Lipophilicity of novel antitumour and analgesic active 8-aryl-2,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3,4-dione derivatives determined by reversed-phase HPLC and computational methods

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2644-2649

  Sztanke, Krzysztof ^a   Markowski, Wojciech ^a   Świeboda, Ryszard ^a   Polak, Beata ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

Correlation between log (1 LD50) and log PHPLC; Correlation between RP HPLC derived lipophilicity and log Pcalc. values; Derivatives of 8 aryl 2,6,7,8 tetrahydroimidazo 2,1 c 1,2,4 triazine 3,4 dione; Drug likeness; Lipophilicity; Partition coefficient, standardization; RP HPLC

Indexed keywords

1,2,4 TRICHLOROBENZENE; 1,3 DICHLOROACETONE; 1,3,5 TRICHLOROBENZENE; 2 NAPHTHOL; 2,6 DICHLOROACETANILIDE; 3 HYDROXYBENZALDEHYDE; 3,4 DICHLOROANILINE; 4 NITROPHENOL; 8 (2 METHOXYPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 (2 METHYLPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 (3 CHLOROPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 (3,4 DICHLOROPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 (4 CHLOROPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 (4 METHOXYPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 (4 METHYLPHENYL) 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; 8 PHENYL 2,6,7,8 TETRAHYDROIMIDAZO[2,1 C][1,2,4]TRIAZINE 3,4 DIONE; ANALGESIC AGENT; ANTINEOPLASTIC AGENT; BENZENE; BIPHENYL; CHLORINE DERIVATIVE; CHLOROBENZENE; ISATIN; METHANOL; PHENOL; PYRIDINE; TOLUENE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ACUTE TOXICITY; ANALGESIC ACTIVITY; ANALYTICAL PARAMETERS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CALIBRATION; COMPUTER PROGRAM; CONCENTRATION RESPONSE; HUMAN; HUMAN CELL; LIPOPHILICITY; PARTITION COEFFICIENT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLUTE; STANDARD;

ANALGESICS; ANTINEOPLASTIC AGENTS; CALIBRATION; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; COMPUTATIONAL BIOLOGY; HUMANS; HYDROPHOBICITY; LETHAL DOSE 50; TRIAZINES;

EID: 77950860910     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.068     Document Type: Article

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