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Volumn 45, Issue 6, 2010, Pages 2644-2649

Lipophilicity of novel antitumour and analgesic active 8-aryl-2,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3,4-dione derivatives determined by reversed-phase HPLC and computational methods

Author keywords

Correlation between log (1 LD50) and log PHPLC; Correlation between RP HPLC derived lipophilicity and log Pcalc. values; Derivatives of 8 aryl 2,6,7,8 tetrahydroimidazo 2,1 c 1,2,4 triazine 3,4 dione; Drug likeness; Lipophilicity; Partition coefficient, standardization; RP HPLC

Indexed keywords

1,2,4 TRICHLOROBENZENE; 1,3 DICHLOROACETONE; 1,3,5 TRICHLOROBENZENE; 2 NAPHTHOL; 2,6 DICHLOROACETANILIDE; 3 HYDROXYBENZALDEHYDE; 3,4 DICHLOROANILINE; 4 NITROPHENOL; 8 (2 METHOXYPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 (2 METHYLPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 (3 CHLOROPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 (3,4 DICHLOROPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 (4 CHLOROPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 (4 METHOXYPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 (4 METHYLPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 PHENYL 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; ANALGESIC AGENT; ANTINEOPLASTIC AGENT; BENZENE; BIPHENYL; CHLORINE DERIVATIVE; CHLOROBENZENE; ISATIN; METHANOL; PHENOL; PYRIDINE; TOLUENE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

EID: 77950860910     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.068     Document Type: Article
Times cited : (24)

References (46)
  • 28
    • 0004698438 scopus 로고
    • inBrown P.R., and Grushka E. (Eds), Marcel Dekker, New York p. 147
    • Kaliszan R. In: inBrown P.R., and Grushka E. (Eds). Advances in Chromatography (1993), Marcel Dekker, New York p. 147
    • (1993) Advances in Chromatography
    • Kaliszan, R.1
  • 36
    • 0003598630 scopus 로고    scopus 로고
    • StatSoft Inc., 2300 East 14th Street, Tulsa, USA
    • Statistica for Windows, Version 5.1 (1997), StatSoft Inc., 2300 East 14th Street, Tulsa, USA
    • (1997) Statistica for Windows, Version 5.1
  • 39
    • 77950866897 scopus 로고    scopus 로고
    • Hypercube Inc.
    • HyperChem v. 6.3 (2000), Hypercube Inc.
    • (2000) HyperChem v. 6.3
  • 40
    • 77950864924 scopus 로고    scopus 로고
    • Wavefunction Inc., Schroedinger Inc.
    • Titan v. 1.07 (2001), Wavefunction Inc., Schroedinger Inc.
    • (2001) Titan v. 1.07
  • 44
    • 77950865485 scopus 로고    scopus 로고
    • K. Sztanke, D. Matosiuk, S. Fidecka, Polish Patent 196752, 2008; Chem. Abstr. 149 (2008) 555668.
    • K. Sztanke, D. Matosiuk, S. Fidecka, Polish Patent 196752, 2008; Chem. Abstr. 149 (2008) 555668.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.