Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol)

Nature

Volumn 240, Issue 5381, 1972, Pages 410-411

  Flower, R J ^a   Vane, J R ^a  

^a ROYAL COLLEGE OF SURGEONS OF ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; INDOMETACIN; LIGASE; PARACETAMOL; PROSTAGLANDIN;

ANIMAL; ARTICLE; BRAIN; COMPARATIVE STUDY; DOG; ENZYMOLOGY; IN VITRO STUDY; RABBIT; SPLEEN;

ACETAMINOPHEN; ANIMAL; ASPIRIN; BRAIN; COMPARATIVE STUDY; DOGS; IN VITRO; INDOMETHACIN; LIGASES; PROSTAGLANDINS; RABBITS; SPLEEN;

EID: 0015511847     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/240410a0     Document Type: Article

References (19)

1. Vane, J. R., Nature New Biology, 231, 232 (1971).
2. Smith, J. B., and Willis, A. L., Nature New Biology, 231, 235 (1971).
3. Ferreira, S. H., Moncada, S., and Vane, J. R., Nature New Biology, 231, 237 (1971).
4. Smith, W. L., and Lands, W. E. M., J. Biol. Chem., 246, 6700.
5. Tomlinson, R. V., Ringold, H. J., Qureshi, M. C., and Forchielli, E., Biochem. Biophys. Res. Comm., 46, 552 (1972).
6. Flower, R., Gryglewski, R., Herbaczynska-Cedro, K., and Vane, J. R., Nature New Biology, 238, 104 (1972).
7. Sykes, J. A. C., and Maddox, I. S., Nature New Biology, 237, 59.
8. Vane, J. R., Hospital Practice, 7, 61 (1972).
9. Vane, J. R., in Inflammation: Mechanisms and Control (edit, by Lepow, I. Hi, and Ward, P. A.) (Academic Press, New York, 1972).
10. Vane, J. R., Proc. Fifth Intern. Congr. Pharmacol. (Karger, Basle, in the press).
11. Willis, A. L., Davison, P., Ramwell, P. W., Brocklehurst, W. E., and Smith, J. B., Prostaglandins in Cellular Biology (edit, by Ramwell, P. W., and Pharriss, B. B.),227 (Plenum Press, New York and London, 1972).
12. Woodbury, D. M., in The Pharmacological Basis of Therapeutics (edit, by Goodman, L. S., and Gilman, A.), fourth ed. (Macmillan, New York, 1970).
13. Milton, A. S., and Wendlandt, S., J. Physiol., 207, 76 (1970).
14. Coceani, F., and Wolfe, L. S., Canad. J. Physiol. Pharmacol., 43, 445 (1965).
15. Feldberg, W., Gupta, K. P., Milton, A. S., and Wendlandt, S., Brit. J. Pharmacol, (in the press).
16. Vane, J. R., Brit. J. Pharmac. Chemother., 12, 344 (1957).
17. Gilmore, N., Vane, J. R., and Wyllie, J. H., Nature, 218, 1135 (1968).
18. Green, K., and Samuelsson, B., J. Lip. Res, 5, 117 (1964).
19. Collier, H. O. J., A dr. Pharmac. Chemother., 7, 333 (1969).