Betacyanins from Portulaca oleracea L. ameliorate cognition deficits and attenuate oxidative damage induced by D-galactose in the brains of senescent mice

Phytomedicine

Volumn 17, Issue 7, 2010, Pages 527-532

  Wang, Chang Quan ^a   Yang, Gui Qin ^b  

^a SHANDONG UNIVERSITY OF TECHNOLOGY   (China)

^b Chinese Medicine Hospital of Zhangdian District   (China)

Author keywords

Cognition; D galactose; Mice; Oxidative stress; Portulaca oleracea L

Indexed keywords

ASCORBIC ACID; BETACYANIN; CATALASE; GALACTOSE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME ACTIVITY; LATENT PERIOD; LEARNING DISORDER; LIPID PEROXIDATION; LOW DRUG DOSE; MALE; MEMORY DISORDER; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SENESCENCE;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BRAIN; CARBOCYANINES; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ENZYMES; GALACTOSE; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED STRAINS; NEUROTOXINS; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PORTULACA;

MUS; PORTULACA OLERACEA;

EID: 77950858577     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.09.006     Document Type: Article

References (46)

1. Aebi H. Catalase in vitro. Methods Enzymol. 105 (1984) 121-127
2. Allegra M., Furtmüller P.G., Jantschko W., Zederbauer M., Tesoriere L., Livrea M.A., and Obinger C. Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid. Biochem. Biophys. Res. Commun. 332 (2005) 837-844
3. Allegra M., Tesoriere L., and Livrea M.A. Betanin inhibits the myeloperoxidase/nitrite-induced oxidation of human low-density lipoproteins. Free Radical Res. 41 (2007) 335-341
4. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
5. Butera D., Tesoriere L., Di Gaudio F., Bongiorno A., Allegra M., Pintaudi A.M., Kohen R., and Livrea M.A. Antioxidant activities of Sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: betanin and indicaxanthin. J. Agric. Food Chem. 50 (2002) 6895-6901
6. Castegna A., Aksenov M., Aksenova M., Thongboonkerd V., Klein J.B., Pierce W.M., Booze R., Markesbery W.R., and Butterfield D.A. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. Free Radical Biol. Med. 33 (2002) 562-571
7. Cai Y., Sun M., and Corke H. Antioxidant activity of betalains from plants of the Amaranthaceae. J. Agric. Food Chem. 51 (2003) 2288-2294
8. Chen D.C. Manual of Standard Compounds of Traditional Chinese Medicine (2000), China Medico-Pharmaceutical Science and Technology Press, Beijing p.109
9. Cui X., Zuo P., Zhang Q., Li X., Hu Y., Long J., Packer L., and Liu J. Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. J. Neurosci. Res. 84 (2006) 647-654
10. Deby C., and Goutier R. New perspectives on the biochemistry of superoxide anion and the efficiency of superoxide dismutases. Biochem. Pharmacol. 39 (1990) 399-405
11. De Iuliis A., Grigoletto J., Recchia A., Giusti P., and Arslan P. A proteomic approach in the study of an animal model of Parkinson's disease. Clin. Chim. Acta 357 (2005) 202-209
12. Escribano J., Pedreño M.A., García-Carmona F., and Muñoz R. Characterization of the antiradical activity of betalains from Beta vulgaris L. roots. Phytochem. Anal. 9 (1998) 124-127
13. Fukui K., Omoi N.O., Hayasaka T., Shinnkai T., Suzuki S., and Urano S. Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E. Ann. NY Acad. Sci. 959 (2002) 275-284
14. Gentile C., Tesoriere L., Allegra M., Livrea M.A., and D'Alessio P. Antioxidant betalains from cactus pear (Opuntia ficus-indica) inhibit endothelial ICAM-1 expression. Ann. NY Acad. Sci. 1028 (2004) 481-486
15. Halliwell B., and Gutteridge J.M.C. Free Radicals in Biology and Medicine (1989), Clarendon, Oxford, UK
16. Harman D. Free radical theory of aging. Mutat. Res. 275 (1992) 257-266
17. Kapadia G.J., Tokuda H., Konoshima T., and Nishino H. Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract. Cancer Lett. 100 (1996) 211-214
18. Kapadia G.J., Azuine M.A., Sridhar R., Okuda Y., Tsuruta A., Ichiishi E., Mukainake T., Takasak M., Konoshima T., Nishino H., and Tokuda H. Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot. Pharmacol. Res. 47 (2003) 141-148
19. Kanner J., Harel S., and Granit R. Betalains - a new class of dietary cationized antioxidants. J. Agric. Food Chem. 49 (2001) 5178-5185
20. Kuramoto Y., Yamada K., Tsuruta O., and Sugano M. Effect of natural food colorings on immunoglobulin production in vitro by rat spleen lymphocytes. Biosci. Biotechnol. Biochem. 60 (1996) 1712-1713
21. Lu J., Zheng Y.L., Wu D.M., Luo L., Sun D.X., and Shan Q. Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Biochem. Pharmacol. 74 (2007) 1078-1090
22. Mizumo Y., and Ohta K. Regional distributions of thiobarbituric acid reactive products, activities of enzymes regulating the metabolism of oxygen free radicals, and some of the related enzymes in adult and aged rat brain. J. Neurochem. 46 (1986) 1344-1352
23. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11 (1984) 47-60
24. Ohkawa H., Ohishi N., and Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95 (1979) 351-358
25. Olanow C.W. A radical hypothesis for neurodegeneration. Trends Neurosci. 16 (1993) 439-444
26. Oyanagui Y. Reevaluation of assay methods and establishment of kit for superoxide dismutase activity. Anal. Biochem. 142 (1984) 290-296
27. Parry O., Okwuasaba F., and Ejike C. Skeletal muscle relaxant action of an aqueous extract of Portulaca oleracea in the rat. J. Ethnopharmacol. 19 (1987) 247-253
28. Parry O., Marks J.A., and Okwuasaba F. The skeletal muscle relaxant action of Portulaca oleracea: role of potassium ions. J. Ethnopharmacol. 40 (1993) 187-194
29. Parle M., and Dhingra D. Ascorbic acid: a promising memory-enhancer in mice. J. Pharmacol. Sci. 93 (2003) 129-135
30. Rashed A.N., Afifi F.U., and Disi A.M. Simple evaluation of the wound healing activity of a crude extract of Portulaca oleracea L. (growing in Jordan) in Mus musculus JVI-1. J. Ethnopharmacol. 88 (2003) 131-136
31. Reddy M.K., Alexande-Lindo R.L., and Nair M.G. Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors. J. Agric. Food Chem. 53 (2005) 9268-9273
32. Schwartz S.J., and von Elbe J.H. Quantitative determination of individual betacyanin pigments by high-performance liquid chromatography. J. Agric. Food Chem. 28 (1980) 540-543
33. Stintzing F.C., Schieber A., and Carle R. Betacyanins in fruits from red-purple pitaya, Hylocereus polyrhizus Britton & Rose. Food Chem. 77 (2002) 101-106
34. Strack D., Vogt T., and Schliemann W. Recent advances in betalain research. Phytochemistry 62 (2003) 247-269
35. Stintzing F.C., and Carle R. Functional properties of anthocyanins and betalains in plants, food, and in human nutrition. Trends Food Sci. Technol. 15 (2004) 19-38
36. Tesoriere L., Butera D., D'Arpa D., Di Gaudio F., Allegra M., Gentile C., and Livrea M.A. Increased resistance to oxidation of betalain-enriched human low density lipoproteins. Free Radical Res. 37 (2003) 689-696
37. Tesoriere L., Butera D., Pintaudi A.M., Allegra M., and Livrea M.A. Supplementation with cactus pear (Opuntia ficus-indica) fruit decreases oxidative stress in healthy humans: a comparative study with vitamin C. Am. J. Clin. Nutr. 80 (2004) 391-395
38. Tesoriere L., Butera D., Allegra M., Fazzari M., and Livrea M.A. Distribution of betalain pigments in red blood cells after consumption of cactus pear fruits and increased resistance of the cells to ex vivo induced oxidative hemolysis in humans. J. Agric. Food Chem. 53 (2005) 1266-1270
39. Ulrich-Merzenich G., Zeitler H., Vetter H., and Kraft K. Synergy research: vitamins and secondary plant components in the maintenance of the redox-homeostasis and in cell signaling. Phytomedicine 16 (2009) 2-16
40. Wei H.F., Li L., Song Q.J., Ai H.X., Chu J., and Li W. Behavioural study of the d-galactose induced aging model in C57BL/6J mice. Behav. Brain Res. 157 (2005) 245-251
41. Zakharova N., and Petrova T. Relationships between the structure and antioxidant activity of certain betalains. Appl. Biochem. Microbiol. 34 (1998) 182-185
42. Zhang X.J., Ji Y.B., Qu Z.Y., Xia J.C., and Wang L. Experimental studies on antibiotic functions of Portulaca oleracea L. in vitro. Chin. J. Microecol. 14 (2002) 277-280
43. Zhang Q., Li X., Cui X., and Zuo P. D-galactose injured neurogenesis in the hippocampus of adult mice. Neurol. Res. 27 (2005) 552-556
44. Zhang X.L., Jiang B., Li Z.B., Hao S., and An L.J. Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Pharmacol. Biochem. Behav. 88 (2007) 64-72
45. Zhang X.L., Zhang A.H., Jiang B., Bao Y.M., Wang J.Y., and An L.J. Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa. Phytomedicine 15 (2008) 484-490
46. Zhong S.Z., Ge Q.H., Qu R., Li Q., and Ma S.P. Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice. J. Neurol. Sci. 277 (2009) 58-64