEOPLASMS; MALE; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; OLIGOPEPTIDES; PROSTATIC NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 77950867040     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-010-9316-1     Document Type: Article

References (60)

1. ZZ Zeng H Yao ED Staszewski KF Rockwood SM Markwart KS Fay AC Spalding DL Livant 2009 Alpha(5)beta(1) Integrin ligand PHSRN induces invasion and alpha(5) mRNA in endothelial cells to stimulate Angiogenesis Transl Oncol 2 8 20 19252747
2. DL Livant RK Brabec KJ Pienta DL Allen K Kurachi S Markwart A Upadhyaya 2000 Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma Cancer Res 60 309 320 1:CAS:528: DC%2BD3cXhtVahs7Y%3D 10667582 (Pubitemid 30070757)
3. ZZ Zeng Y Jia NJ Hahn SM Markwart KF Rockwood DL Livant 2006 Role of focal adhesion kinase and phosphatidylinositol 3′-kinase in integrin fibronectin receptor-mediated, matrix metalloproteinase-1-dependent invasion by metastatic prostate cancer cells Cancer Res 66 8091 8099 10.1158/0008-5472.CAN- 05-4400 1:CAS:528:DC%2BD28XotFWqtLo%3D 16912186 (Pubitemid 44299175)
4. M Fornaro T Manes LR Languino 2001 Integrins and prostate cancer metastases Cancer Metastasis Rev 20 321 331 10.1023/A:1015547830323 1:CAS:528:DC%2BD38XkvVWqs70%3D 12085969 (Pubitemid 34595274)
5. FL Miles FL Pruitt KL van Golen CR Cooper 2008 Stepping out of the flow: capillary extravasation in cancer metastasis Clin Exp Metastasis 25 305 324 10.1007/s10585-007-9098-2 1:CAS:528:DC%2BD1cXptVSqu7o%3D 17906932 (Pubitemid 351748980)
6. M Guba AK Bosserhoff M Steinbauer C Abels M Anthuber R Buettner KW Jauch 2000 Overexpression of melanoma inhibitory activity (MIA) enhances extravasation and metastasis of A-mel 3 melanoma cells in vivo Br J Cancer 83 1216 1222 10.1054/bjoc.2000.1424 1:CAS:528:DC%2BD3cXot1Sqsbs%3D 11027436
7. N Matsuura W Puzon-McLaughlin A Irie Y Morikawa K Kakudo Y Takada 1996 Induction of experimental bone metastasis in mice by transfection of integrin alpha 4 beta 1 into tumor cells Am J Pathol 148 55 61 1:CAS:528: DyaK28Xitlahs7Y%3D 8546226 (Pubitemid 26019643)
8. DL Livant RK Brabec K Kurachi DL Allen Y Wu R Haaseth P Andrews SP Ethier S Markwart 2000 The PHSRN sequence induces extracellular matrix invasion and accelerates wound healing in obese diabetic mice J Clin Invest 105 1537 1545 10.1172/JCI8527 1:CAS:528:DC%2BD3cXjvFWmtro%3D 10841512 (Pubitemid 30390304)
9. S Aota T Nagai KM Yamada 1991 Characterization of regions of fibronectin besides the arginine-glycine-aspartic acid sequence required for adhesive function of the cell-binding domain using site-directed mutagenesis J Biol Chem 266 15938 15943 1:CAS:528:DyaK3MXmtVCgu7g%3D 1874740 (Pubitemid 21907747)
10. AP Mould JA Askari S Aota KM Yamada A Irie Y Takada HJ Mardon MJ Humphries 1997 Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory anti-alpha5 and anti-beta1 monoclonal antibodies. Evidence that the synergy sequence of fibronectin is recognized by the amino-terminal repeats of the alpha5 subunit J Biol Chem 272 17283 17292 10.1074/jbc.272.28.17283 1:CAS:528:DyaK2sXksFOnt7o%3D 9211865 (Pubitemid 27311152)
11. ME Cianfrocca KA Kimmel J Gallo T Cardoso MM Brown G Hudes N Lewis L Weiner GN Lam SC Brown DE Shaw AP Mazar RB Cohen 2006 Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH(2)), a beta integrin antagonist, in patients with solid tumours Br J Cancer 94 1621 1626 1:CAS:528: DC%2BD28XltVOmurg%3D 16705310
12. P Khalili A Arakelian G Chen ML Plunkett I Beck GC Parry F Donate DE Shaw AP Mazar SA Rabbani 2006 A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo Mol Cancer Ther 5 2271 2280 10.1158/1535-7163.MCT-06-0100 1:CAS:528:DC%2BD28Xps1ynsL0%3D 16985061 (Pubitemid 44530464)
13. O Stoeltzing W Liu N Reinmuth F Fan GC Parry AA Parikh MF McCarty CD Bucana AP Mazar LM Ellis 2003 Inhibition of integrin alpha5beta1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice Int J Cancer 104 496 503 10.1002/ijc.10958 1:CAS:528:DC%2BD3sXisVejt7Y%3D 12584749 (Pubitemid 36323922)
14. KL van Golen L Bao GJ Brewer KJ Pienta JM Kamradt DL Livant SD Merajver 2002 Suppression of tumor recurrence and metastasis by a combination of the PHSCN sequence and the antiangiogenic compound tetrathiomolybdate in prostate carcinoma Neoplasia 4 373 379 10.1038/sj.neo.7900258 12192595 (Pubitemid 34976952)
15. KR Stone DD Mickey H Wunderli GH Mickey DF Paulson 1978 Isolation of a human prostate carcinoma cell line (DU 145) Int J Cancer 21 274 281 10.1002/ijc.2910210305 1:STN:280:DyaE1c7ivFajsA%3D%3D 631930
16. ME Kaighn KS Narayan Y Ohnuki JF Lechner LW Jones 1979 Establishment and characterization of a human prostatic carcinoma cell line (PC-3) Invest Urol 17 16 23 1:STN:280:DyaE1M7ptlKlsg%3D%3D 447482
17. Y Jia ZZ Zeng SM Markwart KF Rockwood KM Ignatoski SP Ethier DL Livant 2004 Integrin fibronectin receptors in matrix metalloproteinase-1-dependent invasion by breast cancer and mammary epithelial cells Cancer Res 64 8674 8681 10.1158/0008-5472.CAN-04-0069 1:CAS:528:DC%2BD2cXhtVCjs7rO 15574776 (Pubitemid 39552082)
18. E Kaiser RL Colescott CD Bossinger PI Cook 1970 Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides Anal Biochem 34 595 598 10.1016/0003-2697(70)90146-6 1:CAS:528:DyaE3cXhtVWjur0%3D 5443684
19. Remmer H, Fields G (2000) Chemical synthesis of peptides. In: Reid RE (ed) Peptide and protein drug analysis. Marcel Dekker, Inc., New York
20. Grant GA (2002) Evaluation of the synthetic product. In: Grant GA (ed) Synthetic peptides a user's guide. Oxford University Press, Oxford, New York
21. NS DeSilva I Ofek EC Crouch 2003 Interactions of surfactant protein D with fatty acids Am J Respir Cell Mol Biol 29 757 770 10.1165/rcmb.2003-0186OC 1:CAS:528:DC%2BD3sXhtVSgs7zO 12816736 (Pubitemid 38045944)
22. A Peled O Kollet T Ponomaryov I Petit S Franitza V Grabovsky MM Slav A Nagler O Lider R Alon D Zipori T Lapidot 2000 The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice Blood 95 3289 3296 1:CAS:528:DC%2BD3cXjsl2isrw%3D 10828007
23. TC Chou P Talalay 1984 Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors Adv Enzyme Regul 22 27 55 10.1016/0065-2571(84)90007-4 1:CAS:528:DyaL2cXktlaksLk%3D 6382953
24. H Ren X Tan Y Dong A Giese TC Chou N Rainov B Yang 2009 Differential effect of imatinib and synergism of combination treatment with chemotherapeutic agents in malignant glioma cells Basic Clin Pharmacol Toxicol 104 241 252 10.1111/j.1742-7843.2008.00371.x 1:CAS:528:DC%2BD1MXivF2rsLc%3D 19159435
25. P Godement J Vanselow S Thanos F Bonhoeffer 1987 A study in developing visual systems with a new method of staining neurones and their processes in fixed tissue Development 101 697 713 1:STN:280:DyaL1M%2FjtVaqsQ%3D%3D 2460302
26. Molnar Z, Blakey D, Bystron I (2006) Tract-tracing in developing systems and in postmortem human material using carbocyanine dyes. In: Záborszky L, Lanciego JL, Wouterlood FG (eds) Neuroanatomical tract-tracing 3: molecules, neurons, and systems. Springer Science + Business Media, Inc., Boston, MA
27. A Collazo M Bronner-Fraser SE Fraser 1993 Vital dye labelling of Xenopus laevis trunk neural crest reveals multipotency and novel pathways of migration Development 118 363 376 1:STN:280:DyaK2c%2FjvVKrsw%3D%3D 7693414
28. H Yao EJ Dashner CM van Golen KL van Golen 2006 RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility Oncogene 25 2285 2296 10.1038/sj.onc.1209260 1:CAS:528:DC%2BD28XjsVWku70%3D 16314838
29. HS Baldwin HM Shen HC Yan HM DeLisser A Chung C Mickanin T Trask NE Kirschbaum PJ Newman SM Albelda, et al. 1994 Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development Development 120 2539 2553 1:CAS:528:DyaK2MXmvVGgug%3D%3D 7956830
30. GP Gupta J Perk S Acharyya P de Candia V Mittal K Todorova-Manova WL Gerald E Brogi R Benezra J Massague 2007 ID genes mediate tumor reinitiation during breast cancer lung metastasis Proc Natl Acad Sci U S A 104 19506 19511 10.1073/pnas.0709185104 1:CAS:528:DC%2BD1cXisVOgsw%3D%3D 18048329 (Pubitemid 47175571)
31. FW Orr HH Wang RM Lafrenie S Scherbarth DM Nance 2000 Interactions between cancer cells and the endothelium in metastasis J Pathol 190 310 329 10.1002/(SICI)1096-9896(200002)190:3<310::AID-PATH525>3.0.CO;2-P 1:CAS:528:DC%2BD3cXitFyhsr4%3D 10685065 (Pubitemid 30141377)
32. MA Rowland-Goldsmith H Maruyama K Matsuda T Idezawa M Ralli S Ralli M Korc 2002 Soluble type II transforming growth factor-beta receptor attenuates expression of metastasis-associated genes and suppresses pancreatic cancer cell metastasis Mol Cancer Ther 1 161 167 1:CAS:528:DC%2BD38XpsFalug%3D%3D 12467210
33. TS Lawrence MA Davis J Maybaum SK Mukhopadhyay PL Stetson DP Normolle PE McKeever WD Ensminger 1992 The potential superiority of bromodeoxyuridine to iododeoxyuridine as a radiation sensitizer in the treatment of colorectal cancer Cancer Res 52 3698 3704 1:CAS:528:DyaK38XltVOns7o%3D 1617642
34. A Cesano S Visonneau D Santoli 1998 TALL-104 cell therapy of human solid tumors implanted in immunodeficient (SCID) mice Anticancer Res 18 2289 2295 1:STN:280:DyaK1czmvFCqsw%3D%3D 9703868 (Pubitemid 28386509)
35. A Rephaeli D Blank-Porat N Tarasenko M Entin-Meer I Levovich SM Cutts DR Phillips Z Malik A Nudelman 2005 In vivo and in vitro antitumor activity of butyroyloxymethyl-diethyl phosphate (AN-7), a histone deacetylase inhibitor, in human prostate cancer Int J Cancer 116 226 235 10.1002/ijc.21030 1:CAS:528:DC%2BD2MXmtVaqt70%3D 15800932 (Pubitemid 40967259)
36. A Jemal R Siegel E Ward Y Hao J Xu T Murray MJ Thun 2008 Cancer statistics, 2008 CA Cancer J Clin 58 71 96 10.3322/CA.2007.0010 18287387 (Pubitemid 351521864)
37. V Narain ML Cher DP Wood Jr 2002 Prostate cancer diagnosis, staging and survival Cancer Metastasis Rev 21 17 27 10.1023/A:1020104004588 12400994 (Pubitemid 35205191)
38. L Bubendorf A Schopfer U Wagner G Sauter H Moch N Willi TC Gasser MJ Mihatsch 2000 Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients Hum Pathol 31 578 583 10.1053/hp.2000.6698 1:STN:280: DC%2BD3c3psVartA%3D%3D 10836297 (Pubitemid 30323983)
39. S Plesnicar 1985 The course of metastatic disease originating from carcinoma of the prostate Clin Exp Metastasis 3 103 110 10.1007/BF01758959 1:STN:280:DyaL28%2FgtlSksg%3D%3D 4042459 (Pubitemid 15240089)
40. Bova S, Kirk M, Chan-Tack M, LeCartes M (2001) Lethal metastatic human prostate cancer. Autopsy studies and characteristics of metastasis. In: Chung LWK, Isaacs WB, Simons JW (eds) Prostate cancer: biology, genetics and the new therapeutics. Humana Press, Totowa, NJ
41. M Elkin HP Mueller 1954 Metastases from cancer of the prostate; autopsy and roentgenological findings Cancer 7 1246 1248 10.1002/1097-0142(195411)7: 6<1246::AID-CNCR2820070616>3.0.CO;2-C 1:STN:280:DyaG2M%2FitFWruw%3D%3D 13209524
42. PG de Paso Mora BJ Rios FJ Pascual Pareja C Castillo Torres A Pinto Marin A Sendino Revuelta RJ Vazquez 2005 Pleural effusion as presentation of metastatic adenocarcinoma of prostate South Med J 98 959 960 10.1097/01.smj.0000170725.86732.60 16218001 (Pubitemid 41396106)
43. SM Pulukuri JS Rao 2008 Matrix metalloproteinase-1 promotes prostate tumor growth and metastasis Int J Oncol 32 757 765 1:CAS:528: DC%2BD1cXkslOitrw%3D 18360703
44. M Nomizu K Yamamura HK Kleinman Y Yamada 1993 Multimeric forms of Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide enhance the inhibition of tumor growth and metastasis Cancer Res 53 3459 3461 1:CAS:528:DyaK2cXitlSktg%3D%3D 8339246 (Pubitemid 23229618)
45. P Huhtala MJ Humphries JB McCarthy PM Tremble Z Werb CH Damsky 1995 Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin J Cell Biol 129 867 879 10.1083/jcb.129.3.867 1:CAS:528:DyaK2MXlt1WrsLw%3D 7537277
46. DL Livant 2005 Targeting invasion induction as a therapeutic strategy for the treatment of cancer Curr Cancer Drug Targets 5 489 503 10.2174/ 156800905774574002 1:CAS:528:DC%2BD2MXhtFCgsLnL 16305346 (Pubitemid 41502561)
47. D Greiling RA Clark 1997 Fibronectin provides a conduit for fibroblast transmigration from collagenous stroma into fibrin clot provisional matrix J Cell Sci 110 Pt 7 861 870 1:CAS:528:DyaK2sXjtFeku7s%3D 9133673 (Pubitemid 27196785)
48. F Grinnell M Zhu 1994 Identification of neutrophil elastase as the proteinase in burn wound fluid responsible for degradation of fibronectin J Invest Dermatol 103 155 161 10.1111/1523-1747.ep12392625 1:CAS:528: DyaK2MXotFyhuw%3D%3D 8040604 (Pubitemid 24234599)
49. OW Rokhlin MB Cohen 1995 Expression of cellular adhesion molecules on human prostate tumor cell lines Prostate 26 205 212 10.1002/pros.2990260406 1:CAS:528:DyaK2MXlvFCrs7w%3D 7536326
50. KM Woods Ignatoski NK Grewal S Markwart DL Livant SP Ethier 2003 p38MAPK induces cell surface alpha4 integrin downregulation to facilitate erbB-2-mediated invasion Neoplasia 5 128 134 1:CAS:528:DC%2BD3sXjt1ykt78%3D 12659685 (Pubitemid 36369008)
51. DF Mosher 1984 Physiology of fibronectin Annu Rev Med 35 561 575 10.1146/annurev.me.35.020184.003021 1:CAS:528:DyaL2cXitVKqsr4%3D 6326663
52. E Ruoslahti EG Hayman M Pierschbacher E Engvall 1982 Fibronectin: purification, immunochemical properties, and biological activities Methods Enzymol 82 Pt A 803 831 10.1016/0076-6879(82)82103-4 1:CAS:528: DyaL38XhsFOmsrc%3D 7078457
53. KM Ignatoski T Maehama SM Markwart JE Dixon DL Livant SP Ethier 2000 ERBB-2 overexpression confers PI 3′ kinase-dependent invasion capacity on human mammary epithelial cells Br J Cancer 82 666 674 10.1054/bjoc.1999.0979 1:CAS:528:DC%2BD3cXht1eisbg%3D 10682681 (Pubitemid 30085206)
54. KM Woods Ignatoski DL Livant S Markwart NK Grewal SP Ethier 2003 The role of phosphatidylinositol 3′-kinase and its downstream signals in erbB-2-mediated transformation Mol Cancer Res 1 551 560 1:CAS:528: DC%2BD3sXjvVSltLc%3D 12754302 (Pubitemid 36577050)
55. G Fassina A Corti G Cassani 1992 Affinity enhancement of complementary peptide recognition Int J Pept Protein Res 39 549 556 1:CAS:528: DyaK3sXkt1Sltrw%3D 1399275
56. P Sinnis P Clavijo D Fenyo BT Chait C Cerami V Nussenzweig 1994 Structural and functional properties of region II-plus of the malaria circumsporozoite protein J Exp Med 180 297 306 10.1084/jem.180.1.297 1:CAS:528:DyaK2cXltVKitrc%3D 8006589 (Pubitemid 24181078)
57. E Carlier K Mabrouk M Moulard Z Fajloun H Rochat M De Waard JM Sabatier 2000 Ion channel activation by SPC3, a peptide derived from the HIV-1 gp120 V3 loop J Pept Res 56 427 437 10.1034/j.1399-3011.2000.00815.x 1:CAS:528: DC%2BD3MXivVSn 11152302
58. N Yahi JM Sabatier S Baghdiguian F Gonzalez-Scarano J Fantini 1995 Synthetic multimeric peptides derived from the principal neutralization domain (V3 loop) of human immunodeficiency virus type 1 (HIV-1) gp120 bind to galactosylceramide and block HIV-1 infection in a human CD4-negative mucosal epithelial cell line J Virol 69 320 325 1:CAS:528:DyaK2MXislWrt7k%3D 7983725
59. K Tantivejkul LM Kalikin KJ Pienta 2004 Dynamic process of prostate cancer metastasis to bone J Cell Biochem 91 706 717 10.1002/jcb.10664 1:CAS:528:DC%2BD2cXitlGis7c%3D 14991762
60. VI Romanov MS Goligorsky 1999 RGD-recognizing integrins mediate interactions of human prostate carcinoma cells with endothelial cells in vitro Prostate 39 108 118 10.1002/(SICI)1097-0045(19990501)39:2<108::AID- PROS5>3.0.CO;2-9 1:CAS:528:DyaK1MXivF2gt7Y%3D 10221566 (Pubitemid 29194282)