Fifth complement cascade protein (C5) cleavage fragments disrupt the SDF-1/CXCR4 axis: Further evidence that innate immunity orchestrates the mobilization of hematopoietic stem/progenitor cells

Experimental Hematology

Volumn 38, Issue 4, 2010, Pages 321-332

  Jalili, Ali ^a   Shirvaikar, Neeta ^a   Marquez Curtis, Leah ^a   Qiu, Yuanyuan ^a   Korol, Chris ^a   Lee, HakMo ^b   Turner, A Robert ^a   Ratajczak, Mariusz Z ^b   Janowska Wieczorek, Anna ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYPEPTIDASE; CARBOXYPEPTIDASE M; CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C5A RECEPTOR; GELATINASE B; GRANULOCYTE COLONY STIMULATING FACTOR; INTERSTITIAL COLLAGENASE; PROTEINASE; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; BONE MARROW CELL; CELL NUCLEUS; CELL STIMULATION; CHEMOTAXIS; COLONY FORMING UNIT GM; CONTROLLED STUDY; ENZYME RELEASE; GRANULOCYTE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; INNATE IMMUNITY; LEUKOCYTE COUNT; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; STEM CELL MOBILIZATION;

ANIMALS; CATECHIN; CELLS, CULTURED; CHEMOKINE CXCL12; CHEMOTAXIS; COMPLEMENT C5; COMPLEMENT C5A; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNITY, INNATE; LYMPHOMA, NON-HODGKIN; MICE; PEPTIDE FRAGMENTS; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, CXCR4; UP-REGULATION;

MUS;

EID: 77950845392     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2010.02.002     Document Type: Article

References (43)

1. Levesque J.P., Winkler I.G. Mobilization of hematopoietic stem cells: state of the art. Curr Opin Organ Transplant 2008, 13:53-58.
2. Pelus L.M. Peripheral blood stem cell mobilization: new regimens, new cells, where do we stand. Curr Opin Hematol 2008, 15:285-292.
3. Aiuti A., Webb I.J., Bleul C., Springer T., Gutierrez-Ramos J.C. The chemokine SDF-1 is a chemoattractant for human CD34(+) hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34(+) progenitors to peripheral blood. J Exp Med 1997, 185:111-120.
4. Lee H., Ratajczak M.Z. Innate immunity: a key player in the mobilization of hematopoietic stem/progenitor cells. Arch Immunol Ther Exp 2009, 57:1-9.
5. Spiegel A., Kalinkovich A., Shivtiel S., Kollet O., Lapidot T. Stem cell regulation via dynamic interactions of the nervous and immune systems with the microenvironment. Cell Stem Cell 2008, 3:484-492.
6. Guo R.-F., Ward P.A. Role of C5a in inflammatory responses. Annu Rev Immunol 2005, 23:821-852.
7. Lee H., Whitfield P.L., Mackay C.R. Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. Immunol Cell Biol 2008, 86:153-160.
8. Monk P.N., Scola A.-M., Madala P., Fairlie D.P. Function, structure and therapeutic potential of complement C5a receptors. Br J Pharmacol 2007, 152:429-448.
9. Burger R., Zilow G. Complement-derived anaphylatoxins in natural immunity. The Natural Immune System: Humoral Factors 1993, 209. Oxford, New York. E. Sim (Ed.).
10. + progenitors to peripheral blood: impaired mobilization in chronic granulomatous disease and adenosine deaminase-deficient severe combined immunodeficiency disease patients. Blood 1996, 88:1104-1112.
11. Reca R., Mastellos D., Majka M., et al. Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1. Blood 2003, 101:3784-3793.
12. + stem cells. Exp Hematol 2006, 34:986-995.
13. Ratajczak J., Reca R., Kucia M., et al. Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow. Blood 2004, 103:2071-2078.
14. Reca R., Cramer D., Yan J., et al. A novel role of complement in mobilization: immunodeficient mice are poor granulocyte-colony stimulating factor mobilizers because they lack complement-activating immunoglobulins. Stem Cells 2007, 25:3093-3100.
15. McQuibban G.A., Butler G.S., Gong J.H., et al. Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1. J Biol Chem 2001, 276:43503-43508.
16. Marquez-Curtis L., Jalili A., Deiteren K., et al. Carboxypeptidase M expressed by human bone marrow cells cleaves the C-terminal lysine of stromal cell-derived factor 1 alpha: another player in hematopoietic stem/progenitor cell mobilization?. Stem Cells 2008, 26:1211-1220.
17. + cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. Blood 2001, 97:3075-3085.
18. Son B.R., Marquez-Curtis L.A., Kucia M., et al. Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases. Stem Cells 2006, 24:1254-1264.
19. Lee H.M., Wu W., Wysoczynski M., et al. Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes. Leukemia 2009, 23:2052-2062.
20. + cells in response to chemokines. Exp Hematol 2000, 28:1274-1285.
21. + cells and their transmigration through reconstituted basement membrane. Blood 1999, 93:3379-3390.
22. Kim H.K., De La Luz Sierra M., Williams C.K., Gulino A.V., Tosato G. G-CSF down-regulation of CXCR4 expression identified as a mechanism for mobilization of myeloid cells. Blood 2006, 108:812-820.
23. Bensinger W., DiPersio J.F., McCarty J.M. Improving stem cell mobilization strategies: future directions. Bone Marrow Transplant 2009, 43:181-195.
24. Wysoczynski M., Reca R., Lee H., Wu W., Ratajczak J., Ratajczak M.Z. Defective engraftment of C3aR-/- hematopoietic stem cells reveals a novel role of the C3a-C3aR axis in bone marrow homing. Leukemia 2009, 23:1455-1461.
25. Prujit J.F., Verzaal P., van Os R., et al. Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice. Proc Natl Acad Sci U S A 2002, 99:6228-6233.
26. Molineux G., McCrea C., Yan X.Q., Kerzic P., McNiece I. Flt-3 ligand synergizes with granulocyte colony-stimulating factor to increase neutrophil numbers and to mobilize peripheral blood stem cells with long-term repopulating potential. Blood 1997, 89:3998-4004.
27. Furze R.C., Rankin S.M. Neutrophil mobilization and clearance in the bone marrow. Immunology 2008, 125:281-288.
28. Petit I., Szyper-Kravitz M., Nagler A., et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol 2002, 3:687-694.
29. Winkler I.G., Levesque J.-P. Mechanisms of hematopoietic stem cell mobilization: when innate immunity assails the cells that make blood and bone. Exp Hematol 2006, 34:996-1009.
30. Valenzuela-Fernandez A., Planchenault T., Baleux F., et al. Leukocyte elastase negatively regulates stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4. J Biol Chem 2002, 277:15677-15689.
31. Delgado M.B., Clark-Lewis I., Loetscher P., et al. Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes. Eur J Immunol 2001, 31:699-707.
32. nd, Cooper S, Broxmeyer HE. Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells. Blood 2003, 101:4680-4686.
33. DiScipio R.G., Schraufstatter I.U., Sikora L., Zuraw B.L., Srimarao P. C5a mediates secretion and activation of matrix metalloproteinase 9 from human eosinophils and neutrophils. Int Immunopharmacol 2006, 6:1109-1118.
34. Jin F., Zhai Q., Qiu L., et al. Degradation of BM SDF-1 by MMP-9: the role in G-CSF-induced hematopoietic stem/progenitor cell mobilization. Bone Marrow Transplant 2008, 42:581-588.
35. Barbolina M.V., Stack M.S. Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis. Semin Cell Dev Biol 2008, 19:24-33.
36. Shirvaikar N., Reca R., Jalili A., et al. CFU-Meg progenitors ex vivo-expanded from cord blood maintain their in vitro homing potential and express matrix metalloproteinases. Cytotherapy 2008, 10:182-192.
37. Gálvez B.G., Matías Román S., Albar J.P., et al. Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodelling. J Biol Chem 2001, 276:37491-37500.
38. Matías Román S., Gálvez B.G., Genis L., et al. Membrane type 1-matrix metalloproteinase is involved in migration of human monocytes and is regulated through their interaction with fibronectin or endothelium. Blood 2005, 105:3956-3964.
39. + progenitor cell retention, egress and mobilization. J Clin Invest 2009, 119:492-503.
40. De La Luz Sierra M.D., Yang F.Q., Narazaki M., et al. Differential processing of stromal-derived factor 1-alpha and stromal-derived factor-1 beta explains functional diversity. Blood 2004, 103:2452-2459.
41. Levesque J.P., Hendy J., Takamatsu Y., Williams B., Winkler I.G., Simmons P.J. Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment. Exp Hematol 2002, 5:440-449.
42. Velders G.A., Fibbe W.E. Involvement of proteases in cytokine-induced hematopoietic stem cell mobilization. Ann NY Acad Sci 2005, 1044:60-69.
43. Christopher M.J., Liu F., Hilton M.J., Long F., Link D.C. Suppression of CXCL12 production by BM osteoblasts is a common and critical pathway for cytokine-induced mobilization. Blood 2009, 114:1331-1339.