Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2

Respiratory Research

Volumn 5, Issue , 2004, Pages

  Koth, Laura L ^a,b   Rodriguez, Madeleine W ^a   Bernstein, Xiu Liu ^a   Chan, Salina ^a   Huang, Xiaozhu ^a   Charo, Israel F ^b   Rollins, Barrett J ^c   Erle, David J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; FUNGUS ANTIBODY; FUNGUS ANTIGEN; IMMUNOGLOBULIN E; MONOCYTE CHEMOTACTIC PROTEIN 1;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPERGILLUS; BRONCHUS HYPERREACTIVITY; CELL HYPERPLASIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; EOSINOPHILIA; FEMALE; GOBLET CELL; HISTOPATHOLOGY; IMMUNOGLOBULIN BLOOD LEVEL; LUNG FIBROSIS; MALE; MOUSE; NONHUMAN; TH2 CELL; WILD TYPE;

ANIMALS; ANTIGENS, FUNGAL; ASPERGILLOSIS, ALLERGIC BRONCHOPULMONARY; ASPERGILLUS FUMIGATUS; BRONCHIAL HYPERREACTIVITY; CHEMOKINE CCL2; CYTOKINES; EOSINOPHILIA; FIBROSIS; MICE; MICE, KNOCKOUT; RECEPTORS, CHEMOKINE; TH2 CELLS;

EID: 25444434079     PISSN: 1465993X     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-5-12     Document Type: Article

References (50)

1. Sousa AR, Lane SJ, Nakhosteen JA, Yoshimura T, Lee TH, Poston RN: Increased expression of the monocyte chemoattractant protein-1 in bronchial tissue from asthmatic subjects. Am J Respir Cell Mol Biol 1994, 10:142-147.
2. Alam R, York J, Boyars M, Stafford S, Grant JA, Lee J, Forsythe P, Sim T, Ida N: Increased MCP-1, RANTES, and MIP-1 alpha in bronchoalveolar lavage fluid of allergic asthmatic patients. Am J Respir Crit Care Med 1996, 153:1398-1404.
3. Tonnel AB, Gosset P, Tillie-Leblond I: Characteristics of the Inflammatory response in bronchial lavage fluids from patients with status asthmaticus. Int Arch Allergy Immunol 2001, 124:267-271.
4. Antoniades HN, Neville-Golden J, Galanopoulos T, Kradin RL, Valente AJ, Graves DT: Expression of monocyte chemoattractant protein 1 mRNA in human idiopathic pulmonary fibrosis. Proc Natl Acad Sci U S A 1992, 89:5371-5375.
5. Car BD, Meloni F, Luisetti M, Semenzato G, Gialdroni-Grassi G, Walz A: Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am J Respir Crit Care Med 1994, 149:655-659.
6. Iyonaga K, Takeya M, Saita N, Sakamoto O, Yoshimura T, Ando M, Takahashi K: Monocyte chemoattractant protein-1 in idiopathic pulmonary fibrosis and other interstitial lung diseases. Hum Pathol 1994, 25:455-463.
7. Suga M, Iyonaga K, Ichiyasu H, Saita N, Yamasaki H, Ando M: Clinical significance of MCP-1 levels in BALF and serum in patients with interstitial lung diseases. Eur Respir J 1999, 14:376-382.
8. Valente AJ, Graves DT, Vialle-Valentin CE, Delgado R, Schwartz CJ: Purification of a monocyte chemotactic factor secreted by nonhuman primate vascular cells in culture. Biochemistry 1988, 27:4162-4168.
9. Matsushima K, Larsen CG, DuBois GC, Oppenheim JJ: Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line. J Exp Med 1989, 169:1485-1490.
10. Yoshimura T, Robinson EA, Tanaka S, Appella E, Kuratsu J, Leonard EJ: Purification and amino acid analysis of two human gliomaderived monocyte chemoattractants. J Exp Med 1989, 169:1449-1459.
11. Carr MW, Roth SJ, Luther E, Rose SS, Springer TA: Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci U S A 1994, 91:3652-3656.
12. Allavena P, Bianchi G, Zhou D, van Damme J, Jilek P, Sozzani S, Mantovani A: Induction of natural killer cell migration by monocyte chemotactic protein-1, -2 and -3. Eur J Immunol 1994, 24:3233-3236.
13. Loetscher P, Seitz M, Clark-Lewis I, Baggiolini M, Moser B: Activation of NK cells by CC chemokines. Chemotaxis, Ca2+ mobilization, and enzyme release. J Immunol 1996, 156:322-327.
14. Bischoff SC, Krieger M, Brunner T, Dahinden CA: Monocyte chemotactic protein 1 is a potent activator of human basophils. J Exp Med 1992, 175:1271-1275.
15. Kuna P, Reddigari SR, Rucinski D, Oppenheim JJ, Kaplan AP: Monocyte chemotactic and activating factor is a potent histamine-releasing factor for human basophils. J Exp Med 1992, 175:489-493.
16. Alam R, Lett-Brown MA, Forsythe PA, Anderson-Walters DJ, Kenamore C, Kormos C, Grant JA: Monocyte chemotactic and activating factor is a potent histamine-releasing factor for basophils. J Clin Invest 1992, 89:723-728.
17. Karpus WJ, Lukacs NW, Kennedy KJ, Smith WS, Hurst SD, Barrett TA: Differential CC chemokine-induced enhancement of T helper cell cytokine production. J Immunol 1997, 158:4129-4136.
18. Lloyd C: Chemokines in allergic lung inflammation. Immunology 2002, 105:144-154.
19. Lu B, Rutledge BJ, Gu L, Fiorillo J, Lukacs NW, Kunkel SL, North R, Gerard C, Rollins BJ: Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med 1998, 187:601-608.
20. Gu L, Tseng S, Horner RM, Tam C, Loda M, Rollins BJ: Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature 2000, 404:407-411.
21. Boring L, Gosling J, Chensue SW, Kunkel SL, Farese RV Jr, Broxmeyer HE, Charo IF: Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest 1997, 100:2552-2561.
22. Traynor TR, Kuziel WA, Toews GB, Huffnagle GB: CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infection. J Immunol 2000, 164:2021-2027.
23. Traynor TR, Herring AC, Dorf ME, Kuziel WA, Toews GB, Huffnagle GB: Differential roles of CC chemokine ligand 2/monocyte chemotactic protein-1 and CCR2 in the development of T1 immunity. J Immunol 2002, 168:4659-4666.
24. Warmington KS, Boring L, Ruth JH, Sonstein J, Hogaboam CM, Curtis JL, Kunkel SL, Charo IR, Chensue SW: Effect of C-C chemokine receptor 2 (CCR2) knockout on type-2 (schistosomal antigen-elicited) pulmonary granuloma formation: analysis of cellular recruitment and cytokine responses. Am J Pathol 1999, 154:1407-1416.
25. Kim Y, Sung S, Kuziel WA, Feldman S, Fu SM, Rose CE Jr: Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2). J Immunol 2001, 166:5183-5192.
26. MacLean JA, De Sanctis GT, Ackerman KG, Drazen JM, Sauty A, DeHaan E, Green FH, Charo IF, Luster AD: CC chemokine receptor-2 is not essential for the development of antigen-induced pulmonary eosinophilia and airway hyperresponsiveness. J Immunol 2000, 165:6568-6575.
27. Campbell EM, Charo IF, Kunkel SL, Strieter RM, Boring L, Gosling J, Lukacs NW: Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. J Immunol 1999, 163:2160-2167.
28. Blease K, Mehrad B, Standiford TJ, Lukacs NW, Gosling J, Boring L, Charo IF, Kunkel SL, Hogaboam CM: Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice. J Immunol 2000, 165:2603-2611.
29. Blease K, Mehrad B, Lukacs NW, Kunkel SL, Standiford TJ, Hogaboam CM: Antifungal and airway remodeling roles for murine monocyte chemoattractant protein-1/CCL2 during pulmonary exposure to Asperigillus fumigatus conidia. J Immunol 2001, 166:1832-1842.
30. Corry DB, Grunig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM: Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. Mol Med 1998, 4:344-355.
31. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ: Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002, 8:885-889.
32. Ihaka R, Gentleman R: R: A language for data analysis and graphics. Journal of Computational and Graphical Statistics 1996, 5:299-314.
33. Gonzalo JA, Lloyd CM, Wen D, Albar JP, Wells TN, Proudfoot A, Martinez AC, Dorf M, Bjerke T, Coyle AJ, Gutierrez-Ramos JC: The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J Exp Med 1998, 188:157-167.
34. Kuziel WA, Morgan SJ, Dawson TC, Griffin S, Smithies O, Ley K, Maeda N: Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc Natl Acad Sci U S A 1997, 94:12053-12058.
35. Kurihara T, Warr G, Loy J, Bravo R: Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J Exp Med 1997, 186:1757-1762.
36. Takeda K, Hamelmann E, Joetham A, Shultz LD, Larsen GL, Irvin CG, Gelfand EW: Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J Exp Med 1997, 186:449-454.
37. Zhang Y, Lamm WJ, Albert RK, Chi EY, Henderson WR Jr, Lewis DB: Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response. Am J Respir Crit Care Med 1997, 155:661-669.
38. Schuyler M, Gott K, Cherne A: Experimental hypersensitivity pneumonitis:role of MCP-1. J Lab Clin Med 2003, 142:187-195.
39. Maus UA, Waelsch K, Kuziel WA, Delbeck T, Mack M, Blackwell TS, Christman JW, Schlondorff D, Seeger W, Lohmeyer J: Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis. J Immunol 2003, 170:3273-3278.
40. Rutledge BJ, Rayburn H, Rosenberg R, North RJ, Gladue RP, Corless CL, Rollins BJ: High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens. J Immunol 1995, 155:4838-4843.
41. Fuentes ME, Durham SK, Swerdel MR, Lewin AC, Barton DS, Megill JR, Bravo R, Lira SA: Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1. J Immunol 1995, 155:5769-5776.
42. Gunn MD, Nelken NA, Liao X, Williams LT: Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation. J Immunol 1997, 158:376-383.
43. Zimmermann N, King NE, Laporte J, Yang M, Mishra A, Pope SM, Muntel EE, Witte DP, Pegg AA, Foster PS, Hamid Q, Rothenberg ME: Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest 2003, 111:1863-1874.
44. Chensue SW, Warmington KS, Ruth JH, Sanghi PS, Lincoln P, Kunkel SL: Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigeninduced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production. J Immunol 1996, 157:4602-4608.
45. Nakajima H, Kobayashi M, Pollard RB, Suzuki F: Monocyte chemoattractant protein-1 enhances HSV-induced encephalomyelitis by stimulating Th2 responses. J Leukoc Biol 2001, 70:374-380.
46. Schecter AD, Berman AB, Yi L, Ma H, Daly CM, Soejima K, Rollins BJ, Charo IF, Taubman MB: MCP-1-dependent signaling in CCR2(-/-)aortic smooth muscle cells. J Leukoc Biol 2004, 75:1079-1085.
47. Gharaee-Kermani M, Denholm EM, Phan SH: Costimulation of fibroblast collagen and transforming growth factor beta 1 gene expression by monocyte chemoattractant protein-1 via specific receptors. J Biol Chem 1996, 271:17779-17784.
48. Moore BB, Paine R 3rd, Christensen PJ, Moore TA, Sitterding S, Ngan R, Wilke CA, Kuziel WA, Toews GB: Protection from pulmonary fibrosis in the absence of CCR2 signaling. J Immunol 2001, 167:4368-4377.
49. Zhu Z, Ma B, Zheng T, Homer RJ, Lee CG, Charo IF, Noble P, Elias JA: IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 2002, 168:2953-2962.
50. Hao H, Cohen DA, Jennings CD, Bryson JS, Kaplan AM: Bleomycininduced pulmonary fibrosis is independent of eosinophils. J Leukoc Biol 2000, 68:515-521.